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BMC Neurology

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Open Access 01-12-2024 | Spinal Muscular Atrophy | Case Report

Spinal adhesive arachnoiditis in an adult patient with spinal muscular atrophy type 3 treated with intrathecal therapy

Authors: Jakub Ubysz, Magdalena Koszewicz, Joanna Bladowska, Slawomir Budrewicz

Published in: BMC Neurology | Issue 1/2024

Abstract

Background

Spinal adhesive arachnoiditis is a chronic inflammatory process of the leptomeninges and intrathecal neural elements. The possible causes of arachnoiditis are: infections, injuries of spinal cord, surgical procedures and intrathecal administration of therapeutic substances or contrast.

Case presentation

We present a case of 56-old woman with spinal muscular atrophy type 3 who developed a severe back pain in the lumbosacral region after the fifth dose of nusinersen given intrathecally. Magnetic resonance of lumbosacral spine showed spinal adhesive arachnoiditis. She received high doses of methylprednisolone intravenously, and later non-steroidal anti-inflammatory drugs, alpha lipoic acid, vitamins and rehabilitation with slight improvement.

Conclusions

The authors summarize that scheduled resonance imaging of the lumbosacral spine may be an important element of the algorithm in the monitoring of novel, intrathecal therapy in patients with spinal muscular atrophy.

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Title: Spinal adhesive arachnoiditis in an adult patient with spinal muscular atrophy type 3 treated with intrathecal therapy
Authors: Jakub Ubysz
Magdalena Koszewicz
Joanna Bladowska
Slawomir Budrewicz
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: Spinal Muscular Atrophy
Magnetic Resonance Imaging
Magnetic Resonance Imaging
Back Pain
Back Pain
Back Pain
Published in: BMC Neurology / Issue 1/2024
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-024-03543-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Spinal adhesive arachnoiditis in an adult patient with spinal muscular atrophy type 3 treated with intrathecal therapy

Abstract

Background

Case presentation

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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