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Journal of Assisted Reproduction and Genetics

30-04-2024 | Polycystic Ovary Syndrome | Reproductive physiology and disease

The effect of bariatric surgery on polycystic ovary syndrome patients’ obstetric and neonatal outcomes: a population-based study

Authors: Alyssa Hochberg, Mohammed S. Bazarah, Haitham A. Baghlaf, Ahmad M. Badeghiesh, Michael H. Dahan

Published in: Journal of Assisted Reproduction and Genetics

Abstract

Purpose

To examine the effect of bariatric surgery (BS) on obstetric and neonatal outcomes in patients with polycystic ovary syndrome (PCOS).

Methods

A retrospective population-based cohort study utilizing the Healthcare Cost and Utilization Project Nationwide Inpatient Sample database, including women who delivered in the third trimester or had a maternal death in the USA (2004–2014). We compared obstetric and neonatal outcomes between groups in three analyses: (1) Primary analysis—women with an ICD-9 PCOS diagnosis who underwent BS compared to pregnant PCOS patients without BS. (2) Sub-group analysis—PCOS women with BS compared to obese PCOS women (body mass index (BMI) ≥ 30 kg/m²) without BS. (3) Women with and without PCOS who underwent BS.

Result

In the primary analysis, pregnant PCOS women who underwent BS (N = 141), compared to pregnant PCOS women without BS (N = 14,741), were less likely to develop pregnancy-induced hypertension (PIH) (9.2% vs. 16.2%, respectively, aOR 0.39, 95% CI 0.21–0.72) and gestational diabetes mellitus (GDM) (9.9% vs. 18.8, aOR 0.40, 95% CI 0.23–0.70). In the sub-group analysis, PCOS women with BS, compared to obese PCOS women without BS (N = 3231), were less likely to develop gestational hypertension, preeclampsia, and preeclampsia or eclampsia superimposed on hypertension (P < 0.05). Lastly, PCOS patients with BS had a higher cesarean section rate when compared to non-PCOS patients with BS (N = 9197) (61.7% vs. 49.2%, aOR 1.48, 95% CI 1.05–2.09), with otherwise comparable obstetric and neonatal outcomes.

Conclusions

BS in PCOS patients was associated with reduced risks for GDM and PIH when compared to PCOS controls without BS and reduced risk for gestational hypertension, preeclampsia, and preeclampsia or eclampsia superimposed on hypertension when compared to obese PCOS controls without BS. Moreover, BS was associated with reduced inherent pregnancy risks of PCOS, almost equating them to those of non-PCOS counterparts.

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Title: The effect of bariatric surgery on polycystic ovary syndrome patients’ obstetric and neonatal outcomes: a population-based study
Authors: Alyssa Hochberg
Mohammed S. Bazarah
Haitham A. Baghlaf
Ahmad M. Badeghiesh
Michael H. Dahan
Publication date: 30-04-2024
Publisher: Springer US
Keywords: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome
Bariatric Surgery
Bariatric Surgery
Sectio Caesarea
Sectio Ceasarea
Gestational Diabetes
Gestational Diabetes
Pre-Eclampsia
Hypertension
Hypertension
Published in: Journal of Assisted Reproduction and Genetics
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-024-03123-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The effect of bariatric surgery on polycystic ovary syndrome patients’ obstetric and neonatal outcomes: a population-based study

Abstract

Purpose

Methods

Result

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Result

Conclusions

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