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Open Access 01-12-2021 | Polycystic Ovary Syndrome | Review

Uric acid participating in female reproductive disorders: a review

Authors: Junhao Hu, Wenyi Xu, Haiyan Yang, Liangshan Mu

Published in: Reproductive Biology and Endocrinology | Issue 1/2021

Abstract

Uric acid (UA) is the end metabolic product of purine metabolism. Early on, UA was considered to be a metabolite with a certain antioxidant capacity. As research has progressed, other properties of UA have been explored, and its association with many diseases has been found. The association between UA and kidney disease and cardiovascular disease is well established; however, there is still a paucity of reviews on the association between UA and the female reproductive system. An increasing number of epidemiological studies have shown elevated serum UA levels in patients with polycystic ovary syndrome (PCOS), endometriosis, etc. Additionally, serum UA can be used as a predictor of pregnancy complications and adverse foetal outcomes. An increasing number of animal experiments and clinical studies have revealed possible mechanisms related to the involvement of UA in certain female reproductive disorders: oxidative stress, chronic inflammation, mitochondrial dysfunction, etc. This article reviews the current mainstream mechanisms regarding the pathogenesis of UA and the role of UA in certain specific female reproductive disorders (direct involvement in the development of certain diseases or enhancement of other risk factors) in the hope of contributing to clinical prevention, diagnosis, treatment and improvement in prognosis.

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Title: Uric acid participating in female reproductive disorders: a review
Authors: Junhao Hu
Wenyi Xu
Haiyan Yang
Liangshan Mu
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Polycystic Ovary Syndrome
Endometriosis
Pre-Eclampsia
Polycystic Ovary Syndrome
Published in: Reproductive Biology and Endocrinology / Issue 1/2021
Electronic ISSN: 1477-7827
DOI: https://doi.org/10.1186/s12958-021-00748-7

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Uric acid participating in female reproductive disorders: a review

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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