Skip to main content
Top
Published in: Journal of Clinical Immunology 3/2022

01-04-2022 | Pneumonia | Original Article

Autoantibodies Neutralizing Type I Interferons in 20% of COVID-19 Deaths in a French Hospital

Authors: Angélique Chauvineau-Grenier, Paul Bastard, Antoine Servajean, Adrian Gervais, Jérémie Rosain, Emmanuelle Jouanguy, Aurélie Cobat, Jean-Laurent Casanova, Benjamin Rossi

Published in: Journal of Clinical Immunology | Issue 3/2022

Login to get access

Abstract

Recent studies reported the presence of pre-existing autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) in at least 15% of patients with critical COVID-19 pneumonia. In one study, these auto-Abs were found in almost 20% of deceased patients across all ages. We aimed to assess the prevalence and clinical impact of the auto-Abs to type I IFNs in the Seine-Saint-Denis district, which was one of the most affected areas by COVID-19 in France during the first wave. We tested for the presence of auto-Abs neutralizing type I IFNs in a cohort of patients admitted for critical COVID-19 pneumonia during the first wave in the spring of 2020 in the medicine departments at Robert Ballanger Hospital, Aulnay sous Bois. We found circulating auto-Abs that neutralized 100 pg/mL IFN-α2 and/or IFN-ω in the plasma (diluted 1/10) of 7.9% (11 of 139) of the patients hospitalized for critical COVID-19. The presence of neutralizing auto-Abs was associated with an increased risk of mortality, as these auto-Abs were detected in 21% of patients who died from COVID-19 pneumonia. Deceased patients with and without auto-Abs did not present overt clinical differences. These results confirm both the importance of type I IFN immunity in host defense against SARS-CoV-2 infection and the usefulness of detection of auto-Abs neutralizing type I IFNs in the management of patients.
Literature
3.
go back to reference Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J, Ogishi M, Sabli IKD, Hodeib S, Korol C, Rosain J, Bilguvar K, Ye J, Bolze A, Bigio B, Yang R, Arias AA, Zhou Q, Zhang Y, Onodi F, Korniotis S, Karpf L, Philippot Q, Chbihi M, Bonnet-Madin L, Dorgham K, Smith N, Schneider WM, Razooky BS, Hoffmann H-H, Michailidis E, Moens L, Han JE, Lorenzo L, Bizien L, Meade P, Neehus A-L, Ugurbil AC, Corneau A, Kerner G, Zhang P, Rapaport F, Seeleuthner Y, Manry J, Masson C, Schmitt Y, Schlüter A, Le Voyer T, Khan T, Li J, Fellay J, Roussel L, Shahrooei M, Alosaimi MF, Mansouri D, Al-Saud H, Al-Mulla F, Almourfi F, Al-Muhsen, S. Z.; Alsohime, F.; Al Turki, S.; Hasanato, R.; van de Beek, D.; Biondi, A.; Bettini, L. R.; D’Angio’, M.; Bonfanti, P.; Imberti, L.; Sottini, A.; Paghera, S.; Quiros-Roldan, E.; Rossi, C.; Oler, A. J.; Tompkins, M. F.; Alba, C.; Vandernoot, I.; Goffard, J.-C.; Smits, G.; Migeotte, I.; Haerynck, F.; Soler-Palacin, P.; Martin-Nalda, A.; Colobran, R.; Morange, P.-E.; Keles, S.; Çölkesen, F.; Ozcelik, T.; Yasar, K. K.; Senoglu, S.; Karabela, Ş. N.; Rodríguez-Gallego, C.; Novelli, G.; Hraiech, S.; Tandjaoui-Lambiotte, Y.; Duval, X.; Laouénan, C.; COVID-STORM Clinicians†; COVID Clinicians†; Imagine COVID Group†; French COVID Cohort Study Group†; CoV-Contact Cohort†; Amsterdam UMC Covid-19 Biobank†; COVID Human Genetic Effort†; NIAID-USUHS/TAGC COVID Immunity Group†; Snow, A. L.; Dalgard, C. L.; Milner, J. D.; Vinh, D. C.; Mogensen, T. H.; Marr, N.; Spaan, A. N.; Boisson, B.; Boisson-Dupuis, S.; Bustamante, J.; Puel, A.; Ciancanelli, M. J.; Meyts, I.; Maniatis, T.; Soumelis, V.; Amara, A.; Nussenzweig, M.; García-Sastre, A.; Krammer, F.; Pujol, A.; Duffy, D.; Lifton, R. P.; Zhang, S.-Y.; Gorochov, G.; Béziat, V.; Jouanguy, E.; Sancho-Shimizu, V.; Rice, C. M.; Abel, L.; Notarangelo, L. D.; Cobat, A.; Su, H. C.; Casanova, J.-L. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science 2020; 370(6515), eabd4570. https://doi.org/10.1126/science.abd4570. Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J, Ogishi M, Sabli IKD, Hodeib S, Korol C, Rosain J, Bilguvar K, Ye J, Bolze A, Bigio B, Yang R, Arias AA, Zhou Q, Zhang Y, Onodi F, Korniotis S, Karpf L, Philippot Q, Chbihi M, Bonnet-Madin L, Dorgham K, Smith N, Schneider WM, Razooky BS, Hoffmann H-H, Michailidis E, Moens L, Han JE, Lorenzo L, Bizien L, Meade P, Neehus A-L, Ugurbil AC, Corneau A, Kerner G, Zhang P, Rapaport F, Seeleuthner Y, Manry J, Masson C, Schmitt Y, Schlüter A, Le Voyer T, Khan T, Li J, Fellay J, Roussel L, Shahrooei M, Alosaimi MF, Mansouri D, Al-Saud H, Al-Mulla F, Almourfi F, Al-Muhsen, S. Z.; Alsohime, F.; Al Turki, S.; Hasanato, R.; van de Beek, D.; Biondi, A.; Bettini, L. R.; D’Angio’, M.; Bonfanti, P.; Imberti, L.; Sottini, A.; Paghera, S.; Quiros-Roldan, E.; Rossi, C.; Oler, A. J.; Tompkins, M. F.; Alba, C.; Vandernoot, I.; Goffard, J.-C.; Smits, G.; Migeotte, I.; Haerynck, F.; Soler-Palacin, P.; Martin-Nalda, A.; Colobran, R.; Morange, P.-E.; Keles, S.; Çölkesen, F.; Ozcelik, T.; Yasar, K. K.; Senoglu, S.; Karabela, Ş. N.; Rodríguez-Gallego, C.; Novelli, G.; Hraiech, S.; Tandjaoui-Lambiotte, Y.; Duval, X.; Laouénan, C.; COVID-STORM Clinicians†; COVID Clinicians†; Imagine COVID Group†; French COVID Cohort Study Group†; CoV-Contact Cohort†; Amsterdam UMC Covid-19 Biobank†; COVID Human Genetic Effort†; NIAID-USUHS/TAGC COVID Immunity Group†; Snow, A. L.; Dalgard, C. L.; Milner, J. D.; Vinh, D. C.; Mogensen, T. H.; Marr, N.; Spaan, A. N.; Boisson, B.; Boisson-Dupuis, S.; Bustamante, J.; Puel, A.; Ciancanelli, M. J.; Meyts, I.; Maniatis, T.; Soumelis, V.; Amara, A.; Nussenzweig, M.; García-Sastre, A.; Krammer, F.; Pujol, A.; Duffy, D.; Lifton, R. P.; Zhang, S.-Y.; Gorochov, G.; Béziat, V.; Jouanguy, E.; Sancho-Shimizu, V.; Rice, C. M.; Abel, L.; Notarangelo, L. D.; Cobat, A.; Su, H. C.; Casanova, J.-L. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science 2020; 370(6515), eabd4570. https://​doi.​org/​10.​1126/​science.​abd4570.
4.
go back to reference Asano, T.; Boisson, B.; Onodi, F.; Matuozzo, D.; Moncada-Velez, M.; Maglorius Renkilaraj, M. R. L.; Zhang, P.; Meertens, L.; Bolze, A.; Materna, M.; Korniotis, S.; Gervais, A.; Talouarn, E.; Bigio, B.; Seeleuthner, Y.; Bilguvar, K.; Zhang, Y.; Neehus, A.-L.; Ogishi, M.; Pelham, S. J.; Le Voyer, T.; Rosain, J.; Philippot, Q.; Soler-Palacín, P.; Colobran, R.; Martin-Nalda, A.; Rivière, J. G.; Tandjaoui-Lambiotte, Y.; Chaïbi, K.; Shahrooei, M.; Darazam, I. A.; Olyaei, N. A.; Mansouri, D.; Hatipoğlu, N.; Palabiyik, F.; Ozcelik, T.; Novelli, G.; Novelli, A.; Casari, G.; Aiuti, A.; Carrera, P.; Bondesan, S.; Barzaghi, F.; Rovere-Querini, P.; Tresoldi, C.; Franco, J. L.; Rojas, J.; Reyes, L. F.; Bustos, I. G.; Arias, A. A.; Morelle, G.; Christèle, K.; Troya, J.; Planas-Serra, L.; Schlüter, A.; Gut, M.; Pujol, A.; Allende, L. M.; Rodriguez-Gallego, C.; Flores, C.; Cabrera-Marante, O.; Pleguezuelo, D. E.; de Diego, R. P.; Keles, S.; Aytekin, G.; Akcan, O. M.; Bryceson, Y. T.; Bergman, P.; Brodin, P.; Smole, D.; Smith, C. I. E.; Norlin, A.-C.; Campbell, T. M.; Covill, L. E.; Hammarström, L.; Pan-Hammarström, Q.; Abolhassani, H.; Mane, S.; Marr, N.; Ata, M.; Al Ali, F.; Khan, T.; Spaan, A. N.; Dalgard, C. L.; Bonfanti, P.; Biondi, A.; Tubiana, S.; Burdet, C.; Nussbaum, R.; Kahn-Kirby, A.; Snow, A. L.; COVID Human Genetic Effort†; COVID-STORM Clinicians†; COVID Clinicians†; Imagine COVID Group†; French COVID Cohort Study Group†; CoV-Contact Cohort†; Amsterdam UMC Covid-19; Biobank†; NIAID-USUHS COVID Study Group†; Bustamante, J.; Puel, A.; Boisson-Dupuis, S.; Zhang, S.-Y.; Béziat, V.; Lifton, R. P.; Bastard, P.; Notarangelo, L. D.; Abel, L.; Su, H. C.; Jouanguy, E.; Amara, A.; Soumelis, V.; Cobat, A.; Zhang, Q.; Casanova, J.-L. X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19. Sci. Immunol. 2021, 6 (62), eabl4348. https://doi.org/10.1126/sciimmunol.abl4348. Asano, T.; Boisson, B.; Onodi, F.; Matuozzo, D.; Moncada-Velez, M.; Maglorius Renkilaraj, M. R. L.; Zhang, P.; Meertens, L.; Bolze, A.; Materna, M.; Korniotis, S.; Gervais, A.; Talouarn, E.; Bigio, B.; Seeleuthner, Y.; Bilguvar, K.; Zhang, Y.; Neehus, A.-L.; Ogishi, M.; Pelham, S. J.; Le Voyer, T.; Rosain, J.; Philippot, Q.; Soler-Palacín, P.; Colobran, R.; Martin-Nalda, A.; Rivière, J. G.; Tandjaoui-Lambiotte, Y.; Chaïbi, K.; Shahrooei, M.; Darazam, I. A.; Olyaei, N. A.; Mansouri, D.; Hatipoğlu, N.; Palabiyik, F.; Ozcelik, T.; Novelli, G.; Novelli, A.; Casari, G.; Aiuti, A.; Carrera, P.; Bondesan, S.; Barzaghi, F.; Rovere-Querini, P.; Tresoldi, C.; Franco, J. L.; Rojas, J.; Reyes, L. F.; Bustos, I. G.; Arias, A. A.; Morelle, G.; Christèle, K.; Troya, J.; Planas-Serra, L.; Schlüter, A.; Gut, M.; Pujol, A.; Allende, L. M.; Rodriguez-Gallego, C.; Flores, C.; Cabrera-Marante, O.; Pleguezuelo, D. E.; de Diego, R. P.; Keles, S.; Aytekin, G.; Akcan, O. M.; Bryceson, Y. T.; Bergman, P.; Brodin, P.; Smole, D.; Smith, C. I. E.; Norlin, A.-C.; Campbell, T. M.; Covill, L. E.; Hammarström, L.; Pan-Hammarström, Q.; Abolhassani, H.; Mane, S.; Marr, N.; Ata, M.; Al Ali, F.; Khan, T.; Spaan, A. N.; Dalgard, C. L.; Bonfanti, P.; Biondi, A.; Tubiana, S.; Burdet, C.; Nussbaum, R.; Kahn-Kirby, A.; Snow, A. L.; COVID Human Genetic Effort†; COVID-STORM Clinicians†; COVID Clinicians†; Imagine COVID Group†; French COVID Cohort Study Group†; CoV-Contact Cohort†; Amsterdam UMC Covid-19; Biobank†; NIAID-USUHS COVID Study Group†; Bustamante, J.; Puel, A.; Boisson-Dupuis, S.; Zhang, S.-Y.; Béziat, V.; Lifton, R. P.; Bastard, P.; Notarangelo, L. D.; Abel, L.; Su, H. C.; Jouanguy, E.; Amara, A.; Soumelis, V.; Cobat, A.; Zhang, Q.; Casanova, J.-L. X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19. Sci. Immunol. 2021, 6 (62), eabl4348. https://​doi.​org/​10.​1126/​sciimmunol.​abl4348.
5.
go back to reference Bastard, P.; Rosen, L. B.; Zhang, Q.; Michailidis, E.; Hoffmann, H.-H.; Zhang, Y.; Dorgham, K.; Philippot, Q.; Rosain, J.; Béziat, V.; Manry, J.; Shaw, E.; Haljasmägi, L.; Peterson, P.; Lorenzo, L.; Bizien, L.; Trouillet-Assant, S.; Dobbs, K.; de Jesus, A. A.; Belot, A.; Kallaste, A.; Catherinot, E.; Tandjaoui-Lambiotte, Y.; Le Pen, J.; Kerner, G.; Bigio, B.; Seeleuthner, Y.; Yang, R.; Bolze, A.; Spaan, A. N.; Delmonte, O. M.; Abers, M. S.; Aiuti, A.; Casari, G.; Lampasona, V.; Piemonti, L.; Ciceri, F.; Bilguvar, K.; Lifton, R. P.; Vasse, M.; Smadja, D. M.; Migaud, M.; Hadjadj, J.; Terrier, B.; Duffy, D.; Quintana-Murci, L.; van de Beek, D.; Roussel, L.; Vinh, D. C.; Tangye, S. G.; Haerynck, F.; Dalmau, D.; Martinez-Picado, J.; Brodin, P.; Nussenzweig, M. C.; Boisson-Dupuis, S.; Rodríguez-Gallego, C.; Vogt, G.; Mogensen, T. H.; Oler, A. J.; Gu, J.; Burbelo, P. D.; Cohen, J. I.; Biondi, A.; Bettini, L. R.; D’Angio, M.; Bonfanti, P.; Rossignol, P.; Mayaux, J.; Rieux-Laucat, F.; Husebye, E. S.; Fusco, F.; Ursini, M. V.; Imberti, L.; Sottini, A.; Paghera, S.; Quiros-Roldan, E.; Rossi, C.; Castagnoli, R.; Montagna, D.; Licari, A.; Marseglia, G. L.; Duval, X.; Ghosn, J.; HGID Lab§; NIAID-USUHS Immune Response to COVID Group§; COVID Clinicians§; COVID-STORM Clinicians§; Imagine COVID Group§; French COVID Cohort Study Group§; The Milieu Intérieur Consortium§; CoV-Contact Cohort§; Amsterdam UMC Covid-19 Biobank§; COVID Human Genetic Effort§; Tsang, J. S.; Goldbach-Mansky, R.; Kisand, K.; Lionakis, M. S.; Puel, A.; Zhang, S.-Y.; Holland, S. M.; Gorochov, G.; Jouanguy, E.; Rice, C. M.; Cobat, A.; Notarangelo, L. D.; Abel, L.; Su, H. C.; Casanova, J.-L. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science 2020, 370 (6515), eabd4585. https://doi.org/10.1126/science.abd4585. Bastard, P.; Rosen, L. B.; Zhang, Q.; Michailidis, E.; Hoffmann, H.-H.; Zhang, Y.; Dorgham, K.; Philippot, Q.; Rosain, J.; Béziat, V.; Manry, J.; Shaw, E.; Haljasmägi, L.; Peterson, P.; Lorenzo, L.; Bizien, L.; Trouillet-Assant, S.; Dobbs, K.; de Jesus, A. A.; Belot, A.; Kallaste, A.; Catherinot, E.; Tandjaoui-Lambiotte, Y.; Le Pen, J.; Kerner, G.; Bigio, B.; Seeleuthner, Y.; Yang, R.; Bolze, A.; Spaan, A. N.; Delmonte, O. M.; Abers, M. S.; Aiuti, A.; Casari, G.; Lampasona, V.; Piemonti, L.; Ciceri, F.; Bilguvar, K.; Lifton, R. P.; Vasse, M.; Smadja, D. M.; Migaud, M.; Hadjadj, J.; Terrier, B.; Duffy, D.; Quintana-Murci, L.; van de Beek, D.; Roussel, L.; Vinh, D. C.; Tangye, S. G.; Haerynck, F.; Dalmau, D.; Martinez-Picado, J.; Brodin, P.; Nussenzweig, M. C.; Boisson-Dupuis, S.; Rodríguez-Gallego, C.; Vogt, G.; Mogensen, T. H.; Oler, A. J.; Gu, J.; Burbelo, P. D.; Cohen, J. I.; Biondi, A.; Bettini, L. R.; D’Angio, M.; Bonfanti, P.; Rossignol, P.; Mayaux, J.; Rieux-Laucat, F.; Husebye, E. S.; Fusco, F.; Ursini, M. V.; Imberti, L.; Sottini, A.; Paghera, S.; Quiros-Roldan, E.; Rossi, C.; Castagnoli, R.; Montagna, D.; Licari, A.; Marseglia, G. L.; Duval, X.; Ghosn, J.; HGID Lab§; NIAID-USUHS Immune Response to COVID Group§; COVID Clinicians§; COVID-STORM Clinicians§; Imagine COVID Group§; French COVID Cohort Study Group§; The Milieu Intérieur Consortium§; CoV-Contact Cohort§; Amsterdam UMC Covid-19 Biobank§; COVID Human Genetic Effort§; Tsang, J. S.; Goldbach-Mansky, R.; Kisand, K.; Lionakis, M. S.; Puel, A.; Zhang, S.-Y.; Holland, S. M.; Gorochov, G.; Jouanguy, E.; Rice, C. M.; Cobat, A.; Notarangelo, L. D.; Abel, L.; Su, H. C.; Casanova, J.-L. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science 2020, 370 (6515), eabd4585. https://​doi.​org/​10.​1126/​science.​abd4585.
6.
go back to reference Koning, R.; Bastard, P.; Casanova, J.-L.; Brouwer, M. C.; van de Beek, D.; with the Amsterdam U.M.C. COVID-19 Biobank Investigators; van Agtmael, M.; Algera, A. G.; Appelman, B.; van Baarle, F.; Bax, D.; Beudel, M.; Bogaard, H. J.; Bomers, M.; Bonta, P.; Bos, L.; Botta, M.; de Brabander, J.; Bree, G.; de Bruin, S.; Bugiani, M.; Bulle, E.; Chekrouni, N.; Chouchane, O.; Cloherty, A.; Dongelmans, D. A.; Dujardin, R. W. G.; Elbers, P.; Fleuren, L.; Geerlings, S.; Geijtenbeek, T.; Girbes, A.; Goorhuis, B.; Grobusch, M. P.; Hafkamp, F.; Hagens, L.; Hamann, J.; Harris, V.; Hemke, R.; Hermans, S. M.; Heunks, L.; Hollmann, M.; Horn, J.; Hovius, J. W.; de Jong, M. D.; Koning, R.; Lim, E. H. T.; van Mourik, N.; Nellen, J.; Nossent, E. J.; Olie, S.; Paulus, F.; Peters, E.; van der Poll, T.; Preckel, B.; Prins, J. M.; Raasveld, J.; Reijnders, T.; Schinkel, M.; Schultz, M. J.; Schuurmans, A.; Schuurmans, J.; Sigaloff, K.; Slim, M. A.; Smit, M.; Stijnis, C. S.; Stilma, W.; Teunissen, C.; Thoral, P.; Tsonas, A. M.; van der Valk, M.; Veelo, D.; de Vries, H.; Vught, L. A.; van Vugt, M.; Wouters, D.; Zwinderman, A. H.; Brouwer, M. C.; Wiersinga, W. J.; Vlaar, A. P. J.; van de Beek, D. Autoantibodies against type I interferons are associated with multi-organ failure in COVID-19 patients. Intensive Care Med. 2021, 47 (6), 704–706. https://doi.org/10.1007/s00134-021-06392-4. Koning, R.; Bastard, P.; Casanova, J.-L.; Brouwer, M. C.; van de Beek, D.; with the Amsterdam U.M.C. COVID-19 Biobank Investigators; van Agtmael, M.; Algera, A. G.; Appelman, B.; van Baarle, F.; Bax, D.; Beudel, M.; Bogaard, H. J.; Bomers, M.; Bonta, P.; Bos, L.; Botta, M.; de Brabander, J.; Bree, G.; de Bruin, S.; Bugiani, M.; Bulle, E.; Chekrouni, N.; Chouchane, O.; Cloherty, A.; Dongelmans, D. A.; Dujardin, R. W. G.; Elbers, P.; Fleuren, L.; Geerlings, S.; Geijtenbeek, T.; Girbes, A.; Goorhuis, B.; Grobusch, M. P.; Hafkamp, F.; Hagens, L.; Hamann, J.; Harris, V.; Hemke, R.; Hermans, S. M.; Heunks, L.; Hollmann, M.; Horn, J.; Hovius, J. W.; de Jong, M. D.; Koning, R.; Lim, E. H. T.; van Mourik, N.; Nellen, J.; Nossent, E. J.; Olie, S.; Paulus, F.; Peters, E.; van der Poll, T.; Preckel, B.; Prins, J. M.; Raasveld, J.; Reijnders, T.; Schinkel, M.; Schultz, M. J.; Schuurmans, A.; Schuurmans, J.; Sigaloff, K.; Slim, M. A.; Smit, M.; Stijnis, C. S.; Stilma, W.; Teunissen, C.; Thoral, P.; Tsonas, A. M.; van der Valk, M.; Veelo, D.; de Vries, H.; Vught, L. A.; van Vugt, M.; Wouters, D.; Zwinderman, A. H.; Brouwer, M. C.; Wiersinga, W. J.; Vlaar, A. P. J.; van de Beek, D. Autoantibodies against type I interferons are associated with multi-organ failure in COVID-19 patients. Intensive Care Med. 2021, 47 (6), 704–706. https://​doi.​org/​10.​1007/​s00134-021-06392-4.
9.
go back to reference Goncalves, D.; Mezidi, M.; Bastard, P.; Perret, M.; Saker, K.; Fabien, N.; Pescarmona, R.; Lombard, C.; Walzer, T.; Casanova, J.; Belot, A.; Richard, J.; Trouillet‐Assant, S. Antibodies against type I interferon: detection and association with severe clinical outcome in COVID‐19 patients. Clin. Transl. Immunol. 2021, 10 (8). https://doi.org/10.1002/cti2.1327. Goncalves, D.; Mezidi, M.; Bastard, P.; Perret, M.; Saker, K.; Fabien, N.; Pescarmona, R.; Lombard, C.; Walzer, T.; Casanova, J.; Belot, A.; Richard, J.; Trouillet‐Assant, S. Antibodies against type I interferon: detection and association with severe clinical outcome in COVID‐19 patients. Clin. Transl. Immunol. 2021, 10 (8). https://​doi.​org/​10.​1002/​cti2.​1327.
10.
go back to reference Wang, E. Y.; Mao, T.; Klein, J.; Dai, Y.; Huck, J. D.; Liu, F.; Zheng, N. S.; Zhou, T.; Israelow, B.; Wong, P.; Lucas, C.; Silva, J.; Oh, J. E.; Song, E.; Perotti, E. S.; Fischer, S.; Campbell, M.; Fournier, J. B.; Wyllie, A. L.; Vogels, C. B. F.; Ott, I. M.; Kalinich, C. C.; Petrone, M. E.; Watkins, A. E.; Yale IMPACT Team; Cruz, C. D.; Farhadian, S. F.; Schulz, W. L.; Grubaugh, N. D.; Ko, A. I.; Iwasaki, A.; Ring, A. M. Diverse functional autoantibodies in patients with COVID-19; preprint; Infectious Diseases (except HIV/AIDS), 2020. https://doi.org/10.1101/2020.12.10.20247205. Wang, E. Y.; Mao, T.; Klein, J.; Dai, Y.; Huck, J. D.; Liu, F.; Zheng, N. S.; Zhou, T.; Israelow, B.; Wong, P.; Lucas, C.; Silva, J.; Oh, J. E.; Song, E.; Perotti, E. S.; Fischer, S.; Campbell, M.; Fournier, J. B.; Wyllie, A. L.; Vogels, C. B. F.; Ott, I. M.; Kalinich, C. C.; Petrone, M. E.; Watkins, A. E.; Yale IMPACT Team; Cruz, C. D.; Farhadian, S. F.; Schulz, W. L.; Grubaugh, N. D.; Ko, A. I.; Iwasaki, A.; Ring, A. M. Diverse functional autoantibodies in patients with COVID-19; preprint; Infectious Diseases (except HIV/AIDS), 2020. https://​doi.​org/​10.​1101/​2020.​12.​10.​20247205.
11.
go back to reference van der Wijst, M. G. P.; Vazquez, S. E.; Hartoularos, G. C.; Bastard, P.; Grant, T.; Bueno, R.; Lee, D. S.; Greenland, J. R.; Sun, Y.; Perez, R.; Ogorodnikov, A.; Ward, A.; Mann, S. A.; Lynch, K. L.; Yun, C.; Havlir, D. V.; Chamie, G.; Marquez, C.; Greenhouse, B.; Lionakis, M. S.; Norris, P. J.; Dumont, L. J.; Kelly, K.; Zhang, P.; Zhang, Q.; Gervais, A.; Le Voyer, T.; Whatley, A.; Si, Y.; Byrne, A.; Combes, A. J.; Rao, A. A.; Song, Y. S.; Fragiadakis, G. K.; Kangelaris, K.; Calfee, C. S.; Erle, D. J.; Hendrickson, C.; Krummel, M. F.; Woodruff, P. G.; Langelier, C. R.; Casanova, J.-L.; Derisi, J. L.; Anderson, M. S.; Ye, C. J.; on behalf of the UCSF COMET consortium. Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19. Sci. Transl. Med. 2021, eabh2624. https://doi.org/10.1126/scitranslmed.abh2624. van der Wijst, M. G. P.; Vazquez, S. E.; Hartoularos, G. C.; Bastard, P.; Grant, T.; Bueno, R.; Lee, D. S.; Greenland, J. R.; Sun, Y.; Perez, R.; Ogorodnikov, A.; Ward, A.; Mann, S. A.; Lynch, K. L.; Yun, C.; Havlir, D. V.; Chamie, G.; Marquez, C.; Greenhouse, B.; Lionakis, M. S.; Norris, P. J.; Dumont, L. J.; Kelly, K.; Zhang, P.; Zhang, Q.; Gervais, A.; Le Voyer, T.; Whatley, A.; Si, Y.; Byrne, A.; Combes, A. J.; Rao, A. A.; Song, Y. S.; Fragiadakis, G. K.; Kangelaris, K.; Calfee, C. S.; Erle, D. J.; Hendrickson, C.; Krummel, M. F.; Woodruff, P. G.; Langelier, C. R.; Casanova, J.-L.; Derisi, J. L.; Anderson, M. S.; Ye, C. J.; on behalf of the UCSF COMET consortium. Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19. Sci. Transl. Med. 2021, eabh2624. https://​doi.​org/​10.​1126/​scitranslmed.​abh2624.
12.
go back to reference Lopez J, Mommert M, Mouton W, Pizzorno A, Brengel-Pesce K, Mezidi M, Villard M, Lina B, Richard J-C, Fassier J-B, Cheynet V, Padey B, Duliere V, Julien T, Paul S, Bastard P, Belot A, Bal A, Casanova J-L, Rosa-Calatrava M, Morfin F, Walzer T, Trouillet-Assant S. Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs. J Exp Med. 2021;218(10): e20211211. https://doi.org/10.1084/jem.20211211.CrossRefPubMedPubMedCentral Lopez J, Mommert M, Mouton W, Pizzorno A, Brengel-Pesce K, Mezidi M, Villard M, Lina B, Richard J-C, Fassier J-B, Cheynet V, Padey B, Duliere V, Julien T, Paul S, Bastard P, Belot A, Bal A, Casanova J-L, Rosa-Calatrava M, Morfin F, Walzer T, Trouillet-Assant S. Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs. J Exp Med. 2021;218(10): e20211211. https://​doi.​org/​10.​1084/​jem.​20211211.CrossRefPubMedPubMedCentral
14.
go back to reference Bastard, P.; Gervais, A.; Le Voyer, T.; Rosain, J.; Philippot, Q.; Manry, J.; Michailidis, E.; Hoffmann, H.-H.; Eto, S.; Garcia-Prat, M.; Bizien, L.; Parra-Martínez, A.; Yang, R.; Haljasmägi, L.; Migaud, M.; Särekannu, K.; Maslovskaja, J.; de Prost, N.; Tandjaoui-Lambiotte, Y.; Luyt, C.-E.; Amador-Borrero, B.; Gaudet, A.; Poissy, J.; Morel, P.; Richard, P.; Cognasse, F.; Troya, J.; Trouillet-Assant, S.; Belot, A.; Saker, K.; Garçon, P.; Rivière, J. G.; Lagier, J.-C.; Gentile, S.; Rosen, L. B.; Shaw, E.; Morio, T.; Tanaka, J.; Dalmau, D.; Tharaux, P.-L.; Sene, D.; Stepanian, A.; Megarbane, B.; Triantafyllia, V.; Fekkar, A.; Heath, J. R.; Franco, J. L.; Anaya, J.-M.; Solé-Violán, J.; Imberti, L.; Biondi, A.; Bonfanti, P.; Castagnoli, R.; Delmonte, O. M.; Zhang, Y.; Snow, A. L.; Holland, S. M.; Biggs, C.; Moncada-Vélez, M.; Arias, A. A.; Lorenzo, L.; Boucherit, S.; Coulibaly, B.; Anglicheau, D.; Planas, A. M.; Haerynck, F.; Duvlis, S.; Nussbaum, R. L.; Ozcelik, T.; Keles, S.; Bousfiha, A. A.; El Bakkouri, J.; Ramirez-Santana, C.; Paul, S.; Pan-Hammarström, Q.; Hammarström, L.; Dupont, A.; Kurolap, A.; Metz, C. N.; Aiuti, A.; Casari, G.; Lampasona, V.; Ciceri, F.; Barreiros, L. A.; Dominguez-Garrido, E.; Vidigal, M.; Zatz, M.; van de Beek, D.; Sahanic, S.; Tancevski, I.; Stepanovskyy, Y.; Boyarchuk, O.; Nukui, Y.; Tsumura, M.; Vidaur, L.; Tangye, S. G.; Burrel, S.; Duffy, D.; Quintana-Murci, L.; Klocperk, A.; Kann, N. Y.; Shcherbina, A.; Lau, Y.-L.; Leung, D.; Coulongeat, M.; Marlet, J.; Koning, R.; Reyes, L. F.; Chauvineau-Grenier, A.; Venet, F.; Monneret, G.; Nussenzweig, M. C.; Arrestier, R.; Boudhabhay, I.; Baris-Feldman, H.; Hagin, D.; Wauters, J.; Meyts, I.; Dyer, A. H.; Kennelly, S. P.; Bourke, N. M.; Halwani, R.; Sharif-Askari, N. S.; Dorgham, K.; Sallette, J.; Sedkaoui, S. M.; AlKhater, S.; Rigo-Bonnin, R.; Morandeira, F.; Roussel, L.; Vinh, D. C.; Ostrowski, S. R.; Condino-Neto, A.; Prando, C.; Bonradenko, A.; Spaan, A. N.; Gilardin, L.; Fellay, J.; Lyonnet, S.; Bilguvar, K.; Lifton, R. P.; Mane, S.; HGID Lab§; COVID Clinicians§; COVID-STORM Clinicians§; NIAID Immune Response to COVID Group§; NH-COVAIR Study Group§; Danish CHGE§; Danish Blood Donor Study§; St. James’s Hospital; SARS CoV2 Interest group§; French COVID Cohort Study Group§; Imagine COVID-Group§; The Milieu Intérieur Consortium§; CoV-Contact Cohort§; Amsterdam UMC Covid-19; Biobank Investigators§; COVID Human Genetic Effort§; CONSTANCES cohort§; 3C-Dijon Study§; Cerba Health-Care§; Etablissement du Sang study group§; Anderson, M. S.; Boisson, B.; Béziat, V.; Zhang, S.-Y.; Vandreakos, E.; Hermine, O.; Pujol, A.; Peterson, P.; Mogensen, T. H.; Rowen, L.; Mond, J.; Debette, S.; de Lamballerie, X.; Duval, X.; Mentré, F.; Zins, M.; Soler-Palacin, P.; Colobran, R.; Gorochov, G.; Solanich, X.; Susen, S.; Martinez-Picado, J.; Raoult, D.; Vasse, M.; Gregersen, P. K.; Piemonti, L.; Rodríguez-Gallego, C.; Notarangelo, L. D.; Su, H. C.; Kisand, K.; Okada, S.; Puel, A.; Jouanguy, E.; Rice, C. M.; Tiberghien, P.; Zhang, Q.; Cobat, A.; Abel, L.; Casanova, J.-L. Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths. Sci. Immunol. 2021, 6 (62), eabl4340. https://doi.org/10.1126/sciimmunol.abl4340. Bastard, P.; Gervais, A.; Le Voyer, T.; Rosain, J.; Philippot, Q.; Manry, J.; Michailidis, E.; Hoffmann, H.-H.; Eto, S.; Garcia-Prat, M.; Bizien, L.; Parra-Martínez, A.; Yang, R.; Haljasmägi, L.; Migaud, M.; Särekannu, K.; Maslovskaja, J.; de Prost, N.; Tandjaoui-Lambiotte, Y.; Luyt, C.-E.; Amador-Borrero, B.; Gaudet, A.; Poissy, J.; Morel, P.; Richard, P.; Cognasse, F.; Troya, J.; Trouillet-Assant, S.; Belot, A.; Saker, K.; Garçon, P.; Rivière, J. G.; Lagier, J.-C.; Gentile, S.; Rosen, L. B.; Shaw, E.; Morio, T.; Tanaka, J.; Dalmau, D.; Tharaux, P.-L.; Sene, D.; Stepanian, A.; Megarbane, B.; Triantafyllia, V.; Fekkar, A.; Heath, J. R.; Franco, J. L.; Anaya, J.-M.; Solé-Violán, J.; Imberti, L.; Biondi, A.; Bonfanti, P.; Castagnoli, R.; Delmonte, O. M.; Zhang, Y.; Snow, A. L.; Holland, S. M.; Biggs, C.; Moncada-Vélez, M.; Arias, A. A.; Lorenzo, L.; Boucherit, S.; Coulibaly, B.; Anglicheau, D.; Planas, A. M.; Haerynck, F.; Duvlis, S.; Nussbaum, R. L.; Ozcelik, T.; Keles, S.; Bousfiha, A. A.; El Bakkouri, J.; Ramirez-Santana, C.; Paul, S.; Pan-Hammarström, Q.; Hammarström, L.; Dupont, A.; Kurolap, A.; Metz, C. N.; Aiuti, A.; Casari, G.; Lampasona, V.; Ciceri, F.; Barreiros, L. A.; Dominguez-Garrido, E.; Vidigal, M.; Zatz, M.; van de Beek, D.; Sahanic, S.; Tancevski, I.; Stepanovskyy, Y.; Boyarchuk, O.; Nukui, Y.; Tsumura, M.; Vidaur, L.; Tangye, S. G.; Burrel, S.; Duffy, D.; Quintana-Murci, L.; Klocperk, A.; Kann, N. Y.; Shcherbina, A.; Lau, Y.-L.; Leung, D.; Coulongeat, M.; Marlet, J.; Koning, R.; Reyes, L. F.; Chauvineau-Grenier, A.; Venet, F.; Monneret, G.; Nussenzweig, M. C.; Arrestier, R.; Boudhabhay, I.; Baris-Feldman, H.; Hagin, D.; Wauters, J.; Meyts, I.; Dyer, A. H.; Kennelly, S. P.; Bourke, N. M.; Halwani, R.; Sharif-Askari, N. S.; Dorgham, K.; Sallette, J.; Sedkaoui, S. M.; AlKhater, S.; Rigo-Bonnin, R.; Morandeira, F.; Roussel, L.; Vinh, D. C.; Ostrowski, S. R.; Condino-Neto, A.; Prando, C.; Bonradenko, A.; Spaan, A. N.; Gilardin, L.; Fellay, J.; Lyonnet, S.; Bilguvar, K.; Lifton, R. P.; Mane, S.; HGID Lab§; COVID Clinicians§; COVID-STORM Clinicians§; NIAID Immune Response to COVID Group§; NH-COVAIR Study Group§; Danish CHGE§; Danish Blood Donor Study§; St. James’s Hospital; SARS CoV2 Interest group§; French COVID Cohort Study Group§; Imagine COVID-Group§; The Milieu Intérieur Consortium§; CoV-Contact Cohort§; Amsterdam UMC Covid-19; Biobank Investigators§; COVID Human Genetic Effort§; CONSTANCES cohort§; 3C-Dijon Study§; Cerba Health-Care§; Etablissement du Sang study group§; Anderson, M. S.; Boisson, B.; Béziat, V.; Zhang, S.-Y.; Vandreakos, E.; Hermine, O.; Pujol, A.; Peterson, P.; Mogensen, T. H.; Rowen, L.; Mond, J.; Debette, S.; de Lamballerie, X.; Duval, X.; Mentré, F.; Zins, M.; Soler-Palacin, P.; Colobran, R.; Gorochov, G.; Solanich, X.; Susen, S.; Martinez-Picado, J.; Raoult, D.; Vasse, M.; Gregersen, P. K.; Piemonti, L.; Rodríguez-Gallego, C.; Notarangelo, L. D.; Su, H. C.; Kisand, K.; Okada, S.; Puel, A.; Jouanguy, E.; Rice, C. M.; Tiberghien, P.; Zhang, Q.; Cobat, A.; Abel, L.; Casanova, J.-L. Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths. Sci. Immunol. 2021, 6 (62), eabl4340. https://​doi.​org/​10.​1126/​sciimmunol.​abl4340.
16.
19.
go back to reference Kärner J, Meager A, Laan M, Maslovskaja J, Pihlap M, Remm A, Juronen E, Wolff ASB, Husebye ES, Podkrajšek KT, Bratanic N, Battelino T, Willcox N, Peterson P, Kisand K. Anti-cytokine autoantibodies suggest pathogenetic links with autoimmune regulator deficiency in humans and mice: anti-cytokine autoantibodies in mice and humans. Clin Exp Immunol. 2013;171(3):263–72. https://doi.org/10.1111/cei.12024.CrossRefPubMedPubMedCentral Kärner J, Meager A, Laan M, Maslovskaja J, Pihlap M, Remm A, Juronen E, Wolff ASB, Husebye ES, Podkrajšek KT, Bratanic N, Battelino T, Willcox N, Peterson P, Kisand K. Anti-cytokine autoantibodies suggest pathogenetic links with autoimmune regulator deficiency in humans and mice: anti-cytokine autoantibodies in mice and humans. Clin Exp Immunol. 2013;171(3):263–72. https://​doi.​org/​10.​1111/​cei.​12024.CrossRefPubMedPubMedCentral
20.
go back to reference Bastard P, Orlova E, Sozaeva L, Lévy R, James A, Schmitt MM, Ochoa S, Kareva M, Rodina Y, Gervais A, Le Voyer T, Rosain J, Philippot Q, Neehus A-L, Shaw E, Migaud M, Bizien L, Ekwall O, Berg S, Beccuti G, Ghizzoni L, Thiriez G, Pavot A, Goujard C, Frémond M-L, Carter E, Rothenbuhler A, Linglart A, Mignot B, Comte A, Cheikh N, Hermine O, Breivik L, Husebye ES, Humbert S, Rohrlich P, Coaquette A, Vuoto F, Faure K, Mahlaoui N, Kotnik P, Battelino T, Trebušak Podkrajšek K, Kisand K, Ferré EMN, DiMaggio T, Rosen LB, Burbelo PD, McIntyre M, Kann NY, Shcherbina A, Pavlova M, Kolodkina A, Holland SM, Zhang S-Y, Crow YJ, Notarangelo LD, Su HC, Abel L, Anderson MS, Jouanguy E, Neven B, Puel A, Casanova J-L, Lionakis MS. Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1. J Exp Med. 2021;218(7): e20210554. https://doi.org/10.1084/jem.20210554.CrossRefPubMedPubMedCentral Bastard P, Orlova E, Sozaeva L, Lévy R, James A, Schmitt MM, Ochoa S, Kareva M, Rodina Y, Gervais A, Le Voyer T, Rosain J, Philippot Q, Neehus A-L, Shaw E, Migaud M, Bizien L, Ekwall O, Berg S, Beccuti G, Ghizzoni L, Thiriez G, Pavot A, Goujard C, Frémond M-L, Carter E, Rothenbuhler A, Linglart A, Mignot B, Comte A, Cheikh N, Hermine O, Breivik L, Husebye ES, Humbert S, Rohrlich P, Coaquette A, Vuoto F, Faure K, Mahlaoui N, Kotnik P, Battelino T, Trebušak Podkrajšek K, Kisand K, Ferré EMN, DiMaggio T, Rosen LB, Burbelo PD, McIntyre M, Kann NY, Shcherbina A, Pavlova M, Kolodkina A, Holland SM, Zhang S-Y, Crow YJ, Notarangelo LD, Su HC, Abel L, Anderson MS, Jouanguy E, Neven B, Puel A, Casanova J-L, Lionakis MS. Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1. J Exp Med. 2021;218(7): e20210554. https://​doi.​org/​10.​1084/​jem.​20210554.CrossRefPubMedPubMedCentral
23.
go back to reference Morimoto AM, Flesher DT, Yang J, Wolslegel K, Wang X, Brady A, Abbas AR, Quarmby V, Wakshull E, Richardson B, Townsend MJ, Behrens TW. Association of endogenous anti-interferon-α autoantibodies with decreased interferon-pathway and disease activity in patients with systemic lupus erythematosus. Arthritis Rheum. 2011;63(8):2407–15. https://doi.org/10.1002/art.30399.CrossRefPubMedPubMedCentral Morimoto AM, Flesher DT, Yang J, Wolslegel K, Wang X, Brady A, Abbas AR, Quarmby V, Wakshull E, Richardson B, Townsend MJ, Behrens TW. Association of endogenous anti-interferon-α autoantibodies with decreased interferon-pathway and disease activity in patients with systemic lupus erythematosus. Arthritis Rheum. 2011;63(8):2407–15. https://​doi.​org/​10.​1002/​art.​30399.CrossRefPubMedPubMedCentral
24.
go back to reference Gupta S, Tatouli IP, Rosen LB, Hasni S, Alevizos I, Manna ZG, Rivera J, Jiang C, Siegel RM, Holland SM, Moutsopoulos HM, Browne SK. Distinct functions of autoantibodies against interferon in systemic lupus erythematosus: a comprehensive analysis of anticytokine autoantibodies in common rheumatic diseases: anti-interferon functions in SLE. Arthritis Rheumatol. 2016;68(7):1677–87. https://doi.org/10.1002/art.39607.CrossRefPubMedPubMedCentral Gupta S, Tatouli IP, Rosen LB, Hasni S, Alevizos I, Manna ZG, Rivera J, Jiang C, Siegel RM, Holland SM, Moutsopoulos HM, Browne SK. Distinct functions of autoantibodies against interferon in systemic lupus erythematosus: a comprehensive analysis of anticytokine autoantibodies in common rheumatic diseases: anti-interferon functions in SLE. Arthritis Rheumatol. 2016;68(7):1677–87. https://​doi.​org/​10.​1002/​art.​39607.CrossRefPubMedPubMedCentral
25.
go back to reference Bastard, P.; Michailidis, E.; Hoffmann, H.-H.; Chbihi, M.; Le Voyer, T.; Rosain, J.; Philippot, Q.; Seeleuthner, Y.; Gervais, A.; Materna, M.; de Oliveira, P. M. N.; Maia, M. de L. S.; Dinis Ano Bom, A. P.; Azamor, T.; Araújo da Conceição, D.; Goudouris, E.; Homma, A.; Slesak, G.; Schäfer, J.; Pulendran, B.; Miller, J. D.; Huits, R.; Yang, R.; Rosen, L. B.; Bizien, L.; Lorenzo, L.; Chrabieh, M.; Erazo, L. V.; Rozenberg, F.; Jeljeli, M. M.; Béziat, V.; Holland, S. M.; Cobat, A.; Notarangelo, L. D.; Su, H. C.; Ahmed, R.; Puel, A.; Zhang, S.-Y.; Abel, L.; Seligman, S. J.; Zhang, Q.; MacDonald, M. R.; Jouanguy, E.; Rice, C. M.; Casanova, J.-L. Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine. J. Exp. Med. 2021, 218 (4), e20202486. https://doi.org/10.1084/jem.20202486. Bastard, P.; Michailidis, E.; Hoffmann, H.-H.; Chbihi, M.; Le Voyer, T.; Rosain, J.; Philippot, Q.; Seeleuthner, Y.; Gervais, A.; Materna, M.; de Oliveira, P. M. N.; Maia, M. de L. S.; Dinis Ano Bom, A. P.; Azamor, T.; Araújo da Conceição, D.; Goudouris, E.; Homma, A.; Slesak, G.; Schäfer, J.; Pulendran, B.; Miller, J. D.; Huits, R.; Yang, R.; Rosen, L. B.; Bizien, L.; Lorenzo, L.; Chrabieh, M.; Erazo, L. V.; Rozenberg, F.; Jeljeli, M. M.; Béziat, V.; Holland, S. M.; Cobat, A.; Notarangelo, L. D.; Su, H. C.; Ahmed, R.; Puel, A.; Zhang, S.-Y.; Abel, L.; Seligman, S. J.; Zhang, Q.; MacDonald, M. R.; Jouanguy, E.; Rice, C. M.; Casanova, J.-L. Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine. J. Exp. Med. 2021, 218 (4), e20202486. https://​doi.​org/​10.​1084/​jem.​20202486.
Metadata
Title
Autoantibodies Neutralizing Type I Interferons in 20% of COVID-19 Deaths in a French Hospital
Authors
Angélique Chauvineau-Grenier
Paul Bastard
Antoine Servajean
Adrian Gervais
Jérémie Rosain
Emmanuelle Jouanguy
Aurélie Cobat
Jean-Laurent Casanova
Benjamin Rossi
Publication date
01-04-2022
Publisher
Springer US
Published in
Journal of Clinical Immunology / Issue 3/2022
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-021-01203-3

Other articles of this Issue 3/2022

Journal of Clinical Immunology 3/2022 Go to the issue