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Breast Cancer Research
Published in: Breast Cancer Research 5/2006

Open Access 01-10-2006 | Research article

Plasma levels of leptin and mammographic density among postmenopausal women: a cross-sectional study

Authors: Anne Stuedal, Giske Ursin, Marit B Veierød, Yngve Bremnes, Janne E Reseland, Christian A Drevon, Inger T Gram

Published in: Breast Cancer Research | Issue 5/2006

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Abstract

Introduction

Obesity has been linked to increased risk of breast cancer in postmenopausal women. Increased peripheral production of estrogens has been regarded as the main cause for this association, but other features of increased body fat mass may also play a part. Leptin is a protein produced mainly by adipose tissue and may represent a growth factor in cancer. We examined the association between leptin plasma levels and mammographic density, a biomarker for breast cancer risk.

Methods

We included data from postmenopausal women aged 55 and older, who participated in a cross-sectional mammography study in Tromsø, Norway. Mammograms, plasma leptin measurements as well as information on anthropometric and hormonal/reproductive factors were available from 967 women. We assessed mammographic density using a previously validated computer-assisted method. Multiple linear regression analysis was applied to investigate the association between mammographic density and quartiles of plasma leptin concentration. Because we hypothesized that the effect of leptin on mammographic density could vary depending on the amount of nondense or fat tissue in the breast, we also performed analyses on plasma leptin levels and mammographic density within tertiles of mammographic nondense area.

Results

After adjusting for age, postmenopausal hormone use, number of full-term pregnancies and age of first birth, there was an inverse association between leptin and absolute mammographic density (P trend = 0.001). When we additionally adjusted for body mass index and mammographic nondense area, no statistically significant association between plasma leptin and mammographic density was found (P trend = 0.16). Stratified analyses suggested that the association between plasma leptin and mammographic density could differ with the amount of nondense area of the mammogram, with the strongest association between leptin and mammographic absolute density in the stratum with the medium breast fat content (P trend = 0.003, P for interaction = 0.05).

Conclusion

We found no overall consistent association between the plasma concentration of leptin and absolute mammographic density. Although weak, there was some suggestion that the association between leptin and mammographic density could differ with the amount of fat tissue in the breast.
Literature
1.
van den Brandt PA, Spiegelman D, Yaun SS, Adami HO, Beeson L, Folsom AR, Fraser G, Goldbohm RA, Graham S, Kushi L, et al: Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol. 2000, 152: 514-527. 10.1093/aje/152.6.514.CrossRefPubMed
2.
Key TJ, Appleby PN, Reeves GK, Roddam A, Dorgan JF, Longcope C, Stanczyk FZ, Stephenson HE, Falk RT, Miller R, et al: Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J Natl Cancer Inst. 2003, 95: 1218-1226.CrossRefPubMed
3.
Lahmann PH, Hoffmann K, Allen N, Van Gils CH, Khaw KT, Tehard B, Berrino F, Tjonneland A, Bigaard J, Olsen A, et al: Body size and breast cancer risk: findings from the European prospective investigation into cancer and nutrition (EPIC). Int J Cancer. 2004, 111: 762-771. 10.1002/ijc.20315.CrossRefPubMed
4.
Purohit A, Reed MJ: Regulation of estrogen synthesis in postmenopausal women. Steroids. 2002, 67: 979-983. 10.1016/S0039-128X(02)00046-6.CrossRefPubMed
5.
Boyd NF, Stone J, Martin LJ, Jong R, Fishell E, Yaffe M, Hammond G, Minkin S: The association of breast mitogens with mammographic densities. Br J Cancer. 2002, 87: 876-882. 10.1038/sj.bjc.6600537.CrossRefPubMedPubMedCentral
6.
Ahima RS, Flier JS: Adipose tissue as an endocrine organ. Trends Endocrinol Metab. 2000, 11: 327-332. 10.1016/S1043-2760(00)00301-5.CrossRefPubMed
7.
Rose DP, Komninou D, Stephenson GD: Obesity, adipocytokines, and insulin resistance in breast cancer. Obes Rev. 2004, 5: 153-165. 10.1111/j.1467-789X.2004.00142.x.CrossRefPubMed
8.
van Rossum EF, Nicklas BJ, Dennis KE, Berman DM, Goldberg AP: Leptin responses to weight loss in postmenopausal women: relationship to sex-hormone binding globulin and visceral obesity. Obes Res. 2000, 8: 29-35.CrossRefPubMed
9.
Van Harmelen V, Reynisdottir S, Eriksson P, Thorne A, Hoffstedt J, Lonnqvist F, Arner P: Leptin secretion from subcutaneous and visceral adipose tissue in women. Diabetes. 1998, 47: 913-917.CrossRefPubMed
10.
Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, Moizo L, Lehy T, Guerre-Millo M, Marchand-Brustel Y, et al: The stomach is a source of leptin. Nature. 1998, 394: 790-793. 10.1038/29547.CrossRefPubMed
11.
Masuzaki H, Ogawa Y, Sagawa N, Hosoda K, Matsumoto T, Mise H, Nishimura H, Yoshimasa Y, Tanaka I, Mori T, et al: Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med. 1997, 3: 1029-1033. 10.1038/nm0997-1029.CrossRefPubMed
12.
Reseland JE, Syversen U, Bakke I, Qvigstad G, Eide LG, Hjertner O, Gordeladze JO, Drevon CA: Leptin is expressed in and secreted from primary cultures of human osteoblasts and promotes bone mineralization. J Bone Miner Res. 2001, 16: 1426-1433. 10.1359/jbmr.2001.16.8.1426.CrossRefPubMed
13.
Solberg R, Aas V, Thoresen GH, Kase ET, Drevon CA, Rustan AC, Reseland JE: Leptin expression in human primary skeletal muscle cells is reduced during differentiation. J Cell Biochem. 2005, 96: 89-96. 10.1002/jcb.20521.CrossRefPubMed
14.
Smith-Kirwin SM, O'Connor DM, De Johnston J, Lancey ED, Hassink SG, Funanage VL: Leptin expression in human mammary epithelial cells and breast milk. J Clin Endocrinol Metab. 1998, 83: 1810-1813. 10.1210/jc.83.5.1810.CrossRefPubMed
15.
Friedman JM, Halaas JL: Leptin and the regulation of body weight in mammals. Nature. 1998, 395: 763-770. 10.1038/27376.CrossRefPubMed
16.
17.
Otero M, Lago R, Lago F, Casanueva FF, Dieguez C, Gomez-Reino JJ, Gualillo O: Leptin, from fat to inflammation: old questions and new insights. FEBS Lett. 2005, 579: 295-301. 10.1016/j.febslet.2004.11.024.CrossRefPubMed
18.
Markowska A, Malendowicz K, Drews K: The role of leptin in breast cancer. Eur J Gynaecol Oncol. 2004, 25: 192-194.PubMed
19.
Somasundar P, McFadden DW, Hileman SM, Vona-Davis L: Leptin is a growth factor in cancer. J Surg Res. 2004, 116: 337-349. 10.1016/j.jss.2003.09.004.CrossRefPubMed
20.
Sierra-Honigmann MR, Nath AK, Murakami C, Garcia-Cardena G, Papapetropoulos A, Sessa WC, Madge LA, Schechner JS, Schwabb MB, Polverini PJ, et al: Biological action of leptin as an angiogenic factor. Science. 1998, 281: 1683-1686. 10.1126/science.281.5383.1683.CrossRefPubMed
21.
Bouloumie A, Drexler HC, Lafontan M, Busse R: Leptin, the product of Ob gene, promotes angiogenesis. Circ Res. 1998, 83: 1059-1066.CrossRefPubMed
22.
Iversen PO, Drevon CA, Reseland JE: Prevention of leptin binding to its receptor suppresses rat leukemic cell growth by inhibiting angiogenesis. Blood. 2002, 100: 4123-4128. 10.1182/blood-2001-11-0134.CrossRefPubMed
23.
Hu X, Juneja SC, Maihle NJ, Cleary MP: Leptin – a growth factor in normal and malignant breast cells and for normal mammary gland development. J Natl Cancer Inst. 2002, 94: 1704-1711.CrossRefPubMed
24.
Johns PC, Yaffe MJ: X-ray characterisation of normal and neoplastic breast tissues. Phys Med Biol. 1987, 32: 675-695. 10.1088/0031-9155/32/6/002.CrossRefPubMed
25.
Boyd NF, Lockwood GA, Byng JW, Tritchler DL, Yaffe MJ: Mammographic densities and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 1998, 7: 1133-1144.PubMed
26.
Byrne C, Schairer C, Wolfe J, Parekh N, Salane M, Brinton LA, Hoover R, Haile R: Mammographic features and breast cancer risk: effects with time, age, and menopause status. J Natl Cancer Inst. 1995, 87: 1622-1629.CrossRefPubMed
27.
Ursin G, Ma H, Wu AH, Bernstein L, Salane M, Parisky YR, Astrahan M, Siozon CC, Pike MC: Mammographic density and breast cancer in three ethnic groups. Cancer Epidemiol Biomarkers Prev. 2003, 12: 332-338.PubMed
28.
Ursin G, Hovanessian-Larsen L, Parisky YR, Pike MC, Wu AH: Greatly increased occurrence of breast cancers in areas of mammographically dense tissue. Breast Cancer Res. 2005, 7: R605-R608. 10.1186/bcr1260.CrossRefPubMedPubMedCentral
29.
Boyd NF, Lockwood GA, Martin LJ, Byng JW, Yaffe MJ, Tritchler DL: Mammographic density as a marker of susceptibility to breast cancer: a hypothesis. IARC Sci Publ. 2001, 154: 163-169.PubMed
30.
Gram IT, Bremnes Y, Ursin G, Maskarinec G, Bjurstam N, Lund E: Percentage density, Wolfe's and Tabar's mammographic patterns: agreement and association with risk factors for breast cancer. Breast Cancer Res. 2005, 7: R854-R861. 10.1186/bcr1308.CrossRefPubMedPubMedCentral
31.
Ma Z, Gingerich RL, Santiago JV, Klein S, Smith CH, Landt M: Radioimmunoassay of leptin in human plasma. Clin Chem. 1996, 42: 942-946.PubMed
32.
Ursin G, Astrahan MA, Salane M, Parisky YR, Pearce JG, Daniels JR, Pike MC, Spicer DV: The detection of changes in mammographic densities. Cancer Epidemiol Biomarkers Prev. 1998, 7: 43-47.PubMed
33.
Willett W, Stampfer MJ: Total energy intake: implications for epidemiologic analyses. Am J Epidemiol. 1986, 124: 17-27.PubMed
34.
Petridou E, Papadiamantis Y, Markopoulos C, Spanos E, Dessypris N, Trichopoulos D: Leptin and insulin growth factor I in relation to breast cancer (Greece). Cancer Causes Control. 2000, 11: 383-388. 10.1023/A:1008903727238.CrossRefPubMed
35.
Mantzoros CS, Bolhke K, Moschos S, Cramer DW: Leptin in relation to carcinoma in situ of the breast: a study of pre-menopausal cases and controls. Int J Cancer. 1999, 80: 523-526. 10.1002/(SICI)1097-0215(19990209)80:4<523::AID-IJC7>3.0.CO;2-C.CrossRefPubMed
36.
Stattin P, Soderberg S, Biessy C, Lenner P, Hallmans G, Kaaks R, Olsson T: Plasma leptin and breast cancer risk: a prospective study in northern sweden. Breast Cancer Res Treat. 2004, 86: 191-196. 10.1023/B:BREA.0000036782.11945.d7.CrossRefPubMed
37.
Furberg AS, Jasienska G, Bjurstam N, Torjesen PA, Emaus A, Lipson SF, Ellison PT, Thune I: Metabolic and hormonal profiles: HDL cholesterol as a plausible biomarker of breast cancer risk. The Norwegian EBBA Study. Cancer Epidemiol Biomarkers Prev. 2005, 14: 33-40.PubMed
38.
Lam PB, Vacek PM, Geller BM, Muss HB: The association of increased weight, body mass index, and tissue density with the risk of breast carcinoma in Vermont. Cancer. 2000, 89: 369-375. 10.1002/1097-0142(20000715)89:2<369::AID-CNCR23>3.0.CO;2-J.CrossRefPubMed
39.
Salminen TM, Saarenmaa IE, Heikkila MM, Hakama M: Unfavourable change in mammographic patterns and the breast cancer risk factors. Breast Cancer Res Treat. 1999, 57: 165-173. 10.1023/A:1006235206513.CrossRefPubMed
40.
Gram IT, Funkhouser E, Tabar L: Anthropometric indices in relation to mammographic patterns among peri-menopausal women. Int J Cancer. 1997, 73: 323-326. 10.1002/(SICI)1097-0215(19971104)73:3<323::AID-IJC3>3.0.CO;2-1.CrossRefPubMed
41.
Boyd NF, Rommens JM, Vogt K, Lee V, Hopper JL, Yaffe MJ, Paterson AD: Mammographic breast density as an intermediate phenotype for breast cancer. Lancet Oncol. 2005, 6: 798-808. 10.1016/S1470-2045(05)70390-9.CrossRefPubMed
42.
Capuco AV, Smith JJ, Waldo DR, Rexroad CE: Influence of prepubertal dietary regimen on mammary growth of Holstein heifers. J Dairy Sci. 1995, 78: 2709-2725.CrossRefPubMed
43.
Silva LF, VandeHaar MJ, Weber Nielsen MS, Smith GW: Evidence for a local effect of leptin in bovine mammary gland. J Dairy Sci. 2002, 85: 3277-3286.CrossRefPubMed
44.
Maskarinec G, Meng L: A case-control study of mammographic densities in Hawaii. Breast Cancer Res Treat. 2000, 63: 153-161. 10.1023/A:1006486319848.CrossRefPubMed
45.
Chen Z, Wu AH, Gauderman WJ, Bernstein L, Ma H, Pike MC, Ursin G: Does mammographic density reflect ethnic differences in breast cancer incidence rates?. Am J Epidemiol. 2004, 159: 140-147. 10.1093/aje/kwh028.CrossRefPubMed
46.
47.
Maskarinec G, Takata Y, Franke AA, Williams AE, Murphy SP: A 2-year soy intervention in premenopausal women does not change mammographic densities. J Nutr. 2004, 134: 3089-3094.PubMed
48.
Boyd NF, Greenberg C, Lockwood G, Little L, Martin L, Byng J, Yaffe M, Tritchler D: Effects at two years of a low-fat, high-carbohydrate diet on radiologic features of the breast: results from a randomized trial. Canadian Diet and Breast Cancer Prevention Study Group. J Natl Cancer Inst. 1997, 89: 488-496. 10.1093/jnci/89.7.488.CrossRefPubMed
49.
O'Brien SN, Welter BH, Price TM: Presence of leptin in breast cell lines and breast tumors. Biochem Biophys Res Commun. 1999, 259: 695-698. 10.1006/bbrc.1999.0843.CrossRefPubMed
50.
Laud K, Gourdou I, Pessemesse L, Peyrat JP, Djiane J: Identification of leptin receptors in human breast cancer: functional activity in the T47-D breast cancer cell line. Mol Cell Endocrinol. 2002, 188: 219-226. 10.1016/S0303-7207(01)00678-5.CrossRefPubMed
51.
Okumura M, Yamamoto M, Sakuma H, Kojima T, Maruyama T, Jamali M, Cooper D, Yasuda K: Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: reciprocal involvement of PKC-α and PPAR expression. Biochim Biophys Acta. 2002, 1592: 107-116.CrossRefPubMed
52.
Cleary MP, Phillips FC, Getzin SC, Jacobson TL, Jacobson MK, Christensen TA, Juneja SC, Grande JP, Maihle NJ: Genetically obese MMTV-TGF-α/Lep(ob)Lep(ob) female mice do not develop mammary tumors. Breast Cancer Res Treat. 2003, 77: 205-215. 10.1023/A:1021891825399.CrossRefPubMed
53.
Cleary MP, Juneja SC, Phillips FC, Hu X, Grande JP, Maihle NJ: Leptin receptor-deficient MMTV-TGF-α/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors. Exp Biol Med (Maywood). 2004, 229: 182-193.CrossRef
54.
Ishikawa M, Kitayama J, Nagawa H: Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer. Clin Cancer Res. 2004, 10: 4325-4331. 10.1158/1078-0432.CCR-03-0749.CrossRefPubMed
55.
Caldefie-Chezet F, Damez M, de Latour M, Konska G, Mishellani F, Fusillier C, Guerry M, Penault-Llorca F, Guillot J, Vasson MP: Leptin: a proliferative factor for breast cancer? Study on human ductal carcinoma. Biochem Biophys Res Commun. 2005, 334: 737-741. 10.1016/j.bbrc.2005.06.077.CrossRefPubMed
56.
Glasow A, Kiess W, Anderegg U, Berthold A, Bottner A, Kratzsch J: Expression of leptin (Ob) and leptin receptor (Ob-R) in human fibroblasts: regulation of leptin secretion by insulin. J Clin Endocrinol Metab. 2001, 86: 4472-4479. 10.1210/jc.86.9.4472.CrossRefPubMed
57.
Alowami S, Troup S, Al Haddad S, Kirkpatrick I, Watson PH: Mammographic density is related to stroma and stromal proteoglycan expression. Breast Cancer Res. 2003, 5: R129-R135. 10.1186/bcr622.CrossRefPubMedPubMedCentral
58.
Casabiell X, Pineiro V, Peino R, Lage M, Camina J, Gallego R, Vallejo LG, Dieguez C, Casanueva FF: Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro: dexamethasone and estradiol stimulate leptin release in women, but not in men. J Clin Endocrinol Metab. 1998, 83: 2149-2155. 10.1210/jc.83.6.2149.PubMed
59.
Kristensen K, Pedersen SB, Richelsen B: Interactions between sex steroid hormones and leptin in women. Studies in vivo and in vitro. Int J Obes Relat Metab Disord. 2000, 24: 1438-1444. 10.1038/sj.ijo.0801428.CrossRefPubMed
60.
Thomas T, Burguera B, Melton LJ, Atkinson EJ, O'Fallon WM, Riggs BL, Khosla S: Relationship of serum leptin levels with body composition and sex steroid and insulin levels in men and women. Metabolism. 2000, 49: 1278-1284. 10.1053/meta.2000.9519.CrossRefPubMed
61.
Castracane VD, Kraemer GR, Ogden BW, Kraemer RR: Interrelationships of serum estradiol, estrone, and estrone sulfate, adiposity, biochemical bone markers, and leptin in post-menopausal women. Maturitas. 2006, 53: 217-225. 10.1016/j.maturitas.2005.04.007.CrossRefPubMed
62.
Di Carlo C, Tommaselli GA, Nappi C: Effects of sex steroid hormones and menopause on serum leptin concentrations. Gynecol Endocrinol. 2002, 16: 479-491.CrossRefPubMed
63.
Cauley JA, Gutai JP, Kuller LH, LeDonne D, Powell JG: The epidemiology of serum sex hormones in postmenopausal women. Am J Epidemiol. 1989, 129: 1120-1131.PubMed
64.
Magoffin DA, Weitsman SR, Aagarwal SK, Jakimiuk AJ: Leptin regulation of aromatase activity in adipose stromal cells from regularly cycling women. Ginekol Pol. 1999, 70: 1-7.PubMed
65.
Fogteloo AJ, Pijl H, Roelfsema F, Frolich M, Meinders AE: Impact of meal timing and frequency on the twenty-four-hour leptin rhythm. Horm Res. 2004, 62: 71-78. 10.1159/000079326.PubMed
66.
Licinio J, Negrao AB, Mantzoros C, Kaklamani V, Wong ML, Bongiorno PB, Negro PP, Mulla A, Veldhuis JD, Cearnal L, et al: Sex differences in circulating human leptin pulse amplitude: clinical implications. J Clin Endocrinol Metab. 1998, 83: 4140-4147. 10.1210/jc.83.11.4140.PubMed
67.
Widjaja A, Levy JC, Morris RJ, Frayn KN, Humphreys SM, Horn R, von zur MA, Turner RC, Brabant G: Determinants of within-subject variation of fasting serum leptin concentrations in healthy subjects. Exp Clin Endocrinol Diabetes. 2000, 108: 208-213. 10.1055/s-2000-7888.CrossRefPubMed
68.
Chu NF, Spiegelman D, Hotamisligil GS, Rifai N, Stampfer M, Rimm EB: Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men. Atherosclerosis. 2001, 157: 495-503. 10.1016/S0021-9150(00)00755-3.CrossRefPubMed
69.
Fors H, Matsuoka H, Bosaeus I, Rosberg S, Wikland KA, Bjarnason R: Serum leptin levels correlate with growth hormone secretion and body fat in children. J Clin Endocrinol Metab. 1999, 84: 3586-3590. 10.1210/jc.84.10.3586.PubMed
70.
Lee NA, Rusinek H, Weinreb J, Chandra R, Toth H, Singer C, Newstead G: Fatty and fibroglandular tissue volumes in the breasts of women 20–83 years old: comparison of X-ray mammography and computer-assisted MR imaging. AJR. 1997, 168: 501-506.CrossRefPubMed
71.
Mantzoros C, Petridou E, Dessypris N, Chavelas C, Dalamaga M, Alexe DM, Papadiamantis Y, Markopoulos C, Spanos E, Chrousos G, et al: Adiponectin and breast cancer risk. J Clin Endocrinol Metab. 2004, 89: 1102-1107. 10.1210/jc.2003-031804.CrossRefPubMed
72.
Rahimi N, Saulnier R, Nakamura T, Park M, Elliott B: Role of hepatocyte growth factor in breast cancer: a novel mitogenic factor secreted by adipocytes. DNA Cell Biol. 1994, 13: 1189-1197.CrossRefPubMed
73.
Lorincz AM, Sukumar S: Molecular links between obesity and breast cancer. Endocr Relat Cancer. 2006, 13: 279-292. 10.1677/erc.1.00729.CrossRefPubMed
Metadata
Title
Plasma levels of leptin and mammographic density among postmenopausal women: a cross-sectional study
Authors
Anne Stuedal
Giske Ursin
Marit B Veierød
Yngve Bremnes
Janne E Reseland
Christian A Drevon
Inger T Gram
Publication date
01-10-2006
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 5/2006
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1603

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