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Breast Cancer Research
Published in: Breast Cancer Research 5/2006

01-10-2006 | Commentary

Identification of murine mammary stem cells: implications for studies of mammary development and carcinogenesis

Author: Max S Wicha

Published in: Breast Cancer Research | Issue 5/2006

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Abstract

The epithelial components of the mammary gland are thought to arise from a stem cell capable of both self-renewal and multi-lineage differentiation. Furthermore, there is increasing evidence that mammary carcinomas originate in these cells or their immediate progeny. The recent identification of murine mammary stem cells should facilitate their molecular characterization and help to elucidate their role in mammary carcinogenesis. In addition, an understanding of the biology of these cells including the pathways that regulate their self-renewal and differentiation may suggest new approaches for the prevention and treatment of breast cancer.
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Metadata
Title
Identification of murine mammary stem cells: implications for studies of mammary development and carcinogenesis
Author
Max S Wicha
Publication date
01-10-2006
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 5/2006
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1540

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