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Published in: Diabetologia 9/2006

01-09-2006 | Research Letter

Plasma concentrations of vascular endothelial growth factor are associated with peripheral oedema in patients treated with thiazolidinedione

Authors: M. Emoto, N. Fukuda, Y. Nakamori, A. Taguchi, S. Okuya, Y. Oka, Y. Tanizawa

Published in: Diabetologia | Issue 9/2006

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Excerpt

To the Editor Thiazolidinediones are widely used in patients with type 2 diabetes. In addition to lowering plasma glucose, this class of drugs may reduce the risk of cardiovascular diseases in patients with diabetes. Despite the beneficial effect of thiazolidinediones, their use is sometimes associated with peripheral oedema. This is the most frequent adverse effect leading to discontinued treatment with thiazolidinediones in Japan. However, the mechanism by which thiazolidinediones induce oedema remains to be established. …
Literature
1.
go back to reference Guan Y, Hao C, Cha DR et al (2005) Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt absorption. Nat Med 11:861–866PubMedCrossRef Guan Y, Hao C, Cha DR et al (2005) Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt absorption. Nat Med 11:861–866PubMedCrossRef
2.
go back to reference Williams GH, Dluhy RG (2005) Disorders of the adrenal cortex. In: Kasper DL et al. (eds) Harrison’s principles of internal medicine, 16th edn. McGraw-Hill, New York, pp 2138–2140 Williams GH, Dluhy RG (2005) Disorders of the adrenal cortex. In: Kasper DL et al. (eds) Harrison’s principles of internal medicine, 16th edn. McGraw-Hill, New York, pp 2138–2140
3.
go back to reference Bartter FC, Schwartz WB (1967) The syndrome of inappropriate secretion of antidiuretic hormone. Am J Med 42:790–806PubMedCrossRef Bartter FC, Schwartz WB (1967) The syndrome of inappropriate secretion of antidiuretic hormone. Am J Med 42:790–806PubMedCrossRef
4.
go back to reference Emoto M, Anno T, Sato Y et al (2001) Troglitazone treatment increases plasma vascular endothelial growth factor in diabetic patients and its mRNA in 3T3-L1 adipocytes. Diabetes 50:1166–1170PubMedCrossRef Emoto M, Anno T, Sato Y et al (2001) Troglitazone treatment increases plasma vascular endothelial growth factor in diabetic patients and its mRNA in 3T3-L1 adipocytes. Diabetes 50:1166–1170PubMedCrossRef
5.
go back to reference Kelly IE, Han TS, Walsh K, Lean ME (1999) Effects of a thiazolidinedione compound on body fat and fat distribution of patients with type 2 diabetes. Diabetes Care 22:288–293PubMedCrossRef Kelly IE, Han TS, Walsh K, Lean ME (1999) Effects of a thiazolidinedione compound on body fat and fat distribution of patients with type 2 diabetes. Diabetes Care 22:288–293PubMedCrossRef
6.
go back to reference Hollenberg NK (2003) Considerations for management of fluid dynamic issues associated with thiazolidinediones. Am J Med 115(Suppl 8A):111S–115SPubMedCrossRef Hollenberg NK (2003) Considerations for management of fluid dynamic issues associated with thiazolidinediones. Am J Med 115(Suppl 8A):111S–115SPubMedCrossRef
7.
go back to reference Weis SM, Cheresh DA (2005) Pathophysiological consequences of VEGF-induced vascular permeability. Nature 437:497–504PubMedCrossRef Weis SM, Cheresh DA (2005) Pathophysiological consequences of VEGF-induced vascular permeability. Nature 437:497–504PubMedCrossRef
8.
go back to reference Baba T, Shimada K, Neugebauer S et al (2001) The oral insulin sensitizer, thiazolidinedione, increases plasma vascular endothelial growth factor in type 2 diabetic patients. Diabetes Care 24:953–954PubMedCrossRef Baba T, Shimada K, Neugebauer S et al (2001) The oral insulin sensitizer, thiazolidinedione, increases plasma vascular endothelial growth factor in type 2 diabetic patients. Diabetes Care 24:953–954PubMedCrossRef
9.
go back to reference Tooke JE, Elston LM, Gooding KM et al (2006) The insulin sensitiser pioglitazone does not influence skin microcirculatory function in patients with type 2 diabetes treated with insulin. Diabetologia 49:1064–1070PubMedCrossRef Tooke JE, Elston LM, Gooding KM et al (2006) The insulin sensitiser pioglitazone does not influence skin microcirculatory function in patients with type 2 diabetes treated with insulin. Diabetologia 49:1064–1070PubMedCrossRef
Metadata
Title
Plasma concentrations of vascular endothelial growth factor are associated with peripheral oedema in patients treated with thiazolidinedione
Authors
M. Emoto
N. Fukuda
Y. Nakamori
A. Taguchi
S. Okuya
Y. Oka
Y. Tanizawa
Publication date
01-09-2006
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 9/2006
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-006-0313-5

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