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Published in: Diabetologia 9/2006

01-09-2006 | Erratum

Common variants in MODY genes increase the risk of gestational diabetes mellitus

Authors: N. Shaat, E. Karlsson, Å. Lernmark, S. Ivarsson, K. Lynch, H. Parikh, P. Almgren, K. Berntorp, L. Groop

Published in: Diabetologia | Issue 9/2006

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Excerpt

Unfortunately some of the footnotes in Table 1 of this article were incorrect. The corrected table is reproduced here.
Table 1
Genotype and allele distributions and corresponding odds ratios for GDM
SNP (rs number)
Genotype or allele
GDM n (%)
Controls n (%)
OR (95% CI) for GDM, additive model/allelic effect
OR (95% CI) for GDM, recessive model
OR (95% CI) for GDM, dominant model
GCK −30G→A
GG
435 (67.8)
889 (72.3)
     
(rs1799884)
 
GA
181 (28.2)
316 (25.7)
1.17 (0.94–1.45)
   
 
AA
26 (4.0)
24 (2.0)a
2.21 (1.26–3.90)b
2.12 (1.21–3.72)d
1.24 (1.01–1.53)e
 
A
233 (18.1)
364 (14.8)
1.28 (1.06–1.53)c
   
HNF1A I27L
II
242 (39.4)
559 (46.1)
     
(rs1169288)
 
IL
298 (48.5)
508 (41.8)
1.36 (1.10–1.67)f
   
 
LL
74 (12.1)
147 (12.1)a
1.16 (0.85–1.60)
0.99 (0.74–1.34)
1.31 (1.08–1.60)e
 
L
446 (36.3)
802 (33.0)
1.16 (1.001–1.34)c
   
HNF4A
GG
425 (67.8)
854 (70.1)
     
(rs2144908)
 
GA
167 (26.6)
316 (25.9)
1.06 (0.85–1.32)
   
 
AA
35 (5.6)
48 (4.0)
1.47 (0.93–2.30)
1.44 (0.92–2.25)
1.12 (0.91–1.37)
 
A
237 (18.9)
412 (16.9)
1.14 (0.96–1.37)
   
HNF4A
GG
159 (24.7)
317 (25.8)
     
(rs2425637)
 
GT
310 (48.2)
617 (50.2)
1.00 (0.79–1.27)
   
 
TT
174 (27.1)
295 (24.0)
1.18 (0.90–1.54)
1.17 (0.94–1.46)
1.06 (0.85–1.32)
 
T
658 (51.2)
1207 (49.1)
1.09 (0.95–1.24)
   
HNF4A
GG
412 (65.2)
791 (65.6)
     
(rs1885088)
 
GA
199 (31.5)
354 (29.4)
1.08 (0.87–1.33)
   
 
AA
21 (3.3)
60 (5.0)
0.67 (0.40–1.12)
0.66 (0.40–1.09)
1.02 (0.83–1.25)
 
A
241 (19.1)
474 (19.7)
0.96 (0.81–1.14)
   
aDifferences in genotype frequencies between women with and without GDM (p=0.010 for GCK −30G→A and p=0.016 for HNF1A I27L)
b p=0.006 for comparison of AA genotype vs GG genotype between women with and without GDM
cDifferences in allele frequencies between women with and without GDM (p=0.008 for GCK −30G→A and p=0.048 for HNF1A I27L)
d p=0.009 for comparison between women with and without GDM using a recessive model (AA vs GA+GG)
eComparison between women with and without GDM using a dominant model (p=0.039 for GCK −30G→A and p=0.007 for HNF1A I27L)
f p=0.004 for comparison of IL genotype vs II genotype between women with and without GDM
Metadata
Title
Common variants in MODY genes increase the risk of gestational diabetes mellitus
Authors
N. Shaat
E. Karlsson
Å. Lernmark
S. Ivarsson
K. Lynch
H. Parikh
P. Almgren
K. Berntorp
L. Groop
Publication date
01-09-2006
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 9/2006
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-006-0350-0

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