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Published in: Supportive Care in Cancer 1/2013

01-01-2013 | Special Article

Systematic review of laser and other light therapy for the management of oral mucositis in cancer patients

Authors: Cesar Migliorati, Ian Hewson, Rajesh V. Lalla, Heliton Spindola Antunes, Cherry L. Estilo, Brian Hodgson, Nilza Nelly Fontana Lopes, Mark M. Schubert, Joanne Bowen, Sharon Elad, For the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO)

Published in: Supportive Care in Cancer | Issue 1/2013

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Abstract

Background

The aim of this study was to review the available literature and define clinical practice guidelines for the use of laser and other light therapies for the prevention and treatment of oral mucositis.

Methods

A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology. The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. Based on the evidence level, one of the following three guideline determinations was possible: recommendation, suggestion, and no guideline possible.

Results

A new recommendation was made for low-level laser (wavelength at 650 nm, power of 40 mW, and each square centimeter treated with the required time to a tissue energy dose of 2 J/cm2 (2 s/point)) for the prevention of oral mucositis in adult patients receiving hematopoietic stem cell transplantation conditioned with high-dose chemotherapy, with or without total body irradiation. A new suggestion was made for low-level laser (wavelength around 632.8 nm) for the prevention of oral mucositis in patients undergoing radiotherapy, without concomitant chemotherapy, for head and neck cancer. No guideline was possible in other populations and for other light sources due to insufficient evidence.

Conclusions

The increasing evidence in favor of low-level laser therapy allowed for the development of two new guidelines supporting this modality in the populations listed above. Evidence for other populations was also generally encouraging over a range of wavelengths and intensities. However, additional well-designed research is needed to evaluate the efficacy of laser and other light therapies in various cancer treatment settings.
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Metadata
Title
Systematic review of laser and other light therapy for the management of oral mucositis in cancer patients
Authors
Cesar Migliorati
Ian Hewson
Rajesh V. Lalla
Heliton Spindola Antunes
Cherry L. Estilo
Brian Hodgson
Nilza Nelly Fontana Lopes
Mark M. Schubert
Joanne Bowen
Sharon Elad
For the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO)
Publication date
01-01-2013
Publisher
Springer-Verlag
Published in
Supportive Care in Cancer / Issue 1/2013
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-012-1605-6

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