Top

Journal of Orthopaedic Surgery and Research

Published in:

Open Access 01-12-2024 | Phlebothrombosis | Research article

Nomogram based on high-density lipoprotein cholesterol for the occurrence of preoperative deep vein thrombosis in patients with intertrochanteric femur fracture: a retrospective study

Authors: Wencai Li, He Ling, Rongbin Lu, Zhao Huang, Wei Su

Published in: Journal of Orthopaedic Surgery and Research | Issue 1/2024

Abstract

Background

This study aims to develop a nomogram and forecast the incidence of DVT in individuals suffering from an intertrochanteric femur fracture.

Method

This work created a nomogram using the R programming language and employed logistic regression to determine independent predicting features. An external validation dataset was used to validate the nomogram.

Result

The findings demonstrated the independence of LYM (0.02[0.01–0.09], p < 0.001), ALB (0.83[0.74, 0.94], p = 0.002), and HDL-C (0.18[0.04, 0.71], p = 0.014). Good prediction performance with modest errors was shown by the nomogram in both the training and validation groups.

Conclusion

In conclusion, the nomogram that was created using HDL-C, ALB, and LYM can assist medical professionals in determining the likelihood that DVT will occur.

Di Martino A, Pederiva D, Brunello M, et al. Outcomes of direct anterior approach for uncemented total hip replacement in medial femoral neck fractures: a retrospective comparative study on the first 100 consecutive patients. BMC Musculoskelet Disord. 2023;24(1):7763.CrossRef

Aytek C, Mustafa K, Tarlacık AO. Inflammatory index as a predictor of mortality in elderly patients with intracapsular femoral neck fracture. Cureus. 2023;15:e46318.

Novillo M, Díaz Dilernia F, García Barreiro G, Posadas-Martinez ML, Comba F, Buttaro M. Are lateral view radiographs necessary to properly classify femoral neck fractures? Intra and interobserver analysis using Garden’s classification system. Rev Fac Cien Med Univ Nac Cordoba. 2021;78(1):41–4.CrossRefPubMedPubMedCentral

Chow IH, Miller T, Pang MY. Predictive factors for home discharge after femoral fracture surgery: a prospective cohort study. Eur J Phys Rehabil Med. 2023. https://doi.org/10.23736/s1973-9087.23.07900-55.CrossRefPubMed

Cui L, Zhao S, Tian H, Guo W, Dong X. Curative efficacy of surgical procedures for older patients with femoral neck fracture: a network meta-analysis and systematic review. J Orthop Surg Res. 2022;17(1):127.CrossRefPubMedPubMedCentral

Vergouwen M, James MG, You DZ, et al. Trends in implementation of evidence-based hip fracture management in a major Canadian city. OTA Int. 2023;6:e274.CrossRefPubMedCentral

Chen P, Fan Z, Xu N, et al. A biomechanical investigation of a novel intramedullary nail used to salvage failed internal fixations in intertrochanteric fractures. J Orthop Surg Res. 2023;18:632.CrossRefPubMedPubMedCentral

Fan Y, Xiafei Li, Lei Z, et al. Dual-screw versus single-screw cephalomedullary nails for intertrochanteric femoral fractures: a systematic review and meta-analysis. J Orthop Surg Res. 2023;18:607.CrossRef

Basem. Intertrochanteric femur fracture. Treasure Island (FL): StatPearls Publishing; 2023.

10.

Sarkies Mitchell N, Luke T, Ann C, et al. Perioperative interventions to improve early mobilisation and physical function after hip fracture: a systematic review and meta-analysis. Age Ageing. 2023;52(8):afad154.CrossRefPubMedPubMedCentral

11.

Niikura T, et al. Venous thromboembolism in Japanese patients with fractures of the pelvis and/or lower extremities using physical prophylaxis alone. J Orthop Surg. 2012;20:196–200.CrossRef

12.

Geerts WH, Code KI, Jay RM, Chen E, Szalai JP. A prospective study of venous thromboembolism after major trauma. N Engl J Med. 1994;331(24):1601–6.CrossRefPubMed

13.

Suat İ, Mesut Ö, Sercan Ö, et al. Comparison of medical treatment efficiency with shear wave elastography values of thrombus in patients with lower extremity deep vein thrombosis. Ultrasound Q. 2023;39:158–64.CrossRef

14.

Li X, Ruff C, Vasileios R, et al. Noninvasive and invasive imaging of lower-extremity acute and chronic venous thrombotic disease. Vasc Med. 2023;4:1358863X231198069.

15.

Norikazu Y, Ikuo F, Mashio N, et al. Prognostication of patients with pulmonary thromboembolism with and without residual deep vein thrombosis: a subanalysis of the j’xactly study. Ann Vasc Dis. 2023;16:181–8.CrossRef

16.

Rogers FB, Cipolle MD, Velmahos G, Rozycki G, Luchette FA. Practice management guidelines for the prevention of venous thromboembolism in trauma patients: the EAST practice management guidelines work group. J Trauma. 2002;53:142–64.CrossRef

17.

Chiasakul T, Lam BD, McNichol M, et al. Artificial intelligence in the prediction of venous thromboembolism: a systematic review and pooled analysis. Eur J Haematol. 2023;111(6):951–62.CrossRef

18.

Lv B, Wang H, Zhang Z, et al. Nomogram for predicting postoperative deep vein thrombosis in patients with spinal fractures caused by high-energy injuries. Arch Orthop Trauma Surg. 2023. https://doi.org/10.1007/s00402-023-05085-5.CrossRefPubMed

19.

Zongyou Y, Ren R, Zhizhou Y, et al. Development and validation of a nomogram for predicting deep venous thrombosis in patients with pelvic and acetabular fractures: a retrospective cohort study: predictive model for pelvic/acetabular fractures. BMC Musculoskelet Disord. 2023;24:773.CrossRef

20.

Jiabao J, Fei X, Rong L, et al. Risk factors and prediction model of nomogram for preoperative calf muscle vein thrombosis in geriatric hip fracture patients. Front Med (Lausanne). 2023;10:1236451.

21.

Xu Dongcheng Hu, Xiaojiang ZH, et al. Analysis of risk factors for deep vein thrombosis after spinal infection surgery and construction of a nomogram preoperative prediction model. Front Cell Infect Microbiol. 2023;13:1220456.CrossRefPubMedPubMedCentral

22.

Kobayashi T, Akiyama T, Mawatari M. Predictors of preoperative deep vein thrombosis in hip fractures: a systematic review and meta-analysis. J Orthop Sci. 2023;28(1):222–32.CrossRefPubMed

23.

Wang T, Guo J, Long Y, Yin Y, Hou Z. Risk factors for preoperative deep venous thrombosis in hip fracture patients: a meta-analysis. J Orthop Traumatol. 2022;23(1):19.CrossRefPubMed

24.

Florentin M, Liberopoulos EN, Wierzbicki AS, Mikhailidis DP. Multiple actions of high-density lipoprotein. Curr Opin Cardiol. 2008;23(4):370–8.CrossRefPubMed

25.

Soran H, Hama S, Yadav R, Durrington PN. HDL functionality. Curr Opin Lipidol. 2012;23(4):353–66.CrossRefPubMed

26.

Bin-Bin Xu, Ze-Hui G, Li Z, et al. Low plasma high density lipoprotein-cholesterol level associated with deep vein thrombosis in traumatic fracture patients. Sichuan Da Xue Xue Bao Yi Xue Ban. 2019;50:248–51.

27.

Doğan Z, Bektaşoğlu G, Dümür Ş, Uzun H, Erden İ, Yurtdaş M. Evaluation of the relationship between monocyte to high-density lipoprotein cholesterol ratio and thrombus burden in patients with deep vein thrombosis. Rev Assoc Med Bras (1992). 2023;69(4):e20221211.CrossRef

28.

Yi-Lun Wu, Dan Z, Kai-Yuan Z, et al. The association between admission serum albumin and preoperative deep venous thrombosis in geriatrics hip fracture: a retrospective study of 1819 patients with age ≥ 65 years. BMC Musculoskelet Disord. 2023;24:672.CrossRef

29.

Peng Q, Liu JJ, Liu Y, et al. Application of Padua prediction score and serum albumin level in evaluating venous thromboembolism in rheumatic inpatients. Beijing Da Xue Xue Bao Yi Xue Ban. 2023;55:625–30.PubMed

30.

Solveig H, Ning X, Maximilian M, et al. B lymphocyte-deficiency in mice promotes venous thrombosis. Heliyon. 2022;8: e11740.CrossRef

31.

Xue J, Ma D, Jiang J, Liu Y, et al. Diagnostic and prognostic value of immune/inflammation biomarkers for venous thromboembolism: is it reliable for clinical practice? J Inflamm Res. 2021;14:5059–77.CrossRefPubMedPubMedCentral

Title: Nomogram based on high-density lipoprotein cholesterol for the occurrence of preoperative deep vein thrombosis in patients with intertrochanteric femur fracture: a retrospective study
Authors: Wencai Li
He Ling
Rongbin Lu
Zhao Huang
Wei Su
Publication date: 01-12-2024
Publisher: BioMed Central
Keyword: Phlebothrombosis
Published in: Journal of Orthopaedic Surgery and Research / Issue 1/2024
Electronic ISSN: 1749-799X
DOI: https://doi.org/10.1186/s13018-023-04497-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Nomogram based on high-density lipoprotein cholesterol for the occurrence of preoperative deep vein thrombosis in patients with intertrochanteric femur fracture: a retrospective study

Abstract

Background

Method

Result

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Method

Result

Conclusion

Please log in to get access to this content

Other articles of this Issue 1/2024

Application of machine learning-based multi-sequence MRI radiomics in diagnosing anterior cruciate ligament tears

SP1 transcriptionally activates HTR2B to aggravate traumatic spinal cord injury by shifting microglial M1/M2 polarization

Associations between hyperuricemia and ultrasound-detected knee synovial abnormalities in middle-aged and older population: a cross-sectional study

Predictors of success of pharmacological management in patients with chronic lower back pain: systematic review

Design of a novel lateral mass screw–plate system for the treatment of unstable atlas fractures: a finite element analysis

Non-traumatic osteonecrosis of the femoral head induced by steroid and alcohol exposure is associated with intestinal flora alterations and metabolomic profiles