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01-06-2008 | Review

Phenotypes of major immediate-early gene mutants of mouse cytomegalovirus

Authors: Andreas Busche, Ana Angulo, Penelope Kay-Jackson, Peter Ghazal, Martin Messerle

Published in: Medical Microbiology and Immunology | Issue 2/2008

Abstract

Immediate-early (IE) genes are the first genes to be transcribed during the lytic replication cycle of cytomegaloviruses (CMV), and encode nonstructural proteins, which are assumed to have mainly regulatory functions. The IE proteins may play important roles in the pathogenesis of CMV in vivo, for instance during the establishment of latency and during reactivation. We constructed mouse CMV mutants with disruptions in the major IE genes, ie1 and ie3, to study the roles of these genes in the context of the viral infection. Here we summarize the current results on the characterization of these mutants and give a perspective of the future research in this field.

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Title: Phenotypes of major immediate-early gene mutants of mouse cytomegalovirus
Authors: Andreas Busche
Ana Angulo
Penelope Kay-Jackson
Peter Ghazal
Martin Messerle
Publication date: 01-06-2008
Publisher: Springer Berlin Heidelberg
Published in: Medical Microbiology and Immunology / Issue 2/2008
Print ISSN: 0300-8584
Electronic ISSN: 1432-1831
DOI: https://doi.org/10.1007/s00430-008-0076-3

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