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01-06-2008 | Review

MHC class I immune evasion in MCMV infection

Authors: Carmen M. Doom, Ann B. Hill

Published in: Medical Microbiology and Immunology | Issue 2/2008

Abstract

Murine cytomegalovirus (MCMV) is a well-studied model of natural β-herpesvirus infection. However, many questions remain regarding its control by and evasion of the immune response it generates. CD8 and CD4 T cells have both unique and redundant roles in control of the virus that differ based on the immunocompetence of the infected mice. MCMV encodes major histocompatibility complex (MHC) class I immune evasion genes that can have an impact in vitro, but their role in infection of immunocompetent mice has been difficult to identify. This review addresses the evidence for their in vivo function and suggests why they may be evolutionarily conserved.

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Title: MHC class I immune evasion in MCMV infection
Authors: Carmen M. Doom
Ann B. Hill
Publication date: 01-06-2008
Publisher: Springer Berlin Heidelberg
Published in: Medical Microbiology and Immunology / Issue 2/2008
Print ISSN: 0300-8584
Electronic ISSN: 1432-1831
DOI: https://doi.org/10.1007/s00430-008-0089-y

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