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European Radiology
Published in: European Radiology 6/2016

01-06-2016 | Chest

Persistent pulmonary subsolid nodules with solid portions of 5 mm or smaller: Their natural course and predictors of interval growth

Authors: Jong Hyuk Lee, Chang Min Park, Sang Min Lee, Hyungjin Kim, H. Page McAdams, Jin Mo Goo

Published in: European Radiology | Issue 6/2016

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Abstract

Objective

To investigate the natural course of persistent pulmonary subsolid nodules (SSNs) with solid portions ≤5 mm and the clinico-radiological features that influence interval growth over follow-ups.

Methods

From 2005 to 2013, the natural courses of 213 persistent SSNs in 213 patients were evaluated. To identify significant predictors of interval growth, Kaplan-Meier analysis and Cox proportional hazard regression analysis were performed.

Results

Among the 213 nodules, 136 were pure ground-glass nodules (GGNs; growth, 18; stable, 118) and 77 were part-solid GGNs with solid portions ≤5 mm (growth, 24; stable, 53). For all SSNs, lung cancer history (p = 0.001), part-solid GGNs (p < 0.001), and nodule diameter (p < 0.001) were significant predictors for interval growth. On subgroup analysis, nodule diameter was an independent predictor for the interval growth of both pure GGNs (p < 0.001), and part-solid GGNs (p = 0.037). For part-solid GGNs, lung cancer history (p = 0.002) was another significant predictor of the interval growth. Interval growth of pure GGNs ≥10 mm and part-solid GGNs ≥8 mm were significantly more frequent than in pure GGNs <10 mm (p < 0.001) and part-solid GGNs <8 mm (p = 0.003), respectively.

Conclusion

The natural course of SSNs with solid portions ≤5 mm differed significantly according to their nodule type and nodule diameters, with which their management can be subdivided.

Key Points

• Pure GGNs ≥10 mm have significantly more frequent interval growth than those <10 mm.
• Part-solid GGNs ≥8 mm have significantly more frequent interval growth than those <8 mm.
• Management of SSNs with solid portions ≤5 mm can be subdivided by diameter.
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Metadata
Title
Persistent pulmonary subsolid nodules with solid portions of 5 mm or smaller: Their natural course and predictors of interval growth
Authors
Jong Hyuk Lee
Chang Min Park
Sang Min Lee
Hyungjin Kim
H. Page McAdams
Jin Mo Goo
Publication date
01-06-2016
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 6/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-015-4017-4

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