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BMC Oral Health

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Open Access 01-12-2023 | Pentoxifylline | Research

Drug treatment for oral submucous fibrosis: an update

Authors: Xueru Chen, Hui Xie, Jincai Guo

Published in: BMC Oral Health | Issue 1/2023

Abstract

Objective

The aim of this review is to evaluate the different medicinal interventions available for the management of oral submucous fibrosis (OSF).

Materials and methods

We conducted a comprehensive electronic search on PubMed, Web of Science, and Cochrane Library databases for articles related to OSF patients treated with medications from December 2011 to September 2022. GRADE system was used to evaluate the evidence quality. The reporting of the systematic review is in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. The main outcomes were the improvement of maximum mouth opening, burning sensation, cheek flexibility, and tongue protrusion.

Results

Twenty-nine randomized controlled trials (RCTs), five clinical trials (CCTs) were included, and the use of drugs for OSF treatment were evaluated. Drugs like steroids, hyaluronidase, pentoxifylline, lycopene, curcumin, dpirulina, aloe vera, omega3, oxitard, allicin, colchicine have been used. It was found that drugs with evidence high quality were salvia miltiorrhiza combined with triamcinolone acetonide, lycopene, pentoxifylline, curcumin, and aloe vera, and those with evidence moderate quality were allicin, colchicine, omega 3, and oxitard.

Conclusion

Based on the results of our comprehensive analysis, for long-term treatment, we found lycopene with low side effects, whereas for relieving the symptoms of severe burning sensation, aloe vera is the most effective. Although the recent review has made some progress, drug therapy for OSF remains unclear, and more high-quality RCTs are needed to identify better treatments for OSF.

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Title: Drug treatment for oral submucous fibrosis: an update
Authors: Xueru Chen
Hui Xie
Jincai Guo
Publication date: 01-12-2023
Publisher: BioMed Central
Keyword: Pentoxifylline
Published in: BMC Oral Health / Issue 1/2023
Electronic ISSN: 1472-6831
DOI: https://doi.org/10.1186/s12903-023-03488-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Drug treatment for oral submucous fibrosis: an update

Abstract

Objective

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusion

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