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01-03-2018 | Original Article

Pentosidine concentration is associated with degenerative lumbar scoliosis in older women: preliminary results

Authors: Yawara Eguchi, Toru Toyoguchi, Kazuhide Inage, Kazuki Fujimoto, Sumihisa Orita, Kazuyo Yamauchi, Miyako Suzuki, Hirohito Kanamoto, Koki Abe, Masaki Norimoto, Tomotaka Umimura, Masao Koda, Takeo Furuya, Yasuchika Aoki, Kazuhisa Takahashi, Seiji Ohtori

Published in: European Spine Journal | Issue 3/2018

Abstract

Purpose

Advanced glycation end products (AGEs) have been implicated in the pathogenesis of sarcopenia. The objective of the study was to investigate the prevalence of sarcopenia in degenerative lumbar scoliosis (DLS), and the relationship between biochemical markers including major AGEs, pentosidine, and DLS in older women.

Methods

Our study participants were 20 elderly women with idiopathic DLS (mean age 76.4 years, range 56–88). Nineteen age- and sex-matched volunteers (mean age 74.0 years, range 62–86) served as controls. Spinal and femoral BMD of all participants was measured using dual-energy X-ray absorptiometry. We used a bioelectrical impedance analyzer to analyze body composition, including appendicular skeletal muscle mass index [SMI; appendicular lean mass (kg)/(height (m)]². SMI < 5.75 was considered diagnostic for sarcopenia. Coronal and sagittal spinal alignments were measured. The following biochemical markers were measured: serum and urinary pentosidine, serum homocysteine, 1,25(OA)₂D, and 25(OH)D. The level of each variable was compared between DLS and controls. The relationship between biochemical markers including pentosidine and DLS was examined.

Results

Sarcopenia was observed at a high prevalence in participants with DLS: 50% compared with 15.8% of healthy controls. Height, weight, femoral BMI, appendicular lean mass, total lean mass, and SMI all had significantly lower values in the DLS group. Serum pentosidine was significantly higher for the DLS group compared with controls. Correlations with serum pentosidine revealed a significant positive correlation between lumbar scoliosis, pelvic tilt, and pelvic incidence-lumbar lordosis mismatch, and a significantly negative correlation between thoracic kyphosis (P < 0.05).

Conclusions

We found that sarcopenia was involved in DLS, and high serum pentosidine levels are associated with severity of coronal and sagittal malalignment in older women, suggesting that high levels of AGEs are a potential biomarker for the progression of lumbar scoliosis and kyphotic deformity. Further studies are needed to clarify the pathogenesis of DLS.

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Title: Pentosidine concentration is associated with degenerative lumbar scoliosis in older women: preliminary results
Authors: Yawara Eguchi
Toru Toyoguchi
Kazuhide Inage
Kazuki Fujimoto
Sumihisa Orita
Kazuyo Yamauchi
Miyako Suzuki
Hirohito Kanamoto
Koki Abe
Masaki Norimoto
Tomotaka Umimura
Masao Koda
Takeo Furuya
Yasuchika Aoki
Kazuhisa Takahashi
Seiji Ohtori
Publication date: 01-03-2018
Publisher: Springer Berlin Heidelberg
Published in: European Spine Journal / Issue 3/2018
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-017-5370-6

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Springer Medicine

Pentosidine concentration is associated with degenerative lumbar scoliosis in older women: preliminary results

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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