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Published in: Italian Journal of Pediatrics 1/2022

Open Access 01-12-2022 | Pediatric Dermatology | Review

Narrative review on the management of moderate-severe atopic dermatitis in pediatric age of the Italian Society of Pediatric Allergology and Immunology (SIAIP), of the Italian Society of Pediatric Dermatology (SIDerP) and of the Italian Society of Pediatrics (SIP)

Authors: Elena Galli, Anna Belloni Fortina, Giampaolo Ricci, Nunzia Maiello, Iria Neri, Ermanno Baldo, Irene Berti, Domenico Bonamonte, Lucetta Capra, Elena Carboni, Rossella Carello, Francesca Caroppo, Giovanni Cavagni, Iolanda Chinellato, Francesca Cipriani, Pasquale Comberiati, Andrea Diociaiuti, Vito Di Lernia, Marzia Duse, Cesare Filippeschi, Arianna Giannetti, Mattia Giovannini, Amelia Licari, Gian Luigi Marseglia, Manuela Pace, Annalisa Patrizi, Giovanni Battista Pajno, Diego Peroni, Alberto Villani, Lawrence Eichenfield

Published in: Italian Journal of Pediatrics | Issue 1/2022

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Abstract

Currently, there are a few detailed guidelines on the overall management of children and adolescents with moderate-severe atopic dermatitis. AD ​​is a complex disease presenting with different clinical phenotypes, which require an individualized and multidisciplinary approach. Therefore, appropriate interaction between primary care pediatricians, pediatric allergists, and pediatric dermatologists is crucial to finding the best management strategy. In this manuscript, members of the Italian Society of Pediatric Allergology and Immunology (SIAIP), the Italian Society of Pediatric Dermatology (SIDerP), and the Italian Society of Pediatrics (SIP) with expertise in the management of moderate-severe atopic dermatitis have reviewed the latest scientific evidence in the field. This narrative review aims to define a pathway to appropriately managing children and adolescents with moderate-severe atopic dermatitis.
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Literature
1.
go back to reference Thomas KS, Apfelbacher CA, Chalmers JR, Simpson E, Spuls PI, Gerbens LAA, et al. Recommended core outcome instruments for health-related quality of life, long-term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting. Br J Dermatol. 2020. https://doi.org/10.1111/bjd.19673. Epub ahead of print. Thomas KS, Apfelbacher CA, Chalmers JR, Simpson E, Spuls PI, Gerbens LAA, et al. Recommended core outcome instruments for health-related quality of life, long-term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting. Br J Dermatol. 2020. https://​doi.​org/​10.​1111/​bjd.​19673. Epub ahead of print.
2.
go back to reference Severity scoring of atopic dermatitis: the SCORAD index. Consensus report of the European task force on atopic dermatitis. Dermatology. 1993;186:23–31. Severity scoring of atopic dermatitis: the SCORAD index. Consensus report of the European task force on atopic dermatitis. Dermatology. 1993;186:23–31.
3.
go back to reference Hanifin JM, Thurston M, Omoto M, EASI Evaluator Group, et al. The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis. Exp Dermatol. 2001;10:11–8.PubMedCrossRef Hanifin JM, Thurston M, Omoto M, EASI Evaluator Group, et al. The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis. Exp Dermatol. 2001;10:11–8.PubMedCrossRef
4.
go back to reference Conic RZ, Tamashunas NL, Damiani G, Fabbrocini G, Cantelli M, Young Dermatologists Italian Network, & Bergfeld, W. F. (2020). Comorbidities in pediatric alopecia areata. J Eur Acad Dermatol Venereol. 2020;34(12):2898–901.PubMedCrossRef Conic RZ, Tamashunas NL, Damiani G, Fabbrocini G, Cantelli M, Young Dermatologists Italian Network, & Bergfeld, W. F. (2020). Comorbidities in pediatric alopecia areata. J Eur Acad Dermatol Venereol. 2020;34(12):2898–901.PubMedCrossRef
5.
go back to reference Perugia C, Saraceno R, Ventura A, et al. Atopic dermatitis and dental manifestations. G Ital Dermatol Venereol. 2017;152:122–5.PubMed Perugia C, Saraceno R, Ventura A, et al. Atopic dermatitis and dental manifestations. G Ital Dermatol Venereol. 2017;152:122–5.PubMed
6.
go back to reference Damiani G, Gironi LC, Pacifico A, Pigatto P, Malagoli P, Bindi M, et al. Cutaneous and oral comorbidities in patients with geographic tongue: a multicenter multidisciplinary cross-sectional observational study. J Biol Regul Homeost Agents. 2021;35(21):339–44.PubMed Damiani G, Gironi LC, Pacifico A, Pigatto P, Malagoli P, Bindi M, et al. Cutaneous and oral comorbidities in patients with geographic tongue: a multicenter multidisciplinary cross-sectional observational study. J Biol Regul Homeost Agents. 2021;35(21):339–44.PubMed
7.
go back to reference Damiani G, Calzavara-Pinton P, Stingeni L, Hansel K, Cusano F, “Skin Allergy” Group of SIDeMaST, “ADOI” (Associazione Dermatologi Ospedalieri Italiani), “SIDAPA” (Società Italiana di Dermatologia Allergologica, Professionale e Ambientale), & Pigatto P. Italian guidelines for therapy of atopic dermatitis-Adapted from consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis). Dermatologic Therap. 2019;32(6):e13121. Damiani G, Calzavara-Pinton P, Stingeni L, Hansel K, Cusano F, “Skin Allergy” Group of SIDeMaST, “ADOI” (Associazione Dermatologi Ospedalieri Italiani), “SIDAPA” (Società Italiana di Dermatologia Allergologica, Professionale e Ambientale), & Pigatto P. Italian guidelines for therapy of atopic dermatitis-Adapted from consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis). Dermatologic Therap. 2019;32(6):e13121.
8.
go back to reference Wollenberg A, Barbarot S, Bieber T, Christen-Zaech S, Deleuran M, Fink-Wagner A, et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. J Eur Acad Dermatol Venereol. 2018;32:657–82.PubMedCrossRef Wollenberg A, Barbarot S, Bieber T, Christen-Zaech S, Deleuran M, Fink-Wagner A, et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. J Eur Acad Dermatol Venereol. 2018;32:657–82.PubMedCrossRef
9.
go back to reference Katoh N, Ohya Y, Ikeda M, Ebihara T, Katayama I, Saeki H, et al. Clinical practice guidelines for the management of atopic dermatitis 2018. J Dermatol. 2019;46:1053–101.PubMedCrossRef Katoh N, Ohya Y, Ikeda M, Ebihara T, Katayama I, Saeki H, et al. Clinical practice guidelines for the management of atopic dermatitis 2018. J Dermatol. 2019;46:1053–101.PubMedCrossRef
10.
go back to reference Chiricozzi A, Comberiati P, D’Auria E, Zuccotti G, Peroni DG. Topical corticosteroids for pediatric atopic dermatitis: Thoughtful tips for practice. Pharmacol Res. 2020;158:104878.PubMedCrossRef Chiricozzi A, Comberiati P, D’Auria E, Zuccotti G, Peroni DG. Topical corticosteroids for pediatric atopic dermatitis: Thoughtful tips for practice. Pharmacol Res. 2020;158:104878.PubMedCrossRef
11.
12.
go back to reference Norris DA. Mechanisms of action of topical therapies and the rationale for combination therapy. J Am Acad Dermatol. 2005;53:S17-25.PubMedCrossRef Norris DA. Mechanisms of action of topical therapies and the rationale for combination therapy. J Am Acad Dermatol. 2005;53:S17-25.PubMedCrossRef
13.
go back to reference Sigurgeirsson B, Boznanski A, Todd G, Vertruyen A, Schuttelaar ML, Zhu X, et al. Safety and efficacy of pimecrolimus in atopic dermatitis: a 5-year randomized trial. Pediatrics. 2015;135:597–606.PubMedCrossRef Sigurgeirsson B, Boznanski A, Todd G, Vertruyen A, Schuttelaar ML, Zhu X, et al. Safety and efficacy of pimecrolimus in atopic dermatitis: a 5-year randomized trial. Pediatrics. 2015;135:597–606.PubMedCrossRef
14.
go back to reference Chiricozzi A, Belloni Fortina A, Galli E, Girolomoni G, Neri I, Ricci G, et al. Current therapeutic paradigm in pediatric atopic dermatitis: Practical guidance from a national expert panel. Allergol Immunopathol (Madr). 2019;47:194–206.CrossRef Chiricozzi A, Belloni Fortina A, Galli E, Girolomoni G, Neri I, Ricci G, et al. Current therapeutic paradigm in pediatric atopic dermatitis: Practical guidance from a national expert panel. Allergol Immunopathol (Madr). 2019;47:194–206.CrossRef
15.
go back to reference Wollenberg A, Barbarot S, Bieber T, Christen-Zaech S, Deleuran M, Fink-Wagner A, et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II. J Eur Acad Dermatol Venereol. 2018;32:850–78.PubMedCrossRef Wollenberg A, Barbarot S, Bieber T, Christen-Zaech S, Deleuran M, Fink-Wagner A, et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II. J Eur Acad Dermatol Venereol. 2018;32:850–78.PubMedCrossRef
16.
go back to reference Hoeger PH, Kinsler V, Yan AC, Harper J, Oranje AP, Bodemer CB, Larralde M, Luk D, Mendiratta V, Purvis D. Harper's Textbook of Pediatric Dermatology, 2 Volume Set, 4th Edition. 2019. Hoeger PH, Kinsler V, Yan AC, Harper J, Oranje AP, Bodemer CB, Larralde M, Luk D, Mendiratta V, Purvis D. Harper's Textbook of Pediatric Dermatology, 2 Volume Set, 4th Edition. 2019.
17.
go back to reference Danby SG, Draelos ZD, Gold LFS, Danby SG, Draelos ZD, Gold LFS, et al. Vehicles for atopic dermatitis therapies: more than just a placebo. J Dermatolog Treat. 2020;16:1–14. Danby SG, Draelos ZD, Gold LFS, Danby SG, Draelos ZD, Gold LFS, et al. Vehicles for atopic dermatitis therapies: more than just a placebo. J Dermatolog Treat. 2020;16:1–14.
18.
go back to reference Long CC, Finlay AY. The finger-tip unit–a new practical measure. Clin Exp Dermatol. 1991;16:444–7.PubMedCrossRef Long CC, Finlay AY. The finger-tip unit–a new practical measure. Clin Exp Dermatol. 1991;16:444–7.PubMedCrossRef
19.
go back to reference Hong E, Smith S, Fischer G. Evaluation of the atrophogenic potential of topical corticosteroids in pediatric dermatology patients. Pediatr Dermatol. 2011;28:393–6.PubMedCrossRef Hong E, Smith S, Fischer G. Evaluation of the atrophogenic potential of topical corticosteroids in pediatric dermatology patients. Pediatr Dermatol. 2011;28:393–6.PubMedCrossRef
20.
go back to reference Thomas KS, Armstrong S, Avery A, Po AL, O’Neill C, Young S, et al. Randomised controlled trial of short bursts of a potent topical corticosteroid versus prolonged use of a mild preparation for children with mild or moderate atopic eczema. BMJ. 2002;324:768.PubMedPubMedCentralCrossRef Thomas KS, Armstrong S, Avery A, Po AL, O’Neill C, Young S, et al. Randomised controlled trial of short bursts of a potent topical corticosteroid versus prolonged use of a mild preparation for children with mild or moderate atopic eczema. BMJ. 2002;324:768.PubMedPubMedCentralCrossRef
21.
go back to reference Brazzini B, Pimpinelli N. New and established topical corticosteroids in dermatology: clinical pharmacology and therapeutic use. Am J Clin Dermatol. 2002;3:47–58.PubMedCrossRef Brazzini B, Pimpinelli N. New and established topical corticosteroids in dermatology: clinical pharmacology and therapeutic use. Am J Clin Dermatol. 2002;3:47–58.PubMedCrossRef
22.
go back to reference Wood Heickman LK, Davallow Ghajar L, Conaway M, Rogol AD. Evaluation of hypothalamic-pituitary-adrenal axis suppression following cutaneous use of topical corticosteroids in children: a meta-analysis. Horm Res Paediatr. 2018;89:389–96.PubMedCrossRef Wood Heickman LK, Davallow Ghajar L, Conaway M, Rogol AD. Evaluation of hypothalamic-pituitary-adrenal axis suppression following cutaneous use of topical corticosteroids in children: a meta-analysis. Horm Res Paediatr. 2018;89:389–96.PubMedCrossRef
23.
go back to reference Friedlander SF, Hebert AA, Allen DB, Fluticasone Pediatrics Safety Study Group. Safety of fluticasone propionate cream 0.05% for the treatment of severe and extensive atopic dermatitis in children as young as 3 months. J Am Acad Dermatol. 2002;46:387–93.PubMedCrossRef Friedlander SF, Hebert AA, Allen DB, Fluticasone Pediatrics Safety Study Group. Safety of fluticasone propionate cream 0.05% for the treatment of severe and extensive atopic dermatitis in children as young as 3 months. J Am Acad Dermatol. 2002;46:387–93.PubMedCrossRef
24.
go back to reference Blume-Peytavi U, Wahn U. Optimizing the treatment of atopic dermatitis in children: a review of the benefit/risk ratio of methylprednisolone aceponate. J Eur Acad Dermatol Venereol. 2011;25:508–15.PubMedCrossRef Blume-Peytavi U, Wahn U. Optimizing the treatment of atopic dermatitis in children: a review of the benefit/risk ratio of methylprednisolone aceponate. J Eur Acad Dermatol Venereol. 2011;25:508–15.PubMedCrossRef
25.
go back to reference Berth-Jones J, Damstra RJ, Golsch S, Livden JK, Van Hooteghem O, Allegra F, et al. Twice weekly fluticasone propionate added to emollient maintenance treatment to reduce risk of relapse in atopic dermatitis: randomised, double blind, parallel group study. BMJ. 2003;21:326–67. Berth-Jones J, Damstra RJ, Golsch S, Livden JK, Van Hooteghem O, Allegra F, et al. Twice weekly fluticasone propionate added to emollient maintenance treatment to reduce risk of relapse in atopic dermatitis: randomised, double blind, parallel group study. BMJ. 2003;21:326–67.
26.
go back to reference van Velsen SG, Knol MJ, van Eijk RL, de Vroede MA, de Wit TC, Lam MG, et al. Bone mineral density in children with moderate to severe atopic dermatitis. J Am Acad Dermatol. 2010;63:824–31.PubMedCrossRef van Velsen SG, Knol MJ, van Eijk RL, de Vroede MA, de Wit TC, Lam MG, et al. Bone mineral density in children with moderate to severe atopic dermatitis. J Am Acad Dermatol. 2010;63:824–31.PubMedCrossRef
27.
go back to reference Zhao M, Liang Y, Shen C, Wang Y, Ma L, Ma X. Patient education programs in pediatric atopic dermatitis: a systematic review of randomized controlled trials and meta-analysis. Dermatol Ther (Heidelb). 2020;10:449–64.CrossRef Zhao M, Liang Y, Shen C, Wang Y, Ma L, Ma X. Patient education programs in pediatric atopic dermatitis: a systematic review of randomized controlled trials and meta-analysis. Dermatol Ther (Heidelb). 2020;10:449–64.CrossRef
28.
go back to reference Li AW, Yin ES, Antaya RJ. Topical corticosteroid phobia in atopic dermatitis: a systematic review. JAMA Dermatol. 2017;153:1036–42.PubMedCrossRef Li AW, Yin ES, Antaya RJ. Topical corticosteroid phobia in atopic dermatitis: a systematic review. JAMA Dermatol. 2017;153:1036–42.PubMedCrossRef
29.
go back to reference Moret L, Anthoine E, Aubert-Wastiaux H, Le Rhun A, Leux C, Mazereeuw-Hautier J, et al. TOPICOP©: a new scale evaluating topical corticosteroid phobia among atopic dermatitis outpatients and their parents. PLoS One. 2013;16(8):e76493.CrossRef Moret L, Anthoine E, Aubert-Wastiaux H, Le Rhun A, Leux C, Mazereeuw-Hautier J, et al. TOPICOP©: a new scale evaluating topical corticosteroid phobia among atopic dermatitis outpatients and their parents. PLoS One. 2013;16(8):e76493.CrossRef
32.
go back to reference Chehade A, Rao J, Topical Calcineurin Inhibitors. Topical Calcineurin Inhibitors Comprehensive Dermatologic Drug Therapy. 4th ed. 2021. p. 549–56.CrossRef Chehade A, Rao J, Topical Calcineurin Inhibitors. Topical Calcineurin Inhibitors Comprehensive Dermatologic Drug Therapy. 4th ed. 2021. p. 549–56.CrossRef
33.
go back to reference Nakahara T, Morimoto H, Murakami N, Furue M. Mechanistic insights into topical tacrolimus for the treatment of atopic dermatitis. Pediatr Allergy Immunol. 2018;29:233–8.PubMedCrossRef Nakahara T, Morimoto H, Murakami N, Furue M. Mechanistic insights into topical tacrolimus for the treatment of atopic dermatitis. Pediatr Allergy Immunol. 2018;29:233–8.PubMedCrossRef
34.
go back to reference Pereira U, Boulais N, Lebonvallet N, Pennec JP, Dorange G, Misery L. Mechanisms of the sensory effects of tacrolimus on the skin. Br J Dermatol. 2010;163:70–7.PubMedCrossRef Pereira U, Boulais N, Lebonvallet N, Pennec JP, Dorange G, Misery L. Mechanisms of the sensory effects of tacrolimus on the skin. Br J Dermatol. 2010;163:70–7.PubMedCrossRef
35.
go back to reference Mandelin JM, Remitz A, Virtanen HM, Malmberg LP, Haahtela T, Reitamo S. A 10-year open follow-up of eczema and respiratory symptoms in patients with atopic dermatitis treated with topical tacrolimus for the first 4 years. J Dermatolog Treat. 2010;21:167–70.PubMedCrossRef Mandelin JM, Remitz A, Virtanen HM, Malmberg LP, Haahtela T, Reitamo S. A 10-year open follow-up of eczema and respiratory symptoms in patients with atopic dermatitis treated with topical tacrolimus for the first 4 years. J Dermatolog Treat. 2010;21:167–70.PubMedCrossRef
37.
go back to reference Billich A, Aschauer H, Aszódi A, Stuetz A. Percutaneous absorption of drugs used in atopic eczema: pimecrolimus permeates less through skin than corticosteroids and tacrolimus. Int J Pharmaceutics. 2004;269:29–35.CrossRef Billich A, Aschauer H, Aszódi A, Stuetz A. Percutaneous absorption of drugs used in atopic eczema: pimecrolimus permeates less through skin than corticosteroids and tacrolimus. Int J Pharmaceutics. 2004;269:29–35.CrossRef
38.
go back to reference Chittock J, Brown K, Cork MJ. Comparing the effect of a twice-weekly tacrolimus and betamethasone valerate dose on the subclinical epidermal barrier defect in atopic dermatitis. Acta Derm Venereol. 2015;95:653–8.PubMedCrossRef Chittock J, Brown K, Cork MJ. Comparing the effect of a twice-weekly tacrolimus and betamethasone valerate dose on the subclinical epidermal barrier defect in atopic dermatitis. Acta Derm Venereol. 2015;95:653–8.PubMedCrossRef
39.
go back to reference Dähnhardt D, Bastian M, Dähnhardt-Pfeiffer S, Buchner M, Fölster-Holst R. Comparing the effects of proactive treatment with tacrolimus ointment and mometasone furoate on the epidermal barrier structure and ceramide levels of patients with atopic dermatitis. J Dermatolog Treat. 2020;3:1–9. Dähnhardt D, Bastian M, Dähnhardt-Pfeiffer S, Buchner M, Fölster-Holst R. Comparing the effects of proactive treatment with tacrolimus ointment and mometasone furoate on the epidermal barrier structure and ceramide levels of patients with atopic dermatitis. J Dermatolog Treat. 2020;3:1–9.
40.
go back to reference Remitz A, De Pità O, Mota A, Serra-Baldrich E, Vakirlis E, Kapp A. Position statement: topical calcineurin inhibitors in atopic dermatitis. Eur Acad Dermatol. 2018;32:2074–82.CrossRef Remitz A, De Pità O, Mota A, Serra-Baldrich E, Vakirlis E, Kapp A. Position statement: topical calcineurin inhibitors in atopic dermatitis. Eur Acad Dermatol. 2018;32:2074–82.CrossRef
41.
go back to reference Chen SL, Yan J, Wang FX. Two topical calcineurin inhibitors for the treatment of atopic dermatitis in pediatric patients: a meta-analysis of randomized clinical trials. J Dermatol Treat. 2010;21:144–56.CrossRef Chen SL, Yan J, Wang FX. Two topical calcineurin inhibitors for the treatment of atopic dermatitis in pediatric patients: a meta-analysis of randomized clinical trials. J Dermatol Treat. 2010;21:144–56.CrossRef
42.
go back to reference El-Batawy MM, Bosseila MA, Mashaly HM, Hafez VS. Topical calcineurin inhibitors in atopic dermatitis: a systematic review and meta-analysis. J Dermatol Sci. 2009;54:76–87.PubMedCrossRef El-Batawy MM, Bosseila MA, Mashaly HM, Hafez VS. Topical calcineurin inhibitors in atopic dermatitis: a systematic review and meta-analysis. J Dermatol Sci. 2009;54:76–87.PubMedCrossRef
43.
go back to reference Ohtsuki M, Morimoto H, Nakagawa H. Tacrolimus ointment for the treatment of adult and pediatric atopic dermatitis: review on safety and benefits. J Dermatol. 2018;45:936–42.PubMedPubMedCentralCrossRef Ohtsuki M, Morimoto H, Nakagawa H. Tacrolimus ointment for the treatment of adult and pediatric atopic dermatitis: review on safety and benefits. J Dermatol. 2018;45:936–42.PubMedPubMedCentralCrossRef
44.
go back to reference Siegfried EC, Jaworski JC, Kaiser JD, Hebert AA. Systematic review of published trials: long-term safety of topical corticosteroids and topical calcineurin inhibitors in pediatric patients with atopic dermatitis. BMC Pediatr. 2016;16:75.PubMedPubMedCentralCrossRef Siegfried EC, Jaworski JC, Kaiser JD, Hebert AA. Systematic review of published trials: long-term safety of topical corticosteroids and topical calcineurin inhibitors in pediatric patients with atopic dermatitis. BMC Pediatr. 2016;16:75.PubMedPubMedCentralCrossRef
45.
go back to reference Wollenberg A, Christen-Zäch S, Taieb A, Paul C, Thyssen JP, de Bruin-Weller M. ETFAD/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children. J Eur Acad Dermatol Venereol. 2020;34:2717–44.PubMedCrossRef Wollenberg A, Christen-Zäch S, Taieb A, Paul C, Thyssen JP, de Bruin-Weller M. ETFAD/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children. J Eur Acad Dermatol Venereol. 2020;34:2717–44.PubMedCrossRef
46.
go back to reference Luger T, Augustin M, Lambert J, Paul C, Pincelli C, Torrelo A. Unmet medical needs in the treatment of atopic dermatitis in infants: an expert consensus on safety and efficacy of pimecrolimus. Pediatr Allergy Immunol. 2021;3:414–24.CrossRef Luger T, Augustin M, Lambert J, Paul C, Pincelli C, Torrelo A. Unmet medical needs in the treatment of atopic dermatitis in infants: an expert consensus on safety and efficacy of pimecrolimus. Pediatr Allergy Immunol. 2021;3:414–24.CrossRef
47.
go back to reference Sher LG, Chang J, Patel IB, Balkrishnan R, Fleischer AB Jr. Relieving the pruritus of atopic dermatitis: a meta-analysis. Acta Derm Venereol. 2012;92:455–61.PubMedCrossRef Sher LG, Chang J, Patel IB, Balkrishnan R, Fleischer AB Jr. Relieving the pruritus of atopic dermatitis: a meta-analysis. Acta Derm Venereol. 2012;92:455–61.PubMedCrossRef
48.
go back to reference Thaci D, Chambers C, Sidhu M, Dorsch B, Ehlken B, Fuchs S. Twice weekly treatment with tacrolimus 0.03% ointment in children with atopic dermatitis: clinical efficacy and economic impact over 12 months. J Eur Acad Dermatol Venereol. 2010;24:1040–6.PubMed Thaci D, Chambers C, Sidhu M, Dorsch B, Ehlken B, Fuchs S. Twice weekly treatment with tacrolimus 0.03% ointment in children with atopic dermatitis: clinical efficacy and economic impact over 12 months. J Eur Acad Dermatol Venereol. 2010;24:1040–6.PubMed
49.
go back to reference Katoh N, Ohya Y, Ikeda M, Ebihara T, Katayama I, Saeki H. Japanese guidelines for atopic dermatitis 2020. Allergol Int. 2020;69:356–69.PubMedCrossRef Katoh N, Ohya Y, Ikeda M, Ebihara T, Katayama I, Saeki H. Japanese guidelines for atopic dermatitis 2020. Allergol Int. 2020;69:356–69.PubMedCrossRef
50.
go back to reference Wongpiyabovorn J, Soonthornchai W, Wilantho A, Palasuk M, Payungporn S, Sodsai P, et al. Effect of tacrolimus on skin microbiome in atopic dermatitis. Allergy. 2019;74:1400–6.PubMedCrossRef Wongpiyabovorn J, Soonthornchai W, Wilantho A, Palasuk M, Payungporn S, Sodsai P, et al. Effect of tacrolimus on skin microbiome in atopic dermatitis. Allergy. 2019;74:1400–6.PubMedCrossRef
51.
go back to reference Beck KM, Seitzman GD, Yang EJ, Sanchez IM, Liao W, Ocular Co-Morbidities of Atopic Dermatitis. Part II: ocular disease secondary to treatments. Am J Clin Dermatol. 2019;20:807–15.PubMedCrossRef Beck KM, Seitzman GD, Yang EJ, Sanchez IM, Liao W, Ocular Co-Morbidities of Atopic Dermatitis. Part II: ocular disease secondary to treatments. Am J Clin Dermatol. 2019;20:807–15.PubMedCrossRef
52.
go back to reference Ollech A, Yousif R, Kruse L, Wagner A, Kenner-Bell B, Chamlin S, et al. Topical calcineurin inhibitors for pediatric periorificial dermatitis. J Am Acad Dermatol. 2020;82:1409–14.PubMedCrossRef Ollech A, Yousif R, Kruse L, Wagner A, Kenner-Bell B, Chamlin S, et al. Topical calcineurin inhibitors for pediatric periorificial dermatitis. J Am Acad Dermatol. 2020;82:1409–14.PubMedCrossRef
53.
go back to reference Radovic TC, Kostovic K, Ceovic R, Mokos ZB. Topical calcineurin inhibitors and malignancy risk. Int J Cancer Manag. 2017;10:e6173.CrossRef Radovic TC, Kostovic K, Ceovic R, Mokos ZB. Topical calcineurin inhibitors and malignancy risk. Int J Cancer Manag. 2017;10:e6173.CrossRef
54.
go back to reference Castellsague J, Kuiper JG, Pottegård A, Anveden Berglind I, Dedman D, Gutierrez L, et al. A cohort study on the risk of lymphoma and skin cancer in users of topical tacrolimus, pimecrolimus, and corticosteroids (Joint European Longitudinal Lymphoma and Skin Cancer Evaluation - JOELLE study). Clin Epidemiol. 2018;13(10):299–310.CrossRef Castellsague J, Kuiper JG, Pottegård A, Anveden Berglind I, Dedman D, Gutierrez L, et al. A cohort study on the risk of lymphoma and skin cancer in users of topical tacrolimus, pimecrolimus, and corticosteroids (Joint European Longitudinal Lymphoma and Skin Cancer Evaluation - JOELLE study). Clin Epidemiol. 2018;13(10):299–310.CrossRef
55.
go back to reference Margolis DJ, Abuabara K, Hoffstad OJ, Wan J, Raimondo D, Bilker WB. Association between malignancy and topical use of pimecrolimus. JAMA Dermatol. 2015;151:594–9.PubMedPubMedCentralCrossRef Margolis DJ, Abuabara K, Hoffstad OJ, Wan J, Raimondo D, Bilker WB. Association between malignancy and topical use of pimecrolimus. JAMA Dermatol. 2015;151:594–9.PubMedPubMedCentralCrossRef
56.
go back to reference Paller AS, Fölster-Holst R, Chen SC, Diepgen TL, Elmets C, Margolis DJ. No evidence of increased cancer incidence in children using topical tacrolimus for atopic dermatitis. J Am Acad Dermatol. 2020;83:375–81.PubMedCrossRef Paller AS, Fölster-Holst R, Chen SC, Diepgen TL, Elmets C, Margolis DJ. No evidence of increased cancer incidence in children using topical tacrolimus for atopic dermatitis. J Am Acad Dermatol. 2020;83:375–81.PubMedCrossRef
57.
go back to reference Rafiq M, Hayward A, Warren-Gash C, Denaxas S, Gonzalez-Izquierdo A, Lyratzopoulos G, et al. Allergic disease, corticosteroid use, and risk of hodgkin lymphoma: a United Kingdom nationwide case-control study. J Allergy Clin Immunol. 2020;145:868–76.PubMedPubMedCentralCrossRef Rafiq M, Hayward A, Warren-Gash C, Denaxas S, Gonzalez-Izquierdo A, Lyratzopoulos G, et al. Allergic disease, corticosteroid use, and risk of hodgkin lymphoma: a United Kingdom nationwide case-control study. J Allergy Clin Immunol. 2020;145:868–76.PubMedPubMedCentralCrossRef
58.
go back to reference Asgari MM, Tsai AL, Avalos L, Sokil M, Quesenberry CP Jr. Association between topical calcineurin inhibitor use and keratinocyte carcinoma risk among adults with atopic dermatitis. JAMA Dermatol. 2020;156:1066–73.PubMedCrossRef Asgari MM, Tsai AL, Avalos L, Sokil M, Quesenberry CP Jr. Association between topical calcineurin inhibitor use and keratinocyte carcinoma risk among adults with atopic dermatitis. JAMA Dermatol. 2020;156:1066–73.PubMedCrossRef
59.
go back to reference Wang V, Boguniewicz J, Boguniewicz M, Ong PY. The infectious complications of atopic dermatitis. Ann Allergy Asthma Immunol. 2021;126:3–12.PubMedCrossRef Wang V, Boguniewicz J, Boguniewicz M, Ong PY. The infectious complications of atopic dermatitis. Ann Allergy Asthma Immunol. 2021;126:3–12.PubMedCrossRef
60.
go back to reference Allen HB, Vaze ND, Choi C, Hailu T, Tulbert BH, Cusack CA, et al. The presence and impact of biofilm- producing staphylococci in atopic dermatitis. JAMA Dermatol. 2014;150:260–5.PubMedCrossRef Allen HB, Vaze ND, Choi C, Hailu T, Tulbert BH, Cusack CA, et al. The presence and impact of biofilm- producing staphylococci in atopic dermatitis. JAMA Dermatol. 2014;150:260–5.PubMedCrossRef
62.
go back to reference Kong HH, Segre JA. Skin microbiome: looking back to move forward. J Invest Dermatol. 2012;132:933–9.PubMedCrossRef Kong HH, Segre JA. Skin microbiome: looking back to move forward. J Invest Dermatol. 2012;132:933–9.PubMedCrossRef
63.
go back to reference Kong HH, Oh J, Deming C, Conlan S, Grice EA, Beatson MA, et al. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res. 2012;22:850–9.PubMedPubMedCentralCrossRef Kong HH, Oh J, Deming C, Conlan S, Grice EA, Beatson MA, et al. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res. 2012;22:850–9.PubMedPubMedCentralCrossRef
65.
go back to reference Petry V, Bessa GR, Poziomczyck CS, Oliveira CF, Weber MB, Bonamigo RR, et al. Bacterial skin colonization and infections in patients with atopic dermatitis. An Bras Dermatol. 2012;87:729–34.PubMedCrossRef Petry V, Bessa GR, Poziomczyck CS, Oliveira CF, Weber MB, Bonamigo RR, et al. Bacterial skin colonization and infections in patients with atopic dermatitis. An Bras Dermatol. 2012;87:729–34.PubMedCrossRef
66.
go back to reference Kim J, Kim BE, Ahn K, Leung DYM. Interactions between atopic dermatitis and staphylococcus aureus infection: clinical implications. Allergy Asthma Immunol Res. 2019;11:593–60.PubMedPubMedCentralCrossRef Kim J, Kim BE, Ahn K, Leung DYM. Interactions between atopic dermatitis and staphylococcus aureus infection: clinical implications. Allergy Asthma Immunol Res. 2019;11:593–60.PubMedPubMedCentralCrossRef
67.
go back to reference Stephanie M. Bacterial colonization, overgrowth, and superinfection in atopic dermatitis. Clin Dermatol. 2018;36:641–7.CrossRef Stephanie M. Bacterial colonization, overgrowth, and superinfection in atopic dermatitis. Clin Dermatol. 2018;36:641–7.CrossRef
68.
go back to reference Rosen T, Albareda N, Rosenberg N, Alonso FG, Roth S, Zsolt I, et al. Efficacy and safety of ozenoxacin cream for treatment of adult and pediatric patients with impetigo a randomized clinical trial. Jama Dermatol. 2018;154:806–13.PubMedPubMedCentralCrossRef Rosen T, Albareda N, Rosenberg N, Alonso FG, Roth S, Zsolt I, et al. Efficacy and safety of ozenoxacin cream for treatment of adult and pediatric patients with impetigo a randomized clinical trial. Jama Dermatol. 2018;154:806–13.PubMedPubMedCentralCrossRef
69.
go back to reference Bonamonte D, Belloni Fortina A, Neri L, et al. Fusidic acid in skin infections and infected atopic eczema. G Ital Dermatol Venereol. 2014;149:453–9.PubMed Bonamonte D, Belloni Fortina A, Neri L, et al. Fusidic acid in skin infections and infected atopic eczema. G Ital Dermatol Venereol. 2014;149:453–9.PubMed
70.
go back to reference Bonamonte D, Belloni Fortina A, Neri L, Patrizi A. Topical antibiotics in the dermatological clinical practice: Indications, efficacy, and adverse effects. Dermatol Ther. 2020;12:e13824. Bonamonte D, Belloni Fortina A, Neri L, Patrizi A. Topical antibiotics in the dermatological clinical practice: Indications, efficacy, and adverse effects. Dermatol Ther. 2020;12:e13824.
71.
go back to reference Rangel SM, Paller AS. Bacterial colonization, overgrowth, and superinfection in atopic dermatitis. Clin Dermatol. 2018;36:641–7.PubMedCrossRef Rangel SM, Paller AS. Bacterial colonization, overgrowth, and superinfection in atopic dermatitis. Clin Dermatol. 2018;36:641–7.PubMedCrossRef
72.
go back to reference Chiu LS, Chow VC, Ling JM, Hon KL. Staphylococcus aureus carriage in the anterior nares of close contacts of patients with atopic dermatitis. Arch Dermatol. 2010;146:748–52.PubMedCrossRef Chiu LS, Chow VC, Ling JM, Hon KL. Staphylococcus aureus carriage in the anterior nares of close contacts of patients with atopic dermatitis. Arch Dermatol. 2010;146:748–52.PubMedCrossRef
74.
go back to reference George SM, Karanovic S, Harrison DA, Rani A, Birnie AJ, Bath-Hextall FJ, et al. Interventions to reduce staphylococcus aureus in the management of eczema. Cochrane Database Syst Rev. 2019;10:CD003871. George SM, Karanovic S, Harrison DA, Rani A, Birnie AJ, Bath-Hextall FJ, et al. Interventions to reduce staphylococcus aureus in the management of eczema. Cochrane Database Syst Rev. 2019;10:CD003871.
75.
go back to reference Stevens DL, Bisno AL, Chambers HF, Dellinger EP, Goldstein EJ, Gorbach SL, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of America. Clin Infect Dis. 2014;59:e10-52.PubMedCrossRef Stevens DL, Bisno AL, Chambers HF, Dellinger EP, Goldstein EJ, Gorbach SL, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of America. Clin Infect Dis. 2014;59:e10-52.PubMedCrossRef
76.
go back to reference Montravers P, Snauwaert A, Welsch C. Current guidelines and recommendations for the management of skin and soft tissue infections. Curr Opin Infect Dis. 2016;29:131–8.PubMedCrossRef Montravers P, Snauwaert A, Welsch C. Current guidelines and recommendations for the management of skin and soft tissue infections. Curr Opin Infect Dis. 2016;29:131–8.PubMedCrossRef
77.
go back to reference Koch L, Cerpes U, Binder B, Cerroni L. Disseminated bullous impetigo in atopic dermatitis ('eczema staphylococcatum’). Eur Acad Dermatol Venereol. 2021;35:e280–2.CrossRef Koch L, Cerpes U, Binder B, Cerroni L. Disseminated bullous impetigo in atopic dermatitis ('eczema staphylococcatum’). Eur Acad Dermatol Venereol. 2021;35:e280–2.CrossRef
78.
go back to reference Galli L, Venturini E, Bassi A, Gattinara GC, Chiappini E, Defilippi C, Italian Pediatric Infectious Diseases Society; Italian Pediatric Dermatology Society, et al. Common community-acquired bacterial skin and soft-tissue infections in children: an intersociety consensus on impetigo, abscess, and cellulitis treatment. Clin Ther. 2019;41:532-551.e17.PubMedCrossRef Galli L, Venturini E, Bassi A, Gattinara GC, Chiappini E, Defilippi C, Italian Pediatric Infectious Diseases Society; Italian Pediatric Dermatology Society, et al. Common community-acquired bacterial skin and soft-tissue infections in children: an intersociety consensus on impetigo, abscess, and cellulitis treatment. Clin Ther. 2019;41:532-551.e17.PubMedCrossRef
79.
go back to reference Harkins CP, Holden MTG, Irvine AD. Antimicrobial resistance in atopic dermatitis: need for an urgent rethink. Ann Allergy Asthma Immunol. 2019;122:236–40.PubMedCrossRef Harkins CP, Holden MTG, Irvine AD. Antimicrobial resistance in atopic dermatitis: need for an urgent rethink. Ann Allergy Asthma Immunol. 2019;122:236–40.PubMedCrossRef
80.
go back to reference Majewski S, Bhattacharya T, Asztalos M, Bohaty B, Durham KC, West DP, et al. Sodium hypochlorite body wash in the management of Staphylococcus aureus–colonized moderate-to-Severe atopic dermatitis in infants, children, and adolescents. Pediatric Dermatol. 2019;36:442–7.CrossRef Majewski S, Bhattacharya T, Asztalos M, Bohaty B, Durham KC, West DP, et al. Sodium hypochlorite body wash in the management of Staphylococcus aureus–colonized moderate-to-Severe atopic dermatitis in infants, children, and adolescents. Pediatric Dermatol. 2019;36:442–7.CrossRef
81.
go back to reference Leung TH, Zhang LF, Wang J, Ning S, Knox SJ, Kim SK. Topical hypochlorite ameliorates NF-kappaB-mediated skin diseases in mice. J Clin Invest. 2013;123:5361–70.PubMedPubMedCentralCrossRef Leung TH, Zhang LF, Wang J, Ning S, Knox SJ, Kim SK. Topical hypochlorite ameliorates NF-kappaB-mediated skin diseases in mice. J Clin Invest. 2013;123:5361–70.PubMedPubMedCentralCrossRef
83.
go back to reference Eriksson S. Antibacterial and antibiofilm effects of sodium hypochlorite against staphylococcus aureus isolates derived from patients with atopic dermatitis. Br J Dermatol. 2017;177:513–21.PubMedCrossRef Eriksson S. Antibacterial and antibiofilm effects of sodium hypochlorite against staphylococcus aureus isolates derived from patients with atopic dermatitis. Br J Dermatol. 2017;177:513–21.PubMedCrossRef
84.
go back to reference Rerinck HC, Kamann S, Wollenberg A. Eczema herpeticatum: pathogenese und therapie [Eczema herpeticum: Pathogenesis and therapy]. Hautarzt. 2006;57:586–91.PubMedCrossRef Rerinck HC, Kamann S, Wollenberg A. Eczema herpeticatum: pathogenese und therapie [Eczema herpeticum: Pathogenesis and therapy]. Hautarzt. 2006;57:586–91.PubMedCrossRef
85.
go back to reference Seegräber M, Worm M, Werfel T, Svensson A, Novak N, Simon D, et al. Recurrent eczema herpeticum - a retrospective European multicenter study evaluating the clinical characteristics of eczema herpeticum cases in atopic dermatitis patients. J Eur Acad Dermatol Venereol. 2020;34:1074–9.PubMedCrossRef Seegräber M, Worm M, Werfel T, Svensson A, Novak N, Simon D, et al. Recurrent eczema herpeticum - a retrospective European multicenter study evaluating the clinical characteristics of eczema herpeticum cases in atopic dermatitis patients. J Eur Acad Dermatol Venereol. 2020;34:1074–9.PubMedCrossRef
87.
go back to reference Ong PY, Leung DYM. Bacterial and viral infections in atopic dermatitis: a comprehensive review. Clin Rev Allergy Immunol. 2016;51:329–37.PubMedCrossRef Ong PY, Leung DYM. Bacterial and viral infections in atopic dermatitis: a comprehensive review. Clin Rev Allergy Immunol. 2016;51:329–37.PubMedCrossRef
88.
go back to reference Guzman AK, Schairer DO, Garelik JL, Cohen SR. Safety and efficacy of topical cantharidin for the treatment of pediatric molluscumcontagiosum: a prospective, randomized, double-blind, placebo-controlled pilot trial. Int J Dermatol. 2018;57:1001–6.PubMedCrossRef Guzman AK, Schairer DO, Garelik JL, Cohen SR. Safety and efficacy of topical cantharidin for the treatment of pediatric molluscumcontagiosum: a prospective, randomized, double-blind, placebo-controlled pilot trial. Int J Dermatol. 2018;57:1001–6.PubMedCrossRef
89.
go back to reference Berger EM, Orlow SJ, Patel RR, Schaffer JV. Experience with molluscum contagiosum and associated inflammatory reactions in a pediatric dermatology practice: the bump that rashes. Arch Dermatol. 2012;148:1257–64.PubMedCrossRef Berger EM, Orlow SJ, Patel RR, Schaffer JV. Experience with molluscum contagiosum and associated inflammatory reactions in a pediatric dermatology practice: the bump that rashes. Arch Dermatol. 2012;148:1257–64.PubMedCrossRef
90.
go back to reference Mathes EF, Oza V, Frieden IJ, Cordoro KM, Yagi S, Howard R, et al. “Eczema coxsackium” and unusualcutaneousfindings in an enterovirusoutbreak. Pediatrics. 2013;132:e149-57.PubMedPubMedCentralCrossRef Mathes EF, Oza V, Frieden IJ, Cordoro KM, Yagi S, Howard R, et al. “Eczema coxsackium” and unusualcutaneousfindings in an enterovirusoutbreak. Pediatrics. 2013;132:e149-57.PubMedPubMedCentralCrossRef
91.
go back to reference Neri I, Dondi A, Wollenberg A, Ricci L, Ricci G, Piccirilli G, et al. Atypical forms of hand, foot, and mouth disease: a prospective study of 47 Italian children. Pediatr Dermatol. 2016;33:429–37.PubMedCrossRef Neri I, Dondi A, Wollenberg A, Ricci L, Ricci G, Piccirilli G, et al. Atypical forms of hand, foot, and mouth disease: a prospective study of 47 Italian children. Pediatr Dermatol. 2016;33:429–37.PubMedCrossRef
92.
go back to reference Johnson VK, Hayman JL, McCarthy CA, Cardona ID. Successful treatment of eczema coxsackium with wet wrap therapy and low-dose topical corticosteroid. J Allergy Clin Immunol Pract. 2014;2:803–4.PubMedCrossRef Johnson VK, Hayman JL, McCarthy CA, Cardona ID. Successful treatment of eczema coxsackium with wet wrap therapy and low-dose topical corticosteroid. J Allergy Clin Immunol Pract. 2014;2:803–4.PubMedCrossRef
93.
go back to reference Ikezawa Z, Kondo M, Okajima M, Nishimura Y, Kono M. Clinical usefulness of oral itraconazole, an antimycotic drug, for refractory atopic dermatitis. Eur J Dermatol. 2004;14:400–6.PubMed Ikezawa Z, Kondo M, Okajima M, Nishimura Y, Kono M. Clinical usefulness of oral itraconazole, an antimycotic drug, for refractory atopic dermatitis. Eur J Dermatol. 2004;14:400–6.PubMed
94.
go back to reference Darabi K, Hostetler SG, Bechtel MA, Zirwas M. The role of Malassezia in atopic dermatitis affecting the head and neck of adults. J Am Acad Dermatol. 2009;60:125–36.PubMedCrossRef Darabi K, Hostetler SG, Bechtel MA, Zirwas M. The role of Malassezia in atopic dermatitis affecting the head and neck of adults. J Am Acad Dermatol. 2009;60:125–36.PubMedCrossRef
95.
go back to reference Saunte DML, Gaitanis G, Hay RJ. Malassezia-associated skin diseases, the use of diagnostics and treatment. Front Cell Infect Microbiol. 2020;20(10):112.CrossRef Saunte DML, Gaitanis G, Hay RJ. Malassezia-associated skin diseases, the use of diagnostics and treatment. Front Cell Infect Microbiol. 2020;20(10):112.CrossRef
96.
go back to reference Guglielmo A, Sechi A, Patrizi A, Gurioli C, Neri I. Head and neck dermatitis, a subtype of atopic dermatitis induced by Malassezia spp: clinical aspects and treatment outcomes in adolescent and adult patients. Pediatr Dermatol. 2021;38(1):109–14.PubMedCrossRef Guglielmo A, Sechi A, Patrizi A, Gurioli C, Neri I. Head and neck dermatitis, a subtype of atopic dermatitis induced by Malassezia spp: clinical aspects and treatment outcomes in adolescent and adult patients. Pediatr Dermatol. 2021;38(1):109–14.PubMedCrossRef
97.
go back to reference Mayser P, Kupfer J, Nemetz D, Schäfer U, Nilles M, Hort W, et al. Treatment of head and neck dermatitis with ciclopiroxolamine cream - results of a double-blind, placebo- controlled study. Skin Pharmacol Physiol. 2006;19:153–8.PubMedCrossRef Mayser P, Kupfer J, Nemetz D, Schäfer U, Nilles M, Hort W, et al. Treatment of head and neck dermatitis with ciclopiroxolamine cream - results of a double-blind, placebo- controlled study. Skin Pharmacol Physiol. 2006;19:153–8.PubMedCrossRef
98.
go back to reference Morita E, Hide M, Yoneya Y, Kannbe M, Tanaka A, Yamamoto S. An assessment of the role of Candida albicans antigen in atopic dermatitis. J Dermatol. 1999;26:282–7.PubMedCrossRef Morita E, Hide M, Yoneya Y, Kannbe M, Tanaka A, Yamamoto S. An assessment of the role of Candida albicans antigen in atopic dermatitis. J Dermatol. 1999;26:282–7.PubMedCrossRef
99.
go back to reference Javad G, Taheri Sarvtin M, Hedayati MT, Hajheydari Z, Yazdani J, et al. Evaluation of Candida colonization and specific humoral responses against Candida albicans in patients with atopic dermatitis. Biomed Res Int. 2015;2015:142453.CrossRef Javad G, Taheri Sarvtin M, Hedayati MT, Hajheydari Z, Yazdani J, et al. Evaluation of Candida colonization and specific humoral responses against Candida albicans in patients with atopic dermatitis. Biomed Res Int. 2015;2015:142453.CrossRef
100.
go back to reference Thammahong A, Kiatsurayanon C, Edwards SW, Rerknimitr P, Chiewchengchol D. The clinical significance of fungi in atopic dermatitis. Int J Dermatol. 2020;59:926–35.PubMedCrossRef Thammahong A, Kiatsurayanon C, Edwards SW, Rerknimitr P, Chiewchengchol D. The clinical significance of fungi in atopic dermatitis. Int J Dermatol. 2020;59:926–35.PubMedCrossRef
101.
go back to reference Soeberdt M, Kilic A, Abels C. Small molecule drugs for the treatment of pruritus in patients with atopic dermatitis. Eur J Pharmacol. 2020;881:171242.CrossRef Soeberdt M, Kilic A, Abels C. Small molecule drugs for the treatment of pruritus in patients with atopic dermatitis. Eur J Pharmacol. 2020;881:171242.CrossRef
102.
go back to reference Fahrbach K, Tarpey J, Washington EB, Hughes R, Thom H, Neary MP, et al. Crisaborole ointment, 2%, for treatment of patients with mild-to-moderate atopic dermatitis: systematic literature review and network meta-analysis JC. Dermatol Ther (Heidelb). 2020;10:681–94.CrossRef Fahrbach K, Tarpey J, Washington EB, Hughes R, Thom H, Neary MP, et al. Crisaborole ointment, 2%, for treatment of patients with mild-to-moderate atopic dermatitis: systematic literature review and network meta-analysis JC. Dermatol Ther (Heidelb). 2020;10:681–94.CrossRef
103.
go back to reference Paller AS, Tom WL, Lebwohl MG, Paller AS, Tom WL, Lebwohl MG, et al. Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults. J Am Acad Dermatol. 2016;75:494–503.PubMedCrossRef Paller AS, Tom WL, Lebwohl MG, Paller AS, Tom WL, Lebwohl MG, et al. Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults. J Am Acad Dermatol. 2016;75:494–503.PubMedCrossRef
104.
go back to reference Solimani F, Meier K, Ghoreschi K. Emergin topical and sistemi jak inhibitors in dermatology. Front Immunol. 2019;3(10):2847.CrossRef Solimani F, Meier K, Ghoreschi K. Emergin topical and sistemi jak inhibitors in dermatology. Front Immunol. 2019;3(10):2847.CrossRef
105.
go back to reference Rodrigues MA, Torres T. Jak/STA inhibitors for the treatment of atopic dermatitis. J Dermatolog Treat. 2020;31:33–40.PubMedCrossRef Rodrigues MA, Torres T. Jak/STA inhibitors for the treatment of atopic dermatitis. J Dermatolog Treat. 2020;31:33–40.PubMedCrossRef
106.
go back to reference Guttman-Yassky E, Hanifin JM, Boguniewicz M, Wollenberg A, Bissonnette R, Purohit V, et al. The role of phosphodiesterase 4 in the pathophysiology of atopic dermatitis and the perspective for its inhibition. Exp Dermatol. 2019;28:3–10.PubMed Guttman-Yassky E, Hanifin JM, Boguniewicz M, Wollenberg A, Bissonnette R, Purohit V, et al. The role of phosphodiesterase 4 in the pathophysiology of atopic dermatitis and the perspective for its inhibition. Exp Dermatol. 2019;28:3–10.PubMed
107.
108.
go back to reference Brar KK, Nicol NH, Boguniewicz M. Strategies for successful management of severe atopic dermatitis. J Allergy Clin Immunol Pract. 2019;7:1–16.PubMedCrossRef Brar KK, Nicol NH, Boguniewicz M. Strategies for successful management of severe atopic dermatitis. J Allergy Clin Immunol Pract. 2019;7:1–16.PubMedCrossRef
109.
go back to reference Janmohamed SR, Eichenfield LF, Ring J, Gutermuth J. Medical algorithm: diagnosis of atopic dermatitis in early childhood (part II). Allergy. 2020;00:1–4. Janmohamed SR, Eichenfield LF, Ring J, Gutermuth J. Medical algorithm: diagnosis of atopic dermatitis in early childhood (part II). Allergy. 2020;00:1–4.
110.
go back to reference Cadmus SD, Sebastian KR, Warren D, Hovinga CA, Croce EA, Reveles LA, et al. Efficacy and patient opinion of wet-wrap dressings using 0.1% triamcinolone acetonide ointment vs cream in the treatment of pediatric atopic dermatitis: a randomized split-body control study. Pediatr Dermatol. 2019;36:437–41.PubMed Cadmus SD, Sebastian KR, Warren D, Hovinga CA, Croce EA, Reveles LA, et al. Efficacy and patient opinion of wet-wrap dressings using 0.1% triamcinolone acetonide ointment vs cream in the treatment of pediatric atopic dermatitis: a randomized split-body control study. Pediatr Dermatol. 2019;36:437–41.PubMed
111.
go back to reference Mirza SA. Serum triamcinolone levels during intensive, inpatient wet-dressing therapy. Clin Exp Dermatol. 2020;45:549–54.PubMedCrossRef Mirza SA. Serum triamcinolone levels during intensive, inpatient wet-dressing therapy. Clin Exp Dermatol. 2020;45:549–54.PubMedCrossRef
112.
go back to reference Witte M, Krause L, Zillikens D, Shimanovich I. Black tea dressings - a rapidly effective treatment for facial dermatitis. J Dermatolog Treat. 2019;30:785–9.PubMedCrossRef Witte M, Krause L, Zillikens D, Shimanovich I. Black tea dressings - a rapidly effective treatment for facial dermatitis. J Dermatolog Treat. 2019;30:785–9.PubMedCrossRef
113.
go back to reference Huiling H, Koh MJ, Lee HY, Ang SB. Pilot study of a customized nanotextile wet garment treatment on moderate and severe atopic dermatitis: a randomized clinical trial. Pediatr Dermatol. 2020;37:52–7.CrossRef Huiling H, Koh MJ, Lee HY, Ang SB. Pilot study of a customized nanotextile wet garment treatment on moderate and severe atopic dermatitis: a randomized clinical trial. Pediatr Dermatol. 2020;37:52–7.CrossRef
114.
go back to reference Naylor GRS. Fabric-evoked prickle in worsted spun single jersey fabrics part 4: extension from wool to OptimTMfine Fiber. Text Res J. 2009;80:537–47.CrossRef Naylor GRS. Fabric-evoked prickle in worsted spun single jersey fabrics part 4: extension from wool to OptimTMfine Fiber. Text Res J. 2009;80:537–47.CrossRef
115.
go back to reference Gauger A, Mempel M, Schekatz A, Schäfer T, Ring J, Abeck D. Silver-coated textiles reduce Staphylococcus aureus colonization in patients with atopic eczema. Dermatology. 2003;207:15–21.PubMedCrossRef Gauger A, Mempel M, Schekatz A, Schäfer T, Ring J, Abeck D. Silver-coated textiles reduce Staphylococcus aureus colonization in patients with atopic eczema. Dermatology. 2003;207:15–21.PubMedCrossRef
116.
go back to reference Gauger A, Fischer S, Mempel M, Schaefer T, Foelster-Holst R, Abeck D, et al. Efficacy and functionality of silver-coated textiles in patients with atopic eczema. J Eur Acad Dermatol Venereol. 2006;20:534–41.PubMedCrossRef Gauger A, Fischer S, Mempel M, Schaefer T, Foelster-Holst R, Abeck D, et al. Efficacy and functionality of silver-coated textiles in patients with atopic eczema. J Eur Acad Dermatol Venereol. 2006;20:534–41.PubMedCrossRef
117.
go back to reference Zhai H, Dika E, Goldovsky M, Maibach HI. Tape-stripping method in man: comparison of evaporimetric methods. Skin Res Technol. 2007;13(2):207–10.PubMedCrossRef Zhai H, Dika E, Goldovsky M, Maibach HI. Tape-stripping method in man: comparison of evaporimetric methods. Skin Res Technol. 2007;13(2):207–10.PubMedCrossRef
118.
go back to reference Hipler UC, Elsner P, Fluhr JW. A new silver-loaded cellulosic fiber with antifungal and antibacterial properties. Curr Probl Dermatol. 2006;33:165–78.PubMedCrossRef Hipler UC, Elsner P, Fluhr JW. A new silver-loaded cellulosic fiber with antifungal and antibacterial properties. Curr Probl Dermatol. 2006;33:165–78.PubMedCrossRef
119.
go back to reference Park KY, Jang WS, Yang GW, Rho YH, Kim BJ, Mun SK, et al. A pilot study of silver-loaded cellulose fabric with incorporated seaweed for the treatment of atopic dermatitis. Clin Exp Dermatol. 2012;37:512–5.PubMedCrossRef Park KY, Jang WS, Yang GW, Rho YH, Kim BJ, Mun SK, et al. A pilot study of silver-loaded cellulose fabric with incorporated seaweed for the treatment of atopic dermatitis. Clin Exp Dermatol. 2012;37:512–5.PubMedCrossRef
120.
go back to reference Araújo CP, Gomes J, Vieira AP, Ventura F, Fernandes JC, Brito C. A proposal for the use of new silver-seaweed-cotton fibers in the treatment of atopic dermatitis. Cutan Ocul Toxicol. 2013;32:268–74.PubMedCrossRef Araújo CP, Gomes J, Vieira AP, Ventura F, Fernandes JC, Brito C. A proposal for the use of new silver-seaweed-cotton fibers in the treatment of atopic dermatitis. Cutan Ocul Toxicol. 2013;32:268–74.PubMedCrossRef
121.
go back to reference Pluut OA, Bianco C, Jakasa I, Visser MJ, Krystek P, Larese-Filon F, et al. Percutaneous penetration of silver from a silver containing garment in healthy volunteers and patients with atopic dermatitis. Toxicol Lett. 2015;235:116–22.PubMedCrossRef Pluut OA, Bianco C, Jakasa I, Visser MJ, Krystek P, Larese-Filon F, et al. Percutaneous penetration of silver from a silver containing garment in healthy volunteers and patients with atopic dermatitis. Toxicol Lett. 2015;235:116–22.PubMedCrossRef
122.
go back to reference Lopes C, Soares J, Tavaria F, Duarte A, Correia O, Sokhatska O, et al. Chitosan coated textiles may improve atopic dermatitis severity by modulating skin staphylococcal profile: a randomized controlled trial. PLoS One. 2015;10:e0142844.PubMedPubMedCentralCrossRef Lopes C, Soares J, Tavaria F, Duarte A, Correia O, Sokhatska O, et al. Chitosan coated textiles may improve atopic dermatitis severity by modulating skin staphylococcal profile: a randomized controlled trial. PLoS One. 2015;10:e0142844.PubMedPubMedCentralCrossRef
123.
go back to reference Ricci G, Patrizi A, Bendandi B, Menna G, Varotti E, Masi M. Clinical effectiveness of a silk fabric in the treatment of atopic dermatitis. Br J Dermatol. 2004;150:127–31.PubMedCrossRef Ricci G, Patrizi A, Bendandi B, Menna G, Varotti E, Masi M. Clinical effectiveness of a silk fabric in the treatment of atopic dermatitis. Br J Dermatol. 2004;150:127–31.PubMedCrossRef
124.
go back to reference Ricci G, Patrizi A, Mandrioli P, Specchia F, Medri M, Menna G, et al. Evaluation of the antibacterial activity of a specialsilk textile in the treatment of atopic dermatitis. Dermatology. 2006;213:224–7.PubMedCrossRef Ricci G, Patrizi A, Mandrioli P, Specchia F, Medri M, Menna G, et al. Evaluation of the antibacterial activity of a specialsilk textile in the treatment of atopic dermatitis. Dermatology. 2006;213:224–7.PubMedCrossRef
125.
go back to reference Koller DY, Halmerbauer G, Bock A, Engstler G. Action of a silk fabric treated with AEGIS in children with atopic dermatitis: a 3-month trial. Pediatr Allergy Immunol. 2007;18:335–8.PubMedCrossRef Koller DY, Halmerbauer G, Bock A, Engstler G. Action of a silk fabric treated with AEGIS in children with atopic dermatitis: a 3-month trial. Pediatr Allergy Immunol. 2007;18:335–8.PubMedCrossRef
126.
go back to reference Stinco G, Piccirillo F, Valent F. A randomized double-blind study to investigate the clinical efficacy of adding a non-migrating antimicrobial to a special silk fabric in the treatment of atopic dermatitis. Dermatology. 2008;217:191–5.PubMedCrossRef Stinco G, Piccirillo F, Valent F. A randomized double-blind study to investigate the clinical efficacy of adding a non-migrating antimicrobial to a special silk fabric in the treatment of atopic dermatitis. Dermatology. 2008;217:191–5.PubMedCrossRef
127.
go back to reference Fontanini C, Berti I, Monasta L, Longo G. DermaSilk in long-term control of infantile atopic dermatitis: a double blind randomized controlled trial. G Ital Dermatol Venereol. 2013;148:293–7.PubMed Fontanini C, Berti I, Monasta L, Longo G. DermaSilk in long-term control of infantile atopic dermatitis: a double blind randomized controlled trial. G Ital Dermatol Venereol. 2013;148:293–7.PubMed
128.
go back to reference Thomas KS, Bradshaw LE, Sach TH, Cowdell F, Batchelor JM, Lawton S, et al. Randomised controlled trial of silk therapeutic garments for the management of atopic eczema in children: theCLOTHES trial. Health Technol Assess. 2017;21:1–260.PubMedPubMedCentral Thomas KS, Bradshaw LE, Sach TH, Cowdell F, Batchelor JM, Lawton S, et al. Randomised controlled trial of silk therapeutic garments for the management of atopic eczema in children: theCLOTHES trial. Health Technol Assess. 2017;21:1–260.PubMedPubMedCentral
129.
go back to reference Srour J, Wollenberg A. Evaluation of antimicrobial textiles for atopic dermatitis. Br J Dermatol. 2018;179:e19. Srour J, Wollenberg A. Evaluation of antimicrobial textiles for atopic dermatitis. Br J Dermatol. 2018;179:e19.
130.
go back to reference Jaros J, Wilson C, Shi VY. Fabric selection in atopic dermatitis: an evidence based review. Am J Clin Dermatol. 2020;21:467–82.PubMedCrossRef Jaros J, Wilson C, Shi VY. Fabric selection in atopic dermatitis: an evidence based review. Am J Clin Dermatol. 2020;21:467–82.PubMedCrossRef
131.
go back to reference Drucker AM, Eyerich K, de Bruin-Weller MS, Thyssen JP, Spuls PI, Irvine AD, et al. Use of systemic corticosteroids for atopic dermatitis: international Eczema council consensus statement. Br J Dermatol. 2018;178:768–75.PubMedPubMedCentralCrossRef Drucker AM, Eyerich K, de Bruin-Weller MS, Thyssen JP, Spuls PI, Irvine AD, et al. Use of systemic corticosteroids for atopic dermatitis: international Eczema council consensus statement. Br J Dermatol. 2018;178:768–75.PubMedPubMedCentralCrossRef
132.
go back to reference Yu SH, Drucker AM, Lebwohl M, Silverberg JI. A systematic review of the safety and efficacy of systemic corticosteroids in atopic dermatitis. J Am Acad Dermatol. 2018;78:733-740.e11.PubMedCrossRef Yu SH, Drucker AM, Lebwohl M, Silverberg JI. A systematic review of the safety and efficacy of systemic corticosteroids in atopic dermatitis. J Am Acad Dermatol. 2018;78:733-740.e11.PubMedCrossRef
133.
go back to reference Misery L, Belloni Fortina A, El Hachem M, Chernyshov P, von Kobyletzki L, Heratizadeh A, et al. A position paper on the management of itch and pain in atopic dermatitis from the International Society of Atopic Dermatitis (ISAD)/Oriented Patient-Education Network in Dermatology (OPENED) task force. J Eur Acad Dermatol Venereol. 2021;35:787–96.PubMedCrossRef Misery L, Belloni Fortina A, El Hachem M, Chernyshov P, von Kobyletzki L, Heratizadeh A, et al. A position paper on the management of itch and pain in atopic dermatitis from the International Society of Atopic Dermatitis (ISAD)/Oriented Patient-Education Network in Dermatology (OPENED) task force. J Eur Acad Dermatol Venereol. 2021;35:787–96.PubMedCrossRef
134.
go back to reference Sidbury R, Davis DM, Cohen DE, Cordoro KM, Berger TG, Bergman JN, American Academy of Dermatology, et al. Guidelines of care for the management of atopic dermatitis: section 3. Management and treatment with phototherapy and systemic agents. J Am Acad Dermatol. 2014;71:327–49.PubMedPubMedCentralCrossRef Sidbury R, Davis DM, Cohen DE, Cordoro KM, Berger TG, Bergman JN, American Academy of Dermatology, et al. Guidelines of care for the management of atopic dermatitis: section 3. Management and treatment with phototherapy and systemic agents. J Am Acad Dermatol. 2014;71:327–49.PubMedPubMedCentralCrossRef
135.
go back to reference Chan TC, Wu NL, Wong LS. Taiwanese Dermatological Association consensus for the management of atopic dermatitis: A 2020 update. J Formos Med Assoc. 2020;18:18:S0929-664630237–0. Chan TC, Wu NL, Wong LS. Taiwanese Dermatological Association consensus for the management of atopic dermatitis: A 2020 update. J Formos Med Assoc. 2020;18:18:S0929-664630237–0.
136.
go back to reference Amor KT, Ryan C, Menter A. The use of cyclosporine in dermatology: part I. J Am Acad Dermatol. 2010;63:925–46.PubMedCrossRef Amor KT, Ryan C, Menter A. The use of cyclosporine in dermatology: part I. J Am Acad Dermatol. 2010;63:925–46.PubMedCrossRef
137.
go back to reference Amber T, Tabassum S. Cyclosporin in dermatology: a practical compendium. Dermatol Ther. 2020;30:e13934. Amber T, Tabassum S. Cyclosporin in dermatology: a practical compendium. Dermatol Ther. 2020;30:e13934.
138.
go back to reference Caproni M, Salvatore E, Cardinali C, Brazzini B, Fabbri P. Soluble CD30 andcyclosporin in severe atopic dermatitis. Int Arch Allergy Immunol. 2000;121:324–8.PubMedCrossRef Caproni M, Salvatore E, Cardinali C, Brazzini B, Fabbri P. Soluble CD30 andcyclosporin in severe atopic dermatitis. Int Arch Allergy Immunol. 2000;121:324–8.PubMedCrossRef
139.
go back to reference Roekevisch E, Spuls PI, Kuester D, Limpens J, Schmitt J. Efficacy and safety of systemic treatments for moderate-to-severe atopic dermatitis: a systematic review. J Allergy Clin Immunol. 2014;133:429–38.PubMedCrossRef Roekevisch E, Spuls PI, Kuester D, Limpens J, Schmitt J. Efficacy and safety of systemic treatments for moderate-to-severe atopic dermatitis: a systematic review. J Allergy Clin Immunol. 2014;133:429–38.PubMedCrossRef
140.
go back to reference Schmitt J, Schmitt N, Meurer M. Cyclosporin in the treatment of patients with atopic eczema – a systematic review and meta-analysis. J Eur Acad Dermatol Venereol. 2007;21:606–19.PubMed Schmitt J, Schmitt N, Meurer M. Cyclosporin in the treatment of patients with atopic eczema – a systematic review and meta-analysis. J Eur Acad Dermatol Venereol. 2007;21:606–19.PubMed
141.
go back to reference Berth-Jones J, Finlay AY, Zaki I, Tan B, Goodyear H, Lewis-Jones S, et al. Cyclosporine in severe childhood atopic dermatitis: a multicenter study. J Am Acad Dermatol. 1996;34:1016–21.PubMedCrossRef Berth-Jones J, Finlay AY, Zaki I, Tan B, Goodyear H, Lewis-Jones S, et al. Cyclosporine in severe childhood atopic dermatitis: a multicenter study. J Am Acad Dermatol. 1996;34:1016–21.PubMedCrossRef
142.
go back to reference Zaki I, Emerson R, Allen BR. Treatment of severe atopic dermatitis in childhood with cyclosporine. Br J Dermatol. 1996;135(Suppl 48):21–4.PubMedCrossRef Zaki I, Emerson R, Allen BR. Treatment of severe atopic dermatitis in childhood with cyclosporine. Br J Dermatol. 1996;135(Suppl 48):21–4.PubMedCrossRef
143.
go back to reference Harper JI, Ahmed I, Barclay G, Lacour M, Hoeger P, Cork MJ, et al. Cyclosporin for severe childhood atopic dermatitis: short course versus continuous therapy. Br J Dermatol. 2000;142:52–8.PubMedCrossRef Harper JI, Ahmed I, Barclay G, Lacour M, Hoeger P, Cork MJ, et al. Cyclosporin for severe childhood atopic dermatitis: short course versus continuous therapy. Br J Dermatol. 2000;142:52–8.PubMedCrossRef
144.
go back to reference El-Khalawany MA, Hassan H, Shaaban D, Ghonaim N, Eassa B. Methotrexate versus cyclosporine in the treatment of severe atopic dermatitis in children: a multicenter experience from Egypt. Eur J Pediatr. 2013;172:351–6.PubMedCrossRef El-Khalawany MA, Hassan H, Shaaban D, Ghonaim N, Eassa B. Methotrexate versus cyclosporine in the treatment of severe atopic dermatitis in children: a multicenter experience from Egypt. Eur J Pediatr. 2013;172:351–6.PubMedCrossRef
145.
go back to reference Irvine AD, Jones AP, Beattie P, Baron S, Browne F, Ashoor F, et al. A randomized controlled trial protocol assessing the effectiveness, safety and cost-effectiveness of methotrexate vs. ciclosporin in the treatment of severe atopic eczema in children: the TREatment of severe Atopic eczema Trial (TREAT). Br J Dermatol. 2018;179:1297–306.PubMedCrossRef Irvine AD, Jones AP, Beattie P, Baron S, Browne F, Ashoor F, et al. A randomized controlled trial protocol assessing the effectiveness, safety and cost-effectiveness of methotrexate vs. ciclosporin in the treatment of severe atopic eczema in children: the TREatment of severe Atopic eczema Trial (TREAT). Br J Dermatol. 2018;179:1297–306.PubMedCrossRef
146.
go back to reference Damiani G, Calzavara-Pinton P, Stingeni L, Hansel K, Cusano F, “Skin Allergy” Group of SIDeMaST; “ADOI” (Associazione Dermatologi Ospedalieri Italiani); “SIDAPA” (Società Italiana di Dermatologia Allergologica, Professionale e Ambientale), Pigatto PDM. Italian guidelines for therapy of atopic dermatitis-Adapted from consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis). Dermatol Ther. 2019;32:e13121.PubMedCrossRef Damiani G, Calzavara-Pinton P, Stingeni L, Hansel K, Cusano F, “Skin Allergy” Group of SIDeMaST; “ADOI” (Associazione Dermatologi Ospedalieri Italiani); “SIDAPA” (Società Italiana di Dermatologia Allergologica, Professionale e Ambientale), Pigatto PDM. Italian guidelines for therapy of atopic dermatitis-Adapted from consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis). Dermatol Ther. 2019;32:e13121.PubMedCrossRef
147.
go back to reference Lansang P, Lara-Corrales I, Bergman JN, Hong CH, Joseph M, Kim VHD, et al. Approach to the assessment and management of pediatric patients with atopic dermatitis: a consensus document. Section IV: consensus statements on the assessment and management of pediatric atopic dermatitis. J Cutan Med Surg. 2019;23:32s–9s.PubMedCrossRef Lansang P, Lara-Corrales I, Bergman JN, Hong CH, Joseph M, Kim VHD, et al. Approach to the assessment and management of pediatric patients with atopic dermatitis: a consensus document. Section IV: consensus statements on the assessment and management of pediatric atopic dermatitis. J Cutan Med Surg. 2019;23:32s–9s.PubMedCrossRef
148.
go back to reference Hernández-Martín A, Noguera-Morel L, Bernardino-Cuesta B, Torrelo A, Pérez-Martin MA, Aparicio-López C, et al. Cyclosporine A for severe atopic dermatitis in children efficacy and safety in a retrospective study of 63 patients. J Eur Acad Dermatol Venereol. 2017;31:837–42.PubMedCrossRef Hernández-Martín A, Noguera-Morel L, Bernardino-Cuesta B, Torrelo A, Pérez-Martin MA, Aparicio-López C, et al. Cyclosporine A for severe atopic dermatitis in children efficacy and safety in a retrospective study of 63 patients. J Eur Acad Dermatol Venereol. 2017;31:837–42.PubMedCrossRef
149.
go back to reference Proudfoot LE, Powell AM, Ayis S, Barbarot S, Baselga Torres E, Deleuran M, et al. The European treatment of severe atopic eczema in children taskforce (TREAT) survey. J Eur Acad Dermatol Venereol. 2013;32:850–78. Proudfoot LE, Powell AM, Ayis S, Barbarot S, Baselga Torres E, Deleuran M, et al. The European treatment of severe atopic eczema in children taskforce (TREAT) survey. J Eur Acad Dermatol Venereol. 2013;32:850–78.
150.
go back to reference Drucker AM, Ellis AG, Bohdanowicz M, Mashayekhi S, Yiu ZZN, Rochwerg B, et al. Systemic immunomodulatory treatments for patients with atopic dermatitis: a systematic review and network meta-analysis. JAMA Dermatol. 2020;156:1–10.PubMedCentralCrossRef Drucker AM, Ellis AG, Bohdanowicz M, Mashayekhi S, Yiu ZZN, Rochwerg B, et al. Systemic immunomodulatory treatments for patients with atopic dermatitis: a systematic review and network meta-analysis. JAMA Dermatol. 2020;156:1–10.PubMedCentralCrossRef
151.
go back to reference Cronstein BN, Aune TM. Methotrexate and its mechanisms of action in inflammatory arthritis. Nat Rev Rheumatol. 2020;16:145–54.PubMedCrossRef Cronstein BN, Aune TM. Methotrexate and its mechanisms of action in inflammatory arthritis. Nat Rev Rheumatol. 2020;16:145–54.PubMedCrossRef
152.
go back to reference Weathrhead SC, Wahie S, Reynolds NY. An open label, dose-ranging study of methotrexate for moderate-to-severe adult atopic eczema. Br J Dermatol. 2007;156:346–51.CrossRef Weathrhead SC, Wahie S, Reynolds NY. An open label, dose-ranging study of methotrexate for moderate-to-severe adult atopic eczema. Br J Dermatol. 2007;156:346–51.CrossRef
153.
go back to reference Schram ME, Roekevisch E, Leeflang MM, Bos JD, Schmitt J, Spuls PI. A randomized trial of methotrexate versus azathioprine for severe atopic eczema. J Allergy Clin Immunol. 2011;128:353–9.PubMedCrossRef Schram ME, Roekevisch E, Leeflang MM, Bos JD, Schmitt J, Spuls PI. A randomized trial of methotrexate versus azathioprine for severe atopic eczema. J Allergy Clin Immunol. 2011;128:353–9.PubMedCrossRef
154.
go back to reference Dvorakova V, O’Regan GM, Irvine AD. Methotrexate for severe childhood atopic dermatitis: clinical experience in a tertiary center. Pediatr Dermatol. 2017;34:528–34.PubMedCrossRef Dvorakova V, O’Regan GM, Irvine AD. Methotrexate for severe childhood atopic dermatitis: clinical experience in a tertiary center. Pediatr Dermatol. 2017;34:528–34.PubMedCrossRef
155.
go back to reference Anderson K, Putterman E, Rogers RS, Patel D, Treat JR, Castelo-Soccio L. Treatment of severe pediatric atopic dermatitis with methotrexate: a retrospective review. Pediatr Dermatol. 2019;36:298–302.PubMedCrossRef Anderson K, Putterman E, Rogers RS, Patel D, Treat JR, Castelo-Soccio L. Treatment of severe pediatric atopic dermatitis with methotrexate: a retrospective review. Pediatr Dermatol. 2019;36:298–302.PubMedCrossRef
157.
go back to reference Murphy LA, Atherton DJ. Azathioprine as a treatment for severe atopic eczema in children with a partial thiopurine methyl transferase (TPMT) deficiency. Pediatr Dermatol. 2003;20:531–4.PubMedCrossRef Murphy LA, Atherton DJ. Azathioprine as a treatment for severe atopic eczema in children with a partial thiopurine methyl transferase (TPMT) deficiency. Pediatr Dermatol. 2003;20:531–4.PubMedCrossRef
158.
go back to reference Caufield M, Tom WL. Oral azathioprine for recalcitrant pediatric atopic dermatitis: clinical response and thiopurine monitoring. J Am Acad Dermatol. 2013;68:29–35.PubMedCrossRef Caufield M, Tom WL. Oral azathioprine for recalcitrant pediatric atopic dermatitis: clinical response and thiopurine monitoring. J Am Acad Dermatol. 2013;68:29–35.PubMedCrossRef
159.
go back to reference Chong JH, Koh MJA. Non-topical management of recalcitrant paediatric atopic dermatitis. Arch Dis Child. 2017;102:681–6.PubMedCrossRef Chong JH, Koh MJA. Non-topical management of recalcitrant paediatric atopic dermatitis. Arch Dis Child. 2017;102:681–6.PubMedCrossRef
160.
go back to reference Waxweiler WT, Agans R, Morrell DS. Systemic treatment of pediatric atopic dermatitis with azathioprine and mycophenolate mofetil. Pediatr Dermatol. 2011;28:689–94.PubMedCrossRef Waxweiler WT, Agans R, Morrell DS. Systemic treatment of pediatric atopic dermatitis with azathioprine and mycophenolate mofetil. Pediatr Dermatol. 2011;28:689–94.PubMedCrossRef
161.
go back to reference Heller M, Shin HT, Orlow SJ, Schaffer JV. Mycophenolatemofetil for severe childhood atopic dermatitis: experience in14 patients. Br J Dermatol. 2007;157:127–32.PubMedCrossRef Heller M, Shin HT, Orlow SJ, Schaffer JV. Mycophenolatemofetil for severe childhood atopic dermatitis: experience in14 patients. Br J Dermatol. 2007;157:127–32.PubMedCrossRef
162.
go back to reference Neuber K, Schwartz I, Itschert G, Dieck AT. Treatment of atopic eczema with oral mycophenolate mofetil. Br J Dermatol. 2000;143:385–91.PubMedCrossRef Neuber K, Schwartz I, Itschert G, Dieck AT. Treatment of atopic eczema with oral mycophenolate mofetil. Br J Dermatol. 2000;143:385–91.PubMedCrossRef
164.
go back to reference Silverberg NB, Durán-McKinster C. Special considerations for therapy of pediatric atopic dermatitis. Dermatol Clin. 2017;35:351–63.PubMedCrossRef Silverberg NB, Durán-McKinster C. Special considerations for therapy of pediatric atopic dermatitis. Dermatol Clin. 2017;35:351–63.PubMedCrossRef
165.
go back to reference Lyons JJ, Milner JD, Stone KD. Atopic dermatitis in children: clinical features, pathophysiology, and treatment. Immunol Allergy Clin North Am. 2015;35:161–83.PubMedCrossRef Lyons JJ, Milner JD, Stone KD. Atopic dermatitis in children: clinical features, pathophysiology, and treatment. Immunol Allergy Clin North Am. 2015;35:161–83.PubMedCrossRef
166.
go back to reference He A, Feldman SR, Fleischer AB Jr. An assessment of the use of antihistamines in the management of atopic dermatitis. J Am Acad Dermatol. 2018;79:92–6.PubMedCrossRef He A, Feldman SR, Fleischer AB Jr. An assessment of the use of antihistamines in the management of atopic dermatitis. J Am Acad Dermatol. 2018;79:92–6.PubMedCrossRef
167.
go back to reference Nowicki RJ, Trzeciak M, Kaczmarski M, Wilkowska A, Czarnecka-Operacz M, Kowalewski C, Atopic dermatitis, et al. Interdisciplinary diagnostic and therapeutic recommendations of the polish dermatological society, polish society of allergology, polish pediatric society and polish society of family medicine. Part II. Systemic treatment and new therapeutic methods. Postepy Dermatol Alergol. 2020;37:129–34.PubMedPubMedCentralCrossRef Nowicki RJ, Trzeciak M, Kaczmarski M, Wilkowska A, Czarnecka-Operacz M, Kowalewski C, Atopic dermatitis, et al. Interdisciplinary diagnostic and therapeutic recommendations of the polish dermatological society, polish society of allergology, polish pediatric society and polish society of family medicine. Part II. Systemic treatment and new therapeutic methods. Postepy Dermatol Alergol. 2020;37:129–34.PubMedPubMedCentralCrossRef
168.
go back to reference Wollenberg A, Oranje A, Deleuran M, Simon D, Szalai Z, Kunz B, et al. ETFAD/EADV Eczema task force 2015 position paper on diagnosis and treatment of atopic dermatitis in adult and paediatric patients. J Eur Acad Dermatol Venereol. 2016;30:729–47.PubMedCrossRef Wollenberg A, Oranje A, Deleuran M, Simon D, Szalai Z, Kunz B, et al. ETFAD/EADV Eczema task force 2015 position paper on diagnosis and treatment of atopic dermatitis in adult and paediatric patients. J Eur Acad Dermatol Venereol. 2016;30:729–47.PubMedCrossRef
169.
go back to reference van Zuuren EJ, Apfelbacher CJ, Fedorowicz Z, Jupiter A, Matterne U, Weisshaar E. No high level evidence to support the use of oral H1 antihistamines as monotherapy for eczema: a summary of a Cochrane Systematic review. System Rev. 2014;3:25.CrossRef van Zuuren EJ, Apfelbacher CJ, Fedorowicz Z, Jupiter A, Matterne U, Weisshaar E. No high level evidence to support the use of oral H1 antihistamines as monotherapy for eczema: a summary of a Cochrane Systematic review. System Rev. 2014;3:25.CrossRef
171.
go back to reference Matterne U, Böhmer MM, Weisshaar E, Jupiter A, Carter B, Apfelbacher CJ. Oral H1 antihistamines as ‘add-on’ therapy to topical treatment for eczema. Cochrane Database Syst Rev. 2019;1:CD012167.PubMed Matterne U, Böhmer MM, Weisshaar E, Jupiter A, Carter B, Apfelbacher CJ. Oral H1 antihistamines as ‘add-on’ therapy to topical treatment for eczema. Cochrane Database Syst Rev. 2019;1:CD012167.PubMed
172.
go back to reference Kay GG. The effects of antihistamines on cognition and performance. J Allergy Clin Immunol. 2000;105(6 Pt 2):S622-7.PubMedCrossRef Kay GG. The effects of antihistamines on cognition and performance. J Allergy Clin Immunol. 2000;105(6 Pt 2):S622-7.PubMedCrossRef
173.
go back to reference Yu SH, Attarian H, Zee P, Silverberg JI. Burden of sleep and fatigue in US adults with atopic dermatitis. Dermatitis. 2016;27:50–8.PubMedCrossRef Yu SH, Attarian H, Zee P, Silverberg JI. Burden of sleep and fatigue in US adults with atopic dermatitis. Dermatitis. 2016;27:50–8.PubMedCrossRef
174.
go back to reference Schad CA, Skoner DP. Antihistamines in the pediatric population: achieving optimal outcomes when treating seasonal allergic rhinitis and chronic urticaria. Allergy Asthma Proc. 2008;29:7–13.PubMedCrossRef Schad CA, Skoner DP. Antihistamines in the pediatric population: achieving optimal outcomes when treating seasonal allergic rhinitis and chronic urticaria. Allergy Asthma Proc. 2008;29:7–13.PubMedCrossRef
175.
go back to reference Food and Drug Administration HaHS. Labeling of diphenhydramine-containing drug products for over-the-counter human use. Final rule Fed Regist. 2002;2:72555–9. Food and Drug Administration HaHS. Labeling of diphenhydramine-containing drug products for over-the-counter human use. Final rule Fed Regist. 2002;2:72555–9.
176.
go back to reference Eichenfield LF, Tom WL, Berger TG, Krol A, Paller AS, Schwarzenberger K, Guidelines of care for the management of atopic dermatitis: section 2, et al. Management and treatment of atopic dermatitis with topical therapies. J Am Acad Dermatol. 2014;71:116–32.PubMedPubMedCentralCrossRef Eichenfield LF, Tom WL, Berger TG, Krol A, Paller AS, Schwarzenberger K, Guidelines of care for the management of atopic dermatitis: section 2, et al. Management and treatment of atopic dermatitis with topical therapies. J Am Acad Dermatol. 2014;71:116–32.PubMedPubMedCentralCrossRef
177.
go back to reference Watanabe S, Narisawa Y, Arase S, Okamatsu H, Ikenaga T, Tajiri Y, et al. Differences in fecal microflora between patients with atopic dermatitis and healthy control subjects. J Allergy Clin Immunol. 2003;111:587–91.PubMedCrossRef Watanabe S, Narisawa Y, Arase S, Okamatsu H, Ikenaga T, Tajiri Y, et al. Differences in fecal microflora between patients with atopic dermatitis and healthy control subjects. J Allergy Clin Immunol. 2003;111:587–91.PubMedCrossRef
178.
go back to reference Penders J, Thijs C, van den Brandt PA, Kummeling I, Snijders B, Stelma F, et al. Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study. Gut. 2007;56:661–7.PubMedCrossRef Penders J, Thijs C, van den Brandt PA, Kummeling I, Snijders B, Stelma F, et al. Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study. Gut. 2007;56:661–7.PubMedCrossRef
181.
go back to reference Kwon HK, Lee CG, So JS, Chae CS, Hwang JS, Sahoo A, et al. Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders. Proc Natl Acad Sci U S A. 2010;107:2159–64.PubMedPubMedCentralCrossRef Kwon HK, Lee CG, So JS, Chae CS, Hwang JS, Sahoo A, et al. Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders. Proc Natl Acad Sci U S A. 2010;107:2159–64.PubMedPubMedCentralCrossRef
183.
go back to reference Makrgeorgou A, Leonardi‐Bee J, Bath‐Hextall FJ, Murrell DF, Tang MLK, Roberts A et al. Cochrane Skin Group. Cochrane Database Syst Rev. 2018;11(11):CD006135. Makrgeorgou A, Leonardi‐Bee J, Bath‐Hextall FJ, Murrell DF, Tang MLK, Roberts A et al. Cochrane Skin Group. Cochrane Database Syst Rev. 2018;11(11):CD006135.
184.
go back to reference Kim JY, Park BK, Park HJ, Park YH, Kim BO, Pyo S. Atopic dermatitis-mitigating effects of new Lactobacillus strain, Lactobacillus sakei probio 65 isolated from Kimchi. J Appl Microbiol. 2013;115:517–26.PubMedCrossRef Kim JY, Park BK, Park HJ, Park YH, Kim BO, Pyo S. Atopic dermatitis-mitigating effects of new Lactobacillus strain, Lactobacillus sakei probio 65 isolated from Kimchi. J Appl Microbiol. 2013;115:517–26.PubMedCrossRef
185.
go back to reference Park SB, Im M, Lee Y, Lee JH, Lim J, Park YH, Seo YJ. Effect of emollients containing vegetable-derived lactobacillusin the treatment of atopic dermatitis symptoms: split-body clinical trial. Ann Dermatol. 2014;26:150–5.PubMedPubMedCentralCrossRef Park SB, Im M, Lee Y, Lee JH, Lim J, Park YH, Seo YJ. Effect of emollients containing vegetable-derived lactobacillusin the treatment of atopic dermatitis symptoms: split-body clinical trial. Ann Dermatol. 2014;26:150–5.PubMedPubMedCentralCrossRef
186.
go back to reference Baldwin H, Aguh C, Andriessen A, Benjamin L, Ferberg AS, Hooper D, et al. Atopic dermatitis and the role of skin micobiome in choosing prevention, treatment and maintenance options. J Drugs Dermatol. 2020;19(10):935–40.PubMedCrossRef Baldwin H, Aguh C, Andriessen A, Benjamin L, Ferberg AS, Hooper D, et al. Atopic dermatitis and the role of skin micobiome in choosing prevention, treatment and maintenance options. J Drugs Dermatol. 2020;19(10):935–40.PubMedCrossRef
187.
go back to reference Seitè S, Zelenkova H, Martin R. Clinical efficacy of emollient in atopic dermatitis patients-relationship with the skin microbiota modification. Clin Cosmet Invest Dermatol. 2017;10:25–35.CrossRef Seitè S, Zelenkova H, Martin R. Clinical efficacy of emollient in atopic dermatitis patients-relationship with the skin microbiota modification. Clin Cosmet Invest Dermatol. 2017;10:25–35.CrossRef
188.
go back to reference Gueniche A, Knaudt B, Schuck E, Volz T, Bastien P, Martin R, et al. Effect of nonpathogenic gram negative bacterium vitreoscilla filiformis lysate on atopic dermatitis: a prospective, randomized, double-blind, placebo-controlled clinical study. Br J Dermatol. 2008;159:1357–63.PubMedCrossRef Gueniche A, Knaudt B, Schuck E, Volz T, Bastien P, Martin R, et al. Effect of nonpathogenic gram negative bacterium vitreoscilla filiformis lysate on atopic dermatitis: a prospective, randomized, double-blind, placebo-controlled clinical study. Br J Dermatol. 2008;159:1357–63.PubMedCrossRef
189.
go back to reference Butler É, Lundqvist C, Axelsson J. Lactobacillus reuteri DSM 17938 as a novel topical cosmetic ingredient: a proof of concept clinical study in adults with atopic dermatitis. Microorganisms. 2020;8:1026.PubMedCentralCrossRef Butler É, Lundqvist C, Axelsson J. Lactobacillus reuteri DSM 17938 as a novel topical cosmetic ingredient: a proof of concept clinical study in adults with atopic dermatitis. Microorganisms. 2020;8:1026.PubMedCentralCrossRef
190.
go back to reference Holme SA, Anstey AV. Phototherapy and PUVA photochemotherapy in children. Photodermatol Photoimmunol Photomed. 2004;20:69–75.PubMedCrossRef Holme SA, Anstey AV. Phototherapy and PUVA photochemotherapy in children. Photodermatol Photoimmunol Photomed. 2004;20:69–75.PubMedCrossRef
191.
go back to reference Meduri NB, Vandergriff T, Rasmussen H, Jacobe H. Phototherapy in the management of atopic dermatitis: a systematic review. Photodermatol Photoimmunol Photomed. 2007;23:106–12.PubMedCrossRef Meduri NB, Vandergriff T, Rasmussen H, Jacobe H. Phototherapy in the management of atopic dermatitis: a systematic review. Photodermatol Photoimmunol Photomed. 2007;23:106–12.PubMedCrossRef
192.
go back to reference Ortiz-Salvador JM, Pérez-Ferriols A. Phototherapy in Atopic Dermatitis. Adv Exp Med Biol. 2017;996:279–86.PubMedCrossRef Ortiz-Salvador JM, Pérez-Ferriols A. Phototherapy in Atopic Dermatitis. Adv Exp Med Biol. 2017;996:279–86.PubMedCrossRef
193.
go back to reference Rodenbeck DL, Silverberg JI, Silverberg NB. Phototherapy for atopic dermatitis. Clin Dermatol. 2016;34:607–13.PubMedCrossRef Rodenbeck DL, Silverberg JI, Silverberg NB. Phototherapy for atopic dermatitis. Clin Dermatol. 2016;34:607–13.PubMedCrossRef
194.
go back to reference Darrigade AS. Traitements topiques et photothérapie dans la dermatite atopique: topical treatments and phototherapy in atopic dermatitis. Ann Dermatol Venereol. 2019;146:128S5-129S5.CrossRef Darrigade AS. Traitements topiques et photothérapie dans la dermatite atopique: topical treatments and phototherapy in atopic dermatitis. Ann Dermatol Venereol. 2019;146:128S5-129S5.CrossRef
195.
go back to reference Farahnik B, Patel V, Beroukhim K, Zhu TH, Abrouk M, Nakamura M, et al. Combining biologic and phototherapy treatments for psoriasis: safety, efficacy, and patient acceptability. Psoriasis (Auckl). 2016;6:105–11. Farahnik B, Patel V, Beroukhim K, Zhu TH, Abrouk M, Nakamura M, et al. Combining biologic and phototherapy treatments for psoriasis: safety, efficacy, and patient acceptability. Psoriasis (Auckl). 2016;6:105–11.
196.
go back to reference Cameron H, Yule S, Dawe RS, Ibbotson SH, Moseley H, Ferguson J. Review of an established UK home phototherapy service 1998–2011: improving access to a cost-effective treatment for chronic skin disease. Public Health. 2014;128:317–24.PubMedCrossRef Cameron H, Yule S, Dawe RS, Ibbotson SH, Moseley H, Ferguson J. Review of an established UK home phototherapy service 1998–2011: improving access to a cost-effective treatment for chronic skin disease. Public Health. 2014;128:317–24.PubMedCrossRef
197.
go back to reference Koek MB, Buskens E, Steegmans PH, van Weelden H, Bruijnzeel-Koomen CA, Sigurdsson V. UVB phototherapy in an outpatient setting or at home: a pragmatic randomised single-blind trial designed to settle the discussion. The PLUTO study. BMC Med Res Methodol. 2006;1(6):39.CrossRef Koek MB, Buskens E, Steegmans PH, van Weelden H, Bruijnzeel-Koomen CA, Sigurdsson V. UVB phototherapy in an outpatient setting or at home: a pragmatic randomised single-blind trial designed to settle the discussion. The PLUTO study. BMC Med Res Methodol. 2006;1(6):39.CrossRef
198.
go back to reference Nakajima S, Nomura T, Common J, Kabashima K. Insights into atopic dermatitis gained from genetically defined mouse models. J Allergy Clin Immunol. 2019;143:13–25.PubMedCrossRef Nakajima S, Nomura T, Common J, Kabashima K. Insights into atopic dermatitis gained from genetically defined mouse models. J Allergy Clin Immunol. 2019;143:13–25.PubMedCrossRef
201.
go back to reference Thomson J, Wernham AGH, Williams HC. Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a critical appraisal. Br J Dermatol. 2018;178:897–902.PubMedCrossRef Thomson J, Wernham AGH, Williams HC. Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a critical appraisal. Br J Dermatol. 2018;178:897–902.PubMedCrossRef
202.
go back to reference Thaçi D, Simpson E L, Deleuran M, Kataoka Y, Chen Z, Gadkari A, et al. Efficacy and safety of dupilumab monotherapy in adults with moderate-to-severe atopic dermatitis: a pooled analysis of two phase 3 randomized trials (LIBERTY AD SOLO 1 and LIBERTY AD SOLO 2). J Dermatol Sci. 2019;94:266–75.PubMedCrossRef Thaçi D, Simpson E L, Deleuran M, Kataoka Y, Chen Z, Gadkari A, et al. Efficacy and safety of dupilumab monotherapy in adults with moderate-to-severe atopic dermatitis: a pooled analysis of two phase 3 randomized trials (LIBERTY AD SOLO 1 and LIBERTY AD SOLO 2). J Dermatol Sci. 2019;94:266–75.PubMedCrossRef
203.
go back to reference Simpson E, Paller AS, Siegfried EC. Efficacy and safety of dupilumab in adolescents with uncontrolled moderate to severe atopic dermatitisa phase 3 randomized clinical trial. JAMA Dermatol. 2020;156:44–56.PubMedCrossRef Simpson E, Paller AS, Siegfried EC. Efficacy and safety of dupilumab in adolescents with uncontrolled moderate to severe atopic dermatitisa phase 3 randomized clinical trial. JAMA Dermatol. 2020;156:44–56.PubMedCrossRef
204.
go back to reference Calzavara-Pinton P, Belloni Fortina A, Bonamonte D, Marseglia GL, Miraglia Del Giudice M, Musarra A, Diagnosis and management of moderate to severe atopic dermatitis in adolescents, et al. A Consensus by the Italian Society of Dermatology and Venereology (SIDeMaST), the Italian Association of Hospital Dermatologists and Public Health (ADOI), the Italian Association of Hospital and Territorial Allergists and Immunologists (AAIITO), the Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC), the Italian Society of Pediatric Allergy and Immunology (SIAIP), the Italian Society of Allergological, Occupational and Environmental Dermatology (SIDAPA), and the Italian Society of Pediatric Dermatology (SIDerP). Ital J Dermatol Venerol. 2021;156:184–97.PubMed Calzavara-Pinton P, Belloni Fortina A, Bonamonte D, Marseglia GL, Miraglia Del Giudice M, Musarra A, Diagnosis and management of moderate to severe atopic dermatitis in adolescents, et al. A Consensus by the Italian Society of Dermatology and Venereology (SIDeMaST), the Italian Association of Hospital Dermatologists and Public Health (ADOI), the Italian Association of Hospital and Territorial Allergists and Immunologists (AAIITO), the Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC), the Italian Society of Pediatric Allergy and Immunology (SIAIP), the Italian Society of Allergological, Occupational and Environmental Dermatology (SIDAPA), and the Italian Society of Pediatric Dermatology (SIDerP). Ital J Dermatol Venerol. 2021;156:184–97.PubMed
205.
go back to reference Paller AS, Siegfried EC, Thaçi D, Wollenberg A, Cork MJ, Arkwright PD, et al. Efficacy and safety of dupilumab with concomitant topical corticosteroids in children 6 to 11 years old with severe atopic dermatitis: a randomized, double-blinded, placebo-controlled phase 3 trial. J Am Acad Dermatol. 2020;83:1282–93.PubMedCrossRef Paller AS, Siegfried EC, Thaçi D, Wollenberg A, Cork MJ, Arkwright PD, et al. Efficacy and safety of dupilumab with concomitant topical corticosteroids in children 6 to 11 years old with severe atopic dermatitis: a randomized, double-blinded, placebo-controlled phase 3 trial. J Am Acad Dermatol. 2020;83:1282–93.PubMedCrossRef
206.
go back to reference Agache I, Akdis CA, Akdis M, Brockow K, Chivato T, Del Giacco S, et al. EAACI Biologicals Guidelines—dupilumab for children and adults with moderate-to-severe atopic dermatitis. Allergy. 2021;76:988–1009.PubMedCrossRef Agache I, Akdis CA, Akdis M, Brockow K, Chivato T, Del Giacco S, et al. EAACI Biologicals Guidelines—dupilumab for children and adults with moderate-to-severe atopic dermatitis. Allergy. 2021;76:988–1009.PubMedCrossRef
208.
go back to reference Silverberg JI, Pinter A, Pulka G, et al. Phase 2B randomized study of nemolizumab in adults with moderate-to-severe atopic dermatitis and severe pruritus. J Allergy Clin Immunol. 2020;145:173–82.PubMedCrossRef Silverberg JI, Pinter A, Pulka G, et al. Phase 2B randomized study of nemolizumab in adults with moderate-to-severe atopic dermatitis and severe pruritus. J Allergy Clin Immunol. 2020;145:173–82.PubMedCrossRef
209.
go back to reference Puar N, Chovatiya R, Paller AS. New treatments in atopic dermatitis. Ann Allergy Asthma Immunol. 2020;17:S1081-1206. Puar N, Chovatiya R, Paller AS. New treatments in atopic dermatitis. Ann Allergy Asthma Immunol. 2020;17:S1081-1206.
210.
go back to reference Guttman-Yassky E, Blauvelt A, Eichenfield LF, Paller AS, Armstrong AW, Drew J, et al. Efficacy and safety of lebrikizumab, a high-affinity interleukin 13 inhibitor, in adults with moderate to severe atopic dermatitis: a Phase 2b randomized clinical trial. JAMA Dermatol. 2020;156:411–20.PubMedPubMedCentralCrossRef Guttman-Yassky E, Blauvelt A, Eichenfield LF, Paller AS, Armstrong AW, Drew J, et al. Efficacy and safety of lebrikizumab, a high-affinity interleukin 13 inhibitor, in adults with moderate to severe atopic dermatitis: a Phase 2b randomized clinical trial. JAMA Dermatol. 2020;156:411–20.PubMedPubMedCentralCrossRef
211.
go back to reference Simpson E, Blauvelt A, Guttman-Yassky E, et al. Efficacy and safety of tralokinumab monotherapy in adult patients with moderate-to-severe atopic dermatitis: results from two 52-week Phase 3 trials (ECZTRA 1 and ECZTRA 2). Presented at the American Academy of Dermatology Virtual Meeting Experience (AAD VMX). 2020;4(6). Simpson E, Blauvelt A, Guttman-Yassky E, et al. Efficacy and safety of tralokinumab monotherapy in adult patients with moderate-to-severe atopic dermatitis: results from two 52-week Phase 3 trials (ECZTRA 1 and ECZTRA 2). Presented at the American Academy of Dermatology Virtual Meeting Experience (AAD VMX). 2020;4(6).
212.
go back to reference Simpson EL, Parnes JR, She D, Crouch S, Rees W, Mo M, et al. Tezepelumab, an anti-thymic stromal lymphopoietin monoclonal antibody, in the treatment of moderate to severe atopic dermatitis: a randomized Phase 2a clinical trial. J Am Acad Dermatol. 2019;80:1013–21.PubMedCrossRef Simpson EL, Parnes JR, She D, Crouch S, Rees W, Mo M, et al. Tezepelumab, an anti-thymic stromal lymphopoietin monoclonal antibody, in the treatment of moderate to severe atopic dermatitis: a randomized Phase 2a clinical trial. J Am Acad Dermatol. 2019;80:1013–21.PubMedCrossRef
213.
go back to reference Guttman-Yassky E, Pavel AB, Zhou L, Estrada YD, Zhang N, Xu H, et al. GBR 830, an anti-OX40, improves skin gene signatures and clinical scores in patients with atopic dermatitis. J Allergy Clin Immunol. 2019;144(482–493):e487. Guttman-Yassky E, Pavel AB, Zhou L, Estrada YD, Zhang N, Xu H, et al. GBR 830, an anti-OX40, improves skin gene signatures and clinical scores in patients with atopic dermatitis. J Allergy Clin Immunol. 2019;144(482–493):e487.
214.
go back to reference Guttman-Yassky E, Brunner PM, Neumann AU, Khattri S, Pavel AB, Malik K, et al. Efficacy and safety of fezakinumab (an IL-22 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by conventional treatments: A randomized, double blind, Phase 2a trial. J Am Acad Dermatol. 2018;78(872–881):e876. Guttman-Yassky E, Brunner PM, Neumann AU, Khattri S, Pavel AB, Malik K, et al. Efficacy and safety of fezakinumab (an IL-22 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by conventional treatments: A randomized, double blind, Phase 2a trial. J Am Acad Dermatol. 2018;78(872–881):e876.
215.
go back to reference Fridman JS, Scherle PA, Collins R, Burn TC, Li Y, Li J, et al. Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050. J Immunol. 2010;184:5298–307.PubMedCrossRef Fridman JS, Scherle PA, Collins R, Burn TC, Li Y, Li J, et al. Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050. J Immunol. 2010;184:5298–307.PubMedCrossRef
216.
go back to reference Simpson EL, Lacour JP, Spelman L, Galimberti R, Eichenfield LF, Bissonnette R, et al. Baricitinib in patients with moderate-to-severe atopic dermatitis and inadequate response to topical corticosteroids: results from two randomized monotherapy phase III trials. Br J Dermatol. 2020;183:242–55.PubMedCrossRef Simpson EL, Lacour JP, Spelman L, Galimberti R, Eichenfield LF, Bissonnette R, et al. Baricitinib in patients with moderate-to-severe atopic dermatitis and inadequate response to topical corticosteroids: results from two randomized monotherapy phase III trials. Br J Dermatol. 2020;183:242–55.PubMedCrossRef
217.
go back to reference Biggioggero M, Becciolini A, Crotti C, Agape E, Favalli EG. Upadacitinib and filgotinib: the role of JAK1 selective inhibition in the treatment of rheumatoid arthritis. Drugs Context. 2019;24(8):212595. Biggioggero M, Becciolini A, Crotti C, Agape E, Favalli EG. Upadacitinib and filgotinib: the role of JAK1 selective inhibition in the treatment of rheumatoid arthritis. Drugs Context. 2019;24(8):212595.
218.
go back to reference Guttman-Yassky E, Thaci D, Pangan AL, Hong HC, Papp KA, Reich K, et al. Upadacitinib in adults with moderate to severe atopic dermatitis: 16-week results from a randomized, placebo-controlled trial. J Allergy Clin Immunol. 2020;145:877–84.PubMedCrossRef Guttman-Yassky E, Thaci D, Pangan AL, Hong HC, Papp KA, Reich K, et al. Upadacitinib in adults with moderate to severe atopic dermatitis: 16-week results from a randomized, placebo-controlled trial. J Allergy Clin Immunol. 2020;145:877–84.PubMedCrossRef
219.
go back to reference Napolitano M, Fabbrocini G, Cinelli E, Stingeni L, Patruno C. Profile of baricitinib and its potential in the treatment of moderate to severe atopic dermatitis: a short review on the emerging clinical evidence. J Asthma Allergy. 2020;13:89–94.PubMedPubMedCentralCrossRef Napolitano M, Fabbrocini G, Cinelli E, Stingeni L, Patruno C. Profile of baricitinib and its potential in the treatment of moderate to severe atopic dermatitis: a short review on the emerging clinical evidence. J Asthma Allergy. 2020;13:89–94.PubMedPubMedCentralCrossRef
220.
go back to reference Napolitano M, Ruggiero A, Fontanella G, Fabbrocini G, Patruno C. New emergent therapies for atopic dermatitis: a review of safety profile with respect to female fertility, pregnancy, and breastfeeding. Dermatol Ther. 2020;30:e14475. Napolitano M, Ruggiero A, Fontanella G, Fabbrocini G, Patruno C. New emergent therapies for atopic dermatitis: a review of safety profile with respect to female fertility, pregnancy, and breastfeeding. Dermatol Ther. 2020;30:e14475.
222.
go back to reference Gooderham MJ, Forman SB, Bissonnette R, Beebe JS, Zhang W, Banfield C, et al. Efficacy and safety of oral janus kinase 1 inhibitor abrocitinib for patients with atopic dermatitis. A phase 2 randomized clinical trial. JAMA Dermatol. 2019;155:1371–9.PubMedPubMedCentralCrossRef Gooderham MJ, Forman SB, Bissonnette R, Beebe JS, Zhang W, Banfield C, et al. Efficacy and safety of oral janus kinase 1 inhibitor abrocitinib for patients with atopic dermatitis. A phase 2 randomized clinical trial. JAMA Dermatol. 2019;155:1371–9.PubMedPubMedCentralCrossRef
223.
go back to reference Rizk P, Rodenas M, De Benedetto A. Allergen immunotherapy and atopic dermatitis: the good, the bad, and the unknown. Curr Allergy Asthma Rep. 2019;19:57.PubMedCrossRef Rizk P, Rodenas M, De Benedetto A. Allergen immunotherapy and atopic dermatitis: the good, the bad, and the unknown. Curr Allergy Asthma Rep. 2019;19:57.PubMedCrossRef
224.
go back to reference Pajno GB, Bernardini R, Peroni D, Arasi S, Martelli A, Landi M, et al. Clinical practice recommendations for allergen specific immnotherapy in children. The Italian Consensus report. Ital J Pediatrics. 2017;23(43):13.CrossRef Pajno GB, Bernardini R, Peroni D, Arasi S, Martelli A, Landi M, et al. Clinical practice recommendations for allergen specific immnotherapy in children. The Italian Consensus report. Ital J Pediatrics. 2017;23(43):13.CrossRef
225.
go back to reference Muraro A, Roberts G, Halken S, Agache I, Angier E, Fernandez-Rivas M, et al. EAACI guidelines on allergen immunotherapy: Executive statement. Allergy. 2018;73:739–43.PubMedCrossRef Muraro A, Roberts G, Halken S, Agache I, Angier E, Fernandez-Rivas M, et al. EAACI guidelines on allergen immunotherapy: Executive statement. Allergy. 2018;73:739–43.PubMedCrossRef
226.
go back to reference Ridolo E, Martignago I, Riario-Sforza GG, Incorvaia C. Allergen immunotherapy in atopic dermatitis. Expert Rev Clin Immunol. 2018;4:61–8.CrossRef Ridolo E, Martignago I, Riario-Sforza GG, Incorvaia C. Allergen immunotherapy in atopic dermatitis. Expert Rev Clin Immunol. 2018;4:61–8.CrossRef
227.
go back to reference Tam HH, Calderon MA, Manikam L, Nankervis H, Núñez IG, Williams HC, et al. Specific allergen immunotherapy for the treatment of atopic eczema: a cochrane systematic review. Allergy. 2016;71:1345–56.PubMedCrossRef Tam HH, Calderon MA, Manikam L, Nankervis H, Núñez IG, Williams HC, et al. Specific allergen immunotherapy for the treatment of atopic eczema: a cochrane systematic review. Allergy. 2016;71:1345–56.PubMedCrossRef
228.
go back to reference Liu L, Chen J, Xu J, Yang Q, Gu C, Ni C, et al. Sublingual immunotherapy of atopic dermatitis in mite –sensitized patients: a multi-centre, randomized, double blind, placebo controlled study. Artif Cells Nanomed Biotechnol. 2019;47:35540–3547. Liu L, Chen J, Xu J, Yang Q, Gu C, Ni C, et al. Sublingual immunotherapy of atopic dermatitis in mite –sensitized patients: a multi-centre, randomized, double blind, placebo controlled study. Artif Cells Nanomed Biotechnol. 2019;47:35540–3547.
229.
go back to reference Galli E, Chini L, Nardi S, Benincori N, Panei P, Fraioli G, et al. Use of oral hyposensitization therapy to Dermatophagoides pteronyssinus in children with atopic dermatitis. Allergolol Immnophatol (Madr). 1994;22:18–22. Galli E, Chini L, Nardi S, Benincori N, Panei P, Fraioli G, et al. Use of oral hyposensitization therapy to Dermatophagoides pteronyssinus in children with atopic dermatitis. Allergolol Immnophatol (Madr). 1994;22:18–22.
230.
go back to reference Pajno GB, Caminiti L, Vita D, Barberio G, Salzano G, Lombardo F, et al. Sublingual immunotherapy in mite-sensitized children with atopic dermatitis: a randomized, double-blind, placebo-controlled study. J Allergy Clin Immunol. 2007;120:164–70.PubMedCrossRef Pajno GB, Caminiti L, Vita D, Barberio G, Salzano G, Lombardo F, et al. Sublingual immunotherapy in mite-sensitized children with atopic dermatitis: a randomized, double-blind, placebo-controlled study. J Allergy Clin Immunol. 2007;120:164–70.PubMedCrossRef
231.
go back to reference Eichenfield LF, Ahluwalia J, Waldman A, Borok J, Udkoff J, Boguniewicz M. Current guidelines for the evaluation and management of atopic dermatitis: a comparison of the joint task force practice parameter and american academy of dermatology guidelines. J Allergy Clin Immunol. 2017;139:S49–57.PubMedCrossRef Eichenfield LF, Ahluwalia J, Waldman A, Borok J, Udkoff J, Boguniewicz M. Current guidelines for the evaluation and management of atopic dermatitis: a comparison of the joint task force practice parameter and american academy of dermatology guidelines. J Allergy Clin Immunol. 2017;139:S49–57.PubMedCrossRef
232.
go back to reference Chu H, Park KH, Kim SM, Lee JH, Park JW, Lee KH, et al. Allergen-specific immunotherapy for patients with atopic dermatitis sensitized to animal dander. Immun Inflamm Dis. 2020;8:165–9.PubMedPubMedCentralCrossRef Chu H, Park KH, Kim SM, Lee JH, Park JW, Lee KH, et al. Allergen-specific immunotherapy for patients with atopic dermatitis sensitized to animal dander. Immun Inflamm Dis. 2020;8:165–9.PubMedPubMedCentralCrossRef
233.
go back to reference Cacciapuoti S, Luciano MA, Megna M, Annunziata MC, Napolitano M, Patruno C, et al. The role of thermal water in chronic skin diseases management: a review of the literature. J Clin Med. 2020;9:3047.PubMedCentralCrossRef Cacciapuoti S, Luciano MA, Megna M, Annunziata MC, Napolitano M, Patruno C, et al. The role of thermal water in chronic skin diseases management: a review of the literature. J Clin Med. 2020;9:3047.PubMedCentralCrossRef
234.
go back to reference Harari M. Climatotherapy of skin diseases at the dead sea – an update. Anales de Hidrología Médica. 2012;5:39–51. Harari M. Climatotherapy of skin diseases at the dead sea – an update. Anales de Hidrología Médica. 2012;5:39–51.
235.
go back to reference Heinlin J, Schiffner-Rohe J, Schiffner R, Einsele-Krämer B, Landthaler M, Klein A, et al. A first prospective randomized controlled trial on the efficacy and safety of synchronous balneophototherapy vs narrow-band UVB monotherapy for atopic dermatitis. J Eur Acad Dermatol Venereol. 2011;25:765–73.PubMedCrossRef Heinlin J, Schiffner-Rohe J, Schiffner R, Einsele-Krämer B, Landthaler M, Klein A, et al. A first prospective randomized controlled trial on the efficacy and safety of synchronous balneophototherapy vs narrow-band UVB monotherapy for atopic dermatitis. J Eur Acad Dermatol Venereol. 2011;25:765–73.PubMedCrossRef
236.
go back to reference Merial-Kieny C, Castex-Rizzi N, Selas B, Mery S, Guerrero D. Avène thermal spring water: an active component with specific properties. J Eur Acad Dermatol Venereol. 2011;25:2–5.PubMedCrossRef Merial-Kieny C, Castex-Rizzi N, Selas B, Mery S, Guerrero D. Avène thermal spring water: an active component with specific properties. J Eur Acad Dermatol Venereol. 2011;25:2–5.PubMedCrossRef
237.
go back to reference Pigatto P. The efficacy of avène thermal spring water in light to moderate atopicdermatitis. Ann Dermatol Venereol. 2005;132:6S16–8.PubMed Pigatto P. The efficacy of avène thermal spring water in light to moderate atopicdermatitis. Ann Dermatol Venereol. 2005;132:6S16–8.PubMed
238.
go back to reference Giannetti A. The hydrotherapy centre in avène-les-bains a controlled study in atopic dermatitis. Ann Dermatol Venereol. 2005;132:6S12–5.PubMed Giannetti A. The hydrotherapy centre in avène-les-bains a controlled study in atopic dermatitis. Ann Dermatol Venereol. 2005;132:6S12–5.PubMed
239.
go back to reference Taieb C, Myon E. Dermatite atopique: Impact de l’hydrothèrapie sur la qualite’ de vie. Ann Dermatol Venereol. 2005;132:6S19–21.PubMedCrossRef Taieb C, Myon E. Dermatite atopique: Impact de l’hydrothèrapie sur la qualite’ de vie. Ann Dermatol Venereol. 2005;132:6S19–21.PubMedCrossRef
240.
go back to reference Dikova A. An observational study on patients suffering from atopic dermatitis undergoing balneotherapy. Proceeding in J Am Acad Dermatol. 2016;76:AB41. Dikova A. An observational study on patients suffering from atopic dermatitis undergoing balneotherapy. Proceeding in J Am Acad Dermatol. 2016;76:AB41.
241.
go back to reference Farina S, Gisondi P, Zanoni M, Pace M, Rizzoli L, Baldo E, et al. Balneotherapy for atopic dermatitis in children at Comano spa in Trentino, Italy. J Dermatolog Treat. 2011;22:366–71.PubMedCrossRef Farina S, Gisondi P, Zanoni M, Pace M, Rizzoli L, Baldo E, et al. Balneotherapy for atopic dermatitis in children at Comano spa in Trentino, Italy. J Dermatolog Treat. 2011;22:366–71.PubMedCrossRef
242.
go back to reference Guerrero D, Garrigue E. Eau thermale d’Avène et dermatite atopique: avène’s thermal water and atopic dermatitis. Ann Dermatol Venereol. 2017;144:S27–34.PubMedCrossRef Guerrero D, Garrigue E. Eau thermale d’Avène et dermatite atopique: avène’s thermal water and atopic dermatitis. Ann Dermatol Venereol. 2017;144:S27–34.PubMedCrossRef
243.
go back to reference Martin H, Laborel-Préneron E, Fraysse F, Nguyen T, Schmitt AM, Redoulès D, et al. Aquaphilus dolomiae extract counteracts the effects of cutaneous S. aureus secretome isolated from atopic children on CD4 T cell activation. Pharm Biol. 2016;54:2782–5.PubMedCrossRef Martin H, Laborel-Préneron E, Fraysse F, Nguyen T, Schmitt AM, Redoulès D, et al. Aquaphilus dolomiae extract counteracts the effects of cutaneous S. aureus secretome isolated from atopic children on CD4 T cell activation. Pharm Biol. 2016;54:2782–5.PubMedCrossRef
244.
go back to reference Aries MF, Hernandez-Pigeon H, Vaissière C, Delga H, Caruana A, Lévêque M, et al. Anti-inflammatory and immunomodulatory effects of Aquaphilus dolomiae extract on in vitro models. Clin Cosm Investig Dermatol. 2016;9:421–34.CrossRef Aries MF, Hernandez-Pigeon H, Vaissière C, Delga H, Caruana A, Lévêque M, et al. Anti-inflammatory and immunomodulatory effects of Aquaphilus dolomiae extract on in vitro models. Clin Cosm Investig Dermatol. 2016;9:421–34.CrossRef
245.
go back to reference Seité S. Thermal waters as cosmeceuticals: La Roche Posay thermal spring waterexample. Clin Cosmet Investing Dermatol. 2013;6:23–8.CrossRef Seité S. Thermal waters as cosmeceuticals: La Roche Posay thermal spring waterexample. Clin Cosmet Investing Dermatol. 2013;6:23–8.CrossRef
246.
go back to reference Zeichner J, Seite S. From probiotic to prebiotic using thermal spring water. J Drugs Dermatol. 2018;17:657–62.PubMed Zeichner J, Seite S. From probiotic to prebiotic using thermal spring water. J Drugs Dermatol. 2018;17:657–62.PubMed
247.
go back to reference Pedron R, Esposito A, Bianconi I, Pasolli E, Tett A, Asnicar F, et al. Genomic and metagenomic insights into the microbial community of a thermal spring. Microbiome. 2019;7:8.PubMedPubMedCentralCrossRef Pedron R, Esposito A, Bianconi I, Pasolli E, Tett A, Asnicar F, et al. Genomic and metagenomic insights into the microbial community of a thermal spring. Microbiome. 2019;7:8.PubMedPubMedCentralCrossRef
248.
go back to reference Galli E, Neri I, Ricci G, Baldo E, Barone M, Belloni Fortina A, et al. Consensus conference on clinical management on pediatric atopic dermatitis. Ital J Pediatr. 2016;2(42):26.CrossRef Galli E, Neri I, Ricci G, Baldo E, Barone M, Belloni Fortina A, et al. Consensus conference on clinical management on pediatric atopic dermatitis. Ital J Pediatr. 2016;2(42):26.CrossRef
249.
go back to reference Piano nazionale della cronicità. A cura di Direzione generale della Programmazione sanitaria - Ministero della Salute. Anno. 2016. Piano nazionale della cronicità. A cura di Direzione generale della Programmazione sanitaria - Ministero della Salute. Anno. 2016.
250.
go back to reference Olsson M, Bajpai R, Yew YW, Koh MJA, Thng S, Car J, et al. Association between health-related quality of life and health-related costs among children with atopic dermatitis and their caregivers: across-sectional study. Pediatr Dermatol. 2020;37:284–93.PubMedCrossRef Olsson M, Bajpai R, Yew YW, Koh MJA, Thng S, Car J, et al. Association between health-related quality of life and health-related costs among children with atopic dermatitis and their caregivers: across-sectional study. Pediatr Dermatol. 2020;37:284–93.PubMedCrossRef
251.
go back to reference Maksimovic N, Zaric M, Reljic V, Nikolic M, Gazibara T. Factors associated with improvement of quality of life among parents of children with atopic dermatitis:1-year prospective cohort study. Eur Acad Dermatol Venereol. 2020;34:325–32.CrossRef Maksimovic N, Zaric M, Reljic V, Nikolic M, Gazibara T. Factors associated with improvement of quality of life among parents of children with atopic dermatitis:1-year prospective cohort study. Eur Acad Dermatol Venereol. 2020;34:325–32.CrossRef
252.
go back to reference Bass AM, Anderson KL, Feldman SR. Interventions to increase treatment adherence in pediatric atopic dermatitis: a systematic review. J Clin Med. 2015;4:231–42.PubMedPubMedCentralCrossRef Bass AM, Anderson KL, Feldman SR. Interventions to increase treatment adherence in pediatric atopic dermatitis: a systematic review. J Clin Med. 2015;4:231–42.PubMedPubMedCentralCrossRef
253.
go back to reference Peters EM, Michenko A, Kupfer J, Kummer W, Wiegand S, Niemeier V, et al. Mental stress in atopic dermatitis– neuronal plasticity and the cholinergic system are affected in atopic dermatitis and in response to acute experimental mental stress in a randomized controlled pilot study. PLoS One. 2014;9:e113552.PubMedPubMedCentralCrossRef Peters EM, Michenko A, Kupfer J, Kummer W, Wiegand S, Niemeier V, et al. Mental stress in atopic dermatitis– neuronal plasticity and the cholinergic system are affected in atopic dermatitis and in response to acute experimental mental stress in a randomized controlled pilot study. PLoS One. 2014;9:e113552.PubMedPubMedCentralCrossRef
254.
go back to reference Dalgard FJ, Gieler U, Tomas-Aragones L, Lien L, Poot F, Jemec GBE, et al. The psychosocial burden of skin diseases: a cross-sectional multicenter study among dermatological out-patients in 13 European countries. J Invest Dermatol. 2015;135:984–91.PubMedPubMedCentralCrossRef Dalgard FJ, Gieler U, Tomas-Aragones L, Lien L, Poot F, Jemec GBE, et al. The psychosocial burden of skin diseases: a cross-sectional multicenter study among dermatological out-patients in 13 European countries. J Invest Dermatol. 2015;135:984–91.PubMedPubMedCentralCrossRef
255.
go back to reference Ersser SJ, Cowdell F, Latter S, Gardiner E, Flohr C, Thompson AR, et al. Psychological and educational interventions for atopic eczema in children. Cochrane Database Syst Rev. 2014;2014(7):CD004054.PubMedCentral Ersser SJ, Cowdell F, Latter S, Gardiner E, Flohr C, Thompson AR, et al. Psychological and educational interventions for atopic eczema in children. Cochrane Database Syst Rev. 2014;2014(7):CD004054.PubMedCentral
256.
go back to reference Eicher L, Knop M, Aszodi N, Senner S, French LE, Wollenberg A. A systematic review of factors influencing treatment adherence in chronic inflammatory skin disease - strategies for optimizing treatment outcome. J Eur Acad Dermatol Venereol. 2019;33:2253–63.PubMedCrossRef Eicher L, Knop M, Aszodi N, Senner S, French LE, Wollenberg A. A systematic review of factors influencing treatment adherence in chronic inflammatory skin disease - strategies for optimizing treatment outcome. J Eur Acad Dermatol Venereol. 2019;33:2253–63.PubMedCrossRef
257.
go back to reference El Hachem M, Di Mauro G, Rotunno R, Giancristoforo S, De Ranieri C, Carlevaris CM, et al. Pruritus in pediatric patients with atopic dermatitis: a multidisciplinary approach - summary document from an Italian expert group. Ital J Pediatr. 2020;46:11.PubMedPubMedCentralCrossRef El Hachem M, Di Mauro G, Rotunno R, Giancristoforo S, De Ranieri C, Carlevaris CM, et al. Pruritus in pediatric patients with atopic dermatitis: a multidisciplinary approach - summary document from an Italian expert group. Ital J Pediatr. 2020;46:11.PubMedPubMedCentralCrossRef
258.
go back to reference Leibovic V, Magora F, Cohen S, Ingber A. Effects of virtual reality immersion and audiovisual distraction techniques for patients with pruritus. Pain Res Manag. 2009;14:283–6.CrossRef Leibovic V, Magora F, Cohen S, Ingber A. Effects of virtual reality immersion and audiovisual distraction techniques for patients with pruritus. Pain Res Manag. 2009;14:283–6.CrossRef
Metadata
Title
Narrative review on the management of moderate-severe atopic dermatitis in pediatric age of the Italian Society of Pediatric Allergology and Immunology (SIAIP), of the Italian Society of Pediatric Dermatology (SIDerP) and of the Italian Society of Pediatrics (SIP)
Authors
Elena Galli
Anna Belloni Fortina
Giampaolo Ricci
Nunzia Maiello
Iria Neri
Ermanno Baldo
Irene Berti
Domenico Bonamonte
Lucetta Capra
Elena Carboni
Rossella Carello
Francesca Caroppo
Giovanni Cavagni
Iolanda Chinellato
Francesca Cipriani
Pasquale Comberiati
Andrea Diociaiuti
Vito Di Lernia
Marzia Duse
Cesare Filippeschi
Arianna Giannetti
Mattia Giovannini
Amelia Licari
Gian Luigi Marseglia
Manuela Pace
Annalisa Patrizi
Giovanni Battista Pajno
Diego Peroni
Alberto Villani
Lawrence Eichenfield
Publication date
01-12-2022
Publisher
BioMed Central
Published in
Italian Journal of Pediatrics / Issue 1/2022
Electronic ISSN: 1824-7288
DOI
https://doi.org/10.1186/s13052-022-01278-7

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