Skip to main content
Top
Published in: Multidisciplinary Respiratory Medicine 1/2014

Open Access 01-12-2014 | Original research article

Patient reported experiences of CT guided lung biopsy: a prospective cohort study

Authors: Naomi Winn, Jonathan Spratt, Enid Wright, Julie Cox

Published in: Multidisciplinary Respiratory Medicine | Issue 1/2014

Login to get access

Abstract

Background

CT guided lung biopsy is a commonly performed procedure to obtain tissue for a histological diagnosis in cases of suspected lung cancer.

Methods

This is a prospective cohort study to obtain information directly from patients about their experiences of the biopsy procedure, thus obtaining a more accurate picture of complications compared with previously performed retrospective reviews. Patients participated in a post-procedure telephone interview and information was gathered about any procedural complications and personal experiences. We also compared the patient reported complications with those obtained from a retrospective review of hospital databases, analogous to previously performed retrospective studies.

Results

In our patient group, reported procedural complication rates were 10% pneumothorax rate (4% requiring a chest drain) and 10% haemoptysis. Post-procedural pain and shortness of breath showed positive correlation, with one patient experiencing prolonged pain. No statistical difference was found between the patient reported complication rates and those obtained from retrospective review of the hospital database.

Conclusions

Our study demonstrates CT guided lung biopsy is a safe procedure and is generally well tolerated. Some patients may experience significant and lasting pain and therefore should be counselled about this pre-procedure.
Appendix
Available only for authorised users
Literature
1.
go back to reference Wiener RS, Schwartz LM, Woloshin S, Welch HG: Population-based risk for complications after transthoracic needle lung biopsy of a pulmonary nodule : an analysis of discharge records. Ann Intern Med. 2011, 155: 137-144. 10.7326/0003-4819-155-3-201108020-00003.PubMedCentralCrossRefPubMed Wiener RS, Schwartz LM, Woloshin S, Welch HG: Population-based risk for complications after transthoracic needle lung biopsy of a pulmonary nodule : an analysis of discharge records. Ann Intern Med. 2011, 155: 137-144. 10.7326/0003-4819-155-3-201108020-00003.PubMedCentralCrossRefPubMed
2.
go back to reference Liu A, Southern I, Nicol E: Atrial fibrillation and pneumothorax after transthoracic needle lung biopsy. BMJ Case Reports. 2012, 2012: doi:10.1136/bcr.10.2011.4897 Liu A, Southern I, Nicol E: Atrial fibrillation and pneumothorax after transthoracic needle lung biopsy. BMJ Case Reports. 2012, 2012: doi:10.1136/bcr.10.2011.4897
3.
go back to reference Lee WJ, Chong S, Seo JS, Shim HJ: Transthoracic fine-needle aspiration biopsy of the lungs using a C-arm cone-beam CT system: diagnostic accuracy and post-procedural complications. Br J Radiol. 2012, 85: e217-e222. 10.1259/bjr/64727750.PubMedCentralCrossRefPubMed Lee WJ, Chong S, Seo JS, Shim HJ: Transthoracic fine-needle aspiration biopsy of the lungs using a C-arm cone-beam CT system: diagnostic accuracy and post-procedural complications. Br J Radiol. 2012, 85: e217-e222. 10.1259/bjr/64727750.PubMedCentralCrossRefPubMed
4.
go back to reference Choi JW, Park CM, Goo JM, Park YK, Sung W, Lee HJ, Lee SM, Ko JY, Shim MS: C-arm cone-beam CT-guided percutaneous transthoracic needle biopsy of small (≤20 mm) lung nodules: diagnostic accuracy and complications in 161 patients. AJR Am J Roentgenol. 2012, 199: W322-W330. 10.2214/AJR.11.7576.CrossRefPubMed Choi JW, Park CM, Goo JM, Park YK, Sung W, Lee HJ, Lee SM, Ko JY, Shim MS: C-arm cone-beam CT-guided percutaneous transthoracic needle biopsy of small (≤20 mm) lung nodules: diagnostic accuracy and complications in 161 patients. AJR Am J Roentgenol. 2012, 199: W322-W330. 10.2214/AJR.11.7576.CrossRefPubMed
5.
go back to reference Lim CS, Tan LE, Wang JY, Lee CH, Chang HC, Lan CC, Yang MC, Chang-Yao Tsao T, Wu YK: Risk factors of pneumothorax after CT-guided coaxial cutting needle lung biopsy through aerated versus nonaerated lung. J Vasc Interv Radiol. 2014, 25: 1209-1217. 10.1016/j.jvir.2014.03.031.CrossRefPubMed Lim CS, Tan LE, Wang JY, Lee CH, Chang HC, Lan CC, Yang MC, Chang-Yao Tsao T, Wu YK: Risk factors of pneumothorax after CT-guided coaxial cutting needle lung biopsy through aerated versus nonaerated lung. J Vasc Interv Radiol. 2014, 25: 1209-1217. 10.1016/j.jvir.2014.03.031.CrossRefPubMed
6.
go back to reference Boskovic T, Stanic J, Pena-Karan S, Zarogoulidis P, Drevelegas K, Katsikogiannis N, Machairiotis N, Mpakas A, Tsakiridis K, Kesisis G, Tsiouda T, Kougioumtzi I, Arikas S, Zarogoulidis K: Pneumothorax after transthoracic needle biopsy of lung lesions under CT guidance. J Thorac Dis. 2014, 6 (Suppl 1): S99-S107.PubMedCentralPubMed Boskovic T, Stanic J, Pena-Karan S, Zarogoulidis P, Drevelegas K, Katsikogiannis N, Machairiotis N, Mpakas A, Tsakiridis K, Kesisis G, Tsiouda T, Kougioumtzi I, Arikas S, Zarogoulidis K: Pneumothorax after transthoracic needle biopsy of lung lesions under CT guidance. J Thorac Dis. 2014, 6 (Suppl 1): S99-S107.PubMedCentralPubMed
7.
go back to reference Anderson JM, Murchison J, Patel D: CT-guided lung biopsy: factors influencing diagnostic yield and complication rate. Clin Radiol. 2003, 58: 791-797. 10.1016/S0009-9260(03)00221-6.CrossRefPubMed Anderson JM, Murchison J, Patel D: CT-guided lung biopsy: factors influencing diagnostic yield and complication rate. Clin Radiol. 2003, 58: 791-797. 10.1016/S0009-9260(03)00221-6.CrossRefPubMed
8.
go back to reference Johnstone AL, Win A, Darby M, Bhartia B, Karthik S: Risks and rewards of CT-guided thoracic biopsy. Complications audit and patient experience survey. ClinRadiol. 2014, 69: S12- Johnstone AL, Win A, Darby M, Bhartia B, Karthik S: Risks and rewards of CT-guided thoracic biopsy. Complications audit and patient experience survey. ClinRadiol. 2014, 69: S12-
9.
go back to reference Richardson CM, Pointon KS, Manhire AR, Macfarlane JT: Percutaneous lung biopsies: a survey of UK practice based on 5444 biopsies. Br J Radiol. 2002, 75: 731-735. 10.1259/bjr.75.897.750731.CrossRefPubMed Richardson CM, Pointon KS, Manhire AR, Macfarlane JT: Percutaneous lung biopsies: a survey of UK practice based on 5444 biopsies. Br J Radiol. 2002, 75: 731-735. 10.1259/bjr.75.897.750731.CrossRefPubMed
10.
go back to reference Manhire A, Charig M, Clelland C, Gleeson F, Miller R, Moss H, Pointon K, Richardson C, Sawicka E, BTS: Guidelines for radiologically guided lung biopsy. Thorax. 2003, 58: 920-936. 10.1136/thorax.58.11.920.PubMedCentralCrossRefPubMed Manhire A, Charig M, Clelland C, Gleeson F, Miller R, Moss H, Pointon K, Richardson C, Sawicka E, BTS: Guidelines for radiologically guided lung biopsy. Thorax. 2003, 58: 920-936. 10.1136/thorax.58.11.920.PubMedCentralCrossRefPubMed
11.
go back to reference Wu CC, Maher MM, Shepard J-AO: Complications of CT-guided percutaneous needle biopsy of the chest: prevention and management. AJR Am J Roentgenol. 2011, 196: W678-W682. 10.2214/AJR.10.4659.CrossRefPubMed Wu CC, Maher MM, Shepard J-AO: Complications of CT-guided percutaneous needle biopsy of the chest: prevention and management. AJR Am J Roentgenol. 2011, 196: W678-W682. 10.2214/AJR.10.4659.CrossRefPubMed
12.
go back to reference Nakatani M, Tanigawa N, Kariya S, Komemushi A, Yagi R, Sawada S: Analysis of factors influencing accuracy and complications in CT-guided lung biopsy. Minim Invasive Ther Allied Technol. 2012, 21: 415-422. 10.3109/13645706.2012.662155.CrossRefPubMed Nakatani M, Tanigawa N, Kariya S, Komemushi A, Yagi R, Sawada S: Analysis of factors influencing accuracy and complications in CT-guided lung biopsy. Minim Invasive Ther Allied Technol. 2012, 21: 415-422. 10.3109/13645706.2012.662155.CrossRefPubMed
13.
go back to reference Tsai IC, Tsai WL, Chen MC, Chang GC, Tzeng WS, Chan SW, Chen CC: CT-guided core biopsy of lung lesions: a primer. AJR Am J Roentgenol. 2009, 193: 1228-1235. 10.2214/AJR.08.2113.CrossRefPubMed Tsai IC, Tsai WL, Chen MC, Chang GC, Tzeng WS, Chan SW, Chen CC: CT-guided core biopsy of lung lesions: a primer. AJR Am J Roentgenol. 2009, 193: 1228-1235. 10.2214/AJR.08.2113.CrossRefPubMed
14.
go back to reference Braak SJ, Herder GJM, van Heesewijk JPM, van Strijen MJL: Pulmonary masses: initial results of cone-beam CT guidance with needle planning software for percutaneous lung biopsy. Cardiovasc Intervent Radiol. 2012, 35: 1414-1421. 10.1007/s00270-011-0302-z.CrossRefPubMed Braak SJ, Herder GJM, van Heesewijk JPM, van Strijen MJL: Pulmonary masses: initial results of cone-beam CT guidance with needle planning software for percutaneous lung biopsy. Cardiovasc Intervent Radiol. 2012, 35: 1414-1421. 10.1007/s00270-011-0302-z.CrossRefPubMed
15.
go back to reference Choo JY, Park CM, Lee NK, Lee SM, Lee H-J, Goo JM: Percutaneous transthoracic needle biopsy of small (≤ 1 cm) lung nodules under C-arm cone-beam CT virtual navigation guidance. Eur Radiol. 2013, 23: 712-719. 10.1007/s00330-012-2644-6.CrossRefPubMed Choo JY, Park CM, Lee NK, Lee SM, Lee H-J, Goo JM: Percutaneous transthoracic needle biopsy of small (≤ 1 cm) lung nodules under C-arm cone-beam CT virtual navigation guidance. Eur Radiol. 2013, 23: 712-719. 10.1007/s00330-012-2644-6.CrossRefPubMed
16.
go back to reference Prosch H, Stadler A, Schilling M, Bürklin S, Eisenhuber E, Schober E, Mostbeck G: CT fluoroscopy-guided vs. multislice CT biopsy mode-guided lung biopsies: accuracy, complications and radiation dose. Eur J Radiol. 2012, 81: 1029-1033. 10.1016/j.ejrad.2011.01.064.CrossRefPubMed Prosch H, Stadler A, Schilling M, Bürklin S, Eisenhuber E, Schober E, Mostbeck G: CT fluoroscopy-guided vs. multislice CT biopsy mode-guided lung biopsies: accuracy, complications and radiation dose. Eur J Radiol. 2012, 81: 1029-1033. 10.1016/j.ejrad.2011.01.064.CrossRefPubMed
17.
go back to reference Carlson SK, Clayton AC: Evolution of transthoracic fine needle aspiration and core needle biopsy practice : a comparison of two time periods, 1996-1998 and 2003-2005. Diagn Cytopathol. 2011, 40: 876-881.PubMed Carlson SK, Clayton AC: Evolution of transthoracic fine needle aspiration and core needle biopsy practice : a comparison of two time periods, 1996-1998 and 2003-2005. Diagn Cytopathol. 2011, 40: 876-881.PubMed
18.
go back to reference LU CH, Hsiao CH, Chang YC, Lee JM, Shih JY, Wu LA, Yu CJ, Liu HM, Shih TT, Yang PC: Percutaneous computed tomography-guided coaxial core biopsy for small pulmonary lesions with ground-glass attenuation. J Thorac Oncol. 2012, 7: 143-150. 10.1097/JTO.0b013e318233d7dd.CrossRefPubMed LU CH, Hsiao CH, Chang YC, Lee JM, Shih JY, Wu LA, Yu CJ, Liu HM, Shih TT, Yang PC: Percutaneous computed tomography-guided coaxial core biopsy for small pulmonary lesions with ground-glass attenuation. J Thorac Oncol. 2012, 7: 143-150. 10.1097/JTO.0b013e318233d7dd.CrossRefPubMed
19.
go back to reference Ogbole GI, Adeoye PO, Okolo CA, Iseko K: CT - guided percutaneous transthoracic lung biopsy : first experience in Ibadan, Nigeria. Niger J Clin Pract. 2013, 16: 544-547. 10.4103/1119-3077.116911.CrossRefPubMed Ogbole GI, Adeoye PO, Okolo CA, Iseko K: CT - guided percutaneous transthoracic lung biopsy : first experience in Ibadan, Nigeria. Niger J Clin Pract. 2013, 16: 544-547. 10.4103/1119-3077.116911.CrossRefPubMed
20.
go back to reference Poulou LS, Tsagouli P, Ziakas PD, Politi D, Trigidou R, Thanos L: Computed tomography-guided needle aspiration and biopsy of pulmonary lesions: a single-center experience in 1000 patients. Acta Radiol. 2013, 54: 640-645. 10.1177/0284185113481595.CrossRefPubMed Poulou LS, Tsagouli P, Ziakas PD, Politi D, Trigidou R, Thanos L: Computed tomography-guided needle aspiration and biopsy of pulmonary lesions: a single-center experience in 1000 patients. Acta Radiol. 2013, 54: 640-645. 10.1177/0284185113481595.CrossRefPubMed
21.
go back to reference Yoshimatsu R, Yamagami T, Tanaka O, Miura H, Tanaka T, Suzuki T, Nishimura T: Comparison of fully automated and semi-automated biopsy needles for lung biopsy under CT fluoroscopic guidance. Br J Radiol. 2012, 85: 208-213. 10.1259/bjr/15132704.PubMedCentralCrossRefPubMed Yoshimatsu R, Yamagami T, Tanaka O, Miura H, Tanaka T, Suzuki T, Nishimura T: Comparison of fully automated and semi-automated biopsy needles for lung biopsy under CT fluoroscopic guidance. Br J Radiol. 2012, 85: 208-213. 10.1259/bjr/15132704.PubMedCentralCrossRefPubMed
22.
go back to reference Lal H, Neyaz Z, Nath A, Borah S: CT-guided percutaneous biopsy of intrathoracic lesions. Korean J Radiol. 2012, 13: 210-226. 10.3348/kjr.2012.13.2.210.PubMedCentralCrossRefPubMed Lal H, Neyaz Z, Nath A, Borah S: CT-guided percutaneous biopsy of intrathoracic lesions. Korean J Radiol. 2012, 13: 210-226. 10.3348/kjr.2012.13.2.210.PubMedCentralCrossRefPubMed
23.
go back to reference Khan MF, Straub R, Moghaddam SR, Maataoui A, Gurung J, Wagner TOF, Ackermann H, Thalhammer A, Vogl TJ, Jacobi V: Variables affecting the risk of pneumothorax and intrapulmonal hemorrhage in CT-guided transthoracic biopsy. Eur Radiol. 2008, 18: 1356-1363. 10.1007/s00330-008-0893-1.CrossRefPubMed Khan MF, Straub R, Moghaddam SR, Maataoui A, Gurung J, Wagner TOF, Ackermann H, Thalhammer A, Vogl TJ, Jacobi V: Variables affecting the risk of pneumothorax and intrapulmonal hemorrhage in CT-guided transthoracic biopsy. Eur Radiol. 2008, 18: 1356-1363. 10.1007/s00330-008-0893-1.CrossRefPubMed
24.
go back to reference Geraghty PR, Kee ST, McFarlane G, Razavi MK, Sze DY, Dake MD: CT - guided transthoracic Vascular and interventional radiology needle aspiration biopsy of pulmonary nodules: needle size and pneumothorax rate 1. Radiology. 2003, 229: 475-481. 10.1148/radiol.2291020499.CrossRefPubMed Geraghty PR, Kee ST, McFarlane G, Razavi MK, Sze DY, Dake MD: CT - guided transthoracic Vascular and interventional radiology needle aspiration biopsy of pulmonary nodules: needle size and pneumothorax rate 1. Radiology. 2003, 229: 475-481. 10.1148/radiol.2291020499.CrossRefPubMed
25.
go back to reference Li Y, Du Y, Yang HF, Yu JH, Xu XX: CT-guided percutaneous core needle biopsy for small (≤20 mm) pulmonary lesions. Clin Radiol. 2013, 68: e43-e48. 10.1016/j.crad.2012.09.008.CrossRefPubMed Li Y, Du Y, Yang HF, Yu JH, Xu XX: CT-guided percutaneous core needle biopsy for small (≤20 mm) pulmonary lesions. Clin Radiol. 2013, 68: e43-e48. 10.1016/j.crad.2012.09.008.CrossRefPubMed
Metadata
Title
Patient reported experiences of CT guided lung biopsy: a prospective cohort study
Authors
Naomi Winn
Jonathan Spratt
Enid Wright
Julie Cox
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Multidisciplinary Respiratory Medicine / Issue 1/2014
Electronic ISSN: 2049-6958
DOI
https://doi.org/10.1186/2049-6958-9-53

Other articles of this Issue 1/2014

Multidisciplinary Respiratory Medicine 1/2014 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.