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Clinical Collections
Women’s Health Knowledge Hub Advances in Alzheimer’s

Navigating neuroimaging in Alzheimer disease care

PET imaging is playing an increasingly critical role in managing AD, but how can you effectively integrate it into clinical practice? Our expert-led program will empower you with practical strategies and real-world case studies.

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Parkinson's Disease

Disappearing facial features in Parkinson disease psychosis

As PD progresses, minor perceptual disturbances can evolve into formed hallucinations and delusions. This unique case describes aprosopsia, which is transient perceptual absence of facial features.

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Editor's Choice

Gait changes: an early warning sign

Growing evidence suggests that age-related gait changes are not a consequence of aging, but instead indicate underlying age-related disease.

Genetic therapies for movement disorders

What advances have been made in developing genetic therapy approaches for movement disorders such as Parkinson and Huntington diseases and rarer monogenic conditions of childhood onset?

Vaccines for neurological disease

How far off are vaccine-based approaches to prevent and modify the progression of diseases such as Alzheimers, Parkinsons, multiple sclerosis, Huntingtons, ALS, and CJD?

Smart tool for diagnosing progressive supranuclear palsy

Diagnosing PSP remains a major challenge due to the variety of clinical phenotypes and overlap with other neurodegenerative diseases. Could this practical tool help you?

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Keynote webinar | Spotlight on sleep in brain health

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.

Dr. Rolf Fronczek
Dr. Renata Riha
Dr. Sven Rupprecht
Developed by: Springer Medicine
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Video

Latest News

Automated imaging differentiation could enhance PD diagnosis

Exenatide lacks disease-modifying benefit for Parkinson’s disease

TAK-071 fails to improve gait variability in PD

Hearing loss linked to increased PD risk in military veterans

SGLT2 inhibitors may lower risk for neurodegenerative disorders

Substantia nigra pathology may explain increased parkinsonism risk in CTE

Case Studies

Disappearing facial features in Parkinson disease psychosis

As PD progresses, minor perceptual disturbances can evolve into formed hallucinations and delusions. This unique case describes aprosopsia, which is transient perceptual absence of facial features.

Can a circadian reset repair long COVID symptoms?

Bright light treatment can resynchronize circadian disruption in prodromal Parkinson's disease. This case series tests whether light treatment can repair post-encephalitic symptoms of long COVID, which closely approximate prodromal PD.

Argyrophilic grain disease initially diagnosed as Parkinson's disease

AGD is an age-related tauopathy that contributes to cognitive decline. This case demonstrates that AGD should be included in the differential diagnosis of PD without dementia in older people.

Episode 4: Stem cell therapy for PD

A new era for managing Parkinson’s disease?

STEM-PD, the first in-human safety trial of stem cell therapy for Parkinson’s disease, began this year and marks a huge step forward for this type of treatment.

We talk to Prof. Malin Parmar about why stem cell therapy is such a good option for patients with Parkinson’s disease and get an update on the current status of the trial.

Dr. Malin Parmar
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Podcast

Current Reviews

Exploring the therapeutic potential of NLRP3 inhibitors in Parkinson's Disease: a systematic review of in-vivo studies

Parkinson's disease (PD) is a notable neurodegenerative disorder that affects humans aged 60 and older around the world (Ascherio and Schwarzschild 2016 ). Previous research indicates that approximately 1 million people in the USA are living with …

Sphingolipidoses: expanding the spectrum of α-synucleinopathies

  • Open Access
  • Sphingolipidosis
  • Neurology and Preclinical Neurological Studies - Review Article

Although α-synuclein pathology is typically associated with Lewy body diseases and multiple systems atrophy, increasing evidence indicates that it also occurs in a group of lysosomal storage disorders termed sphingolipidoses caused by the …

Effectiveness of the Hayling and Brixton Tests for Detecting Dementia, Progressive Cognitive Decline, and Mild Cognitive Impairment in Middle to Older Aged Adults: A Systematic Review and Meta-analysis

The aging population is increasing the prevalence of dementia, neurodegenerative disorders, and mild cognitive impairment, which are associated with cognitive declines in executive functioning. In people with these disorders, accurate tests can …

Gut microbiota and Parkinson’s Disease: a new frontier in understanding neurological health

Increasingly recognized as a neurodegenerative disease with motor manifestations and progressive cognitive decline, PD has more frequently been linked to the gut microbiome. The gut-brain axis, a bidirectional communication system between the gut …

Further Reading

Integrated Analysis of Single-Cell and Transcriptome Data Reveals the Role and Regulatory Mechanisms of Neuroinflammation in Parkinson's Disease

There is increasing interest in developing therapeutic interventions aimed at preventing neuroinflammation in Parkinson's disease (PD). However, the specific characteristics of inflammation across different cell types and the underlying mechanisms …

Mild motor signs and depression: more than just medication side effects?

The relationship between major depressive disorder (MDD) and mild motor signs (MMS) remains to be elucidated. The present study aims to assess the association between neurological symptoms and medications and treatment response. Neurological signs …

Multimodal imaging analysis of autosomal recessive Parkinson’s disease

Parkinson’s disease (PD), characterized by nigrostriatal dopaminergic denervation, is clinically and genetically heterogeneous. The diagnosis requires the presence of bradykinesia, resting tremor and/or rigidity, even though patients also exhibit …

Ventral STN stimulation is associated with improved axial motor outcomes in Parkinson’s disease

Subthalamic nucleus (STN) deep brain stimulation (DBS) is well-established for improving appendicular motor signs but its effect on axial motor signs is less clear. Additionally, the location of active electrode contact within the STN has been …

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