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Neurological Sciences

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01-05-2021 | Parkinson's Disease | Original Article

Reduced serum SIRT1 levels in patients with Parkinson’s disease: a cross-sectional study in China

Authors: Yuting Zhu, Xiangyang Zhu, Yong Zhou, Dongmei Zhang

Published in: Neurological Sciences | Issue 5/2021

Abstract

Background

Parkinson’s disease (PD) is a movement disorder lacking of validated biomarkers. Experimental studies support the potential value of silent information regulator 1 (SIRT1) in neurodegeneration including PD. We aim to detect the serum levels of SIRT1 in PD patients in order to assess its value as a potential biomarker of PD.

Methods

Fifty-eight PD patients and 91 healthy controls were included. Serum SIRT1 was determined by enzyme-linked immunosorbent assay (ELISA) and compared between controls and PD patients. Spearman correlation coefficient was analyzed to study the relationship between serum SIRT1 and clinical parameters in PD patients. Receiver operating characteristic (ROC) analysis was conducted to assess the diagnostic value of serum SIRT1 in PD identification.

Results

Serum SIRT1 was significantly reduced in PD patients compared with controls. According to the ROC curve, the optimal cut-off point was 0.47 ng/ml with the sensitivity of 71% and specificity of 71%. Serum SIRT1 level was related to age of onset, disease duration, Hoehn-Yahr staging scale (H-Y stage), Unified Parkinson’s Disease Rating Scale III (UPDRS III), and Mini-Mental State Examination (MMSE). PD patients with cognitive impairment had lower serum SIRT1 than those with normal cognitive ability.

Conclusions

Serum SIRT1 was reduced in PD patients and associated with disease severity and cognitive function. Our results indicate that SIRT1 may be a potential biomarker for PD.

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Title: Reduced serum SIRT1 levels in patients with Parkinson’s disease: a cross-sectional study in China
Authors: Yuting Zhu
Xiangyang Zhu
Yong Zhou
Dongmei Zhang
Publication date: 01-05-2021
Publisher: Springer International Publishing
Keywords: Parkinson's Disease
Biomarkers
Published in: Neurological Sciences / Issue 5/2021
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-020-04711-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Reduced serum SIRT1 levels in patients with Parkinson’s disease: a cross-sectional study in China

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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