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Open Access 01-12-2020 | Paracetamol | Original Research

Real-World Evidence in Prescription Medication Use Among U.S. Adults with Neck Pain

Authors: Jin-Feng Huang, Zhou Meng, Xuan-Qi Zheng, Zongshi Qin, Xiao-Lei Sun, Kai Zhang, Hai-Jun Tian, Xiao-Bing Wang, Ze Gao, Yan Michael Li, Ai-Min Wu

Published in: Pain and Therapy | Issue 2/2020

Abstract

Introduction

Neck pain is a common condition that leads to serious pain, disability, and increased healthcare costs worldwide. Pharmacotherapy is one of the most common strategies to reduce neck pain in patients. The aim of this study was to analyze the real-world pattern of drugs prescribed for patients with neck pain in the USA.

Methods

Data on individuals who reported current neck pain in the 2009−2010 US National Health and Nutrition Examination Survey (NHANES) and with a history of persistent pain for at least 6 weeks or 3 months were extracted from the NHANES database. Those included in the study were divided into three groups based on the duration of pain: the without neck pain group (Group A); subacute group (Group B) with a history of 6 weeks of neck pain; and the chronic neck pain group (Group C) with a history of 3 months of neck pain. The use and duration of medication prescribed for Group A, B, and C patients were compared.

Results

The analysis revealed that opioid use was significantly more prevalent in the subacute and chronic neck pain group than in the without neck pain group (Group A) (adjusted odds ratio [aOR] 4.20, 95% confidence interval [CI] 2.07–8.52 and aOR 7.00, 95% CI 4.32–11.33, respectively). The factors strongly associated with higher opioid use included older age, low education level, and low family income. In the chronic neck group, opioids, followed in decreasing order of frequency by acetaminophen and nonsteroidal anti-infammatory drugs, were the most common analgesics used in combination with other analgesics.

Conclusion

Our analysis of the data shows that the long-term excessive use of opioids and the underutilization of other analgesics are two major issues in the treatment of neck pain in the USA. Possible improvements include improved education of patients by healthcare professionals on the use of opioids and more consideration given to non-pharmacotherapy options. Our results reveal the potential problem in pharmacotherapy choices for neck pain treatment and may help improve the current clinical practice in the USA and other countries.

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Title: Real-World Evidence in Prescription Medication Use Among U.S. Adults with Neck Pain
Authors: Jin-Feng Huang
Zhou Meng
Xuan-Qi Zheng
Zongshi Qin
Xiao-Lei Sun
Kai Zhang
Hai-Jun Tian
Xiao-Bing Wang
Ze Gao
Yan Michael Li
Ai-Min Wu
Publication date: 01-12-2020
Publisher: Springer Healthcare
Keywords: Paracetamol
Opioids
Opioids
Analgesics in Dentistry
Neck Pain
Muscle Relaxant
Muscle Relaxant
Published in: Pain and Therapy / Issue 2/2020
Print ISSN: 2193-8237
Electronic ISSN: 2193-651X
DOI: https://doi.org/10.1007/s40122-020-00193-1

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Abstract

Introduction

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