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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2021

Open Access 01-12-2021 | Pancreatic Cancer | Review

NOX4: a potential therapeutic target for pancreatic cancer and its mechanism

Authors: Yawei Bi, Xiao Lei, Ningli Chai, Enqiang Linghu

Published in: Journal of Translational Medicine | Issue 1/2021

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Abstract

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) is one of the seven isoforms of NOX family, which is upregulated in pancreatic cancer cell, mouse model of pancreatic cancer and human pancreatic cancer tissue. NOX4 is a constitutively active enzyme that primarily produces hydrogen peroxide, which exhibits completely different properties from other subtypes of NOX family. More importantly, recent studies illuminate that NOX4 promotes pancreatic cancer occurrence and development in different ways. This review summarizes the potential roles and its mechanism of NOX4 in pancreatic cancer and explores NOX4 as the potential therapeutic target in pancreatic cancer.
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Metadata
Title
NOX4: a potential therapeutic target for pancreatic cancer and its mechanism
Authors
Yawei Bi
Xiao Lei
Ningli Chai
Enqiang Linghu
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue 1/2021
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/s12967-021-03182-w

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