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Published in: Cancer Cell International 1/2020

01-12-2020 | Ovarian Cancer | Primary research

TNFAIP8 variants as potential epidemiological and predictive biomarkers in ovarian cancer

Authors: Hongyu Gao, Zhiran Zhang, Liangliang Jiang, Lei Zhang, Ling Qin, Tianbo Liu, Shanshan Yang

Published in: Cancer Cell International | Issue 1/2020

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Abstract

Background

This research aimed to investigate the association between tumor necrosis factor-a-induced protein 8 (TNFAIP8) polymorphisms and ovarian cancer (OC) susceptibility.

Methods

A case–control study of 210 patients with OC and 231 healthy controls was conducted to assess the association between TNFAIP8 polymorphisms (rs11064, rs1045241, and rs1045242) and OC risk in Heilongjiang Province of China. The SNaPshot SNP assay was conducted to detect SNP genotype. Logistic regression analysis was applied to illustrate the underlying association.

Results

Our research found that TNFAIP8 rs11064 and rs1045242 were significantly connected with the susceptibility of OC. Additionally, rs1045242 increased the risk of OC, while rs11064 performed a protective role in the risk of OC. Data revealed that rs1045242 strongly related with advanced FIGO stage, larger residual tumor, and the presence of recurrence.

Conclusions

TNFAIP8 genetic variants, which may play difference roles, were significantly associated with OC susceptibility. The underlying molecular mechanism needs be clarified with scientific evidence.
Appendix
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Metadata
Title
TNFAIP8 variants as potential epidemiological and predictive biomarkers in ovarian cancer
Authors
Hongyu Gao
Zhiran Zhang
Liangliang Jiang
Lei Zhang
Ling Qin
Tianbo Liu
Shanshan Yang
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2020
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-020-01490-7

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