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01-12-2021 | Osteoporosis | Original Article

FRAX-based intervention thresholds in eight Eurasian countries: Armenia, Belarus, Georgia, Kazakhstan, the Kyrgyz Republic, Moldova, the Russian Federation, and Uzbekistan

Authors: Olga Lesnyak, Alla Zakroyeva, Varta Babalyan, Victor Cazac, Gulzhan Gabdulina, Said Ismailov, Olga Lobanchenko, Ema Rudenka, Marina Tsagareli, Helena Johansson, Nickolas C. Harvey, Eugene McCloskey, John A. Kanis

Published in: Archives of Osteoporosis | Issue 1/2021

Abstract

Summary

Age-specific intervention and assessment thresholds based on FRAX® were developed for eight Eurasian countries participating in the EVA study (Armenia, Belarus, Georgia, Moldova, Kazakhstan, the Kyrgyz Republic, the Russian Federation, and Uzbekistan). The intervention thresholds (major osteoporotic fracture) ranged from 3.6 (Armenia and Georgia) to 12.3% (Uzbekistan) for people at age 50 years, and from 16 (Armenia) to 27% (Belarus) at the age of 90 years. These thresholds enable a substantial advance in the ease of detection of individuals at high fracture risk.

Introduction

The purpose of this study was to derive and compare FRAX-based intervention and BMD assessment thresholds for 8 Eurasian countries in the EVA study.

Methods

The intervention threshold (IT) was set at a 10-year probability of a major osteoporotic fracture (MOF), calculated without BMD, equivalent to a woman with a prior fragility fracture but no other clinical risk factors, and a body mass index (BMI) of 25.0 kg/m². The lower assessment threshold was set at a 10-year probability of a MOF in women with BMI of 25.0 kg/m², without previous fracture or other clinical risk factors. The upper assessment threshold was set at 1.2 times the IT.

Results

The age-specific intervention thresholds ranged from 3.6 (Armenia and Georgia) to 12.3% (Uzbekistan) for men and women at the age of 50 years and from 16 (Armenia) to 27% (Belarus) at the age of 90 years. The difference between countries was most evident at younger ages and become progressively less with advancing age.

Conclusions

For the 8 Eurasian countries, the newly established FRAX-based intervention thresholds provide an opportunity to improve the clinical detection of both men and women with a high risk of fracture and improve treatment rates.

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Title: FRAX-based intervention thresholds in eight Eurasian countries: Armenia, Belarus, Georgia, Kazakhstan, the Kyrgyz Republic, Moldova, the Russian Federation, and Uzbekistan
Authors: Olga Lesnyak
Alla Zakroyeva
Varta Babalyan
Victor Cazac
Gulzhan Gabdulina
Said Ismailov
Olga Lobanchenko
Ema Rudenka
Marina Tsagareli
Helena Johansson
Nickolas C. Harvey
Eugene McCloskey
John A. Kanis
Publication date: 01-12-2021
Publisher: Springer London
Keywords: Osteoporosis
Osteoporosis
Published in: Archives of Osteoporosis / Issue 1/2021
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI: https://doi.org/10.1007/s11657-021-00962-1

At a glance: The STEP trials

Springer Medicine

FRAX-based intervention thresholds in eight Eurasian countries: Armenia, Belarus, Georgia, Kazakhstan, the Kyrgyz Republic, Moldova, the Russian Federation, and Uzbekistan

Abstract

Summary

Introduction

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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