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Archives of Osteoporosis
Published in: Archives of Osteoporosis 1/2020

Open Access 01-12-2020 | Forearm Fracture | Original Article

Epidemiology of osteoporotic fracture in Kazakhstan and development of a country specific FRAX model

Authors: S. Issayeva, O. Lesnyak, A. Zakroyeva, B. Issayeva, D. Dilmanova, H. Johansson, E. Liu, M. Lorentzon, N.C. Harvey, E. McCloskey, J.A. Kanis

Published in: Archives of Osteoporosis | Issue 1/2020

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Abstract

Summary

Retrospective and prospective population-based survey in a region of the Republic of Kazakhstan determined the incidence of fractures at the hip, proximal humerus and distal forearm. The hip fracture rates were used to create a FRAX® model to enhance fracture risk assessment in Kazakhstan.

Objective

This paper describes the epidemiology of osteoporotic fractures in the Republic of Kazakhstan that was used to develop a country specific FRAX® tool for fracture prediction.

Methods

We carried out a retrospective population-based survey in Taldykorgan in the Republic of Kazakhstan representing approximately 1% of the country’s population. Hip, forearm and humerus fractures were identified retrospectively in 2015 and 2016 from hospital registers and the trauma centre. Hip fractures were prospectively identified in 2017 from the same sources and additionally from primary care data. Age- and sex-specific incidence of hip fracture and national mortality rates were incorporated into a FRAX model for Kazakhstan. Fracture probabilities were compared with those from neighbouring countries having FRAX models.

Results

The difference in hip fracture incidence between the retrospective and prospective survey indicated that approximately 25% of hip fracture cases did not come to hospital attention. The incidence of hip fracture applied nationally suggested that the estimated number of hip fractures nationwide in persons over the age of 50 years for 2015 was 11,690 and is predicted to increase by 140% to 28,000 in 2050. Hip fracture incidence was a good predictor of forearm and humeral fractures in men but not in women.

Conclusion

The FRAX model should enhance accuracy of determining fracture probability among the Kazakh population and help guide decisions about treatment.
Literature
1.
Hernlund E, Svedbom A, Ivergård M, Compston J, Cooper C, Stenmark J, McCloskey EV, Jönsson B, Kanis JA (2013) Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the international Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Archives of osteoporosis 8:136CrossRef
2.
Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17:1726–1733CrossRef
3.
Kanis JA, Cooper C, Rizzoli R, Reginster J-Y, Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis (ESCEO) and the Committees of Scientific Advisors and National Societies of the International Osteoporosis Foundation (IOF) (2019) European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 30:3–44CrossRef
4.
5.
Kanis JA, Johnell O, Oden A, Johansson H, McCloskey E (2008a) FRAX™ and the assessment of fracture probability in men and women from the UK. Osteoporos Int 19:385–397CrossRef
6.
Odén A, McCloskey EV, Kanis JA, Harvey NC, Johansson H (2015) Burden of high fracture probability worldwide: secular increases 2010-2040. Osteoporos Int 26:2243–2248CrossRef
7.
Kanis JA, Harvey NC, Cyrus Cooper C, Johansson H, Odén A, McCloskey EV the Advisory Board of the National Osteoporosis Guideline Group (2016) A systematic review of intervention thresholds based on FRAX. A report prepared for the National Osteoporosis Guideline Group and the International Osteoporosis Foundation. Arch Osteoporos 11:25
8.
9.
10.
11.
12.
Zakroyeva A, Lesnyak O, Cazac V, Groppa L, Russu E, Chislari L, Rotaru L, Johansson H, Harvey NC, McCloskey E, Kanis JA (2019) Epidemiology of osteoporotic fracture in Moldova and development of a country specific FRAX model. Arch Osteoporos
13.
14.
15.
16.
Kanis JA, Oden A, Johnell O, Jonsson B, de Laet C, Dawson A (2001) The burden of osteoporotic fractures: a method for setting intervention thresholds. Osteoporos Int 12:417–427CrossRef
17.
Siggeirsdottir K, Aspelund T, Johansson H, Gudmundsson EF, Mogensen B, Jonsson BY, Gudnason V, McCloskey E, Oden A, Sigurdsson G, Kanis JA (2014) The incidence of a first major osteoporotic fracture in Iceland and implications for FRAX. Osteoporos Int 25:2445–2451CrossRef
18.
Lam A, LeslieWD LLM, Yogendran M, Morin SN, Majumdar SR (2014) Major osteoporotic to hip fracture ratios in Canadian men and women with Swedish comparisons: a population-based analysis. J Bone Miner Res 29:1067–1073CrossRef
19.
20.
Kanis JA, Johnell O, De Laet C, Jonsson B, Oden A, Ogelsby AK (2002) International variations in hip fracture probabilities: implications for risk assessment. J Bone Miner Res 17:1237–1244CrossRef
21.
Tuzun S, Eskiyurt N, Akarırmak U, Sarıdoğan M, Senocak M, Johansson H, Kanis JA, the Turkish Osteoporosis Society (2012) Incidence of hip fracture and prevalence of osteoporosis in Turkey: the FRACTURK study. Osteoporos Int 23:949–955CrossRef
22.
Clark P, Lavielle P, Franco-Morina F, Ramirez E, Salmeron J, Kanis JA, Cummings SR (2005) Incidence rates and life-time risk of hip fractures in Mexicans over 50 years of age: a population-based study. Osteoporos Int 16:2025–2030CrossRef
23.
Czerwinski E, Kanis JA, Trybulec B, Johansson H, Borowy P, Osieleniec J (2009) The incidence and risk of hip fracture in Poland. Osteoporos Int 20:1363–1367CrossRef
24.
Grigorie D, Sucaliuc A, Johansson H, Kanis JA, McCloskey E (2013) Incidence of hip fracture in Romania and the development of a Romanian FRAX model. Calcif Tiss Int 92:429–436CrossRef
25.
Povoroznyuk VV, Grygorieva NV, Kanis JA, McCloskey EV, Johansson H, Harvey NC, Korzh MO, Strafun SS, Vaida VM, Klymovytsky FV, Vlasenko RO, Forosenko VS (2017) Epidemiology of hip fracture and the development of FRAX in Ukraine. Arch Osteoporos 12:53CrossRef
26.
Stepan JJ, Vaculik J, Pavelka K, Zofka J, Johansson H, Kanis JA (2012) Hip fracture incidence from 1981 to 2009 in the Czech Republic as a basis of the country-specific FRAX model. Calcif Tissue Int 90:365–372CrossRef
27.
Péntek M, Horváth C, Boncz I, Falusi ZTóth E, Sebestyén A, Májer I, Brodszky V, Gulácsi L (2008) Epidemiology of osteoporosis related fractures in Hungary from the nationwide health insurance database, 1999–2003. Osteoporos Int 19:243–249CrossRef
28.
Dimai HP, Svedbom A, Fahrleitner-Pammer A, Resch H, Muschitz C, Thaler H, Szivak M, Amrein K, Borgström F (2014) Epidemiology of distal forearm fractures in Austria between 1989 and 2010. Osteoporos Int 25:2297–2306CrossRef
29.
Kanis JA, Oden A, McCloskey EV, Johansson HD, Wahl A, Cooper C (2012) A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporos Int 23(9):2239–2256CrossRef
30.
Cooper C, Cole ZA, Holroyd CR, Earl SC, Harvey NC, Dennison EM, Melton LJ, Cummings SR, Kanis JA, the IOF CSA Working Group on Fracture Epidemiology (2011) Secular trends in the incidence of hip and other osteoporotic fractures. Osteoporos Int 22:1277–1288CrossRef
31.
32.
Melton LJ, Crowson CS, O’Fallon WM (1999) Fracture incidence in Olmsted County, Minnesota: comparison of urban and with rural rates and changes in urban rates over time. Osteoporos Int 9:29–37CrossRef
33.
Singer BR, McLauchlan CJ, Robinson CM, Christie J (1998) Epidemiology of fracture in 15.000 adults. The influence of age and gender. J Bone Joint Surg 80B:234–238
34.
Sanders KM, Seeman E, Ugoni AM, Pasco JA, Martin TJ, Skoric B, Nicholson GC, Kotowicz MA (1999) Age- and gender specific rate of fractures in Australia: a population-based study. Osteoporos Int 10(2):40–47
35.
Kanis JA, Johnell O, Oden A, Sernbo I, Redlund-Johnell I, Dawson A, de Laet C, Jonsson B (2000) Long-term risk of osteoporotic fractures in Malmo. Osteoporos Int 11:669–674CrossRef
36.
Johnell O, Gullberg B, Kanis JA (1997) The hospital burden of vertebral fracture in Europe: a study of national register sources. Osteoporos Int 7:138–144CrossRef
37.
Melton LJ (1995) Epidemiology of fractures. In: Riggs BL, Melton LJ (eds) Osteoporosis: etiology, diagnosis and management, 2ndedn. Lippincott-Raven, Philadelphia, pp 225–227
38.
Cauley JA, Chalhoub D, Kassem AM, El-H FG (2014) Geographic and ethnic disparities in osteoporotic fractures. Nat Rev Endocrinol 10:338–351CrossRef
39.
Karacić TP, Kopjar B (2009) Hip fracture incidence in Croatia in patients aged 65 years and more. Lijec Vjesn 131:9–13PubMed
40.
Lippuner K, Johansson H, Kanis JA, Rizzoli R (2010) FRAX assessment of osteoporotic fracture probability in Switzerland. Osteoporos Int 21:381–389CrossRef
41.
Emaus N, Olsen LR, Ahmed LA, Balteskard L, Jacobsen BK, Magnus T, Ytterstad B (2011) Hip fractures in a city in northern Norway over 15 years: time trends, seasonal variation and mortality: the Harstad injury prevention study. Osteoporos Int 22:2603–2610CrossRef
42.
Morosano M, Masoni A, Sánchez A (2005) Incidence of hip fractures in the city of Rosario. Argentina: Osteoporos Int 16:1339–1344PubMed
43.
Elffors L, Allander E, Kanis JA, Gullberg B, Johnell O, Dequeker J, Dilzen G, Gennari C, Lopez-Vaz AA, Lyritis G, Mazzuoli GF, Miravet L, Passeri M, Perez Cano R, Rapado A, Ribot C (1994) The variable incidence of hip fracture in southern Europe. The MEDOS study. Osteoporos Int 4:253–263CrossRef
44.
Sanders KM, Pasco JA, Ugoni AM, Nicholson GC, Seeman E, Martin TJ, Skoric B, Panahi S, Kotowicz MA (1998) The exclusion of high trauma fractures may underestimate the prevalence of bone fragility fractures in the community: the Geelong osteoporosis study. J Bone Miner Res 13:1337–1342CrossRef
45.
Mackey DC, Lui LY, Cawthon PM, Bauer DC, Nevitt MC, Cauley JA, Hillier TA, Lewis CE, Barrett-Connor E, Cummings SR, Study of Osteoporotic Fractures (SOF) and Osteoporotic Fractures in Men Study (MrOS) Research Groups (2007) High-trauma fractures and low bone mineral density in older women and men. JAMA 298:2381–2388CrossRef
46.
Leslie WD, Schousboe JT, Morin SN, Martineau P, Lix JM, Johansson H, McCloskey EV, Harvey NC, Kanis JA (2020) Fracture risk following high-trauma versus non-trauma fracture: a registry-based cohort study. Osteoporos Int, in press
47.
Kanis JA, Johansson H, Oden A, Dawson-Hughes B, Melton LJ 3rd, McCloskey EV (2010) The effects of a FRAX® revision for the USA. Osteoporos Int 21:35–40CrossRef
Metadata
Title
Epidemiology of osteoporotic fracture in Kazakhstan and development of a country specific FRAX model
Authors
S. Issayeva
O. Lesnyak
A. Zakroyeva
B. Issayeva
D. Dilmanova
H. Johansson
E. Liu
M. Lorentzon
N.C. Harvey
E. McCloskey
J.A. Kanis
Publication date
01-12-2020
Publisher
Springer London
Published in
Archives of Osteoporosis / Issue 1/2020
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-020-0701-3

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