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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2020

Open Access 01-12-2020 | Osteoarthrosis | Review

Recent progress on the role of miR-140 in cartilage matrix remodelling and its implications for osteoarthritis treatment

Authors: Li Duan, Yujie Liang, Xiao Xu, Yin Xiao, Daping Wang

Published in: Arthritis Research & Therapy | Issue 1/2020

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Abstract

Cartilage matrix remodelling homeostasis is a crucial factor in maintaining cartilage integrity. Loss of cartilage integrity is a typical characteristic of osteoarthritis (OA). Strategies aimed at maintaining cartilage integrity have attracted considerable attention in the OA research field. Recently, a series of studies have suggested dual functions of microRNA-140 (miR-140) in cartilage matrix remodelling. Here, we discuss the significance of miR-140 in promoting cartilage formation and inhibiting degeneration. Additionally, we focused on the role of miR-140 in the chondrogenesis of mesenchymal stem cells (MSCs). Of note, we carefully reviewed recent advances in MSC exosomes for miRNA delivery in OA treatment.
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Metadata
Title
Recent progress on the role of miR-140 in cartilage matrix remodelling and its implications for osteoarthritis treatment
Authors
Li Duan
Yujie Liang
Xiao Xu
Yin Xiao
Daping Wang
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 1/2020
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/s13075-020-02290-0

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