Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Archives of Virology
Published in: Archives of Virology 3/2024

Open Access 01-03-2024 | Orf Virus | Brief Report

Human orf virus (family Poxviridae) infection following a lamb bite in Hungary

Authors: Csongor Németh, Ákos Boros, Endre Mészáros, Csaba Gyömörei, Ervin Albert, Péter Pankovics, Gábor Reuter

Published in: Archives of Virology | Issue 3/2024

Login to get access

Abstract

Human orf disease (called ecthyma contagiosum or contagious/infectious pustular dermatitis in animals) was confirmed on the fingers of both hands of a 24-year-old female, after feeding diseased lambs with a nursing bottle in April 2023. In addition to skin symptoms, she had low-grade fever (37.6°C) and swollen lymph nodes in both axilla. The presence of orf virus (genus Parapoxvirus, family Poxviridae) was confirmed, and this strain, Baja/2023/HUN (OR372161-OR372163), was found to have > 98% nucleotide sequence identity to sheep-origin orf viruses in four tested genome regions (ORF011/B2L, ORF019, ORF020/VIR, and ORF056). This is the first report of a human case of infection with the neglected zoonotic orf virus in Hungary.
Appendix
Available only for authorised users
Literature
1.
McInnes CJ, Damon IK, Smith GL, McFadden G, Isaacs SN, Roper RL, Evans DH, Damaso CR, Carulei O, Wise LM, Lefkowitz EJ (2023) ICTV virus taxonomy profile: Poxviridae 2023. J Gen Virol 104:001849CrossRef
2.
Veraldi S, Esposito L, Pontini P, Vaira F, Nazzaro G (2019) Feast of sacrifice and orf, Milan, Italy, 2015–2018. Emerg Infect Dis 25(8):1586–1586CrossRef
3.
Bergqvist C, Kurban M, Abbas O (2017) Orf virus infection. Rev Med Virol 27(4):e1932CrossRef
4.
Coradduzza E, Sanna D, Rocchigiani AM, Pintus D, Scarpa F, Scivoli R, Bechere R, Dettori MA, Montesu MA, Marras V, Lobrano R, Ligios C, Puggioni G (2021) Molecular insights into the genetic variability of ORF virus in a Mediterranean region (Sardinia, Italy). Life (Basel) 11(5):416ADSPubMed
5.
Kitchen M, Müller H, Zobl A, Windisch A, Romani N, Huemer H (2014) Orf virus infection in a hunter in Western Austria, presumably transmitted by game. Acta Derm Venereol 94:212–214CrossRefPubMed
6.
Andreani J, Fongue J, Khalil JYB, David L, Mougari S, Le Bideau M, Brahao J, Berbis P, La Scola B (2019) Human infection with orf virus and description of its whole genome, France, 2017. Emerg Infect Dis 25(12):2197–2204CrossRefPubMedPubMedCentral
7.
Lawan Z, Bala JA, Bukar AM, Balakrishnan KN, Mangga HK, Abdullah FFJ, Noordin MM, Mohd-Azmi M (2021) Contagious ecthyma: how serious is the disease worldwide? Anim Health Res Rev 22(1):40–55CrossRefPubMed
8.
Tobler C, Ritter-Schenk C, Zimmermann P (2022) Orf virus infection: ecthyma contagiosum. J Pediatr 243:236–237CrossRefPubMed
9.
Cavalieri C, Dupond AS, Ferrier-Rembert A, Ferraris O, Klopfenstein T, Zayet S (2023) Orf nodule with erythema multiforme during a monkeypox outbreak, France, 2022. Emerg Infect Dis 29(4):860–862CrossRefPubMedPubMedCentral
10.
Li Y, Meyer H, Zhao H, Damon IK (2010) GC content-based pan-pox universal PCR assays for poxvirus detection. J Clin Microbiol 48(1):268–270CrossRefPubMed
11.
Mercer AA, Ueda N, Friederichs SM, Hofmann K, Fraser KM, Bateman T, Fleming SB (2006) Comparative analysis of genome sequences of three isolates of Orf virus reveals unexpected sequence variation. Vir Res 116:146–158CrossRef
12.
13.
Oláh P, Elek P, Szabó J (1953) The role of the virus of contagious pustular dermatitis of sheep and goats in the etiology of the so called stinking lameness in sheep. Acta Vet Hungarica 3:237–243
14.
Leavell UW Jr, McNamara MJ, Muelling R, Talbert WM, Rucker RC, Dalton AJ (1968) Orf. Report of 19 human cases with clinical and pathological observations. JAMA 204(8):657–664CrossRefPubMed
15.
16.
Uzel M, Sasmaz S, Bakaris S, Cetinus E, Bilgic E, Karaoguz A, Ozkul A, Arican O (2005) A viral infection of the hand commonly seen after the feast of sacrifice: human Orf (Orf of the hand). Epidemiol Infect 133:653–657CrossRefPubMedPubMedCentral
17.
Coradduzza E, Sanna D, Scarpa F, Azzena I, Fiori MS, Scivoli R, Rocchigiani AM, Bechere R, Dettori MA, Pintus D, Evangelista E, Casu M, Ligios C, Puggioni G (2022) A deeper insight into evolutionary patterns and phylogenetic history of ORF virus through the whole genome sequencing of the first Italian strains. Viruses 14(7):1473CrossRefPubMedPubMedCentral
18.
Metadata
Title
Human orf virus (family Poxviridae) infection following a lamb bite in Hungary
Authors
Csongor Németh
Ákos Boros
Endre Mészáros
Csaba Gyömörei
Ervin Albert
Péter Pankovics
Gábor Reuter
Publication date
01-03-2024
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 3/2024
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-024-06002-w

Other articles of this Issue 3/2024

Archives of Virology 3/2024 Go to the issue

Brief Report

Molecular identification of Crimean-Congo haemorrhagic fever virus in Hyalomma rufipes and Amblyomma variegatum in the Upper East Region of Ghana

Annotated Sequence Record

A novel alternavirus with three dsRNA segments from Fusarium pseudograminearum, the pathogen of Fusarium crown rot in wheat

Correction

Correction to: Characteristics and mechanisms of latency-reversing agents in the activation of the human immunodeficiency virus 1 reservoir

Annotated Sequence Record

Genomic characterization of a novel cytorhabdovirus infecting Ixeris denticulata in China

Review

Antiviral alternatives against important members of the subfamily Parvovirinae: a review

Original Article

Characterization of cleavage patterns and assembly of N-terminally modified GII.6 norovirus VP1 proteins
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits