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1023 search results for:

Poxvirus 

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  1. 01-02-2024 | Smallpox | ReviewPaper

    Tracing the journey of poxviruses: insights from history

    The historical significance of the poxviruses is profound, largely due to the enduring impact left by smallpox virus across many centuries. The elimination of smallpox is a remarkable accomplishment in the history of science and medicine, with …

  2. 01-09-2023 | Poxvirus | OriginalPaper

    Poxvirus sensitivity of a novel diploid sheep embryonic heart cell line

    Lumpy skin disease virus (LSDV), camelpox virus (CPV), and orf virus (ORFV) are members of the family Poxviridae. These viruses are usually isolated or produced in embryonated eggs or primary cells because continuous cell lines are less sensitive …

  3. Open Access 01-12-2021 | Poxvirus | OriginalPaper

    First molecular characterization of poxviruses in cattle, sheep, and goats in Botswana

    Poxviruses exist throughout the world and are responsible for several economically significant zoonotic diseases affecting humans, wildlife, farming animals, and domestic animals [ 1 , 2 ]. Generally, poxviruses are epitheliotropic and may cause …

  4. Open Access 01-06-2021 | Poxvirus | BriefCommunication

    Geographic distribution and genetic characterization of poxviruses from human infections in Georgia, 2009–2014

    Anthrax is endemic in Georgia, as are multiple zoonotic poxviruses. Poxvirus-associated infections share some clinical manifestations and exposure risks with anthrax, and so it is important to distinguish between the two. With this in mind, an …

  5. Open Access 01-04-2021 | Poxvirus | BriefCommunication

    Discovery of a phylogenetically distinct poxvirus in diseased Crocodilurus amazonicus (family Teiidae)

    A novel poxvirus was discovered in Crocodilurus amazonicus (Teiidae) presenting with a debilitating skin disease. The generated first genome sequence of a reptilian poxvirus revealed the closest phylogenetic relationship to avipoxviruses …

  6. 01-01-2019 | BriefCommunication

    Evidence of avian poxvirus and papillomavirus infection in Gyps fulvus in Italy

    The identification of avian poxvirus and avian papillomavirus associated with cutaneous lesions in griffon vultures (Gyps fulvus) by histopathology, electron microscopy and PCR analysis is reported. Sequence analysis of the fpv140 gene revealed …

  7. 01-09-2017 | Report

    Spread of poxviruses in livestock in Brazil associated with cases of double and triple infection

    The objective of this work is to describe the distribution of outbreaks of vaccinia virus (VACV), pseudocowpox virus (PCPV), and bovine papular stomatitis virus (BSPV) in Brazil. The Official Laboratory of the Brazilian Ministry of Agriculture …

  8. Open Access 01-12-2005 | OriginalPaper

    Host-derived pathogenicity islands in poxviruses

    Poxviruses comprise a family of large dsDNA viruses that replicate in the cytoplasm of eukaryotic cells; they have a wide host range that includes insects, reptiles, birds and mammals [ 1 ]. The poxviruses are relatively self-sufficient and encode …

  9. Open Access 01-12-2003 | OriginalPaper

    Prevention of poxvirus infection by tetrapyrroles

    Smallpox, while not found in the world's population at present, remains a potential health hazard especially due to the possibility of its use as a bioweapon [ 1 – 5 ]. There is currently no accepted treatment for smallpox, although a number of …

  10. 01-09-2009 | ReviewPaper

    The immunologic aspects of poxvirus oncolytic therapy

    The concept of using replicating oncolytic viruses in cancer therapy dates to the beginning of the twentieth century. However, in the last few years, an increasing number of pre-clinical and clinical trials have been carried out with promising …

  11. 01-03-2006 | OriginalPaper

    Genetic identification of novel poxviruses of cetaceans and pinnipeds

    Novel poxviruses were identified in skin lesions of several species of cetaceans and pinnipeds using polymerase chain reaction targeting DNA polymerase and DNA topoisomerase I genes of members of the subfamily Chordopoxvirinae. With the exception …

  12. 01-06-1998 | OriginalPaper

    Morphological and molecular characterization of the poxvirus BeAn 58058

    BeAn 58058 virus (BAV) was isolated from an Oryzomis rodent in Brazil. BAV was shown to be antigenically related to another poxvirus also isolated in Brazil, the Cotia virus, but it remained ungrouped. Electron microscopy revealed that BAV has a …

  13. Open Access 01-12-2012 | Report

    Antiviral activity of the EB peptide against zoonotic poxviruses

    The EB peptide (NH 2 - RRKKAAVALLPAVLLALLAP-COOH) is a 20-mer derived from the signal peptide of the human FGF4 protein [ 1 ] and was originally identified as an inhibitor of herpes simplex virus entry [ 2 ]. Subsequent work demonstrated that EB …

  14. Open Access 01-12-2007 | ReviewPaper

    From actually toxic to highly specific – novel drugs against poxviruses

    The potential use of variola virus, the causative agent of smallpox, as a bioweapon and the endemic presence of monkeypox virus in Africa demonstrate the need for better therapies for orthopoxvirus infections. Chemotherapeutic approaches to …

  15. Open Access 01-12-2007 | OriginalPaper

    Poxvirus-based vaccine therapy for patients with advanced pancreatic cancer

    Pancreatic cancer is associated with a poor prognosis and high mortality rate. An estimated 37,170 new cases will be diagnosed in the United States in 2007 and 33,370 patients will die from the disease [ 1 ]. The median overall survival rate in …

  16. 01-01-1998 | OriginalPaper

    Use of recombinant poxviruses to stimulate anti-melanoma T cell reactivity

    Background: Dendritic cells (DC) are potent professional antigen-presenting cells that can activate naive T lymphocytes and initiate cellular immune responses. As adjuvants, DC may be useful for enhancing immunogenicity and mediating tumor …

  17. Open Access 01-05-2016 | OriginalPaper

    Poxvirus-based active immunotherapy synergizes with CTLA-4 blockade to increase survival in a murine tumor model by improving the magnitude and quality of cytotoxic T cells

    The dramatic clinical benefit of immune checkpoint blockade for a fraction of cancer patients suggests the potential for further clinical benefit in a broader cancer patient population by combining immune checkpoint inhibitors with active …

  18. Open Access 01-12-2010 | OriginalPaper

    ESR and NMR studies provide evidence that phosphatidyl glycerol specifically interacts with poxvirus membranes

    Membrane contacts occur at the very early steps of pulmonary viral infection [ 1 ]. This is especially important under circumstances where aerosol dispersion of viruses occurs readily [ 2 ] and an aerosol respiratory contamination would be an easy …

  19. 01-02-2004 | Abstract

    CpG oligonucleotides enhance the effect of a poxvirus vaccine targeting p53 in murine tumor models

  20. 01-07-2008 | OriginalPaper

    Morphogenesis of salmonid gill poxvirus associated with proliferative gill disease in farmed Atlantic salmon (Salmo salar) in Norway

    Proliferative gill disease (PGD) is an emerging problem in Norwegian culture of Atlantic salmon (Salmo salar). Parasites (Ichthyobodo spp.) and bacteria (Flexibacter/Flavobacterium) may cause PGD, but for most cases of PGD in farmed salmon in …

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