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International Journal of Hematology
Published in: International Journal of Hematology 4/2020

01-10-2020 | Oral Cancer | Original Article

Programmed death 1 ligand (PD-L1) in solid cancers after allogeneic hematopoietic stem cell transplantation: a retrospective analysis by the Nagasaki Transplant Group

Authors: Sachie Kasai, Hidehiro Itonaga, Daisuke Niino, Hiroaki Miyoshi, Takeharu Kato, Daisuke Imanishi, Machiko Fujioka, Takafumi Furumoto, Shinya Sato, Yasushi Sawayama, Jun Taguchi, Yoshitaka Imaizumi, Tomoko Hata, Shinichiro Yoshida, Yukiyoshi Moriuchi, Koichi Ohshima, Yasushi Miyazaki

Published in: International Journal of Hematology | Issue 4/2020

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Abstract

Programmed death 1 ligand (PD-L1) is an immunomodulatory molecule expressed by cancer cells, and it has been widely demonstrated to inhibit host antitumor responses. The aim of the present study was to identify clinicopathological features associated with PD-L1 expression in the secondary solid cancers of patients after allogeneic hematopoietic stem cell transplantation. In this database of 530 patients who received allo-HSCT between 1990 and 2017, 15 developed solid cancers with a median interval of 3487 days after transplantation. Three patients had 2 different solid cancers. Eighteen solid cancer cases were identified. A multivariate analysis showed that chronic graft-versus-host disease (GVHD) was associated with an increased risk of solid cancer. The presence of chronic GVHD was observed in 8 out of 18 cases at the diagnosis of secondary malignancies. PD-L1 expression levels in cancers were significantly higher in patients with active chronic GVHD than in those without chronic GVHD (P = 0.020). Five cases of cancer that developed in the involved organs of chronic GVHD showed 30% or higher PD-L1 positivity. The present results revealed distinct PD-L1 expression in the secondary solid cancers of post-transplant patients with chronic GVHD.
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Metadata
Title
Programmed death 1 ligand (PD-L1) in solid cancers after allogeneic hematopoietic stem cell transplantation: a retrospective analysis by the Nagasaki Transplant Group
Authors
Sachie Kasai
Hidehiro Itonaga
Daisuke Niino
Hiroaki Miyoshi
Takeharu Kato
Daisuke Imanishi
Machiko Fujioka
Takafumi Furumoto
Shinya Sato
Yasushi Sawayama
Jun Taguchi
Yoshitaka Imaizumi
Tomoko Hata
Shinichiro Yoshida
Yukiyoshi Moriuchi
Koichi Ohshima
Yasushi Miyazaki
Publication date
01-10-2020
Publisher
Springer Singapore
Published in
International Journal of Hematology / Issue 4/2020
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-020-02926-6

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