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Open Access 01-12-2024 | Optic Neuritis | Case report

Optic neuritis and mydriasis after vaccination: a case report

Authors: Elcio Luiz Bonamigo, Pamela Kuyava, Taísa Sacomori Paula Zanotto Reginatto, Arthur Gabriel Duran, Luisa Truculo, Eglas Emanuel Rossi, Ricardo Alexandre Stock, Claudia Elisa Grasel

Published in: Journal of Medical Case Reports | Issue 1/2024

Abstract

Background

Optic neuritis (ON) is an inflammatory demyelinating condition of the optic nerve, with various causes. Its incidence is higher in children and young adults than in older adults of both genders, but is more common in women than in men. ON is rarely associated with mydriasis, and it is seldom triggered by vaccines against tetanus and diphtheria.

Case report

A 36-year-old Caucasian woman presented with bilateral ON that had started 18 days after administration of a booster dose of the double adult vaccine (dT) against diphtheria and tetanus. Bilateral mydriasis persisted after treatment and clinical resolution of the ON. She experienced severe headache, blurred vision, decreased visual acuity in the right eye and bilateral mydriasis, a diagnosis confirmed by imaging tests. Treatment with oral corticosteroids resulted in rapid resolution of the neuritis; however, mydriasis persisted for several months.

Conclusion

This study describes a very unusual case of bilateral ON associated with prolonged mydriasis after vaccination against tetanus and diphtheria that regressed after treatment with oral corticosteroids. Prolonged mydriasis was the manifestation that differed from the other cases previously described.

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Title: Optic neuritis and mydriasis after vaccination: a case report
Authors: Elcio Luiz Bonamigo
Pamela Kuyava
Taísa Sacomori Paula Zanotto Reginatto
Arthur Gabriel Duran
Luisa Truculo
Eglas Emanuel Rossi
Ricardo Alexandre Stock
Claudia Elisa Grasel
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: Optic Neuritis
Diphtheria
Tetanus
Vaccination
Headache
Published in: Journal of Medical Case Reports / Issue 1/2024
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/s13256-024-04526-y

At a glance: The STEP trials

Springer Medicine

Optic neuritis and mydriasis after vaccination: a case report

Abstract

Background

Case report

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Case report

Conclusion

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