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18-11-2022 | Opioids

Accelerating Solutions for the Overdose Crisis: an Effectiveness-Implementation Hybrid Protocol for the HEAL Prevention Cooperative

Authors: S. V. Patel, J. D. Cance, E. E. Bonar, P. M. Carter, D. L. Dickerson, L. E. Fiellin, C. S. F. Fernandes, A. I. Palimaru, T. M. Pendergrass Boomer, L. Saldana, R. R. Singh, E. Tinius, M. A. Walton, S. Youn, S. Young, S. Philbrick, B. H. Lambdin

Published in: Prevention Science | Special Issue 1/2023

Abstract

Given increasing opioid overdose mortality rates in the USA over the past 20 years, accelerating the implementation of prevention interventions found to be effective is critical. The Helping End Addiction Long-Term (HEAL) Prevention Cooperative (HPC) is a consortium of research projects funded to implement and test interventions designed to prevent the onset or escalation of opioid misuse among youth and young adults. The HPC offers a unique opportunity to synthesize and share lessons learned from participating research projects’ varied implementation experiences, which can facilitate quicker integration of effective prevention interventions into practice. This protocol paper describes our hybrid approach to collecting and analyzing information about the implementation experiences of nine of the HPC research projects while they maintain their focus on assessing the effectiveness and cost-effectiveness of prevention interventions. To better understand implementation within this context, we will address five research questions: (1) What were the context and approach for implementing the prevention interventions, and how was the overall implementation experience? (2) How representative of the target population are the participants who were enrolled and retained in the research projects’ effectiveness trials? (3) For what purposes and how were stakeholders engaged by the research projects? (4) What are the adaptable components of the prevention interventions? And finally, (5) how might implementation of the prevention interventions vary for non-trial implementation? This work will result in intervention-specific and general practical dissemination resources that can help potential adopters and deliverers of opioid misuse prevention make adoption decisions and prepare for successful implementation.

Ahmad, F., Rossen, L., & Sutton, P. (2021). Provisional drug overdose death counts. Retrieved July 9, 2021, from https://www.cdc.gov/nchs/nvss/vsrr/drug-overdose-data.htm

Balas, E. A., & Boren, S. A. (2000). Managing clinical knowledge for health care improvement. Yearbook of medical informatics, 9(1), 65–70.

Bloom, A. W. (2016). Advances in substance abuse prevention and treatment interventions among racial, ethnic, and sexual minority populations. Alcohol Research, 38(1), 47–54.

Bohnert, A. S., Guy Jr, G. P., & Losby, J. L. (2018). Opioid prescribing in the United States before and after the Centers for Disease Control and Prevention’s 2016 Opioid Guideline. Annals of Internal Medicine, 169(6), 367–375. https://doi.org/10.7326/m18-1243

Bonar, E. E., Coughlin, L., Roche, J. S., Philyaw-Kotov, M. L., Bixler, E. A., Sinelnikov, S., & Walton, M. A. (2020). Prescription opioid misuse among adolescents and emerging adults in the United States: A scoping review. Preventive Medicine, 132, 105972. https://doi.org/10.1016/j.ypmed.2019.105972CrossRefPubMedPubMedCentral

Brown, C. H., Curran, G., Palinkas, L. A., Aarons, G. A., Wells, K. B., Jones, L., & Cruden, G. (2017). An overview of research and evaluation designs for dissemination and implementation. Annual Review of Public Health, 38, 1–22. https://doi.org/10.1146/annurev-publhealth-031816-044215CrossRefPubMedPubMedCentral

Centers for Disease Control and Prevention, National Center for Health Statistics. (2020). CDC WONDER (Wide-ranging online data for epidemiologic research). Retrieved Nov 2, 2021, from http://wonder.cdc.gov

Compton, W. M., Thomas, Y. F., Stinson, F. S., & Grant, B. F. (2007). Prevalence, correlates, disability, and comorbidity of DSM-IV drug abuse and dependence in the United States: Results from the National Epidemiologic Survey on Alcohol and Related Conditions. Archives of General Psychiatry, 64(5), 566–576. https://doi.org/10.1001/archpsyc.64.5.566CrossRefPubMed

Crowe, S., Cresswell, K., Robertson, A., Huby, G., Avery, A., & Sheikh, A. (2011). The case study approach. BMC Medical Research Methodology, 11(1), 100. https://doi.org/10.1186/1471-2288-11-100CrossRefPubMedPubMedCentral

Crowley, D. M., Jones, D. E., Coffman, D. L., & Greenberg, M. T. (2014). Can we build an efficient response to the prescription drug abuse epidemic? Assessing the cost effectiveness of universal prevention in the PROSPER trial. Preventive Medicine, 62, 71–77. https://doi.org/10.1016/j.ypmed.2014.01.029CrossRefPubMedPubMedCentral

Cunningham, R. M., Chermack, S. T., Ehrlich, P. F., Carter, P. M., Booth, B. M., Blow, F. C., & Walton, M. A. (2015). Alcohol interventions among underage drinkers in the ED: A randomized controlled trial. Pediatrics, 136(4), e783–793. https://doi.org/10.1542/peds.2015-1260CrossRefPubMedPubMedCentral

Curran, G. M., Bauer, M., Mittman, B., Pyne, J. M., & Stetler, C. (2012). Effectiveness-implementation hybrid designs: Combining elements of clinical effectiveness and implementation research to enhance public health impact. Medical Care, 50(3), 217–226. https://doi.org/10.1097/MLR.0b013e3182408812CrossRefPubMedPubMedCentral

Damschroder, L. J., Aron, D. C., Keith, R. E., Kirsh, S. R., Alexander, J. A., & Lowery, J. C. (2009). Fostering implementation of health services research findings into practice: A consolidated framework for advancing implementation science. Implementation Science, 4(1), 50. https://doi.org/10.1186/1748-5908-4-50CrossRefPubMedPubMedCentral

Evans, W., Andrade, E., Pratt, M., Mottern, A., Chavez, S., Calzetta-Raymond, A., & Gu, J. (2020). Peer-to-peer social media as an effective prevention strategy: Quasi-experimental evaluation. JMIR mHealth and uHealth, 8(5), e16207. https://doi.org/10.2196/16207CrossRefPubMedPubMedCentral

Fernandez, M. E., Ten Hoor, G. A., van Lieshout, S., Rodriguez, S. A., Beidas, R. S., Parcel, G., & Kok, G. (2019). Implementation mapping: Using intervention mapping to develop implementation strategies. Frontiers in Public Health, 7, 158. https://doi.org/10.3389/fpubh.2019.00158CrossRefPubMedPubMedCentral

Forman, J., & Damschroder, L. (2007). Qualitative content analysis. In Empirical methods for bioethics: A primer: Emerald Group Publishing Limited.

Grimshaw, J. M., Thomas, R. E., MacLennan, G., Fraser, C., Ramsay, C. R., Vale, L., Donaldson, C. (2004). Effectiveness and efficiency of guideline dissemination and implementation strategies. Health Technol Assess, 8(6), iii–iv, 1–72. https://doi.org/10.3310/hta8060

Hoffmann, T. C., Glasziou, P. P., Boutron, I., Milne, R., Perera, R., Moher, D., & Michie, S. (2014). Better reporting of interventions: Template for intervention description and replication (TIDieR) checklist and guide. British Medical Journal, 348, https://doi.org/10.1136/bmj.g1687

Jones, C. M., Clayton, H. B., Deputy, N. P., Roehler, D. R., Ko, J. Y., Esser, M. B., & Hertz, M. F. (2020). Prescription opioid misuse and use of alcohol and other substances among high school students — Youth Risk Behavior Survey, United States, 2019. Morbidity and Mortality Weekly Report, 69(1), 38–46. https://doi.org/10.15585/mmwr.su6901a5CrossRef

Kotter, J. P. (1996). Leading change. Boston: Harvard Business School Press.

Landes, S. J., McBain, S. A., & Curran, G. M. (2019). An introduction to effectiveness-implementation hybrid designs. Psychiatry Research, 280, 112513. https://doi.org/10.1016/j.psychres.2019.112513CrossRefPubMedPubMedCentral

Manchikanti, L., Vanaparthy, R., Atluri, S., Sachdeva, H., Kaye, A. D., & Hirsch, J. A. (2021). COVID-19 and the opioid epidemic: Two public health emergencies that intersect with chronic pain. Pain and Therapy, 10(1), 269–286. https://doi.org/10.1007/s40122-021-00243-2CrossRefPubMedPubMedCentral

Marques, L., Youn, S. J., Zepeda, E. D., Chablani-Medley, A., Bartuska, A. D., Baldwin, M., & Shtasel, D. L. (2020). Effectiveness of a modular cognitive-behavioral skills curriculum in high-risk justice-involved youth. The Journal of Nervous and Mental Disease, 208(12), 925–932. https://doi.org/10.1097/nmd.0000000000001232CrossRefPubMed

Moullin, J. C., Dickson, K. S., Stadnick, N. A., Rabin, B., & Aarons, G. A. (2019). Systematic review of the Exploration, Preparation, Implementation, Sustainment (EPIS) framework. Implementation Science, 14(1), 1. https://doi.org/10.1186/s13012-018-0842-6CrossRefPubMedPubMedCentral

National Academies of Sciences, E., Medicine Division of, B., Social, S., Education Board on Children, Y., Youth. (2019). The National Academies Collection: Reports funded by National Institutes of Health. Fostering Healthy Mental, Emotional, and Behavioral Development in Children and Youth: A National Agenda. Washington (DC): National Academies Press (US). Copyright 2019 by the National Academy of Sciences. All rights reserved.

Powell, B. J., Waltz, T. J., Chinman, M. J., Damschroder, L. J., Smith, J. L., Matthieu, M. M., & Kirchner, J. E. (2015). A refined compilation of implementation strategies: Results from the Expert Recommendations for Implementing Change (ERIC) project. Implementation Science, 10(1), 21. https://doi.org/10.1186/s13012-015-0209-1CrossRefPubMedPubMedCentral

Proctor, E. K., Powell, B. J., & McMillen, J. C. (2013). Implementation strategies: Recommendations for specifying and reporting. Implementation Science, 8(1), 139. https://doi.org/10.1186/1748-5908-8-139CrossRefPubMedPubMedCentral

Rhodes, E., Wilson, M., Robinson, A., Hayden, J. A., & Asbridge, M. (2019). The effectiveness of prescription drug monitoring programs at reducing opioid-related harms and consequences: A systematic review. BMC Health Services Research, 19(1), 784. https://doi.org/10.1186/s12913-019-4642-8CrossRefPubMedPubMedCentral

SAMHSA. (2019). A guide to SAMHSA's strategic prevention framework. Rockville, MD: Center for Substance Abuse Prevention, Substance Abuse and Mental Health Services Administration.

Substance Abuse and Mental Health Services Administration (SAMHSA). (2020). Key substance use and mental health indicators in the United States: Results from the 2019 National Survey on Drug Use and Health. Rockville, MD: (HHS Publication No. PEP20–07–01–001, NSDUH Series H-55).

Spoth, R., Trudeau, L., Shin, C., Ralston, E., Redmond, C., Greenberg, M., & Feinberg, M. (2013). Longitudinal effects of universal preventive intervention on prescription drug misuse: Three randomized controlled trials with late adolescents and young adults. American Journal of Public Health, 103(4), 665–672. https://doi.org/10.2105/ajph.2012.301209CrossRefPubMedPubMedCentral

Walton, M. A., Resko, S., Barry, K. L., Chermack, S. T., Zucker, R. A., Zimmerman, M. A., & Blow, F. C. (2014). A randomized controlled trial testing the efficacy of a brief cannabis universal prevention program among adolescents in primary care. Addiction, 109(5), 786–797. https://doi.org/10.1111/add.12469CrossRefPubMedPubMedCentral

Wiltsey Stirman, S., Baumann, A. A., & Miller, C. J. (2019). The FRAME: An expanded framework for reporting adaptations and modifications to evidence-based interventions. Implementation Science, 14(1), 58. https://doi.org/10.1186/s13012-019-0898-yCrossRefPubMedPubMedCentral

Title: Accelerating Solutions for the Overdose Crisis: an Effectiveness-Implementation Hybrid Protocol for the HEAL Prevention Cooperative
Authors: S. V. Patel
J. D. Cance
E. E. Bonar
P. M. Carter
D. L. Dickerson
L. E. Fiellin
C. S. F. Fernandes
A. I. Palimaru
T. M. Pendergrass Boomer
L. Saldana
R. R. Singh
E. Tinius
M. A. Walton
S. Youn
S. Young
S. Philbrick
B. H. Lambdin
Publication date: 18-11-2022
Publisher: Springer US
Keywords: Opioids
Opioids
Published in: Prevention Science / Issue Special Issue 1/2023
Print ISSN: 1389-4986
Electronic ISSN: 1573-6695
DOI: https://doi.org/10.1007/s11121-022-01465-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Accelerating Solutions for the Overdose Crisis: an Effectiveness-Implementation Hybrid Protocol for the HEAL Prevention Cooperative

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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