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Published in: Prevention Science 1/2023

10-08-2022 | Addiction

Economic Evaluation Design within the HEAL Prevention Cooperative

Authors: Laura J. Dunlap, Margaret R. Kuklinski, Alexander Cowell, Kathryn E. McCollister, Diana M. Bowser, Mark Campbell, Claudia-Santi F. Fernandes, Pranav Kemburu, Bethany J. Livingston, Lisa A. Prosser, Vinod Rao, Rosanna Smart, Tansel Yilmazer

Published in: Prevention Science | Special Issue 1/2023

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Abstract

The rapid rise in opioid misuse, disorder, and opioid-involved deaths among older adolescents and young adults is an urgent public health problem. Prevention is a vital part of the nation’s response to the opioid crisis, yet preventive interventions for those at risk for opioid misuse and opioid use disorder are scarce. In 2019, the National Institutes of Health (NIH) launched the Preventing Opioid Use Disorder in Older Adolescents and Young Adults cooperative as part of its broader Helping to End Addiction Long-term (HEAL) Initiative (https://​heal.​nih.​gov/​). The HEAL Prevention Cooperative (HPC) includes ten research projects funded with the goal of developing effective prevention interventions across various settings (e.g., community, health care, juvenile justice, school) for older adolescent and young adults at risk for opioid misuse and opioid use disorder (OUD). An important component of the HPC is the inclusion of an economic evaluation by nine of these research projects that will provide information on the costs, cost-effectiveness, and sustainability of these interventions. The HPC economic evaluation is integrated into each research project’s overall design with start-up costs and ongoing delivery costs collected prospectively using an activity-based costing approach. The primary objectives of the economic evaluation are to estimate the intervention implementation costs to providers, estimate the cost-effectiveness of each intervention for reducing opioid misuse initiation and escalation among youth, and use simulation modeling to estimate the budget impact of broader implementation of the interventions within the various settings over multiple years. The HPC offers an extraordinary opportunity to generate economic evidence for substance use prevention programming, providing policy makers and providers with critical information on the investments needed to start-up prevention interventions, as well as the cost-effectiveness of these interventions relative to alternatives. These data will help demonstrate the valuable role that prevention can play in combating the opioid crisis.
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Literature
go back to reference Bjornestad, J., McKay, J. R., Berg, H., Moltu, C., & Nesvåg, S. (2020). How often are outcomes other than change in substance use measured? A systematic review of outcome measures in contemporary randomised controlled trials. Drug and Alcohol Review, 39, 394–414. https://doi.org/10.1111/dar.13051. Epub 2020 Mar 9 PMID: 32147903.CrossRefPubMed Bjornestad, J., McKay, J. R., Berg, H., Moltu, C., & Nesvåg, S. (2020). How often are outcomes other than change in substance use measured? A systematic review of outcome measures in contemporary randomised controlled trials. Drug and Alcohol Review, 39, 394–414. https://​doi.​org/​10.​1111/​dar.​13051. Epub 2020 Mar 9 PMID: 32147903.CrossRefPubMed
go back to reference Busch, S. H., Fiellin, D. A., Chawarski, M. C., Owens, P. H., Pantalon, M. V., Hawk, K., Bernstein, S. L., O’Connor, P. G., & D’Onofrio, G. (2017). Cost-effectiveness of emergency department-initiated treatment for opioid dependence. Addiction (abingdon, England), 112, 2002–2010. https://doi.org/10.1111/add.13900CrossRefPubMed Busch, S. H., Fiellin, D. A., Chawarski, M. C., Owens, P. H., Pantalon, M. V., Hawk, K., Bernstein, S. L., O’Connor, P. G., & D’Onofrio, G. (2017). Cost-effectiveness of emergency department-initiated treatment for opioid dependence. Addiction (abingdon, England), 112, 2002–2010. https://​doi.​org/​10.​1111/​add.​13900CrossRefPubMed
go back to reference Crowley, D. M., Dodge, K. A., Barnett, W. S., Corso, P., Duffy, S., Graham, P., & Plotnick, R. (2018). Standards of evidence for conducting and reporting economic evaluations in prevention science. Prevention Science, 19, 366–390.CrossRefPubMedPubMedCentral Crowley, D. M., Dodge, K. A., Barnett, W. S., Corso, P., Duffy, S., Graham, P., & Plotnick, R. (2018). Standards of evidence for conducting and reporting economic evaluations in prevention science. Prevention Science, 19, 366–390.CrossRefPubMedPubMedCentral
go back to reference Dunlap, L. J., Orme, S., Zarkin, G. A., Arias, S. A., Miller, I. W., Camargo, C. A., Jr., Sullivan, A. F., Allen, M. H., Goldstein, A. B., Manton, A. P., Clark, R., & Boudreaux, E. D. (2019). Screening and intervention for suicide prevention: A cost-effectiveness analysis of the ED-SAFE interventions. Psychiatric. Services, 70, 1082–1087. https://doi.org/10.1176/appi.ps.201800445CrossRefPubMed Dunlap, L. J., Orme, S., Zarkin, G. A., Arias, S. A., Miller, I. W., Camargo, C. A., Jr., Sullivan, A. F., Allen, M. H., Goldstein, A. B., Manton, A. P., Clark, R., & Boudreaux, E. D. (2019). Screening and intervention for suicide prevention: A cost-effectiveness analysis of the ED-SAFE interventions. Psychiatric. Services, 70, 1082–1087. https://​doi.​org/​10.​1176/​appi.​ps.​201800445CrossRefPubMed
go back to reference Gomes, T., Tadrous, M., Mamdani, M. M., Paterson, J. M., & Juurlink, D. N. (2018). The burden of opioid-related mortality in the United States. JAMA Network Open, 1, e180217–e180217.CrossRefPubMedPubMedCentral Gomes, T., Tadrous, M., Mamdani, M. M., Paterson, J. M., & Juurlink, D. N. (2018). The burden of opioid-related mortality in the United States. JAMA Network Open, 1, e180217–e180217.CrossRefPubMedPubMedCentral
go back to reference Jensen, P. S., Garcia, J. A., Glied, S., Crowe, M., Foster, M., Schlander, M., Hinshaw, S., Vitiello, B., Arnold, L. E., Elliott, G., Hechtman, L., Newcorn, J. H., Pelham, W. E., Swanson, J., & Wells, K. (2005). Cost-effectiveness of ADHD treatments: Findings from the multimodal treatment study of children with ADHD. American Journal of Psychiatry, 162, 1628–1636. https://doi.org/10.1176/appi.ajp.162.9.1628CrossRefPubMed Jensen, P. S., Garcia, J. A., Glied, S., Crowe, M., Foster, M., Schlander, M., Hinshaw, S., Vitiello, B., Arnold, L. E., Elliott, G., Hechtman, L., Newcorn, J. H., Pelham, W. E., Swanson, J., & Wells, K. (2005). Cost-effectiveness of ADHD treatments: Findings from the multimodal treatment study of children with ADHD. American Journal of Psychiatry, 162, 1628–1636. https://​doi.​org/​10.​1176/​appi.​ajp.​162.​9.​1628CrossRefPubMed
go back to reference Murphy, S. M., McCollister, K. E., Leff, J. A., Yang, X., Jeng, P. J., Lee, J. D., Nunes, E. V., Novo, P., Rotrosen, J., & Schackman, B. R. (2019). Cost-effectiveness of buprenorphine-naloxone versus extended-release naltrexone to prevent opioid relapse. Annals of Internal Medicine, 170, 90–98. https://doi.org/10.7326/M18-0227CrossRefPubMed Murphy, S. M., McCollister, K. E., Leff, J. A., Yang, X., Jeng, P. J., Lee, J. D., Nunes, E. V., Novo, P., Rotrosen, J., & Schackman, B. R. (2019). Cost-effectiveness of buprenorphine-naloxone versus extended-release naltrexone to prevent opioid relapse. Annals of Internal Medicine, 170, 90–98. https://​doi.​org/​10.​7326/​M18-0227CrossRefPubMed
go back to reference Neumann, P. J., Sanders, G. D., Russell, L. B., Siegel, J. E., & Ganiats, T. G. (2016). Cost- effectiveness in health and medicine. CrossRef Neumann, P. J., Sanders, G. D., Russell, L. B., Siegel, J. E., & Ganiats, T. G. (2016). Cost- effectiveness in health and medicine. CrossRef
go back to reference Ridenour, T. A., Cruden, R., Yang, Y., Bonar, E., Rodriguez, A., Saavedra, L., Hussong, A., Walton, M., Deeds, B., Ford, J., Knight, D., Haggerty, K., Stormshak, E., Kominsky, T., Aherns, K., Woodward, D., Feng, X., Fiellin, L., Wilens, T., Klein, D., & Fernandes, C. S. (2022; Under review). Methodological strategies for prospective harmonization of studies: Application to the HEAL Prevention Cooperative. Ridenour, T. A., Cruden, R., Yang, Y., Bonar, E., Rodriguez, A., Saavedra, L., Hussong, A., Walton, M., Deeds, B., Ford, J., Knight, D., Haggerty, K., Stormshak, E., Kominsky, T., Aherns, K., Woodward, D., Feng, X., Fiellin, L., Wilens, T., Klein, D., & Fernandes, C. S. (2022; Under review). Methodological strategies for prospective harmonization of studies: Application to the HEAL Prevention Cooperative.
go back to reference Sanders, G. D., Neumann, P. J., Basu, A., Brock, D. W., Feeny, D., Krahn, M., Kuntz, K. M., Meltzer, D. O., Owens, D. K., Prosser, L. A., Salomon, J. A., Sculpher, M. J., Trikalinos, T. A., Russell, L. B., Siegel, J. E., & Ganiats, T. G. (2016). Recommendations for conduct, methodological practices, and reporting of cost-effectiveness analyses: Second panel on cost-effectiveness in health and medicine. JAMA, 316, 1093–1103. https://doi.org/10.1001/jama.2016.12195CrossRefPubMed Sanders, G. D., Neumann, P. J., Basu, A., Brock, D. W., Feeny, D., Krahn, M., Kuntz, K. M., Meltzer, D. O., Owens, D. K., Prosser, L. A., Salomon, J. A., Sculpher, M. J., Trikalinos, T. A., Russell, L. B., Siegel, J. E., & Ganiats, T. G. (2016). Recommendations for conduct, methodological practices, and reporting of cost-effectiveness analyses: Second panel on cost-effectiveness in health and medicine. JAMA, 316, 1093–1103. https://​doi.​org/​10.​1001/​jama.​2016.​12195CrossRefPubMed
go back to reference Spoth, R., Trudeau, L., Shin, C., Ralston, E., Redmond, C., Greenberg, M., & Feinberg, M. (2013). Longitudinal effects of universal preventive intervention on prescription drug misuse: Three randomized controlled trials with late adolescents and young adults. American Journal of Public Health, 103(4), 665–672. https://doi.org/10.2105/AJPH.2012.301209 Spoth, R., Trudeau, L., Shin, C., Ralston, E., Redmond, C., Greenberg, M., & Feinberg, M. (2013). Longitudinal effects of universal preventive intervention on prescription drug misuse: Three randomized controlled trials with late adolescents and young adults. American Journal of Public Health, 103(4), 665–672. https://​doi.​org/​10.​2105/​AJPH.​2012.​301209
go back to reference Steuerle, E., Jackson, L. M., Committee on the Use of Economic Evidence to Inform Investments in Children, Youth, and Families, Board on Children, Youth, and Families, Division of Behavioral and Social Sciences and Education, & National Academies of Sciences, Engineering, and Medicine (Eds.). (2016). Advancing the power of economic evidence to inform investments in children, youth, and families. Washington, DC: The National Academies Press. https://doi.org/10.17226/23481 Steuerle, E., Jackson, L. M., Committee on the Use of Economic Evidence to Inform Investments in Children, Youth, and Families, Board on Children, Youth, and Families, Division of Behavioral and Social Sciences and Education, & National Academies of Sciences, Engineering, and Medicine (Eds.). (2016). Advancing the power of economic evidence to inform investments in children, youth, and families. Washington, DC: The National Academies Press. https://​doi.​org/​10.​17226/​23481
go back to reference Substance Abuse and Mental Health Services Administration, Office of the Surgeon General. (2016, November). Facing addiction in America: The Surgeon General’s Report on alcohol, drugs, and health. Washington, DC: U.S. Department of Health and Human Services, Reports of the Surgeon General. PMID: 28252892. Substance Abuse and Mental Health Services Administration, Office of the Surgeon General. (2016, November). Facing addiction in America: The Surgeon General’s Report on alcohol, drugs, and health. Washington, DC: U.S. Department of Health and Human Services, Reports of the Surgeon General. PMID: 28252892.
go back to reference Wichmann, A. B., Adang, E. M., Stalmeier, P. F., Kristanti, S., Van den Block, L., Vernooij-Dassen, M. J., Engels, Y., & PACE. (2017). The use of quality-adjusted life years in cost-effectiveness analyses in palliative care: Mapping the debate through an integrative review. Palliative Medicine, 31, 306–322. https://doi.org/10.1177/0269216316689652CrossRefPubMed Wichmann, A. B., Adang, E. M., Stalmeier, P. F., Kristanti, S., Van den Block, L., Vernooij-Dassen, M. J., Engels, Y., & PACE. (2017). The use of quality-adjusted life years in cost-effectiveness analyses in palliative care: Mapping the debate through an integrative review. Palliative Medicine, 31, 306–322. https://​doi.​org/​10.​1177/​0269216316689652​CrossRefPubMed
Metadata
Title
Economic Evaluation Design within the HEAL Prevention Cooperative
Authors
Laura J. Dunlap
Margaret R. Kuklinski
Alexander Cowell
Kathryn E. McCollister
Diana M. Bowser
Mark Campbell
Claudia-Santi F. Fernandes
Pranav Kemburu
Bethany J. Livingston
Lisa A. Prosser
Vinod Rao
Rosanna Smart
Tansel Yilmazer
Publication date
10-08-2022
Publisher
Springer US
Published in
Prevention Science / Issue Special Issue 1/2023
Print ISSN: 1389-4986
Electronic ISSN: 1573-6695
DOI
https://doi.org/10.1007/s11121-022-01400-5

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