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01-02-2006 | Review

Ontogeny of drug elimination by the human kidney

Authors: Nancy Chen, Katarina Aleksa, Cindy Woodland, Michael Rieder, Gideon Koren

Published in: Pediatric Nephrology | Issue 2/2006

Abstract

Renal clearance is an important route of drug elimination. While during the neonatal period there is minimal glomerular filtration and active tubular secretion of drugs, there is a well-described rapid development in these processes in the post-neonatal period. A less appreciated fact is that during toddlerhood, there is an “overshoot” of the glomerular filtration rate (GFR) well above the levels encountered in older children and adults, and there is an early achievement of adult levels in active drug secretion, which stays at a plateau throughout childhood and adulthood with an “overshoot” in toddlers due to specific transport mechanisms. This phenomenon leads to dose requirements for renally excreted drugs in this age group being, on a per-kilogram basis, much larger than in adults. This review discusses the mechanisms related to renal ontogeny in drug handling.

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Title: Ontogeny of drug elimination by the human kidney
Authors: Nancy Chen
Katarina Aleksa
Cindy Woodland
Michael Rieder
Gideon Koren
Publication date: 01-02-2006
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 2/2006
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-005-2105-4

At a glance: The STEP trials

Springer Medicine

Ontogeny of drug elimination by the human kidney

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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