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Pediatric Nephrology
Published in: Pediatric Nephrology 2/2006

01-02-2006 | Educational Feature

Teaching molecular genetics: Chapter 1—Background principles and methods of molecular biology

Authors: Nine V. A. M. Knoers, Leo A. H. Monnens

Published in: Pediatric Nephrology | Issue 2/2006

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Abstract

In this first chapter of the series “Teaching molecular genetics,” an introduction to molecular genetics is presented. We describe the structure of DNA and genes and explain in detail the central dogma of molecular biology, that is, the flow of genetic information from DNA via RNA to polypeptide (protein). In addition, several basic and frequently used general molecular tools, such as restriction enzymes, Southern blotting, DNA amplification and sequencing are discussed, in order to lay the foundations for the forthcoming chapters.
Literature
Mueller RF, Young ID (eds) (2001) Emery’s elements of medical genetics, 11th edn. Harcourt, London
Passarge E (2001) Color atlas of genetics, 2nd edn. Thieme, Stuttgart
Strachan T, Read A (eds) (2004) Human molecular genetics, 3rd edn. Garland, London
Metadata
Title
Teaching molecular genetics: Chapter 1—Background principles and methods of molecular biology
Authors
Nine V. A. M. Knoers
Leo A. H. Monnens
Publication date
01-02-2006
Publisher
Springer-Verlag
Published in
Pediatric Nephrology / Issue 2/2006
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-005-2154-8

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