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Virchows Archiv

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01-12-2013 | Letter to the Editor

On the prevalence of KRAS mutations in GISTs

Authors: Riccardo Ricci, Angelo Paolo Dei Tos, Guido Rindi

Published in: Virchows Archiv | Issue 6/2013

Excerpt

Dear Editor, …

Ricci R, Dei Tos AP, Rindi G (2013) GISTogram: a graphic presentation of the growing GIST complexity. Virchows Arch 463:481–487

Miranda C, Nucifora M, Molinari F, Conca E, Anania MC, Bordoni A, Saletti P, Mazzucchelli L, Pilotti S, Pierotti MA, Tamborini E, Greco A, Frattini M (2012) KRAS and BRAF mutations predict primary resistance to imatinib in gastrointestinal stromal tumors. Clin Cancer Res 18:1769–1776PubMedCrossRef

Lasota J, Xi L, Coates T, Dennis R, Evbuomwan MO, Wang ZF, Raffeld M, Miettinen M (2013) No KRAS mutations found in gastrointestinal stromal tumors (GISTs): molecular genetic study of 514 cases. Mod Pathol. doi:10.1038/modpathol.2013.89 PubMed

Agaimy A, Terracciano LM, Dirnhofer S, Tornillo L, Foerster A, Hartmann A, Bihl MP (2009) V600E BRAF mutations are alternative early molecular events in a subset of KIT/PDGFRA wild-type gastrointestinal stromal tumours. J Clin Pathol 62:613–616PubMedCrossRef

Martinho O, Gouveia A, Viana-Pereira M, Silva P, Pimenta A, Reis RM, Lopes JM (2009) Low frequency of MAP kinase pathway alterations in KIT and PDGFRA wild-type GISTs. Histopathology 55:53–62PubMedCrossRef

Daniels M, Lurkin I, Pauli R, Erbstösser E, Hildebrandt U, Hellwig K, Zschille U, Lüders P, Krüger G, Knolle J, Stengel B, Prall F, Hertel K, Lobeck H, Popp B, Theissig F, Wünsch P, Zwarthoff E, Agaimy A, Schneider-Stock R (2011) Spectrum of KIT/PDGFRA/BRAF mutations and phosphatidylinositol-3-kinase pathway gene alterations in gastrointestinal stromal tumors (GIST). Cancer Lett 312:43–54PubMedCrossRef

Origone P, Gargiulo S, Mastracci L, Ballestrero A, Battistuzzi L, Casella C, Comandini D, Cusano R, Dei Tos AP, Fiocca R, Garuti A, Ghiorzo P, Martinuzzi C, Toffolatti L, Liguria GIST Unit, Bianchi Scarrà G (2013) Molecular characterization of an Italian series of sporadic GISTs. Gastric Cancer 16:596–601

Title: On the prevalence of KRAS mutations in GISTs
Authors: Riccardo Ricci
Angelo Paolo Dei Tos
Guido Rindi
Publication date: 01-12-2013
Publisher: Springer Berlin Heidelberg
Published in: Virchows Archiv / Issue 6/2013
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-013-1496-z

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On the prevalence of KRAS mutations in GISTs

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