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01-12-2013 | Original Article

In myofibroblastic sarcomas of the head and neck, mitotic activity and necrosis define grade: a case study and literature review

Authors: Chunyu Cai, Louis P. Dehner, Samir K. El-Mofty

Published in: Virchows Archiv | Issue 6/2013

Abstract

Low-grade myofibroblastic sarcoma (LGMFS) is considered a distinct entity in the World Health Organization classification of soft tissue neoplasms, defined as an atypical myofibroblastic proliferation with fibromatosis-like features and a predilection for the head and neck. A substantial subset of previously reported myofibroblastic sarcomas (MFS), particularly in the head and neck region, are associated with appreciable tumor-associated morbidity and mortality and should be differentiated from the more indolent LGMFS. However, no specific morphological criteria have been developed to define the entity of LGMFS. We have reviewed histological findings in conjunction with clinical follow-up information of previously reported MFS in the head and neck region in the English literature, with the addition of five new cases from our institution. We found that MFSs with 6 or more mitoses per 10 high power fields and/or presence of spontaneous necrosis were accompanied by a higher mortality rate that is statistically significant.

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Title: In myofibroblastic sarcomas of the head and neck, mitotic activity and necrosis define grade: a case study and literature review
Authors: Chunyu Cai
Louis P. Dehner
Samir K. El-Mofty
Publication date: 01-12-2013
Publisher: Springer Berlin Heidelberg
Published in: Virchows Archiv / Issue 6/2013
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-013-1494-1

At a glance: The STEP trials

Springer Medicine

In myofibroblastic sarcomas of the head and neck, mitotic activity and necrosis define grade: a case study and literature review

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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