Skip to main content
Top
Published in: Current Obesity Reports 4/2020

01-12-2020 | Obesity | Childhood Obesity (A Kelly and C Fox, Section Editor)

Weight Management in Youth with Type 1 Diabetes and Obesity: Challenges and Possible Solutions

Authors: Dessi P. Zaharieva, Ananta Addala, Kimber M. Simmons, David M. Maahs

Published in: Current Obesity Reports | Issue 4/2020

Login to get access

Abstract

Purpose of Review

This review highlights challenges associated with weight management in children and adolescents with type 1 diabetes (T1D). Our purpose is to propose potential solutions to improve weight outcomes in youth with T1D.

Recent Findings

A common barrier to weight management in T1D is reluctance to engage in exercise for fear of hypoglycemia. Healthcare practitioners generally provide limited guidance for insulin dosing and carbohydrate modifications to maintain stable glycemia during exercise. Adherence to dietary guidelines is associated with improved glycemia; however, youth struggle to meet recommendations. When psychosocial factors are addressed in combination with glucose trends, this often leads to successful T1D management. Newer medications also hold promise to potentially aid in glycemia and weight management, but further research is necessary.

Summary

Properly addressing physical activity, nutrition, pharmacotherapy, and psychosocial factors while emphasizing weight management may reduce the likelihood of obesity development and its perpetuation in this population.
Literature
4.
go back to reference Liu LL, Lawrence JM, Davis C, Liese AD, Pettitt DJ, Pihoker C, et al. Prevalence of overweight and obesity in youth with diabetes in USA: the search for diabetes in youth study. Pediatr Diabetes. 2010;11:4–11.CrossRefPubMed Liu LL, Lawrence JM, Davis C, Liese AD, Pettitt DJ, Pihoker C, et al. Prevalence of overweight and obesity in youth with diabetes in USA: the search for diabetes in youth study. Pediatr Diabetes. 2010;11:4–11.CrossRefPubMed
6.
go back to reference Keeley TJH, Fox KR. The impact of physical activity and fitness on academic achievement and cognitive performance in children. Int J Sport Exerc Psychol. 1999;2:198–214.CrossRef Keeley TJH, Fox KR. The impact of physical activity and fitness on academic achievement and cognitive performance in children. Int J Sport Exerc Psychol. 1999;2:198–214.CrossRef
7.
go back to reference Kemper HC, Twisk JW, Koppes LL, Wv M, Post GB. A 15-year physical activity pattern is positively related to aerobic fitness in young males and females (13-27 years). Eur J Appl Physiol. 2001;84:395–402.CrossRefPubMed Kemper HC, Twisk JW, Koppes LL, Wv M, Post GB. A 15-year physical activity pattern is positively related to aerobic fitness in young males and females (13-27 years). Eur J Appl Physiol. 2001;84:395–402.CrossRefPubMed
11.
go back to reference MacMillan F, Kirk A, Mutrie N, Matthews L, Robertson K, Saunders DH. A systematic review of physical activity and sedentary behavior intervention studies in youth with type 1 diabetes: study characteristics, intervention design, and efficacy. Pediatr Diabetes. 2014;15:175–89. https://doi.org/10.1111/pedi.12060.CrossRefPubMed MacMillan F, Kirk A, Mutrie N, Matthews L, Robertson K, Saunders DH. A systematic review of physical activity and sedentary behavior intervention studies in youth with type 1 diabetes: study characteristics, intervention design, and efficacy. Pediatr Diabetes. 2014;15:175–89. https://​doi.​org/​10.​1111/​pedi.​12060.CrossRefPubMed
21.
go back to reference Hagan JF, Shaw JS, PM D. Bright futures: guidelines for health supervision of infants, children, and adolescents. 4th ed: American Academy of Pediatrics; 2017. Hagan JF, Shaw JS, PM D. Bright futures: guidelines for health supervision of infants, children, and adolescents. 4th ed: American Academy of Pediatrics; 2017.
28.
go back to reference The Physical Activity Guidelines Advisory Committee. 2018 Physical activity guidelines advisory committee scientific report. Washington, DC: Department of Health and Human Services; 2018. The Physical Activity Guidelines Advisory Committee. 2018 Physical activity guidelines advisory committee scientific report. Washington, DC: Department of Health and Human Services; 2018.
31.
go back to reference Maggio AB, Rizzoli RR, Marchand LM, Ferrari S, Beghetti M, Farpour-Lambert NJ. Physical activity increases bone mineral density in children with type 1 diabetes. Med Sci Sports Exerc. 2012;44:1206–11.CrossRefPubMed Maggio AB, Rizzoli RR, Marchand LM, Ferrari S, Beghetti M, Farpour-Lambert NJ. Physical activity increases bone mineral density in children with type 1 diabetes. Med Sci Sports Exerc. 2012;44:1206–11.CrossRefPubMed
61.
go back to reference Zaharieva D, McGaugh S, Pooni R, Vienneau T, Ly T, Riddell M. Improved open-loop glucose control with basal insulin reduction 90 minutes before aerobic exercise in patients with type 1 diabetes on continuous subcutaneous insulin infusion. Diabetes Care. 2019;42:824–31.CrossRefPubMed Zaharieva D, McGaugh S, Pooni R, Vienneau T, Ly T, Riddell M. Improved open-loop glucose control with basal insulin reduction 90 minutes before aerobic exercise in patients with type 1 diabetes on continuous subcutaneous insulin infusion. Diabetes Care. 2019;42:824–31.CrossRefPubMed
64.
72.
go back to reference Maahs DM, Horton LA, Chase HP. The use of insulin pumps in youth with type 1 diabetes. Diabetes Technol Ther. 2010;12(Suppl 1):S59–65.CrossRefPubMed Maahs DM, Horton LA, Chase HP. The use of insulin pumps in youth with type 1 diabetes. Diabetes Technol Ther. 2010;12(Suppl 1):S59–65.CrossRefPubMed
77.
go back to reference Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group. Effectiveness of continuous glucose monitoring in a clinical care environment: evidence from the juvenile diabetes research foundation continuous glucose monitoring (JDRF-CGM) trial. Diabetes Care. 2010;33:17–22. https://doi.org/10.2337/dc09-1502.CrossRef Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group. Effectiveness of continuous glucose monitoring in a clinical care environment: evidence from the juvenile diabetes research foundation continuous glucose monitoring (JDRF-CGM) trial. Diabetes Care. 2010;33:17–22. https://​doi.​org/​10.​2337/​dc09-1502.CrossRef
78.
go back to reference Riveline JP, Schaepelynck P, Chaillous L, Renard E, Sola-Gazagnes A, Penfornis A, et al. Assessment of patient-led or physician-driven continuous glucose monitoring in patients with poorly controlled type 1 diabetes using basal-bolus insulin regimens: a 1-year multicenter study. Diabetes Care. 2012;35:965–71. https://doi.org/10.2337/dc11-2021.CrossRefPubMedPubMedCentral Riveline JP, Schaepelynck P, Chaillous L, Renard E, Sola-Gazagnes A, Penfornis A, et al. Assessment of patient-led or physician-driven continuous glucose monitoring in patients with poorly controlled type 1 diabetes using basal-bolus insulin regimens: a 1-year multicenter study. Diabetes Care. 2012;35:965–71. https://​doi.​org/​10.​2337/​dc11-2021.CrossRefPubMedPubMedCentral
94.
go back to reference Leow ZZX, Guelfi KJ, Davis EA, Jones TW, Fournier PA. The glycaemic benefits of a very-low-carbohydrate ketogenic diet in adults with type 1 diabetes mellitus may be opposed by increased hypoglycaemia risk and dyslipidaemia. Diabet Med. 2018. https://doi.org/10.1111/dme.13663. Leow ZZX, Guelfi KJ, Davis EA, Jones TW, Fournier PA. The glycaemic benefits of a very-low-carbohydrate ketogenic diet in adults with type 1 diabetes mellitus may be opposed by increased hypoglycaemia risk and dyslipidaemia. Diabet Med. 2018. https://​doi.​org/​10.​1111/​dme.​13663.
97.
106.
go back to reference Diabetes Control and Complications Trial Research Group, Nathan DM, Genuth S, Lachin J, Cleary P, et al. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977–86. https://doi.org/10.1056/NEJM199309303291401.CrossRef Diabetes Control and Complications Trial Research Group, Nathan DM, Genuth S, Lachin J, Cleary P, et al. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977–86. https://​doi.​org/​10.​1056/​NEJM199309303291​401.CrossRef
107.
go back to reference Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group. Intensive diabetes treatment and cardiovascular outcomes in type 1 diabetes: the DCCT/EDIC study 30-year follow-up. Diabetes Care. 2016;39:686–93. https://doi.org/10.2337/dc15-1990.CrossRef Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group. Intensive diabetes treatment and cardiovascular outcomes in type 1 diabetes: the DCCT/EDIC study 30-year follow-up. Diabetes Care. 2016;39:686–93. https://​doi.​org/​10.​2337/​dc15-1990.CrossRef
113.
go back to reference Biester T, Aschemeier B, Fath M, Frey M, Scheerer MF, Kordonouri O, et al. Effects of dapagliflozin on insulin-requirement, glucose excretion and ss-hydroxybutyrate levels are not related to baseline hba1c in youth with type 1 diabetes. Diabetes Obes Metab. 2017;19:1635–9. https://doi.org/10.1111/dom.12975.CrossRefPubMed Biester T, Aschemeier B, Fath M, Frey M, Scheerer MF, Kordonouri O, et al. Effects of dapagliflozin on insulin-requirement, glucose excretion and ss-hydroxybutyrate levels are not related to baseline hba1c in youth with type 1 diabetes. Diabetes Obes Metab. 2017;19:1635–9. https://​doi.​org/​10.​1111/​dom.​12975.CrossRefPubMed
114.
go back to reference Biester T, Nieswandt A, Biester S, Remus K, Muller I, Atlas E, et al. Adjunctive therapy with dapagliflozin improves full closed loop post prandial glycaemic control in type 1 diabetic young adults - The DAPADream. International Diabetes Federation 2017 Congress. 2017: Abu Dhabi. Biester T, Nieswandt A, Biester S, Remus K, Muller I, Atlas E, et al. Adjunctive therapy with dapagliflozin improves full closed loop post prandial glycaemic control in type 1 diabetic young adults - The DAPADream. International Diabetes Federation 2017 Congress. 2017: Abu Dhabi.
121.
go back to reference Marlow AL, Rowe CW, Anderson D, Wynne K, King BR, Howley P, et al. Young children, adolescent girls and women with type 1 diabetes are more overweight and obese than reference populations, and this is associated with increased cardiovascular risk factors. Diabet Med. 2019;36:1487–93. https://doi.org/10.1111/dme.14133.CrossRefPubMed Marlow AL, Rowe CW, Anderson D, Wynne K, King BR, Howley P, et al. Young children, adolescent girls and women with type 1 diabetes are more overweight and obese than reference populations, and this is associated with increased cardiovascular risk factors. Diabet Med. 2019;36:1487–93. https://​doi.​org/​10.​1111/​dme.​14133.CrossRefPubMed
Metadata
Title
Weight Management in Youth with Type 1 Diabetes and Obesity: Challenges and Possible Solutions
Authors
Dessi P. Zaharieva
Ananta Addala
Kimber M. Simmons
David M. Maahs
Publication date
01-12-2020
Publisher
Springer US
Published in
Current Obesity Reports / Issue 4/2020
Electronic ISSN: 2162-4968
DOI
https://doi.org/10.1007/s13679-020-00411-z

Other articles of this Issue 4/2020

Current Obesity Reports 4/2020 Go to the issue

Psychological Issues (V Drapeau and V Ivezaj, Section Editors)

The Role of Eating Behaviours in Genetic Susceptibility to Obesity

The Obesity Epidemic: Causes and Consequences (A Cameron and K Backholer, Section Editors)

Measuring Food Culture: a Tool for Public Health Practice

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.