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BMC Endocrine Disorders
Published in: BMC Endocrine Disorders 1/2024

Open Access 01-12-2024 | Obesity | Research

The associations of oxidative stress and inflammatory markers with obesity in Iranian population: MASHAD cohort study

Authors: Hamideh Ghazizadeh, Amin Mansoori, Toktam Sahranavard, Mohamad Nasrabadi, Kaveh Hadiloo, Nazanin Sheikh Andalibi, Marzyeh Azmon, Shima Tavallaei, Ameneh Timar, Gordon A Ferns, Majid Ghayour-Mobarhan

Published in: BMC Endocrine Disorders | Issue 1/2024

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Abstract

Background

Low-grade inflammation and stress oxidative condition play a role in the pathogenesis of obesity, and the serum levels of these markers, such as pro-oxidant-antioxidant balance (PAB), high-sensitivity C-reactive protein (hs-CRP), and uric acid may indicate obesity progression. In this study, we aimed to investigate the relationship between obesity with PAB, hs-CRP, and uric acid in the Iranian population.

Methods

This study was derived from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study. A total of 7985 subjects aged 35 to 65 years were divided into three groups according to body mass index (BMI) as: normal, overweight and obese groups. Anthropometric indices and biochemical parameters such as PAB, superoxide dismutase type 1 (SOD1), hs-CRP, and uric acid were measured in all the participants. We evaluated the association of obesity with inflammatory factors by using multivariate regression analysis. Also, those participants with hypertension, an endocrine disorder, history of cardiovascular diseases and diabetes mellitus were excluded from the study.

Results

There was a positive significant correlation between BMI and serum PAB, hs-CRP and uric acid (p < 0.001). While no statistically significant relation was observed between BMI and SOD1 (p = 0.85). Multivariate regression analysis showed that the risk of overweight and obesity increased 1.02 and 1.03-fold according to increase 10 units of PAB raise in comparison to reference group (normal weight) [(odds ratio (OR): 1.02, 95% CI (1.01–1.03)] and [OR: 1.03, 95% CI (1.01–1.04)], respectively). In addition, hs-CRP serum concentration was significantly associated with a high risk of obesity [(OR: 1.02; 95% CI (1.01–1.03)]. While the high levels of serum uric acid were associated with increased odds of overweight and obesity risk [OR: 1.4; CI (1.39–1.58) and OR: 1.76; CI (1.63–1.89), respectively].

Conclusions

Generally, we showed a significant association between BMI and serum PAB, hs-CRP values and uric acid levels, suggesting the role of these factors as risk stratification factors for obesity.
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Metadata
Title
The associations of oxidative stress and inflammatory markers with obesity in Iranian population: MASHAD cohort study
Authors
Hamideh Ghazizadeh
Amin Mansoori
Toktam Sahranavard
Mohamad Nasrabadi
Kaveh Hadiloo
Nazanin Sheikh Andalibi
Marzyeh Azmon
Shima Tavallaei
Ameneh Timar
Gordon A Ferns
Majid Ghayour-Mobarhan
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Endocrine Disorders / Issue 1/2024
Electronic ISSN: 1472-6823
DOI
https://doi.org/10.1186/s12902-024-01590-9

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