Published in:
Open Access
15-05-2023 | Obesity | Editorial
Obesity and non-alcoholic steatohepatitis in immunotherapy for hepatocellular carcinoma
Authors:
Shuichiro Shiina, Hitoshi Maruyama, Maki Tobari, Tatsuya Yamashita
Published in:
Hepatology International
|
Issue 4/2023
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Excerpt
The atezolizumab plus bevacizumab combination therapy (Atezo/Beva) opened the door to immunotherapy for unresectable hepatocellular carcinoma (HCC) [
1]. Following Atezo/Beva, three other combination immunotherapies, sintilimab plus a bevacizumab biosimilar (ORIENT-32) [
2], tremelimumab plus durvalumab (HIMALAYA) [
3], atezolizumab plus cabozantinib (COSMIC-312) [
4], have shown survival benefits as first line systemic therapy for unresectable HCC. Systemic therapy for HCC is shifting toward immunotherapy. …