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European Journal of Pediatrics
Published in: European Journal of Pediatrics 1/2021

01-01-2021 | Obesity | Original Article

Lipid profile assessed in the family pediatrician’s office: the COLIBRI’- SIMPeF study

Authors: Marco Giussani, Laura Antolini, Monica de’ Angelis, Ornella Guardamagna, Massimiliano Dozzi, Simonetta Genovesi

Published in: European Journal of Pediatrics | Issue 1/2021

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Abstract

There is limited information on the prevalence of dyslipidemia in the Italian pediatric population. Aim of the study was to evaluate total cholesterol, high-density lipoprotein (HDL)-cholesterol and triglyceride levels, and associated factors in a large sample of Italian children, applying a micro-sampling procedure in the family pediatrician’s office. In a population of 1910 children (50.2% males, age 7–11 years), 27.6% was overweight or obese and 28.3% had at least one parent with referred hypercholesterolemia. Total cholesterol and triglyceride levels were elevated in 4.5% and 23.5% of the subjects, respectively, while HDL cholesterol was below 40 mg/dl in 3.3%. Male gender (OR 1.58, 95% CI 1.01–2.49) and positive family history (OR 2.13, 95% CI 1.36–3.32) were independent predictors of hypercholesterolemia, while BMI z-score was associated with low HDL cholesterol (OR 1.46, 95% CI 1.13–1.88) and high levels of triglycerides (OR 1.39, 95% CI 1.26–1.55).
Conclusion: The prevalence of dyslipidemia in our sample is worthy of attention. The study suggests the opportunity and feasibility to check for the presence of dyslipidemia at the family pediatrician’s office. Familiarity is associated with high cholesterol levels, regardless of the children’s weight class, while weight excess identifies subjects with the typical lipid profile of metabolic syndrome.
What is Known:
• Few data are available on the lipid profile in Italian children.
• Early treatment of hypercholesterolemia is effective in reducing cardiovascular events later in life; there is no agreement on how to screen for dyslipidemia in childhood, however.
What is New:
• In a large sample of Italian children, familiarity doubles the risk of hypercholesterolemia, while increased BMI is associated with low HDL cholesterol levels and hypertriglyceridemia.
• The pediatrician may perform an assessment of plasma lipids in his office as a first step to diagnose familial hypercholesterolemia.
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Metadata
Title
Lipid profile assessed in the family pediatrician’s office: the COLIBRI’- SIMPeF study
Authors
Marco Giussani
Laura Antolini
Monica de’ Angelis
Ornella Guardamagna
Massimiliano Dozzi
Simonetta Genovesi
Publication date
01-01-2021
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Pediatrics / Issue 1/2021
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-020-03726-0

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