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Reviews in Endocrine and Metabolic Disorders
Published in: Reviews in Endocrine and Metabolic Disorders 5/2023

10-04-2023 | Obesity

Genetics and epigenetics in the obesity phenotyping scenario

Authors: Khanh Trang, Struan F.A. Grant

Published in: Reviews in Endocrine and Metabolic Disorders | Issue 5/2023

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Abstract

Obesity is a common complex trait that elevates the risk for various diseases, including type 2 diabetes and cardiovascular disease. A combination of environmental and genetic factors influences the pathogenesis of obesity. Advances in genomic technologies have driven the identification of multiple genetic loci associated with this disease, ranging from studying severe onset cases to investigating common multifactorial polygenic forms. Additionally, findings from epigenetic analyses of modifications to the genome that do not involve changes to the underlying DNA sequence have emerged as key signatures in the development of obesity. Such modifications can mediate the effects of environmental factors, including diet and lifestyle, on gene expression and clinical presentation. This review outlines what is known about the genetic and epigenetic contributors to obesity susceptibility, along with the albeit limited therapeutic options currently available. Furthermore, we delineate the potential mechanisms of actions through which epigenetic changes can mediate environmental influences and the related opportunities they present for future interventions in the management of obesity.
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Metadata
Title
Genetics and epigenetics in the obesity phenotyping scenario
Authors
Khanh Trang
Struan F.A. Grant
Publication date
10-04-2023
Publisher
Springer US
Published in
Reviews in Endocrine and Metabolic Disorders / Issue 5/2023
Print ISSN: 1389-9155
Electronic ISSN: 1573-2606
DOI
https://doi.org/10.1007/s11154-023-09804-6

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