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Open Access 01-12-2014 | Review

Monogenic forms of childhood obesity due to mutations in the leptin gene

Authors: Jan-Bernd Funcke, Julia von Schnurbein, Belinda Lennerz, Georgia Lahr, Klaus-Michael Debatin, Pamela Fischer-Posovszky, Martin Wabitsch

Published in: Molecular and Cellular Pediatrics | Issue 1/2014

Abstract

Congenital leptin deficiency is a rare autosomal recessive monogenic obesity syndrome caused by mutations in the leptin gene. This review describes the molecular and cellular characteristics of the eight distinct mutations found so far in humans.

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Title: Monogenic forms of childhood obesity due to mutations in the leptin gene
Authors: Jan-Bernd Funcke
Julia von Schnurbein
Belinda Lennerz
Georgia Lahr
Klaus-Michael Debatin
Pamela Fischer-Posovszky
Martin Wabitsch
Publication date: 01-12-2014
Publisher: Springer Berlin Heidelberg
Published in: Molecular and Cellular Pediatrics / Issue 1/2014
Electronic ISSN: 2194-7791
DOI: https://doi.org/10.1186/s40348-014-0003-1

At a glance: The STEP trials

Springer Medicine

Monogenic forms of childhood obesity due to mutations in the leptin gene

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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