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International Journal of Colorectal Disease
Published in: International Journal of Colorectal Disease 1/2023

Open Access 01-12-2023 | Obesity | REVIEW

Diverticulosis and cardiometabolic risk factors: a systematic literature review

Authors: Andreas Völkerer, Sarah Wernly, Georg Semmler, Maria Flamm, Elmar Aigner, Christian Datz, Bernhard Wernly

Published in: International Journal of Colorectal Disease | Issue 1/2023

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Abstract

Background

There is a hypothesis of an association between diverticulosis and metabolic syndrome (MS) or its components, but data on this topic are inconsistent, and a systematic review has not been performed. We conducted a systematic review to investigate the possible association between cardiometabolic risk factors and diverticulosis.

Methods

A systematic literature search was conducted via PubMed, Cochrane Library, and Web of Science in December 2022 to collect the necessary data. Studies that examined the association between MS or individual metabolic factors and asymptomatic diverticulosis were included in the review.

Results

Of the potentially relevant articles identified via PubMed (477), Cochrane Library (224), and Web of Science (296), 29 articles met the inclusion criteria and were used for this work. These studies were assessed for study quality using GRADE. Overall, 6 studies were rated as “very low,” 19 studies as “low,” and 4 studies as “moderate.” The data suggest an association between arterial hypertension, obesity, and fatty liver disease in younger patients and diverticulosis. Patient age appears to play an important role in diverticular formation. Data on diabetes mellitus is inconclusive and may require further investigation depending on the location of the diverticula.

Conclusion

Based on the synthesized data, there is an association between arterial hypertension, obesity, and fatty liver disease in younger patients. The formation of diverticula seems to be influenced by age and genetic factors. The study suggests a connection with cardiometabolic risk factors. To gain a better understanding of the role of metabolic risk factors in asymptomatic diverticulosis, targeted studies are necessary based on these findings.
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Metadata
Title
Diverticulosis and cardiometabolic risk factors: a systematic literature review
Authors
Andreas Völkerer
Sarah Wernly
Georg Semmler
Maria Flamm
Elmar Aigner
Christian Datz
Bernhard Wernly
Publication date
01-12-2023
Publisher
Springer Berlin Heidelberg
Published in
International Journal of Colorectal Disease / Issue 1/2023
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-023-04532-4

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