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European Journal of Medical Research
Published in: European Journal of Medical Research 1/2023

Open Access 01-12-2023 | Obesity | Research

Comparison of insulin resistance indices in predicting albuminuria among patients with type 2 diabetes

Authors: Seyed Ali Nabipoorashrafi, Azam Adeli, Seyed Arsalan Seyedi, Soghra Rabizadeh, Razman Arabzadeh Bahri, Fatemeh Mohammadi, Amirhossein Yadegar, Manouchehr Nakhjavani, Alireza Esteghamati

Published in: European Journal of Medical Research | Issue 1/2023

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Abstract

Purpose

Diabetes is the leading cause of kidney disease. Up to 40% of the population with diabetes experience diabetic kidney disease (DKD). The correlation of DKD with insulin resistance (IR) indices has been shown in previous studies. In this study, the objective was to evaluate surrogate IR indices, including the Triglyceride-Glucose (TyG) index, Visceral Adiposity Index (VAI), Lipid Accumulation Product (LAP), and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) to find the most valuable index for the correlation between albuminuria and IR in the type 2 diabetes (T2D) population. Albuminuria is defined as urine albumin excretion of > 30 mg/day.

Methods

In this cross-sectional study, 2934 participants were enrolled and evaluated for urinary albumin excretion, and albuminuria was detected in 526 of the entries. The logistic regression models and Receiver Operating Characteristic (ROC) curve analysis were performed to assess the relationship of TyG index, VAI, LAP, and HOMA-IR's with albuminuria in patients with T2D.

Results

The TyG index had the highest association (OR 1.67) with the presence of albuminuria in patients with T2D, followed by HOMA-IR (OR 1.127), VAI (OR 1.028), and LAP (OR 1.004). These four indices remained independent after adjustment for multiple confounders. Based on the ROC curve, TyG revealed the best area under the curve (AUC) for revealing albuminuria with sufficient accuracy (AUC: 0.62) in comparison with other measured indices. The calculated TyG index cut-off point for the presence of albuminuria was 9.39.

Conclusion

Among the indices, TyG index had the most significant correlation with albuminuria in patients with T2D.
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Metadata
Title
Comparison of insulin resistance indices in predicting albuminuria among patients with type 2 diabetes
Authors
Seyed Ali Nabipoorashrafi
Azam Adeli
Seyed Arsalan Seyedi
Soghra Rabizadeh
Razman Arabzadeh Bahri
Fatemeh Mohammadi
Amirhossein Yadegar
Manouchehr Nakhjavani
Alireza Esteghamati
Publication date
01-12-2023
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue 1/2023
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/s40001-023-01134-2

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