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Current Allergy and Asthma Reports

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01-12-2017 | Food Allergy (T Green, Section Editor)

Non-IgE-mediated Adverse Food Reactions

Author: Stephanie A. Leonard

Published in: Current Allergy and Asthma Reports | Issue 12/2017

Abstract

Purpose of Review

The purpose of this review is to update what is currently known about the major non-IgE-mediated food allergies: food protein-induced enterocolitis syndrome (FPIES), food protein-induced allergic proctocolitis (FPIAP), and food protein-induced enteropathy (FPE). These conditions are similar in that symptoms are regulated to the gastrointestinal tract; therefore understanding their specific features is important for diagnosis and management.

Recent Findings

The most progress has been made in understanding FPIES with several recent large cohorts being described. The first international consensus guidelines for FPIES were published in 2017 and propose specific diagnostic criteria for acute FPIES as well as guidance for diagnosing chronic FPIES. Recent studies in FPIAP have challenged our thinking about the recommended duration of food avoidance and that cow’s milk avoidance is the primary management with reports of self-resolution without dietary management. FPE continues to appear to be on the decline.

Summary

FPIES, FPIAP, and FPE are distinguished from one another by their main clinical features: delayed repetitive vomiting in FPIES, benign blood in stool in FPIAP, and chronic diarrhea in FPE. Due to the risk of nutritional deficiencies with food avoidance in both infant and maternal diets if breastfeeding, confirmation of diagnosis with challenges is encouraged. Additional studies are needed for these conditions to elucidate pathophysiology, search for diagnostic markers, and understand natural history.

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Title: Non-IgE-mediated Adverse Food Reactions
Author: Stephanie A. Leonard
Publication date: 01-12-2017
Publisher: Springer US
Published in: Current Allergy and Asthma Reports / Issue 12/2017
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-017-0744-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Non-IgE-mediated Adverse Food Reactions

Abstract

Purpose of Review

Recent Findings

Summary

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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