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Current Allergy and Asthma Reports

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Open Access 01-12-2017 | Basic and Applied Science (I Lewkowich, Section Editor)

Endoplasmic Reticulum Stress and Allergic Diseases

Authors: Jae Seok Jeong, So Ri Kim, Seong Ho Cho, Yong Chul Lee

Published in: Current Allergy and Asthma Reports | Issue 12/2017

Abstract

Purpose of Review

In this review, we will integrate recent knowledge on endoplasmic reticulum (ER) stress and allergy, thereby highlighting the therapeutic potential of ER stress in the context of precision medicine for allergic diseases.

Recent Findings

Emerging evidence suggests that allergic diseases are very heterogeneous having numerous endotypes. This leads to the new era of modern medicine, which assumes that a particular endotype-driven therapy, called precision medicine, would be more efficacious in a specific group of patients rather than in all patients. Currently, a dichotomy involving type 2/non-type 2 immune response underlies most of the studies on inflammatory and immunologic mechanisms of allergic disorders. Whereas there are several approved or investigational endotype-driven therapeutic agents targeting type 2 immune responses, investigation of mechanisms and endotype-driven interventions regarding non-type 2 immune response lags far behind.

Summary

Considering that non-type 2 immune response may represent a significant proportion of allergic disease, particularly corticosteroid-resistant severe disease, defining a novel concept of endotype-driven approach may be essential. Recently, stress responses originate from the endoplasmic reticulum (ER) and the associated inflammatory molecular platform has been suggested as a crucial player of immune and inflammatory responses. This implies that ER stress-related pathways may represent a new endotype-driven therapeutic strategy in the treatment of allergic diseases.

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Title: Endoplasmic Reticulum Stress and Allergic Diseases
Authors: Jae Seok Jeong
So Ri Kim
Seong Ho Cho
Yong Chul Lee
Publication date: 01-12-2017
Publisher: Springer US
Published in: Current Allergy and Asthma Reports / Issue 12/2017
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-017-0751-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Endoplasmic Reticulum Stress and Allergic Diseases

Abstract

Purpose of Review

Recent Findings

Summary

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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