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BMC Gastroenterology
Published in: BMC Gastroenterology 1/2023

Open Access 01-12-2023 | Research

Nomogram predicts risk of perineural invasion based on serum biomarkers for pancreatic cancer

Authors: Wenbo Zou, Dingguo Wu, Yunyang Wu, Kuiping Zhou, Yuanshu Lian, Gengyun Chang, Yuze Feng, Jifeng Liang, Gao Huang

Published in: BMC Gastroenterology | Issue 1/2023

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Abstract

Background

Pancreatic cancer is a fatal tumor, and the status of perineural invasion (PNI) of pancreatic cancer was positively related to poor prognosis including overall survival and recurrence-free survival. This study aims to develop and validate a predictive model based on serum biomarkers to accurately predict the perineural invasion.

Materials and methods

The patients from No.924 Hospital of PLA Joint Logistic Support Force were included. The predictive model was developed in the training cohort using logistic regression analysis, and then tested in the validation cohort. The area under curve (AUC), calibration curves and decision curve analysis were used to validate the predictive accuracy and clinical benefits of nomogram.

Results

A nomogram was developed using preoperative total bilirubin, preoperative blood glucose, preoperative CA19-9. It achieved good AUC values of 0.753 and 0.737 in predicting PNI in training and validation cohorts, respectively. Calibration curves showed nomogram had good uniformity of the practical probability of PNI. Decision curve analyses revealed that the nomogram provided higher diagnostic accuracy and superior net benefit compared to single indicators.

Conclusion

The present study constructed and validate a novel nomogram predicted the PNI of resectable PHAC patients with high stability and accuracy. Besides, it could better screen high-risk probability of PNI in these patients, and optimize treatment decision-making.
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Metadata
Title
Nomogram predicts risk of perineural invasion based on serum biomarkers for pancreatic cancer
Authors
Wenbo Zou
Dingguo Wu
Yunyang Wu
Kuiping Zhou
Yuanshu Lian
Gengyun Chang
Yuze Feng
Jifeng Liang
Gao Huang
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Gastroenterology / Issue 1/2023
Electronic ISSN: 1471-230X
DOI
https://doi.org/10.1186/s12876-023-02819-y

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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