Published in:
01-02-2004 | Poster presentation
Nitric oxide in ischemic heart disease. Defective production or impaired function?
Authors:
A Rizk, N Samir, A El Hadidi, A El Naggar, E Omar, H Mowafi, S Mokhtar
Published in:
Critical Care
|
Special Issue 1/2004
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Excerpt
Among the mediators released by coronary arterial endothelium, namely prostacyclin, endothelin, thrombomodulin, and so on, nitric oxide (NO) (i.e. endothelial-derived relaxing factor) has been the subject of our intense research. A biologic link between endothelial damage and atherosclerotic coronary arterial disease has been presumably related to decreased arterial bioavailability of NO through predisposing to leucocyte and platelet adhesion, vasoconstriction and smooth muscle cell proliferation. …