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Critical Care
Published in: Critical Care 1/2004

01-02-2004 | Poster presentation

N-Acetylcysteine inhibits peroxynitrite-mediated damage in oleic acid-induced lung injury

Authors: O Koksel, I Cinel, L Tamer, L Cinel, A Ozdulger, U Oral

Published in: Critical Care | Special Issue 1/2004

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Excerpt

Since oleic acid (OA) induces morphologic and cellular changes similar to those observed in human acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), it has become a widely used model to investigate the effects of several agents on pathogenesis of lung injury. The antioxidant, anti-inflammatory and antiapoptotic properties of N-acetylcysteine (NAC) have been documented in many lung injury models [1]. In this study, we evaluated the role of NAC in an OA-induced lung injury model by measuring myeloperoxidase (MPO) activity, malondialdehyde (MDA) and 3-nitrotyrosine (3-NT) levels in lung tissue. …
Literature
1.
Ozdulger A, Cinel I, Koksel O, et al.: The protective effect of N -acetylecysteine on apoptotic lung injury in CLP-induced sepsis model. Shock 2003, 19: 366-372. 10.1097/00024382-200304000-00012CrossRefPubMed
Metadata
Title
N-Acetylcysteine inhibits peroxynitrite-mediated damage in oleic acid-induced lung injury
Authors
O Koksel
I Cinel
L Tamer
L Cinel
A Ozdulger
U Oral
Publication date
01-02-2004
Publisher
BioMed Central
Published in
Critical Care / Issue Special Issue 1/2004
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc2671

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