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01-12-2015 | CLINICAL

New advances in ovarian autotransplantation to restore fertility in cancer patients

Authors: Mahmoud Salama, Teresa K. Woodruff

Published in: Cancer and Metastasis Reviews | Issue 4/2015

Abstract

Human ovary autotransplantation is a promising option for fertility preservation of young women and girls undergoing gonadotoxic treatments for cancer or some autoimmune diseases. Although experimental, it resulted in at least 42 healthy babies worldwide. According to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic literature review was performed for all relevant full-text articles published in English from 1 January 2000 to 01 October 2015 in PubMed to explore the latest clinical and research advances of human ovary autotransplantation. Human ovary autotransplantation involves ovarian tissue extraction, freezing/thawing, and transplantation back into the same patient. Three major forms of human ovary autotransplantation exist including (a) transplantation of cortical ovarian tissue, (b) transplantation of whole ovary, and (c) transplantation of ovarian follicles (artificial ovary). According to the recent guidelines, human ovary autotransplantation is still considered experimental; however, it has unique advantages in comparison to other options of female fertility preservation. Human ovary autotransplantation (i) does not need prior ovarian stimulation, (ii) allows immediate initiation of cancer therapy, (iii) can restore both endocrine and reproductive ovarian functions, and (iv) may be the only fertility preservation option suitable for prepubertal girls or for young women with estrogen-sensitive malignancies. As any other fertility preservation option, human ovary autotransplantation has both advantages and disadvantages and may not be feasible for all cases. The major challenges facing this option are how to avoid the risk of reintroducing malignant cells and how to prolong the lifespan of ovarian transplant as well as how to improve artificial ovary results.

De Vos, M., Smitz, J., & Woodruff, T. K. (2014). Fertility preservation in women with cancer. Lancet, 4;384(9950), 1302–1310.CrossRef

Salama, M., Winkler, K., Murach, K. F., Seeber, B., Ziehr, S. C., & Wildt, L. (2013). Female fertility loss and preservation: threats and opportunities. Annals of Oncology, 24(3), 598–608.PubMedCrossRef

Hirshfeld-Cytron, J., Gracia, C., & Woodruff, T. K. (2011). Nonmalignant diseases and treatments associated with primary ovarian failure: an expanded role for fertility preservation. Journal of Women’s Health (2002), 20(10), 1467–1477.CrossRef

Rodriguez-Wallberg, K. A., & Oktay, K. (2014). Fertility preservation during cancer treatment: clinical guidelines. Cancer Management and Research, 6, 105–117.PubMedCentralPubMed

Anderson, R.A., Mitchell, R.T., Kelsey, T.W., Spears, N., Telfer, E.E., Wallace, W.H. (2015). Cancer treatment and gonadal function: experimental and established strategies for fertility preservation in children and young adults. Lancet Diabetes Endocrinology, 3(7), 556–567.

Lee, S. J., Schover, L. R., Partridge, A. H., Patrizio, P., Wallace, W. H., Hagerty, K., Beck, L. N., Brennan, L. V., Oktay, K., & American Society of Clinical Oncology. (2006). American Society of Clinical Oncology recommendations on fertility preservation in cancer patients. Journal of Clinical Oncology, 24(18), 2917–2931.PubMedCrossRef

Loren, A. W., Mangu, P. B., Beck, L. N., Brennan, L., Magdalinski, A. J., Partridge, A. H., Quinn, G., Wallace, W. H., Oktay, K., & American Society of Clinical Oncology. (2013). Fertility preservation for patients with cancer: American Society of Clinical Oncology clinical practice guideline update. Journal of Clinical Oncology, 1;31(19), 2500–2510.CrossRef

Ethics Committee of the American Society for Reproductive Medicine, et al. (2005). Fertility preservation and reproduction in cancer patients. Fertility and Sterility, 83(6), 1622–1628.CrossRef

Ethics Committee of American Society for Reproductive Medicine. (2013). Fertility preservation and reproduction in patients facing gonadotoxic therapies: a committee opinion. Fertility and Sterility, 100(5), 1224–1231.CrossRef

10.

Practice Committee of American Society for Reproductive Medicine. (2013). Fertility preservation in patients undergoing gonadotoxic therapy or gonadectomy: a committee opinion. Fertility and Sterility, 100(5), 1214–1223.CrossRef

11.

Pentheroudakis, G., Orecchia, R., Hoekstra, H. J., Pavlidis, N., & ESMO Guidelines Working Group. (2010). Cancer, fertility and pregnancy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology, 21(Suppl 5), v266–v273.PubMedCrossRef

12.

Peccatori, F. A., Azim, H. A., Jr., Orecchia, R., Hoekstra, H. J., Pavlidis, N., Kesic, V., Pentheroudakis, G., & ESMO Guidelines Working Group. (2013). Cancer, pregnancy and fertility: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology, 24(Suppl 6), vi160–vi170.PubMedCrossRef

13.

Woodruff, T. K. (2010). The Oncofertility Consortium—addressing fertility in young people with cancer. Nature Reviews. Clinical Oncology, 7(8), 466–475.PubMedCentralPubMedCrossRef

14.

Waimey, K. E., Duncan, F. E., Su, H. I., Smith, K., Wallach, H., Jona, K., Coutifaris, C., Gracia, C. R., Shea, L. D., Brannigan, R. E., Chang, R. J., Zelinski, M. B., Stouffer, R. L., Taylor, R. L., & Woodruff, T. K. (2013). Future directions in oncofertility and fertility preservation: a report from the 2011 Oncofertility Consortium Conference. J Adolesc Young Adult Oncol, 2(1), 25–30.PubMedCentralPubMedCrossRef

15.

Practice Committee, I. S. F. P., Kim, S. S., Donnez, J., Barri, P., Pellicer, A., Patrizio, P., Rosenwaks, Z., Nagy, P., Falcone, T., Andersen, C., Hovatta, O., Wallace, H., Meirow, D., Gook, D., Kim, S. H., Tzeng, C. R., Suzuki, S., Ishizuka, B., & Dolmans, M. M. (2012). Recommendations for fertility preservation in patients with lymphoma, leukemia, and breast cancer. Journal of Assisted Reproduction and Genetics, 29(6), 465–468.CrossRef

16.

Klemp, J. R., Kim, S. S., & ISFP Practice Committee. (2012). Fertility preservation in young women with breast cancer. Journal of Assisted Reproduction and Genetics, 29(6), 469–472.PubMedCentralPubMedCrossRef

17.

Jadoul, P., Kim, S. S., & ISFP Practice Committee. (2012). Fertility considerations in young women with hematological malignancies. Journal of Assisted Reproduction and Genetics, 29(6), 479–487.PubMedCentralPubMedCrossRef

18.

Schmidt, K. T., Andersen, C. Y., & ISFP Practice Committee. (2012). Recommendations for fertility preservation in patients with lymphomas. Journal of Assisted Reproduction and Genetics, 29(6), 473–477.PubMedCentralPubMedCrossRef

19.

von Wolff, M., Montag, M., Dittrich, R., Denschlag, D., Nawroth, F., & Lawrenz, B. (2011). Fertility preservation in women—a practical guide to preservation techniques and therapeutic strategies in breast cancer, Hodgkin’s lymphoma and borderline ovarian tumours by the fertility preservation network FertiPROTEKT. Archives of Gynecology and Obstetrics, 284(2), 427–435.CrossRef

20.

Fallat, M. E., Hutter, J., & American Academy of Pediatrics Committee on Bioethics; American Academy of Pediatrics Section on Hematology/Oncology; American Academy of Pediatrics Section on Surgery. (2008). Preservation of fertility in pediatric and adolescent patients with cancer. Pediatrics, 121(5), e1461–e1469.PubMedCrossRef

21.

Fernbach, A., Lockart, B., Armus, C. L., Bashore, L. M., Levine, J., Kroon, L., Sylvain, G., & Rodgers, C. (2014). Evidence-based recommendations for fertility preservation options for inclusion in treatment protocols for pediatric and adolescent patients diagnosed with cancer. Journal of Pediatric Oncology Nursing, 31(4), 211–222.PubMedCrossRef

22.

Practice Committee of American Society for Reproductive Medicine. (2014). Ovarian tissue cryopreservation: a committee opinion. Fertility and Sterility, 101(5), 1237–1243.CrossRef

23.

Grynberg, M., Poulain, M., Sebag-Peyrelevade, S., le Parco, S., Fanchin, R., & Frydman, N. (2012). Ovarian tissue and follicle transplantation as an option for fertility preservation. Fertility and Sterility, 97(6), 1260–1268.PubMedCrossRef

24.

Jeruss, J. S., & Woodruff, T. K. (2009). Preservation of fertility in patients with cancer. New England Journal of Medicine, 360(9), 902–911.PubMedCentralPubMedCrossRef

25.

Donnez, J., & Dolmans, M. M. (2010). Cryopreservation and transplantation of ovarian tissue. Clinical Obstetrics and Gynecology, 53(4), 787–796.PubMedCrossRef

26.

Donnez, J., & Dolmans, M. M. (2013). Fertility preservation in women. Nature Reviews Endocrinology, 9(12), 735–749.PubMedCrossRef

27.

Imbert, R., Moffa, F., Tsepelidis, S., Simon, P., Delbaere, A., Devreker, F., Dechene, J., Ferster, A., Veys, I., Fastrez, M., Englert, Y., & Demeestere, I. (2014). Safety and usefulness of cryopreservation of ovarian tissue to preserve fertility: a 12-year retrospective analysis. Human Reproduction, 29(9), 1931–1940.PubMedCrossRef

28.

Andersen, C. Y., Rosendahl, M., Byskov, A. G., Loft, A., Ottosen, C., Dueholm, M., Schmidt, K. L., Andersen, A. N., & Ernst, E. (2008). Two successful pregnancies following autotransplantation of frozen/thawed ovarian tissue. Human Reproduction, 23(10), 2266–2272.PubMedCrossRef

29.

Ernst, E., Bergholdt, S., Jørgensen, J. S., & Andersen, C. Y. (2010). The first woman to give birth to two children following transplantation of frozen/thawed ovarian tissue. Human Reproduction, 25(5), 1280–1281.PubMedCrossRef

30.

Rosendahl, M., Schmidt, K. T., Ernst, E., Rasmussen, P. E., Loft, A., Byskov, A. G., Andersen, A. N., & Andersen, C. Y. (2011). Cryopreservation of ovarian tissue for a decade in Denmark: a view of the technique. Reproductive Biomedicine Online, 22(2), 162–171.PubMedCrossRef

31.

Macklon, K. T., Jensen, A. K., Loft, A., Ernst, E., & Andersen, C. Y. (2014). Treatment history and outcome of 24 deliveries worldwide after autotransplantation of cryopreserved ovarian tissue, including two new Danish deliveries years after autotransplantation. Journal of Assisted Reproduction and Genetics, 31(11), 1557–1564.PubMedCentralPubMedCrossRef

32.

Demeestere, I., Simon, P., Emiliani, S., Delbaere, A., & Englert, Y. (2007). Fertility preservation: successful transplantation of cryopreserved ovarian tissue in a young patient previously treated for Hodgkin’s disease. The Oncologist, 12(12), 1437–1442.PubMedCrossRef

33.

Demeestere, I., Simon, P., Moffa, F., Delbaere, A., & Englert, Y. (2010). Birth of a second healthy girl more than 3 years after cryopreserved ovarian graft. Human Reproduction, 25(6), 1590–1591.PubMedCrossRef

34.

Demeestere, I., Simon, P., Dedeken, L., Moffa, F., Tsépélidis, S., Brachet, C., Delbaere, A., Devreker, F., & Ferster, A. (2015). Live birth after autograft of ovarian tissue cryopreserved during childhood. Human Reproduction. doi:10.1093/humrep/dev128.

35.

Donnez, J., Dolmans, M. M., Demylle, D., Jadoul, P., Pirard, C., Squifflet, J., Martinez-Madrid, B., & van Langendonckt, A. (2004). Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet, 364(9443), 1405–1410.PubMedCrossRef

36.

Donnez, J., Martinez-Madrid, B., Jadoul, P., Van Langendonckt, A., Demylle, D., & Dolmans, M. M. (2006). Ovarian tissue cryopreservation and transplantation: a review. Human Reproduction Update, 12, 519–535.PubMedCrossRef

37.

Donnez, J., Jadoul, P., Squifflet, J., Van Langendonckt, A., Donnez, O., van Eyck, A. S., et al. (2010). Ovarian tissue cryopreservation and transplantation in cancer patients. Best Pract Res Clin Obstet Gynecol, 24, 87–100.CrossRef

38.

Donnez, J., Silber, S., Andersen, C. Y., Demeestere, I., Piver, P., Meirow, D., Pellicer, A., & Dolmans, M. M. (2011). Children born after autotransplantation of cryopreserved ovarian tissue. a review of 13 live births. Annals of Medicine, 43, 437–450.PubMedCrossRef

39.

Donnez, J., Squifflet, J., Jadoul, P., Demylle, D., Cheron, A.C., Van Langendonckt, A., Dolmans, M.M. (2011). Pregnancy and live birth after autotransplantation of frozen-thawed ovarian tissue in a patient with metastatic disease undergoing chemotherapy and hematopoietic stem cell transplantation. Fertility and Sterility, 95(5), 1787.e1-4.

40.

Donnez, J., Jadoul, P., Pirard, C., Hutchings, G., Demylle, D., Squifflet, J., Smitz, J., & Dolmans, M. M. (2012). Live birth after transplantation of frozen-thawed ovarian tissue after bilateral oophorectomy for benign disease. Fertility and Sterility, 98(3), 720–725.PubMedCrossRef

41.

Donnez, J., Dolmans, M. M., Pellicer, A., Diaz-Garcia, C., Sanchez Serrano, M., Schmidt, K. T., Ernst, E., Luyckx, V., & Andersen, C. Y. (2013). Restoration of ovarian activity and pregnancy after transplantation of cryopreserved ovariantissue: a review of 60 cases of reimplantation. Fertility and Sterility, 99(6), 1503–1513.PubMedCrossRef

42.

Meirow, D., Levron, J., Eldar-Geva, T., Hardan, I., Fridman, E., Zalel, Y., Schiff, E., & Dor, J. (2005). Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy. New England Journal of Medicine, 353(3), 318–821.PubMedCrossRef

43.

Meirow, D., Levron, J., Eldar-Geva, T., Hardan, I., Fridman, E., Yemini, Z., Dor, J. (2007). Monitoring the ovaries after autotransplantation of cryopreserved ovarian tissue: endocrinestudies, in vitro fertilization cycles, and live birth. Fertility and Sterility, 87(2), 418.e7-418.e15.

44.

Revel, A., Laufer, N., Ben Meir, A., Lebovich, M., & Mitrani, E. (2011). Micro-organ ovarian transplantation enables pregnancy: a case report. Human Reproduction, 26, 1097–1105.PubMedCrossRef

45.

Burmeister, L., Kovacs, G. T., & Osianlis, T. (2013). First Australian pregnancy after ovarian tissue cryopreservation and subsequent autotransplantation. Medical Journal of Australia, 198(3), 158–159.PubMedCrossRef

46.

Sánchez-Serrano, M., Crespom, J., Mirabet, V., Cobo, A.C., Escribá, M.J., Simón, C., Pellicer, A. (2010). Twins born after transplantation of ovarian cortical tissue and oocyte vitrification. Fertility and Sterility, 93(1), 268.e11-13.

47.

García Rada, A. (2012). Spanish woman becomes pregnant through ovarian tissue transplantation. BMJ, 344, d8350. doi:10.1136/bmj.d8350.

48.

Piver, P., Amiot, C., Agnani, G., Pech, J., Rohrlich, P.S., Vidal, E, et al. (2009). Two pregnancies obtained after a new technique of autotransplantation of cryopreserved ovarian tissue. In: 25th Annual Meeting of ESHRE, 28 June – 1 July, 2009 (pp. i15). Amsterdam, the Netherlands: Oxford University Press, Hum Reprod.

49.

Roux, C., Amiot, C., Agnani, G., Aubard, Y., Rohrlich, P.S., Piver, P. (2010). Live birth after ovarian tissue autograft in a patient with sickle cell disease treated by allogeneic bone marrow transplantation. Fertility and Sterility, 93, 2413.e15–19.

50.

Revelli, A., Marchino, G., Dolfin, E., Molinari, E., Delle Piane, L., Salvagno, F., & Benedetto, C. (2013). Live birth after orthotopic grafting of autologous cryopreserved ovarian tissue and spontaneous conception in Italy. Fertility and Sterility, 99, 227–230.PubMedCrossRef

51.

Dittrich, R., Lotz, L., Keck, G., Hoffmann, I., Mueller, A., Beckmann, M. W., van der Ven, H., & Montag, M. (2012). Live birth after ovarian tissue autotransplantation following overnight transportation before cryopreservation. Fertility and Sterility, 97, 387–390.PubMedCrossRef

52.

Dittrich, R., Hackl, J., Lotz, L., Hoffmann, I., & Beckmann, M. W. (2015). Pregnancies and live births after 20 transplantations of cryopreserved ovarian tissue in a single center. Fertility and Sterility, 103(2), 462–468.PubMedCrossRef

53.

Silber, S. J., DeRosa, M., Pineda, J., Lenahan, K., Grenia, D., Gorman, K., & Gosden, R. G. (2008). A series of monozygotic twins discordant for ovarian failure: ovary transplantation (cortical versus microvascular) and cryopreservation. Human Reproduction, 23, 1531–1537.PubMedCrossRef

54.

Silber, S., Kagawa, N., Kuwayama, M., & Gosden, R. (2010). Duration of fertility after fresh and frozen ovary transplantation. Fertility and Sterility, 94, 2191–2196.PubMedCrossRef

55.

Silber, S. J. (2012). Ovary cryopreservation and transplantation for fertility preservation. Molecular Human Reproduction, 18(2), 59–67.PubMedCrossRef

56.

Stoop, D., Cobo, A., & Silber, S. (2014). Fertility preservation for age-related fertility decline. Lancet, 4;384(9950), 1311–1319.CrossRef

57.

Rodriguez-Wallberg, K. A., Karlström, P. O., Rezapour, M., Castellanos, E., Hreinsson, J., Rasmussen, C., Sheikhi, M., Ouvrier, B., Bozóky, B., Olofsson, J. I., Lundqvist, M., & Hovatta, O. (2015). Full-term newborn after repeated ovarian tissue transplants in a patient treated for Ewing sarcoma by sterilizing pelvic irradiation and chemotherapy. Acta Obstetricia et Gynecologica Scandinavica, 94(3), 324–328.PubMedPubMedCentralCrossRef

58.

Kawamura, K., Cheng, Y., Suzuki, N., Deguchi, M., Sato, Y., Takae, S., Ho, C. H., Kawamura, N., Tamura, M., Hashimoto, S., Sugishita, Y., Morimoto, Y., Hosoi, Y., Yoshioka, N., Ishizuka, B., & Hsueh, A. J. (2013). Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment. Proceedings of the National Academy of Sciences of the United States of America, 110(43), 17474–17479.PubMedCentralPubMedCrossRef

59.

Suzuki, N., Yoshioka, N., Takae, S., Sugishita, Y., Tamura, M., Hashimoto, S., Morimoto, Y., & Kawamura, K. (2015). Successful fertility preservation following ovarian tissue vitrification in patients with primary ovarian insufficiency. Human Reproduction, 30(3), 608–615.PubMedCrossRef

60.

Stern, C. J., Gook, D., Hale, L. G., Agresta, F., Oldham, J., Rozen, G., & Jobling, T. (2014). Delivery of twins following heterotopic grafting of frozen-thawed ovarian tissue. Human Reproduction, 29(8), 1828.PubMedCrossRef

61.

Wallace, W. H., Smith, A. G., Kelsey, T. W., Edgar, A. E., & Anderson, R. A. (2014). Fertility preservation for girls and young women with cancer: population-based validation of criteria for ovarian tissue cryopreservation. Lancet Oncology, 15(10), 1129–1136.PubMedCrossRef

62.

Isachenko, E., Isachenko, V., Nawroth, F., Rahimi, G., & Weiss, J. M. (2009). Effect of long-term exposure at suprazero temperatures on activity and viability of human ovarian cortex. Fertility and Sterility, 91(4 Suppl), 1556–1559.PubMedCrossRef

63.

von Wolff, M., Donnez, J., Hovatta, O., Keros, V., Maltaris, T., Montag, M., Salle, B., Sonmezer, M., & Andersen, C. Y. (2009). Cryopreservation and autotransplantation of human ovarian tissue prior to cytotoxic therapy - a technique in its infancy but already successful in fertility preservation. European Journal of Cancer, 45(9), 1547–1553.CrossRef

64.

Hovatta, O. (2005). Methods for cryopreservation of human ovarian tissue. Reproductive Biomedicine Online, 10(6), 729–734.PubMedCrossRef

65.

Jeong, K., Aslan, E., Ozkaya, E., Sonmezer, M., & Oktay, K. (2012). Ovarian cryopreservation. Minerva Medica, 103(1), 37–46.PubMed

66.

Sarnacki, S. (2014). Ovarian tissue cryopreservation in children with cancer. Lancet Oncology, 15(10), 1049–1050.PubMedCrossRef

67.

Isachenko, V., Isachenko, E., & Weiss, J. M. (2009). Human ovarian tissue: vitrification versus conventional freezing. Human Reproduction, 24(7), 1767–1768. author reply 1768–1769.PubMedCrossRef

68.

Isachenko, V., Lapidus, I., Isachenko, E., Krivokharchenko, A., Kreienberg, R., Woriedh, M., Bader, M., & Weiss, J. M. (2009). Human ovarian tissue vitrification versus conventional freezing: morphological, endocrinological, and molecular biological evaluation. Reproduction, 138(2), 319–327.PubMedCrossRef

69.

Keros, V., Xella, S., Hultenby, K., Pettersson, K., Sheikhi, M., Volpe, A., Hreinsson, J., & Hovatta, O. (2009). Vitrification versus controlled-rate freezing in cryopreservation of human ovarian tissue. Human Reproduction, 24(7), 1670–1683.PubMedCrossRef

70.

Amorim, C. A., Curaba, M., Van Langendonckt, A., Dolmans, M. M., & Donnez, J. (2011). Vitrification as an alternative means of cryopreserving ovarian tissue. Reproductive Biomedicine Online, 23(2), 160–186.PubMedCrossRef

71.

Klocke, S., Bündgen, N., Köster, F., Eichenlaub-Ritter, U., & Griesinger, G. (2015). Slow-freezing versus vitrification for human ovarian tissue cryopreservation. Archives of Gynecology and Obstetrics, 291(2), 419–426.PubMedCrossRef

72.

Fatemi, H.M., Kyrou, D., Al-Azemi, M., Stoop, D., De Sutter, P., Bourgain, C., Devroey, P. (2011). Ex-vivo oocyte retrieval for fertility preservation. Fertility and Sterility, 95(5), 1787.e15-17.

73.

Bocca, S., Dedmond, D., Jones, E., Stadtmauer, L., & Oehninger, S. (2011). Successful extracorporeal mature oocyte harvesting after laparoscopic oophorectomy following controlled ovarian hyperstimulation for the purpose of fertility preservation in a patient with borderline ovarian tumor. Journal of Assisted Reproduction and Genetics, 28(9), 771–772.PubMedCentralPubMedCrossRef

74.

Escribá, M. J., Grau, N., Escrich, L., Novella-Maestre, E., & Sánchez-Serrano, M. (2012). Spontaneous in vitro maturation of oocytes prior to ovarian tissue cryopreservation in natural cycles of oncologic patients. Journal of Assisted Reproduction and Genetics, 29(11), 1261–1265.PubMedCentralPubMedCrossRef

75.

Prasath, E. B., Chan, M. L., Wong, W. H., Lim, C. J., Tharmalingam, M. D., Hendricks, M., Loh, S. F., & Chia, Y. N. (2014). First pregnancy and live birth resulting from cryopreserved embryos obtained from in vitro matured oocytes after oophorectomy in an ovarian cancer patient. Human Reproduction, 29(2), 276–278.PubMedCrossRef

76.

Fabbri, R., Pasquinelli, G., Keane, D., Mozzanega, B., Magnani, V., Tamburini, F., & Venturoli, S. (2009). Culture of cryopreserved ovarian tissue: state of the art in 2008. Fertility and Sterility, 91(5), 1619–1629.PubMedCrossRef

77.

Meirow, D., Hardan, I., Dor, J., Fridman, E., Elizur, S., Ra’anani, H., Slyusarevsky, E., Amariglio, N., Schiff, E., Rechavi, G., Nagler, A., & Yehuda, B. D. (2008). Searching for evidence of disease and malignant cell contamination in ovarian tissue stored from hematologic cancer patients. Human Reproduction, 23(5), 1007–1013.PubMedCrossRef

78.

Rosendahl, M., Andersen, M. T., Ralfkiær, E., Kjeldsen, L., Andersen, M. K., & Andersen, C. Y. (2010). Evidence of residual disease in cryopreserved ovarian cortex from female patients with leukemia. Fertility and Sterility, 94(6), 2186–2190.PubMedCrossRef

79.

Rosendahl, M., Timmermans Wielenga, V., Nedergaard, L., Kristensen, S. G., Ernst, E., Rasmussen, P. E., Anderson, M., Schmidt, K. T., & Andersen, C. Y. (2011). Cryopreservation of ovarian tissue for fertility preservation: no evidence of malignant cell contamination in ovarian tissue from patients with breast cancer. Fertility and Sterility, 95(6), 2158–2161.PubMedCrossRef

80.

Bastings, L., Liebenthron, J., Westphal, J. R., Beerendonk, C. C., van der Ven, H., Meinecke, B., Montag, M., Braat, D. D., & Peek, R. (2014). Efficacy of ovarian tissue cryopreservation in a major European center. Journal of Assisted Reproduction and Genetics, 31(8), 1003–1012.PubMedCentralPubMedCrossRef

81.

Gook, D. A., Edgar, D. H., Borg, J., Archer, J., & McBain, J. C. (2005). Diagnostic assessment of the developmental potential of human cryopreserved ovarian tissue from multiple patients using xenografting. Human Reproduction, 20(1), 72–78.PubMedCrossRef

82.

Schubert, B., Canis, M., Darcha, C., Artonne, C., Smitz, J., & Grizard, G. (2008). Follicular growth and estradiol follow-up after subcutaneous xenografting of fresh and cryopreserved human ovarian tissue. Fertility and Sterility, 89(6), 1787–1794.PubMedCrossRef

83.

Dittrich, R., Lotz, L., Fehm, T., Krüssel, J., von Wolff, M., Toth, B., van der Ven, H., Schüring, A. N., Würfel, W., Hoffmann, I., & Beckmann, M. W. (2015). Xenotransplantation of cryopreserved human ovarian tissue-a systematic review of MII oocyte maturation and discussion of it as a realistic option for restoring fertility after cancer treatment. Fertility and Sterility, 103(6), 1557–1565.PubMedCrossRef

84.

Macklon, K. T., Ernst, E., Andersen, A. N., & Andersen, C. Y. (2014). Cryobanking of human ovarian tissue: do women still want their tissue stored beyond 5 years? Reproductive Biomedicine Online, 29(4), 452–456.PubMedCrossRef

85.

Demeestere, I., Simon, P., Emiliani, S., Delbaere, A., & Englert, Y. (2009). Orthotopic and heterotopic ovarian tissue transplantation. Human Reproduction Update, 15(6), 649–665.PubMedCentralPubMedCrossRef

86.

Sonmezer, M., & Oktay, K. (2010). Orthotopic and heterotopic ovarian tissue transplantation. Best Practice & Research. Clinical Obstetrics & Gynaecology, 24(1), 113–126.CrossRef

87.

Gamzatova, Z., Komlichenko, E., Kostareva, A., Galagudza, M., Ulrikh, E., Zubareva, T., Sheveleva, T., Nezhentseva, E., & Kalinina, E. (2014). Autotransplantation of cryopreserved ovarian tissue—effective method of fertility preservation in cancer patients. Gynecological Endocrinology, 30(Suppl 1), 43–47.PubMedCrossRef

88.

Donnez, J., & Dolmans, M. M. (2014). Transplantation of ovarian tissue. Best Practice & Research. Clinical Obstetrics & Gynaecology, 28(8), 1188–1197.CrossRef

89.

Meirow, D., Ra’anani, H., & Biderman, H. (2014). Ovarian tissue cryopreservation and transplantation: a realistic, effective technology for fertility preservation. Methods in Molecular Biology, 1154, 455–473.PubMedCrossRef

90.

Silber, S., Pineda, J., Lenahan, K., DeRosa, M., & Melnick, J. (2015). Fresh and cryopreserved ovary transplantation and resting follicle recruitment. Reproductive Biomedicine Online, 30(6), 643–650.PubMedCrossRef

91.

Oktay, K., Türkçüoğlu, I., Rodriguez-Wallberg, K.A. (2011). Four spontaneous pregnancies and three live births following subcutaneous transplantation of frozen banked ovarian tissue: what is the explanation? Fertility and Sterility, 95(2), 804.e7-10.

92.

Yang, H., Heun Lee, H., Chang Lee, H., Sung Ko, D., & Kim, S. S. (2008). Assessment of vascular endothelial growth factor expression and apoptosis in the ovarian graft: can exogenous gonadotropin promote angiogenesis after transplantation? Fertility and Sterility, 90(4 Suppl), 1550–1558.PubMedCrossRef

93.

Rahimi, G., Isachenko, V., Kreienberg, R., Sauer, H., Todorov, P., Tawadros, S., Mallmann, P., Nawroth, F., & Isachenko, E. (2010). Re-vascularisation in human ovarian tissue after conventional freezing or vitrification and xenotransplantation. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 149(1), 63–67.PubMedCrossRef

94.

Van Eyck, A. S., Bouzin, C., Feron, O., Romeu, L., Van Langendonckt, A., Donnez, J., & Dolmans, M. M. (2010). Both host and graft vessels contribute to revascularization of xenografted human ovarian tissue in a murine model. Fertility and Sterility, 93(5), 1676–1685.PubMedCrossRef

95.

Soleimani, R., Heytens, E., Oktay, K. (2011). Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants. PLoS One, 6(4), e19475.

96.

Friedman, O., Orvieto, R., Fisch, B., Felz, C., Freud, E., Ben-Haroush, A., & Abir, R. (2012). Possible improvements in human ovarian grafting by various host and graft treatments. Human Reproduction, 27(2), 474–482.PubMedCrossRef

97.

Xia, X., Yin, T., Yan, J., Yan, L., Jin, C., Lu, C., Wang, T., Zhu, X., Zhi, X., Wang, J., Tian, L., Liu. J, Li, R., Qiao, J. (2015). Mesenchymal stem cells enhance angiogenesis and follicle survival in human cryopreserved ovarian cortex transplantation. Cell Transplantation, 24(10), 1999–2010.

98.

Rosendahl, M., Greve, T., & Andersen, C. Y. (2013). The safety of transplanting cryopreserved ovarian tissue in cancer patients: a review of the literature. Journal of Assisted Reproduction and Genetics, 30(1), 11–24.PubMedCentralPubMedCrossRef

99.

Bastings, L., Beerendonk, C. C., Westphal, J. R., Massuger, L. F., Kaal, S. E., van Leeuwen, F. E., Braat, D. D., & Peek, R. (2013). Autotransplantation of cryopreserved ovarian tissue in cancer survivors and the risk of reintroducing malignancy: a systematic review. Human Reproduction Update, 19(5), 483–506.PubMedCrossRef

100.

Dolmans, M. M., Luyckx, V., Donnez, J., Andersen, C. Y., & Greve, T. (2013). Risk of transferring malignant cells with transplanted frozen-thawed ovarian tissue. Fertility and Sterility, 99(6), 1514–1522.PubMedCrossRef

101.

Silber, S. J., Woodruff, T. K., & Shea, L. D. (2010). To transplant or not to transplant—that is the question. Cancer Treatment and Research, 156, 41–54.PubMedCentralPubMedCrossRef

102.

Berwanger, A. L., Finet, A., El Hachem, H., le Parco, S., Hesters, L., & Grynberg, M. (2012). New trends in female fertility preservation: in vitro maturation of oocytes. Future Oncology, 8(12), 1567–1573.PubMedCrossRef

103.

Chian, R. C., Uzelac, P. S., & Nargund, G. (2013). In vitro maturation of human immature oocytes for fertility preservation. Fertility and Sterility, 99(5), 1173–1181.PubMedCrossRef

104.

Baird, D. T., Campbell, B., de Souza, C., & Telfer, E. (2004). Long-term ovarian function in sheep after ovariectomy and autotransplantation of cryopreserved cortical strips. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 113(Suppl 1), S55–S59.PubMedCrossRef

105.

Shaw, J. M., & Trounson, A. O. (2002). Experimental models for ovarian tissue and immature follicles. Seminars in Reproductive Medicine, 20(1), 51–62.PubMedCrossRef

106.

Oktay, K., Buyuk, E., Veeck, L., Zaninovic, N., Xu, K., Takeuchi, T., Opsahl, M., & Rosenwaks, Z. (2004). Embryo development after heterotopic transplantation of cryopreserved ovarian tissue. Lancet, 363(9412), 837–840.PubMedCrossRef

107.

Rosendahl, M., Loft, A., Byskov, A. G., Ziebe, S., Schmidt, K. T., Andersen, A. N., Ottosen, C., & Andersen, C. Y. (2006). Biochemical pregnancy after fertilization of an oocyte aspirated from a heterotopic autotransplant of cryopreserved ovarian tissue: case report. Human Reproduction, 21(8), 2006–2009.PubMedCrossRef

108.

Stern, C. J., Gook, D., Hale, L. G., Agresta, F., Oldham, J., Rozen, G., & Jobling, T. (2013). First reported clinical pregnancy following heterotopic grafting of cryopreserved ovarian tissue in a woman after a bilateral oophorectomy. Human Reproduction, 28(11), 2996–2999.PubMedCrossRef

109.

Lee, D. M., Yeoman, R. R., Battaglia, D. E., Stouffer, R. L., Zelinski-Wooten, M. B., Fanton, J. W., & Wolf, D. P. (2004). Live birth after ovarian tissue transplant. Nature, 428(6979), 137–138.PubMedCrossRef

110.

Bedaiwy, M. A., Hussein, M. R., Biscotti, C., & Falcone, T. (2006). Cryopreservation of intact human ovary with its vascular pedicle. Human Reproduction, 21(12), 3258–3269.PubMedCrossRef

111.

Martinez-Madrid, B., Camboni, A., Dolmans, M. M., Nottola, S., Van Langendonckt, A., & Donnez, J. (2007). Apoptosis and ultrastructural assessment after cryopreservation of whole human ovaries with their vascular pedicle. Fertility and Sterility, 87(5), 1153–1165.PubMedCrossRef

112.

Jadoul, P., Donnez, J., Dolmans, M. M., Squifflet, J., Lengele, B., & Martinez-Madrid, B. (2007). Laparoscopic ovariectomy for whole human ovary cryopreservation: technical aspects. Fertility and Sterility, 87(4), 971–975.PubMedCrossRef

113.

Bedaiwy, M. A., Shahin, A. Y., & Falcone, T. (2008). Reproductive organ transplantation: advances and controversies. Fertility and Sterility, 90(6), 2031–2055.PubMedCrossRef

114.

Silber, S. J. (2009). Fresh ovarian tissue and whole ovary transplantation. Seminars in Reproductive Medicine, 27(6), 479–485.PubMedCrossRef

115.

Bromer, J. G., & Patrizio, P. (2009). Fertility preservation: the rationale for cryopreservation of the whole ovary. Seminars in Reproductive Medicine, 27(6), 465–471.PubMedCrossRef

116.

Kim, S. S. (2010). Time to re-think: ovarian tissue transplantation versus whole ovary transplantation. Reproductive Biomedicine Online, 20(2), 171–174.PubMedCrossRef

117.

Bedaiwy, M. A., & Falcone, T. (2010). Whole ovary transplantation. Clinical Obstetrics and Gynecology, 53(4), 797–803.PubMedCrossRef

118.

Zhang, J. M., Sheng, Y., Cao, Y. Z., Wang, H. Y., & Chen, Z. J. (2011). Cryopreservation of whole ovaries with vascular pedicles: vitrification or conventional freezing? Journal of Assisted Reproduction and Genetics, 28(5), 445–452.PubMedCentralPubMedCrossRef

119.

Bedaiwy, M. A., & Falcone, T. (2007). Harvesting and autotransplantation of vascularized ovarian grafts: approaches and techniques. Reproductive Biomedicine Online, 14(3), 360–371.PubMedCrossRef

120.

Wang, X., Chen, H., Yin, H., Kim, S. S., Lin Tan, S., & Gosden, R. G. (2002). Fertility after intact ovary transplantation. Nature, 415(6870), 385.PubMedCrossRef

121.

Silber, S. J., Grudzinskas, G., & Gosden, R. G. (2008). Successful pregnancy after microsurgical transplantation of an intact ovary. New England Journal of Medicine, 359, 2617–2618.PubMedCrossRef

122.

Salle, B., Demirci, B., Franck, M., Rudigoz, R. C., Guerin, J. F., & Lornage, J. (2002). Normal pregnancies and live births after autograft of frozen-thawed hemiovaries into ewes. Fertility and Sterility, 77(2), 403–408.PubMedCrossRef

123.

Imhof, M., Hofstetter, G., Bergmeister, H., Rudas, M., Kain, R., Lipovac, M., & Huber, J. (2004). Cryopreservation of a whole ovary as a strategy for restoring ovarian function. Journal of Assisted Reproduction and Genetics, 21(12), 459–965.PubMedCentralPubMedCrossRef

124.

Imhof, M., Bergmeister, H., Lipovac, M., Rudas, M., Hofstetter, G., & Huber, J. (2006). Orthotopic microvascular reanastomosis of whole cryopreserved ovine ovaries resulting in pregnancy and live birth. Fertility and Sterility, 85(Suppl 1), 1208–1215.PubMedCrossRef

125.

Courbiere, B., Caquant, L., Mazoyer, C., Franck, M., Lornage, J., & Salle, B. (2009). Difficulties improving ovarian functional recovery by microvascular transplantation and whole ovary vitrification. Fertility and Sterility, 91(6), 2697–2706.PubMedCrossRef

126.

Shikanov, A., Smith, R. M., Xu, M., Woodruff, T. K., & Shea, L. D. (2011). Hydrogel network design using multifunctional macromers to coordinate tissue maturation inovarian follicle culture. Biomaterials, 32(10), 2524–2531.PubMedCentralPubMedCrossRef

127.

Vanacker, J., Luyckx, V., Dolmans, M. M., Des Rieux, A., Jaeger, J., Van Langendonckt, A., Donnez, J., & Amorim, C. A. (2012). Transplantation of an alginate-matrigel matrix containing isolated ovarian cells: first step in developing a biodegradable scaffold to transplant isolated preantral follicles and ovarian cells. Biomaterials, 33(26), 6079–6085.PubMedCrossRef

128.

Luyckx, V., Dolmans, M. M., Vanacker, J., Scalercio, S. R., Donnez, J., & Amorim, C. A. (2013). First step in developing a 3D biodegradable fibrin scaffold for an artificial ovary. J Ovarian Res, 6(1), 83.PubMedCentralPubMedCrossRef

129.

Luyckx, V., Dolmans, M. M., Vanacker, J., Legat, C., Fortuño Moya, C., Donnez, J., & Amorim, C. A. (2014). A new step toward the artificial ovary: survival and proliferation of isolated murine follicles after autologous transplantation in a fibrin scaffold. Fertility and Sterility, 101(4), 1149–1156.PubMedCrossRef

130.

Shea, L. D., Woodruff, T. K., & Shikanov, A. (2014). Bioengineering the ovarian follicle microenvironment. Annual Review of Biomedical Engineering, 16, 29–52.PubMedCentralPubMedCrossRef

131.

Soares, M., Sahrari, K., Chiti, M.C., Amorim, C.A., Ambroise, J., Donnez, J., Dolmans, M.M. (2015). The best source of isolated stromal cells for the artificial ovary: medulla or cortex, cryopreserved or fresh? Human Reproduction, 30(7), 1589–1598.

132.

Woodruff, T. K., & Shea, L. D. (2007). The role of the extracellular matrix in ovarian follicle development. Reproductive Sciences, 14(8 Suppl), 6–10.PubMedCentralPubMedCrossRef

133.

West, E. R., Shea, L. D., & Woodruff, T. K. (2007). Engineering the follicle microenvironment. Seminars in Reproductive Medicine, 25(4), 287–299.PubMedCentralPubMedCrossRef

134.

Smith, R. M., Woodruff, T. K., & Shea, L. D. (2010). Designing follicle-environment interactions with biomaterials. Cancer Treatment and Research, 156, 11–24.PubMedCentralPubMedCrossRef

135.

Smitz, J., Dolmans, M. M., Donnez, J., Fortune, J. E., Hovatta, O., Jewgenow, K., Picton, H. M., Plancha, C., Shea, L. D., Stouffer, R. L., Telfer, E. E., Woodruff, T. K., & Zelinski, M. B. (2010). Current achievements and future research directions in ovarian tissue culture, in vitro follicle development and transplantation: implications for fertility preservation. Human Reproduction Update, 16(4), 395–414.PubMedCentralPubMedCrossRef

136.

Xu, M., Barrett, S. L., West-Farrell, E., Kondapalli, L. A., Kiesewetter, S. E., Shea, L. D., & Woodruff, T. K. (2009). In vitro grown human ovarian follicles from cancer patients support oocyte growth. Human Reproduction, 24(10), 2531–2540.PubMedCentralPubMedCrossRef

137.

Amorim, C. A., van Langendonckt, A., David, A., Dolmans, M. M., & Donnez, J. (2009). Survival of human pre-antral follicles after cryopreservation of ovarian tissue, follicular isolation and in vitro culture in a calcium alginate matrix. Human Reproduction, 24(1), 92–99.PubMedCrossRef

138.

Dolmans, M. M., Martinez-Madrid, B., Gadisseux, E., Guiot, Y., Yuan, W. Y., Torre, A., Camboni, A., Van Langendonckt, A., & Donnez, J. (2007). Short-term transplantation of isolated human ovarian follicles and cortical tissue into nude mice. Reproduction, 134(2), 253–262.PubMedCrossRef

139.

Dolmans, M. M., Yuan, W. Y., Camboni, A., Torre, A., Van Langendonckt, A., Martinez-Madrid, B., & Donnez, J. (2008). Development of antral follicles after xenografting of isolated small human preantral follicles. Reproductive Biomedicine Online, 16(5), 705–711.PubMedCrossRef

140.

Ting, A. Y., Yeoman, R. R., Lawson, M. S., & Zelinski, M. B. (2011). In vitro development of secondary follicles from cryopreserved rhesus macaque ovarian tissue after slow-rate freeze or vitrification. Human Reproduction, 26(9), 2461–2472.PubMedCentralPubMedCrossRef

141.

Ting, A. Y., Yeoman, R. R., Campos, J. R., Lawson, M. S., Mullen, S. F., Fahy, G. M., & Zelinski, M. B. (2013). Morphological and functional preservation of pre-antral follicles after vitrification of macaque ovarian tissue in a closed system. Human Reproduction, 28(5), 1267–1279.PubMedCentralPubMedCrossRef

142.

Xu, J., Lawson, M. S., Yeoman, R. R., Pau, K. Y., Barrett, S. L., Zelinski, M. B., & Stouffer, R. L. (2011). Secondary follicle growth and oocyte maturation during encapsulated three-dimensional culture in rhesus monkeys: effects of gonadotrophins, oxygen and fetuin. Human Reproduction, 26(5), 1061–1072.PubMedCentralPubMedCrossRef

143.

Xu, M., Fazleabas, A. T., Shikanov, A., Jackson, E., Barrett, S. L., Hirshfeld-Cytron, J., Kiesewetter, S. E., Shea, L. D., & Woodruff, T. K. (2011). In vitro oocyte maturation and preantral follicle culture from the luteal-phase baboon ovary produce mature oocytes. Biology of Reproduction, 84(4), 689–697.PubMedCentralPubMedCrossRef

144.

Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D. M., Forman, D., & Bray, F. (2014). Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer, 136, E359–E386.CrossRef

145.

Siegel, R., Ma, J., Zou, Z., & Jemal, A. (2014). Cancer statistics, 2014. CA: A Cancer Journal for Clinicians, 64, 9–29.

146.

Ward, E., DeSantis, C., Robbins, A., Kohler, B., & Jemal, A. (2014). Childhood and adolescent cancer statistics, 2014. CA: A Cancer Journal for Clinicians, 64(2), 83–103.

147.

Magelssen, H., Melve, K. K., Skjaerven, R., & Fosså, S. D. (2008). Parenthood probability and pregnancy outcome in patients with a cancer diagnosis during adolescence and young adulthood. Human Reproduction, 23, 178–186.PubMedCrossRef

148.

Mueller, B. A., Chow, E. J., Kamineni, A., Daling, J. R., Fraser, A., Wiggins, C. L., Mineau, G. P., Hamre, M. R., Severson, R. K., & Drews-Botsch, C. (2009). Pregnancy outcomes in female childhood and adolescent cancer survivors: a linked cancer-birth registry analysis. Archives of Pediatrics & Adolescent Medicine, 163(10), 879–886.CrossRef

149.

Stensheim, H., Cvancarova, M., Møller, B., & Fosså, S. D. (2011). Pregnancy after adolescent and adult cancer: a population-based matched cohort study. International Journal of Cancer, 129, 1225–1236.CrossRef

150.

Meirow, D., & Nugent, D. (2001). The effects of radiotherapy and chemotherapy on female reproduction. Human Reproduction Update, 7(6), 534–543.CrossRef

151.

Green, D. M., Sklar, C. A., Boice, J. D., Jr., Mulvihill, J. J., Whitton, J. A., Stovall, M., & Yasui, Y. (2009). Ovarian failure and reproductive outcomes after childhood cancer treatment: results from the Childhood Cancer Survivor Study. Journal of Clinical Oncology, 27(14), 2374–2381.PubMedCentralPubMedCrossRef

152.

Shelling, A. N. (2010). Premature ovarian failure. Reproduction, 140(5), 633–641.PubMedCrossRef

153.

Stroud, J. S., Mutch, D., Rader, J., Powell, M., Thaker, P. H., & Grigsby, P. W. (2009). Effects of cancer treatment on ovarian function. Fertility and Sterility, 92(2), 417–427.PubMedCrossRef

154.

Meirow, D., Biederman, H., Anderson, R. A., & Wallace, W. (2010). Toxicity of chemotherapy and radiation on female reproduction. Clinical Obstetrics and Gynecology, 53, 727–739.PubMedCrossRef

155.

von Wolff, M., Germeyer, A., & Nawroth, F. (2015). Fertility preservation for non-medical reasons: controversial, but increasingly common. Deutsches Ärzteblatt International, 112(3), 27–32.

156.

Xu, J., Xu, M., Bernuci, M. P., Fisher, T. E., Shea, L. D., Woodruff, T. K., Zelinski, M. B., & Stouffer, R. L. (2013). Primate follicular development and oocyte maturation in vitro. Advances in Experimental Medicine & Biology, 761, 43–67.CrossRef

157.

Telfer, E. E., & Zelinski, M. B. (2013). Ovarian follicle culture: advances and challenges for human and nonhuman primates. Fertility and Sterility, 99(6), 1523–1533.PubMedCentralPubMedCrossRef

158.

Chung, K., Donnez, J., Ginsburg, E., & Meirow, D. (2013). Emergency IVF versus ovarian tissue cryopreservation: decision making in fertility preservation for female cancer patients. Fertility and Sterility, 99(6), 1534–1542.PubMedCrossRef

159.

Dittrich, R., Lotz, L., Mueller, A., Hoffmann, I., Wachter, D. L., Amann, K. U., Beckmann, M. W., & Hildebrandt, T. (2013). Oncofertility: combination of ovarian stimulation with subsequent ovarian tissue extractionon the day of oocyte retrieval. Reproductive Biology and Endocrinology, 11, 19.PubMedCentralPubMedCrossRef

160.

Salama, M., & Mallmann, P. (2015). Emergency fertility preservation for female patients with cancer: clinical perspectives. Anticancer Research, 35(6), 3117–3127.PubMed

Title: New advances in ovarian autotransplantation to restore fertility in cancer patients
Authors: Mahmoud Salama
Teresa K. Woodruff
Publication date: 01-12-2015
Publisher: Springer US
Published in: Cancer and Metastasis Reviews / Issue 4/2015
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-015-9600-2

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