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Open Access 01-12-2023 | Neuroblastoma | Review

Role of the CASZ1 transcription factor in tissue development and disease

Authors: Tiantian Liu, Tao Li, Shaorui Ke

Published in: European Journal of Medical Research | Issue 1/2023

Abstract

The zinc finger transcription factor gene, CASZ1/Castor (Castor zinc finger 1), initially identified in Drosophila, plays a critical role in neural, cardiac, and cardiovascular development, exerting a complex, multifaceted influence on cell fate and tissue morphogenesis. During neurogenesis, CASZ1 exhibits dynamic expression from early embryonic development to the perinatal period, constituting a key regulator in this process. Additionally, CASZ1 controls the transition between neurogenesis and gliomagenesis. During human cardiovascular system development, CASZ1 is essential for cardiomyocyte differentiation, cardiac morphogenesis, and vascular morphology homeostasis and formation. The deletion or inactivation of CASZ1 mutations can lead to human developmental diseases or tumors, including congenital heart disease, cardiovascular disease, and neuroblastoma. CASZ1 can be used as a biomarker for disease prevention and diagnosis as well as a prognostic indicator for cancer. This review explores the unique functions of CASZ1 in tissue morphogenesis and associated diseases, offering new insights for elucidating the molecular mechanisms underlying diseases and identifying potential therapeutic targets for disease prevention and treatment.

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Title: Role of the CASZ1 transcription factor in tissue development and disease
Authors: Tiantian Liu
Tao Li
Shaorui Ke
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Neuroblastoma
Neuroblastoma
Biomarkers
Published in: European Journal of Medical Research / Issue 1/2023
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/s40001-023-01548-y

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Role of the CASZ1 transcription factor in tissue development and disease

Abstract

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Abstract

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